FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SPP1-CLU (FusionGDB2 ID:85384)

Fusion Gene Summary for SPP1-CLU

check button Fusion gene summary
Fusion gene informationFusion gene name: SPP1-CLU
Fusion gene ID: 85384
HgeneTgene
Gene symbol

SPP1

CLU

Gene ID

30827

1191

Gene nameCXXC finger protein 1clusterin
Synonyms2410002I16Rik|5830420C16Rik|CFP1|CGBP|HsT2645|PCCX1|PHF18|SPP1|ZCGPC1|hCGBPAAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2
Cytomap

18q21.1

8p21.1

Type of geneprotein-codingprotein-coding
DescriptionCXXC-type zinc finger protein 1CXXC finger 1 (PHD domain)CpG binding proteinDNA-binding protein with PHD finger and CXXC domainPHD finger and CXXC domain-containing protein 1cpG-binding proteinzinc finger, CpG binding-type containing 1clusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40epididymis secretory sperm binding proteinku70-binding protein 1sulfated glycoprotein 2testosterone-r
Modification date2020031320200327
UniProtAcc.

Q15846

Ensembl transtripts involved in fusion geneENST00000237623, ENST00000395080, 
ENST00000360804, ENST00000509659, 
ENST00000316403, ENST00000546343, 
ENST00000560366, ENST00000405140, 
ENST00000523500, 
Fusion gene scores* DoF score9 X 6 X 5=27023 X 24 X 12=6624
# samples 930
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/6624*10)=-4.46466826700344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPP1 [Title/Abstract] AND CLU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPP1(88901586)-CLU(27464041), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPP1

GO:0006355

regulation of transcription, DNA-templated

10688657

HgeneSPP1

GO:0045893

positive regulation of transcription, DNA-templated

10688657

HgeneSPP1

GO:0051568

histone H3-K4 methylation

17355966

TgeneCLU

GO:0000902

cell morphogenesis

15857407

TgeneCLU

GO:0001774

microglial cell activation

15857407

TgeneCLU

GO:0017038

protein import

24446231

TgeneCLU

GO:0031333

negative regulation of protein complex assembly

22179788|23106396

TgeneCLU

GO:0031334

positive regulation of protein complex assembly

22179788

TgeneCLU

GO:0032760

positive regulation of tumor necrosis factor production

15857407

TgeneCLU

GO:0045429

positive regulation of nitric oxide biosynthetic process

15857407

TgeneCLU

GO:0050821

protein stabilization

11123922|12176985

TgeneCLU

GO:0051131

chaperone-mediated protein complex assembly

17412999

TgeneCLU

GO:0051788

response to misfolded protein

19996109

TgeneCLU

GO:0061077

chaperone-mediated protein folding

11123922

TgeneCLU

GO:0061518

microglial cell proliferation

15857407

TgeneCLU

GO:1900221

regulation of amyloid-beta clearance

24446231

TgeneCLU

GO:1901214

regulation of neuron death

17412999

TgeneCLU

GO:1901216

positive regulation of neuron death

15857407

TgeneCLU

GO:1902430

negative regulation of amyloid-beta formation

12047389|17412999

TgeneCLU

GO:1905907

negative regulation of amyloid fibril formation

22179788


check buttonFusion gene breakpoints across SPP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-BQ-5876-01ASPP1chr4

88901586

+CLUchr8

27464041

-


Top

Fusion Gene ORF analysis for SPP1-CLU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000237623ENST00000316403SPP1chr4

88901586

+CLUchr8

27464041

-
intron-3CDSENST00000237623ENST00000546343SPP1chr4

88901586

+CLUchr8

27464041

-
intron-3CDSENST00000237623ENST00000560366SPP1chr4

88901586

+CLUchr8

27464041

-
intron-3CDSENST00000237623ENST00000405140SPP1chr4

88901586

+CLUchr8

27464041

-
intron-3CDSENST00000237623ENST00000523500SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000395080ENST00000316403SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000395080ENST00000546343SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000395080ENST00000560366SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000395080ENST00000405140SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000395080ENST00000523500SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000360804ENST00000316403SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000360804ENST00000546343SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000360804ENST00000560366SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000360804ENST00000405140SPP1chr4

