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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRD5A1-GRK4 (FusionGDB2 ID:85677)

Fusion Gene Summary for SRD5A1-GRK4

check button Fusion gene summary
Fusion gene informationFusion gene name: SRD5A1-GRK4
Fusion gene ID: 85677
HgeneTgene
Gene symbol

SRD5A1

GRK4

Gene ID

6715

2868

Gene namesteroid 5 alpha-reductase 1G protein-coupled receptor kinase 4
SynonymsS5AR 1GPRK2L|GPRK4|GRK4a|IT11
Cytomap

5p15.31

4p16.3

Type of geneprotein-codingprotein-coding
Description3-oxo-5-alpha-steroid 4-dehydrogenase 1SR type 1steroid 5-alpha-reductase type Isteroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)G protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-like
Modification date2020031320200313
UniProtAcc.

P32298

Ensembl transtripts involved in fusion geneENST00000274192, ENST00000537411, 
ENST00000504286, ENST00000538824, 
ENST00000398051, ENST00000398052, 
ENST00000504933, ENST00000345167, 
ENST00000503518, ENST00000442472, 
ENST00000509545, 
Fusion gene scores* DoF score6 X 2 X 5=607 X 7 X 4=196
# samples 67
** MAII scorelog2(6/60*10)=0log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRD5A1 [Title/Abstract] AND GRK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRD5A1(6663079)-GRK4(3024140), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRK4

GO:0031623

receptor internalization

20074556


check buttonFusion gene breakpoints across SRD5A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GRK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NWSRD5A1chr5

6663079

+GRK4chr4

3024140

+
ChimerDB4ESCATCGA-L5-A8NWSRD5A1chr5

6663079

+GRK4chr4

3024140

+


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Fusion Gene ORF analysis for SRD5A1-GRK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000274192ENST00000398051SRD5A1chr5