88901586

+CLUchr8

27464041

-
In-frameENST00000360804ENST00000523500SPP1chr4

88901586

+CLUchr8

27464041

-
3UTR-3CDSENST00000509659ENST00000316403SPP1chr4

88901586

+CLUchr8

27464041

-
3UTR-3CDSENST00000509659ENST00000546343SPP1chr4

88901586

+CLUchr8

27464041

-
3UTR-3CDSENST00000509659ENST00000560366SPP1chr4

88901586

+CLUchr8

27464041

-
3UTR-3CDSENST00000509659ENST00000405140SPP1chr4

88901586

+CLUchr8

27464041

-
3UTR-3CDSENST00000509659ENST00000523500SPP1chr4

88901586

+CLUchr8

27464041

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395080SPP1chr488901586+ENST00000316403CLUchr827464041-277134341446480
ENST00000395080SPP1chr488901586+ENST00000546343CLUchr827464041-275334341446480
ENST00000395080SPP1chr488901586+ENST00000560366CLUchr827464041-275334341446480
ENST00000395080SPP1chr488901586+ENST00000405140CLUchr827464041-188034341446480
ENST00000395080SPP1chr488901586+ENST00000523500CLUchr827464041-169234341446480
ENST00000360804SPP1chr488901586+ENST00000316403CLUchr827464041-2664236561339427
ENST00000360804SPP1chr488901586+ENST00000546343CLUchr827464041-2646236561339427
ENST00000360804SPP1chr488901586+ENST00000560366CLUchr827464041-2646236561339427
ENST00000360804SPP1chr488901586+ENST00000405140CLUchr827464041-1773236561339427
ENST00000360804SPP1chr488901586+ENST00000523500CLUchr827464041-1585236561339427

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395080ENST00000316403SPP1chr488901586+CLUchr827464041-0.0018788770.9981211
ENST00000395080ENST00000546343SPP1chr488901586+CLUchr827464041-0.0019791340.9980209
ENST00000395080ENST00000560366SPP1chr488901586+CLUchr827464041-0.0019791340.9980209
ENST00000395080ENST00000405140SPP1chr488901586+CLUchr827464041-0.0060134830.9939865
ENST00000395080ENST00000523500SPP1chr488901586+CLUchr827464041-0.0089682050.99103177
ENST00000360804ENST00000316403SPP1chr488901586+CLUchr827464041-0.0013349950.998665
ENST00000360804ENST00000546343SPP1chr488901586+CLUchr827464041-0.001414270.9985857
ENST00000360804ENST00000560366SPP1chr488901586+CLUchr827464041-0.001414270.9985857
ENST00000360804ENST00000405140SPP1chr488901586+CLUchr827464041-0.0040704590.99592954
ENST00000360804ENST00000523500SPP1chr488901586+CLUchr827464041-0.0064424080.99355763

Top

Fusion Genomic Features for SPP1-CLU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SPP1-CLU


check button Go to

FGviewer for the breakpoints of chr4:88901586-chr8:27464041

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLU

Q15846

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLUchr4:88901586chr8:27464041ENST0000031640329443_44782.0450.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST0000040514029443_44782.0450.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST0000052350018443_44782.0450.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST0000054634329443_44793.0461.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST0000056036629443_447134.0502.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPP1chr4:88901586chr8:27464041ENST00000237623+16159_1610301.0MotifNote=Cell attachment site
HgeneSPP1chr4:88901586chr8:27464041ENST00000360804+46159_16145.0288.0MotifNote=Cell attachment site
HgeneSPP1chr4:88901586chr8:27464041ENST00000395080+57159_16172.0315.0MotifNote=Cell attachment site
TgeneCLUchr4:88901586chr8:27464041ENST000003164032978_8182.0450.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST000004051402978_8182.0450.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST000005235001878_8182.0450.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST000005463432978_8193.0461.0MotifNuclear localization signal
TgeneCLUchr4:88901586chr8:27464041ENST000005603662978_81134.0502.0MotifNuclear localization signal