6663079

+GRK4chr4

3024140

+
In-frameENST00000274192ENST00000398052SRD5A1chr5

6663079

+GRK4chr4

3024140

+
In-frameENST00000274192ENST00000504933SRD5A1chr5

6663079

+GRK4chr4

3024140

+
In-frameENST00000274192ENST00000345167SRD5A1chr5

6663079

+GRK4chr4

3024140

+
5CDS-intronENST00000274192ENST00000503518SRD5A1chr5

6663079

+GRK4chr4

3024140

+
5CDS-intronENST00000274192ENST00000442472SRD5A1chr5

6663079

+GRK4chr4

3024140

+
5CDS-intronENST00000274192ENST00000509545SRD5A1chr5

6663079

+GRK4chr4

3024140

+
3UTR-3CDSENST00000537411ENST00000398051SRD5A1chr5

6663079

+GRK4chr4

3024140

+
3UTR-3CDSENST00000537411ENST00000398052SRD5A1chr5

6663079

+GRK4chr4

3024140

+
3UTR-3CDSENST00000537411ENST00000504933SRD5A1chr5

6663079

+GRK4chr4

3024140

+
3UTR-3CDSENST00000537411ENST00000345167SRD5A1chr5

6663079

+GRK4chr4

3024140

+
3UTR-intronENST00000537411ENST00000503518SRD5A1chr5

6663079

+GRK4chr4

3024140

+
3UTR-intronENST00000537411ENST00000442472SRD5A1chr5

6663079

+GRK4chr4

3024140

+
3UTR-intronENST00000537411ENST00000509545SRD5A1chr5

6663079

+GRK4chr4

3024140

+
intron-3CDSENST00000504286ENST00000398051SRD5A1chr5

6663079

+GRK4chr4

3024140

+
intron-3CDSENST00000504286ENST00000398052SRD5A1chr5

6663079

+GRK4chr4

3024140

+
intron-3CDSENST00000504286ENST00000504933SRD5A1chr5

6663079

+GRK4chr4

3024140

+
intron-3CDSENST00000504286ENST00000345167SRD5A1chr5

6663079

+GRK4chr4

3024140

+
intron-intronENST00000504286ENST00000503518SRD5A1chr5

6663079

+GRK4chr4

3024140

+
intron-intronENST00000504286ENST00000442472SRD5A1chr5

6663079

+GRK4chr4

3024140

+
intron-intronENST00000504286ENST00000509545SRD5A1chr5

6663079

+GRK4chr4

3024140

+
In-frameENST00000538824ENST00000398051SRD5A1chr5

6663079

+GRK4chr4

3024140

+
In-frameENST00000538824ENST00000398052SRD5A1chr5

6663079

+GRK4chr4

3024140

+
In-frameENST00000538824ENST00000504933SRD5A1chr5

6663079

+GRK4chr4

3024140

+
In-frameENST00000538824ENST00000345167SRD5A1chr5

6663079

+GRK4chr4

3024140

+
5CDS-intronENST00000538824ENST00000503518SRD5A1chr5

6663079

+GRK4chr4

3024140

+
5CDS-intronENST00000538824ENST00000442472SRD5A1chr5

6663079

+GRK4chr4

3024140

+
5CDS-intronENST00000538824ENST00000509545SRD5A1chr5

6663079

+GRK4chr4

3024140

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274192SRD5A1chr56663079+ENST00000398051GRK4chr43024140+17169471591613484
ENST00000274192SRD5A1chr56663079+ENST00000398052GRK4chr43024140+18749471591751530
ENST00000274192SRD5A1chr56663079+ENST00000504933GRK4chr43024140+17369471591613484
ENST00000274192SRD5A1chr56663079+ENST00000345167GRK4chr43024140+18749471591751530
ENST00000538824SRD5A1chr56663079+ENST00000398051GRK4chr43024140+1424655831321412
ENST00000538824SRD5A1chr56663079+ENST00000398052GRK4chr43024140+1582655831459458
ENST00000538824SRD5A1chr56663079+ENST00000504933GRK4chr43024140+1444655831321412
ENST00000538824SRD5A1chr56663079+ENST00000345167GRK4chr43024140+1582655831459458

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274192ENST00000398051SRD5A1chr56663079+GRK4chr43024140+0.0059175310.9940825
ENST00000274192ENST00000398052SRD5A1chr56663079+GRK4chr43024140+0.0044243230.99557567
ENST00000274192ENST00000504933SRD5A1chr56663079+GRK4chr43024140+0.0054611780.99453884
ENST00000274192ENST00000345167SRD5A1chr56663079+GRK4chr43024140+0.0044243230.99557567
ENST00000538824ENST00000398051SRD5A1chr56663079+GRK4chr43024140+0.0608000680.9391999
ENST00000538824ENST00000398052SRD5A1chr56663079+GRK4chr43024140+0.0349465760.9650534
ENST00000538824ENST00000504933SRD5A1chr56663079+GRK4chr43024140+0.0587765760.94122344
ENST00000538824ENST00000345167SRD5A1chr56663079+GRK4chr43024140+0.0349465760.9650534

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Fusion Genomic Features for SRD5A1-GRK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SRD5A1chr56663079+GRK4chr43024140+0.0006621160.99933785
SRD5A1chr56663079+GRK4chr43024140+0.0006621160.99933785