Top

Fusion Gene Sequence for SPP1-CLU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000395080_ENST00000316403_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=2771nt_BP=343nt
AATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCC
TTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACC
AGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAACCCTGACCC
ATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGAC
CAGGGAATCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAA
ACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTC
GCCCTTCTACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGA
CCACTTCAGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCC
CTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCT
GAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCA
GCACCCGCCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGAT
GAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGA
CGAATCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTT
GCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCAC
GGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGAC
GGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGA
GGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTC
TGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGA
CTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCT
TTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGC
AGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTC
AAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATA
AAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTA
CTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTAT
TGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTT
CCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCA
GTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTG
ATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTAT
AGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTA
TTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTAT

>In-frame_ENST00000395080_ENST00000316403_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=480AA_start in transcript=4_stop in transcript=1446
MGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPS
QKQNLLAPQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSP
FYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLN
FHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDE
SLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTV

--------------------------------------------------------------
>In-frame_ENST00000395080_ENST00000546343_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=2753nt_BP=343nt
AATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCC
TTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACC
AGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAACCCTGACCC
ATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGAC
CAGGGAATCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAA
ACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTC
GCCCTTCTACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGA
CCACTTCAGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCC
CTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCT
GAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCA
GCACCCGCCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGAT
GAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGA
CGAATCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTT
GCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCAC
GGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGAC
GGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGA
GGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTC
TGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGA
CTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCT
TTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGC
AGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTC
AAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATA
AAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTA
CTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTAT
TGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTT
CCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCA
GTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTG
ATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTAT
AGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTA
TTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTAT

>In-frame_ENST00000395080_ENST00000546343_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=480AA_start in transcript=4_stop in transcript=1446
MGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPS
QKQNLLAPQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSP
FYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLN
FHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDE
SLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTV

--------------------------------------------------------------
>In-frame_ENST00000395080_ENST00000560366_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=2753nt_BP=343nt
AATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCC
TTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACC
AGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAACCCTGACCC
ATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGAC
CAGGGAATCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAA
ACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTC
GCCCTTCTACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGA
CCACTTCAGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCC
CTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCT
GAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCA
GCACCCGCCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGAT
GAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGA
CGAATCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTT
GCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCAC
GGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGAC
GGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGA
GGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTC
TGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGA
CTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCT
TTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGC
AGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTC
AAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATA
AAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTA
CTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTAT
TGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTT
CCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCA
GTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTG
ATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTAT
AGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTA
TTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTAT

>In-frame_ENST00000395080_ENST00000560366_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=480AA_start in transcript=4_stop in transcript=1446
MGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPS
QKQNLLAPQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSP
FYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLN
FHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDE
SLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTV

--------------------------------------------------------------
>In-frame_ENST00000395080_ENST00000405140_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=1880nt_BP=343nt
AATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCC
TTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACC
AGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAACCCTGACCC
ATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGAC
CAGGGAATCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAA
ACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTC
GCCCTTCTACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGA
CCACTTCAGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCC
CTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCT
GAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCA
GCACCCGCCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGAT
GAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGA
CGAATCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTT
GCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCAC
GGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGAC
GGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGA
GGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTC
TGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGA
CTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCT
TTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGC

>In-frame_ENST00000395080_ENST00000405140_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=480AA_start in transcript=4_stop in transcript=1446
MGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPS
QKQNLLAPQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSP
FYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLN
FHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDE
SLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTV

--------------------------------------------------------------
>In-frame_ENST00000395080_ENST00000523500_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=1692nt_BP=343nt
AATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCC
TTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACC
AGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAACCCTGACCC
ATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGAC
CAGGGAATCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAA
ACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTC
GCCCTTCTACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGA
CCACTTCAGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCC
CTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCT
GAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCA
GCACCCGCCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGAT
GAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGA
CGAATCCCTCCAGGTCGCTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTT
GCTGGAGCAGCTGAACGAGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCAC
GGTGGCTTCCCACACTTCTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGAC
GGTCCCTGTAGAAGTCTCCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGA
GGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTC
TGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGA

>In-frame_ENST00000395080_ENST00000523500_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=480AA_start in transcript=4_stop in transcript=1446
MGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPS
QKQNLLAPQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSP
FYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLN
FHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDE
SLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTV

--------------------------------------------------------------
>In-frame_ENST00000360804_ENST00000316403_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=2664nt_BP=236nt
AGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAA
AACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTT
CTGAGGAAAAGCAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAA
AGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGT
TCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGA
TGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGT
CCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACC
GGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGT
TCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAAT
TCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACA
AGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGACGAATCCCTCCAGGTCG
CTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACG
AGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTT
CTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCT
CCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATG
TTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAA
CCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGA
AGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCT
GCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTAT
AGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTC
AGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTC
TGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCA
TAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTT
TATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTT
TATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAG
CAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATC
AGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTA
AGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCA
AGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTATTTGCTTAAGTGATCATA

>In-frame_ENST00000360804_ENST00000316403_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=427AA_start in transcript=56_stop in transcript=1339
MQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEE
CKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQD
TYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS
TGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQY

--------------------------------------------------------------
>In-frame_ENST00000360804_ENST00000546343_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=2646nt_BP=236nt
AGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAA
AACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTT
CTGAGGAAAAGCAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAA
AGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGT
TCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGA
TGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGT
CCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACC
GGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGT
TCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAAT
TCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACA
AGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGACGAATCCCTCCAGGTCG
CTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACG
AGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTT
CTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCT
CCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATG
TTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAA
CCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGA
AGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCT
GCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTAT
AGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTC
AGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTC
TGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCA
TAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTT
TATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTT
TATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAG
CAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATC
AGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTA
AGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCA
AGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTATTTGCTTAAGTGATCATA

>In-frame_ENST00000360804_ENST00000546343_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=427AA_start in transcript=56_stop in transcript=1339
MQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEE
CKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQD
TYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS
TGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQY

--------------------------------------------------------------
>In-frame_ENST00000360804_ENST00000560366_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=2646nt_BP=236nt
AGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAA
AACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTT
CTGAGGAAAAGCAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAA
AGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGT
TCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGA
TGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGT
CCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACC
GGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGT
TCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAAT
TCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACA
AGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGACGAATCCCTCCAGGTCG
CTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACG
AGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTT
CTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCT
CCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATG
TTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAA
CCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGA
AGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCT
GCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTAT
AGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTC
AGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTC
TGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCA
TAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTT
TATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTT
TATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAG
CAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATC
AGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTA
AGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCA
AGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTATTTGCTTAAGTGATCATA

>In-frame_ENST00000360804_ENST00000560366_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=427AA_start in transcript=56_stop in transcript=1339
MQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEE
CKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQD
TYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS
TGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQY

--------------------------------------------------------------
>In-frame_ENST00000360804_ENST00000405140_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=1773nt_BP=236nt
AGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAA
AACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTT
CTGAGGAAAAGCAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAA
AGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGT
TCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGA
TGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGT
CCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACC
GGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGT
TCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAAT
TCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACA
AGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGACGAATCCCTCCAGGTCG
CTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACG
AGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTT
CTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCT
CCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATG
TTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAA
CCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGA
AGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCT
GCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTAT

>In-frame_ENST00000360804_ENST00000405140_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=427AA_start in transcript=56_stop in transcript=1339
MQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEE
CKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQD
TYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS
TGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQY

--------------------------------------------------------------
>In-frame_ENST00000360804_ENST00000523500_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(transcript)=1585nt_BP=236nt
AGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAA
AACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTT
CTGAGGAAAAGCAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAA
AGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGT
TCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGA
TGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGT
CCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACC
GGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGT
TCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAAT
TCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACA
AGTGCCGGGAGATCTTGTCTGTGGACTGTTCCACCAACAACCCCTCCCAGGCTAAGCTGCGGCGGGAGCTCGACGAATCCCTCCAGGTCG
CTGAGAGGTTGACCAGGAAATACAACGAGCTGCTAAAGTCCTACCAGTGGAAGATGCTCAACACCTCCTCCTTGCTGGAGCAGCTGAACG
AGCAGTTTAACTGGGTGTCCCGGCTGGCAAACCTCACGCAAGGCGAAGACCAGTACTATCTGCGGGTCACCACGGTGGCTTCCCACACTT
CTGACTCGGACGTTCCTTCCGGTGTCACTGAGGTGGTCGTGAAGCTCTTTGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCT
CCAGGAAGAACCCTAAATTTATGGAGACCGTGGCGGAGAAAGCGCTGCAGGAATACCGCAAAAAGCACCGGGAGGAGTGAGATGTGGATG
TTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAA
CCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGA

>In-frame_ENST00000360804_ENST00000523500_TCGA-BQ-5876-01A_SPP1_chr4_88901586_+_CLU_chr8_27464041_length(amino acids)=427AA_start in transcript=56_stop in transcript=1339
MQPSQPNADQGKLTTMRIAVICFCLLGITCAIPVKQADSGSSEEKQNAVSSEETNDFKQEDALNETRESETKLKELPGVCNETMMALWEE
CKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQD
TYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNS
TGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SPP1-CLU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SPP1-CLU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SPP1-CLU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPP1C0024141Lupus Erythematosus, Systemic5ORPHANET
HgeneSPP1C0001418Adenocarcinoma2CTD_human
HgeneSPP1C0003949Asbestosis2CTD_human
HgeneSPP1C0006142Malignant neoplasm of breast2CTD_human
HgeneSPP1C0006663Calcinosis2CTD_human
HgeneSPP1C0022650Kidney Calculi2CTD_human
HgeneSPP1C0022660Kidney Failure, Acute2CTD_human
HgeneSPP1C0024121Lung Neoplasms2CTD_human
HgeneSPP1C0025500Mesothelioma2CTD_human
HgeneSPP1C0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneSPP1C0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneSPP1C0205643Carcinoma, Cribriform2CTD_human
HgeneSPP1C0205644Carcinoma, Granular Cell2CTD_human
HgeneSPP1C0205645Adenocarcinoma, Tubular2CTD_human
HgeneSPP1C0242379Malignant neoplasm of lung2CTD_human
HgeneSPP1C0263628Tumoral calcinosis2CTD_human
HgeneSPP1C0521174Microcalcification2CTD_human
HgeneSPP1C0678222Breast Carcinoma2CTD_human
HgeneSPP1C1257931Mammary Neoplasms, Human2CTD_human
HgeneSPP1C1458155Mammary Neoplasms2CTD_human
HgeneSPP1C1565662Acute Kidney Insufficiency2CTD_human
HgeneSPP1C2609414Acute kidney injury2CTD_human
HgeneSPP1C2930617Pulmonary Fibrosis - from Asbestos Exposure2CTD_human
HgeneSPP1C4704874Mammary Carcinoma, Human2CTD_human
HgeneSPP1C0006118Brain Neoplasms1CTD_human
HgeneSPP1C0007282Carotid Stenosis1CTD_human
HgeneSPP1C0013221Drug toxicity1CTD_human
HgeneSPP1C0017638Glioma1CTD_human
HgeneSPP1C0017668Focal glomerulosclerosis1CTD_human
HgeneSPP1C0018799Heart Diseases1CTD_human
HgeneSPP1C0018824Heart valve disease1CTD_human
HgeneSPP1C0019193Hepatitis, Toxic1CTD_human
HgeneSPP1C0019207Hepatoma, Morris1CTD_human
HgeneSPP1C0019208Hepatoma, Novikoff1CTD_human
HgeneSPP1C0020517Hypersensitivity1CTD_human
HgeneSPP1C0022658Kidney Diseases1CTD_human
HgeneSPP1C0023890Liver Cirrhosis1CTD_human
HgeneSPP1C0023896Alcoholic Liver Diseases1CTD_human
HgeneSPP1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneSPP1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneSPP1C0027627Neoplasm Metastasis1CTD_human
HgeneSPP1C0027659Neoplasms, Experimental1CTD_human
HgeneSPP1C0030286Pancreatic Diseases1CTD_human
HgeneSPP1C0032229Pleural Neoplasms1CTD_human
HgeneSPP1C0032285Pneumonia1CTD_human
HgeneSPP1C0032300Lobar Pneumonia1CTD_human
HgeneSPP1C0033687Proteinuria1CTD_human
HgeneSPP1C0034069Pulmonary Fibrosis1CTD_human
HgeneSPP1C0041755Adverse reaction to drug1CTD_human
HgeneSPP1C0041948Uremia1CTD_human
HgeneSPP1C0086404Experimental Hepatoma1CTD_human
HgeneSPP1C0086432Hyalinosis, Segmental Glomerular1CTD_human
HgeneSPP1C0153633Malignant neoplasm of brain1CTD_human
HgeneSPP1C0162820Dermatitis, Allergic Contact1CTD_human
HgeneSPP1C0239946Fibrosis, Liver1CTD_human
HgeneSPP1C0259783mixed gliomas1CTD_human
HgeneSPP1C0270612Leukoencephalopathy1CTD_human
HgeneSPP1C0340569Internal Carotid Artery Stenosis1CTD_human
HgeneSPP1C0496899Benign neoplasm of brain, unspecified1CTD_human
HgeneSPP1C0555198Malignant Glioma1CTD_human
HgeneSPP1C0750974Brain Tumor, Primary1CTD_human
HgeneSPP1C0750977Recurrent Brain Neoplasm1CTD_human
HgeneSPP1C0750979Primary malignant neoplasm of brain1CTD_human
HgeneSPP1C0751633Carotid Artery Plaque1CTD_human
HgeneSPP1C0751634Carotid Ulcer1CTD_human
HgeneSPP1C0751635Common Carotid Artery Stenosis1CTD_human
HgeneSPP1C0751636External Carotid Artery Stenosis1CTD_human
HgeneSPP1C0853897Diabetic Cardiomyopathies1CTD_human
HgeneSPP1C0860207Drug-Induced Liver Disease1CTD_human
HgeneSPP1C0887898Experimental Lung Inflammation1CTD_human
HgeneSPP1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneSPP1C1527304Allergic Reaction1CTD_human
HgeneSPP1C1527390Neoplasms, Intracranial1CTD_human
HgeneSPP1C1858991Childhood Ataxia with Central Nervous System Hypomyelinization1CTD_human
HgeneSPP1C2937358Cerebral Hemorrhage1CTD_human
HgeneSPP1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneSPP1C3714636Pneumonitis1CTD_human
HgeneSPP1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneSPP1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneSPP1C4721411Osteolysis1CTD_human
HgeneSPP1C4721507Alveolitis, Fibrosing1CTD_human
TgeneCLUC0022660Kidney Failure, Acute6CTD_human
TgeneCLUC1565662Acute Kidney Insufficiency6CTD_human
TgeneCLUC2609414Acute kidney injury6CTD_human
TgeneCLUC0002395Alzheimer's Disease3CTD_human
TgeneCLUC0011265Presenile dementia3CTD_human
TgeneCLUC0022658Kidney Diseases3CTD_human
TgeneCLUC0276496Familial Alzheimer Disease (FAD)3CTD_human
TgeneCLUC0494463Alzheimer Disease, Late Onset3CTD_human
TgeneCLUC0546126Acute Confusional Senile Dementia3CTD_human
TgeneCLUC0750900Alzheimer's Disease, Focal Onset3CTD_human
TgeneCLUC0750901Alzheimer Disease, Early Onset3CTD_human
TgeneCLUC0013221Drug toxicity2CTD_human
TgeneCLUC0029408Degenerative polyarthritis2CTD_human
TgeneCLUC0041755Adverse reaction to drug2CTD_human
TgeneCLUC0086743Osteoarthrosis Deformans2CTD_human
TgeneCLUC0019193Hepatitis, Toxic1CTD_human
TgeneCLUC0022333Jacksonian Seizure1CTD_human
TgeneCLUC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneCLUC0025202melanoma1CTD_human
TgeneCLUC0027686Pathologic Neovascularization1CTD_human
TgeneCLUC0033578Prostatic Neoplasms1CTD_human
TgeneCLUC0036341Schizophrenia1PSYGENET
TgeneCLUC0036572Seizures1CTD_human
TgeneCLUC0087031Juvenile-Onset Still Disease1CTD_human
TgeneCLUC0149958Complex partial seizures1CTD_human
TgeneCLUC0234533Generalized seizures1CTD_human
TgeneCLUC0234535Clonic Seizures1CTD_human
TgeneCLUC0234985Mental deterioration1CTD_human
TgeneCLUC0242380Libman-Sacks Disease1CTD_human
TgeneCLUC0270824Visual seizure1CTD_human
TgeneCLUC0270844Tonic Seizures1CTD_human
TgeneCLUC0270846Epileptic drop attack1CTD_human
TgeneCLUC0333641Atrophic1CTD_human
TgeneCLUC0338656Impaired cognition1CTD_human
TgeneCLUC0376358Malignant neoplasm of prostate1CTD_human
TgeneCLUC0422850Seizures, Somatosensory1CTD_human
TgeneCLUC0422852Seizures, Auditory1CTD_human
TgeneCLUC0422853Olfactory seizure1CTD_human
TgeneCLUC0422854Gustatory seizure1CTD_human
TgeneCLUC0422855Vertiginous seizure1CTD_human
TgeneCLUC0494475Tonic - clonic seizures1CTD_human
TgeneCLUC0751056Non-epileptic convulsion1CTD_human
TgeneCLUC0751110Single Seizure1CTD_human
TgeneCLUC0751123Atonic Absence Seizures1CTD_human
TgeneCLUC0751494Convulsive Seizures1CTD_human
TgeneCLUC0751495Seizures, Focal1CTD_human
TgeneCLUC0751496Seizures, Sensory1CTD_human
TgeneCLUC0860207Drug-Induced Liver Disease1CTD_human
TgeneCLUC1262760Hepatitis, Drug-Induced1CTD_human
TgeneCLUC1270972Mild cognitive disorder1CTD_human
TgeneCLUC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneCLUC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneCLUC3495559Juvenile arthritis1CTD_human
TgeneCLUC3495874Nonepileptic Seizures1CTD_human
TgeneCLUC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCLUC3714758Juvenile psoriatic arthritis1CTD_human
TgeneCLUC4048158Convulsions1CTD_human
TgeneCLUC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCLUC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCLUC4316903Absence Seizures1CTD_human
TgeneCLUC4317109Epileptic Seizures1CTD_human
TgeneCLUC4317123Myoclonic Seizures1CTD_human
TgeneCLUC4505436Generalized Absence Seizures1CTD_human
TgeneCLUC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
TgeneCLUC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneCLUC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human