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SRD5A1-GRK4


check button Go to

FGviewer for the breakpoints of chr5:6663079-chr4:3024140

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRK4

P32298

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRD5A1chr5:6663079chr4:3024140ENST00000274192+45111_131237.66666666666666260.0TransmembraneHelical
HgeneSRD5A1chr5:6663079chr4:3024140ENST00000274192+4512_29237.66666666666666260.0TransmembraneHelical
HgeneSRD5A1chr5:6663079chr4:3024140ENST00000274192+45151_171237.66666666666666260.0TransmembraneHelical
HgeneSRD5A1chr5:6663079chr4:3024140ENST00000274192+45209_229237.66666666666666260.0TransmembraneHelical
HgeneSRD5A1chr5:6663079chr4:3024140ENST00000274192+4586_106237.66666666666666260.0TransmembraneHelical
TgeneGRK4chr5:6663079chr4:3024140ENST00000345167715450_515278.6666666666667547.0DomainAGC-kinase C-terminal
TgeneGRK4chr5:6663079chr4:3024140ENST00000398051714450_515278.6666666666667501.0DomainAGC-kinase C-terminal
TgeneGRK4chr5:6663079chr4:3024140ENST00000398052816450_515310.6666666666667579.0DomainAGC-kinase C-terminal
TgeneGRK4chr5:6663079chr4:3024140ENST00000504933815450_515310.6666666666667533.0DomainAGC-kinase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRK4chr5:6663079chr4:3024140ENST00000345167715187_449278.6666666666667547.0DomainProtein kinase
TgeneGRK4chr5:6663079chr4:3024140ENST0000034516771552_172278.6666666666667547.0DomainRGS
TgeneGRK4chr5:6663079chr4:3024140ENST00000398051714187_449278.6666666666667501.0DomainProtein kinase
TgeneGRK4chr5:6663079chr4:3024140ENST0000039805171452_172278.6666666666667501.0DomainRGS
TgeneGRK4chr5:6663079chr4:3024140ENST00000398052816187_449310.6666666666667579.0DomainProtein kinase
TgeneGRK4chr5:6663079chr4:3024140ENST0000039805281652_172310.6666666666667579.0DomainRGS
TgeneGRK4chr5:6663079chr4:3024140ENST00000504933815187_449310.6666666666667533.0DomainProtein kinase
TgeneGRK4chr5:6663079chr4:3024140ENST0000050493381552_172310.6666666666667533.0DomainRGS
TgeneGRK4chr5:6663079chr4:3024140ENST00000345167715193_201278.6666666666667547.0Nucleotide bindingATP
TgeneGRK4chr5:6663079chr4:3024140ENST00000398051714193_201278.6666666666667501.0Nucleotide bindingATP
TgeneGRK4chr5:6663079chr4:3024140ENST00000398052816193_201310.6666666666667579.0Nucleotide bindingATP
TgeneGRK4chr5:6663079chr4:3024140ENST00000504933815193_201310.6666666666667533.0Nucleotide bindingATP
TgeneGRK4chr5:6663079chr4:3024140ENST000003451677151_154278.6666666666667547.0RegionNote=N-terminal
TgeneGRK4chr5:6663079chr4:3024140ENST000003980517141_154278.6666666666667501.0RegionNote=N-terminal
TgeneGRK4chr5:6663079chr4:3024140ENST000003980528161_154310.6666666666667579.0RegionNote=N-terminal
TgeneGRK4chr5:6663079chr4:3024140ENST000005049338151_154310.6666666666667533.0RegionNote=N-terminal


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Fusion Gene Sequence for SRD5A1-GRK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000274192_ENST00000398051_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1716nt_BP=947nt
TGGGGCGCTTGCAGGTCCCTCCCCGCGCAAGTGCTCGCCCCGCCCCCGGGGCCGCACCCACAGCCCCGGCTACCCCGGAGAAGCCTGACT
TGAGAACCCTTTCTGCAGAGTCCCGGCAGTGCGGGACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCT
ATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGCACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTG
CTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGGCTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCG
CTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCC
AGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTAATTTAC
CCATTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCGTGTACAATGGCGATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGC
AGATACTTGAGCCATTGTGCAGTGTATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACGGGCATG
TTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAA
TACGTAACTGCAGCCAACTATTTTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCT
TTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACAC
ATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCT
GAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCA
TTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAG
GATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAG
CACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGT
AAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACC
GGGTGTGTCTCCATCCCCTGGCAGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCC
CGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTCGTCCCACCTGGAATTGTAATAAATACATCTAAAT

>In-frame_ENST00000274192_ENST00000398051_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=484AA_start in transcript=159_stop in transcript=1613
MPPRRRPICCPPRPLGHGARCPALAMATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLA
LPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGF
GLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEDLKPENI
LLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE
YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADED

--------------------------------------------------------------
>In-frame_ENST00000274192_ENST00000398052_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1874nt_BP=947nt
TGGGGCGCTTGCAGGTCCCTCCCCGCGCAAGTGCTCGCCCCGCCCCCGGGGCCGCACCCACAGCCCCGGCTACCCCGGAGAAGCCTGACT
TGAGAACCCTTTCTGCAGAGTCCCGGCAGTGCGGGACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCT
ATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGCACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTG
CTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGGCTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCG
CTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCC
AGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTAATTTAC
CCATTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCGTGTACAATGGCGATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGC
AGATACTTGAGCCATTGTGCAGTGTATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACGGGCATG
TTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAA
TACGTAACTGCAGCCAACTATTTTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCT
TTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACAC
ATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCT
GAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCA
TTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAG
GATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAG
CACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGT
AAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACC
GGGTGTGTCTCCATCCCCTGGCAGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGTGAAAGTGAGGAAGCTTTGCCA
TTAGATCTAGACAAGAACATACATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTCAGAAGAGGGGGCTGCCTGACC
ATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCA

>In-frame_ENST00000274192_ENST00000398052_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=530AA_start in transcript=159_stop in transcript=1751
MPPRRRPICCPPRPLGHGARCPALAMATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLA
LPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGF
GLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEDLKPENI
LLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE
YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADED

--------------------------------------------------------------
>In-frame_ENST00000274192_ENST00000504933_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1736nt_BP=947nt
TGGGGCGCTTGCAGGTCCCTCCCCGCGCAAGTGCTCGCCCCGCCCCCGGGGCCGCACCCACAGCCCCGGCTACCCCGGAGAAGCCTGACT
TGAGAACCCTTTCTGCAGAGTCCCGGCAGTGCGGGACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCT
ATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGCACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTG
CTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGGCTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCG
CTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCC
AGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTAATTTAC
CCATTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCGTGTACAATGGCGATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGC
AGATACTTGAGCCATTGTGCAGTGTATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACGGGCATG
TTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAA
TACGTAACTGCAGCCAACTATTTTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCT
TTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACAC
ATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCT
GAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCA
TTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAG
GATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAG
CACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGT
AAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACC
GGGTGTGTCTCCATCCCCTGGCAGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCC
CGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTCGTCCCACCTGGAATTGTAATAAATACATCTAAAT

>In-frame_ENST00000274192_ENST00000504933_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=484AA_start in transcript=159_stop in transcript=1613
MPPRRRPICCPPRPLGHGARCPALAMATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLA
LPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGF
GLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEDLKPENI
LLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE
YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADED

--------------------------------------------------------------
>In-frame_ENST00000274192_ENST00000345167_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1874nt_BP=947nt
TGGGGCGCTTGCAGGTCCCTCCCCGCGCAAGTGCTCGCCCCGCCCCCGGGGCCGCACCCACAGCCCCGGCTACCCCGGAGAAGCCTGACT
TGAGAACCCTTTCTGCAGAGTCCCGGCAGTGCGGGACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCT
ATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGCACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTG
CTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGGCTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCG
CTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCC
AGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTAATTTAC
CCATTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCGTGTACAATGGCGATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGC
AGATACTTGAGCCATTGTGCAGTGTATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACGGGCATG
TTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAA
TACGTAACTGCAGCCAACTATTTTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCT
TTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACAC
ATCCGGATTTCAGACCTCGGTTTGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCT
GAAGTTGTCAATAATGAAAAGTATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCA
TTCAAAAAATACAAAGAGAAAGTCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAG
GATGCCAAATCTATCTGCAGGATGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAG
CACCCCGTGTTCAAGGACATCAACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGT
AAGGACGTCCTGGATATCGAGCAGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACC
GGGTGTGTCTCCATCCCCTGGCAGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGTGAAAGTGAGGAAGCTTTGCCA
TTAGATCTAGACAAGAACATACATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTCAGAAGAGGGGGCTGCCTGACC
ATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCA

>In-frame_ENST00000274192_ENST00000345167_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=530AA_start in transcript=159_stop in transcript=1751
MPPRRRPICCPPRPLGHGARCPALAMATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLA
LPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGF
GLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEDLKPENI
LLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE
YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADED

--------------------------------------------------------------
>In-frame_ENST00000538824_ENST00000398051_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1424nt_BP=655nt
ACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCTATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGC
ACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGG
CTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGC
CGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAA
CTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTTTTGGCTTGTGGTTAACGGGCATGTTGATAAACATCCATTCAGATC
ATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATT
TTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCTTTCTTCACGTTTTGTTTTTTAT
CTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTT
TGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGT
ATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAG
TCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGA
TGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCA
ACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGC
AGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGC
AGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGAC

>In-frame_ENST00000538824_ENST00000398051_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=412AA_start in transcript=83_stop in transcript=1321
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRAIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAA
RPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFC
FLSGRAKEHHEDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYK
EKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD

--------------------------------------------------------------
>In-frame_ENST00000538824_ENST00000398052_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1582nt_BP=655nt
ACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCTATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGC
ACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGG
CTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGC
CGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAA
CTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTTTTGGCTTGTGGTTAACGGGCATGTTGATAAACATCCATTCAGATC
ATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATT
TTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCTTTCTTCACGTTTTGTTTTTTAT
CTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTT
TGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGT
ATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAG
TCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGA
TGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCA
ACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGC
AGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGC
AGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGTGAAAGTGAGGAAGCTTTGCCATTAGATCTAGACAAGAACATAC
ATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTCAGAAGAGGGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAG
TGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTCGTCCCACC

>In-frame_ENST00000538824_ENST00000398052_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=458AA_start in transcript=83_stop in transcript=1459
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRAIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAA
RPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFC
FLSGRAKEHHEDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYK
EKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSE

--------------------------------------------------------------
>In-frame_ENST00000538824_ENST00000504933_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1444nt_BP=655nt
ACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCTATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGC
ACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGG
CTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGC
CGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAA
CTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTTTTGGCTTGTGGTTAACGGGCATGTTGATAAACATCCATTCAGATC
ATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATT
TTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCTTTCTTCACGTTTTGTTTTTTAT
CTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTT
TGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGT
ATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAG
TCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGA
TGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCA
ACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGC
AGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGC
AGAATGAGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAGTGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGAC
CCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTCGTCCCACCTGGAATTGTAATAAATACATCTAAATAAAACATGCCTTGGGAGTGTAC

>In-frame_ENST00000538824_ENST00000504933_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=412AA_start in transcript=83_stop in transcript=1321
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRAIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAA
RPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFC
FLSGRAKEHHEDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYK
EKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD

--------------------------------------------------------------
>In-frame_ENST00000538824_ENST00000345167_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(transcript)=1582nt_BP=655nt
ACTCCGGTAGCCGCCCCTCCGGTAGCCGCCCCTCCTGCCCCCGCGCCGCCGCCCTATATGTTGCCCGCCGCGGCCTCTGGGGCATGGAGC
ACGCTGCCCAGCCCTGGCGATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAGTGCGCCGTGGG
CTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGCCACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGC
CGCCTGGGTGGTGCAGGAGCTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGCAGCGCGCCCAA
CTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTTTTGGCTTGTGGTTAACGGGCATGTTGATAAACATCCATTCAGATC
ATATCCTAAGGAATCTCAGAAAACCAGGAGATACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATT
TTGGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCTTTTGCTTTCTTCACGTTTTGTTTTTTAT
CTGGTAGAGCAAAAGAGCATCATGAAGACTTGAAGCCTGAGAATATTCTCCTTGATGATCGTGGACACATCCGGATTTCAGACCTCGGTT
TGGCCACAGAGATCCCAGAAGGACAGAGGGTTCGAGGAAGAGTTGGAACAGTCGGCTACATGGCACCTGAAGTTGTCAATAATGAAAAGT
ATACGTTTAGTCCCGATTGGTGGGGACTTGGCTGTCTGATCTATGAAATGATTCAGGGACATTCTCCATTCAAAAAATACAAAGAGAAAG
TCAAATGGGAGGAGGTCGATCAAAGAATCAAGAATGATACCGAGGAGTATTCTGAGAAGTTTTCAGAGGATGCCAAATCTATCTGCAGGA
TGTTACTCACCAAGAATCCAAGCAAGCGGCTGGGCTGCAGGGGCGAGGGAGCGGCTGGGGTGAAGCAGCACCCCGTGTTCAAGGACATCA
ACTTCAGGAGGCTGGAGGCAAACATGCTGGAGCCCCCTTTCTGTCCTGATCCTCATGCCGTTTACTGTAAGGACGTCCTGGATATCGAGC
AGTTCTCGGTGGTGAAAGGGATCTACCTGGACACCGCAGATGAAGACTTCTATGCTCGGTTTGCTACCGGGTGTGTCTCCATCCCCTGGC
AGAATGAGATGATCGAATCTGGGTGTTTCAAAGACATCAACAAAAGTGAAAGTGAGGAAGCTTTGCCATTAGATCTAGACAAGAACATAC
ATACCCCGGTTTCCAGACCAAACAGAGGCTTCTTCTATAGACTCTTCAGAAGAGGGGGCTGCCTGACCATGGTCCCCAGTGAGAAGGAAG
TGGAACCCAAGCAATGCTGAGCACCCCGGTGCGGACCACAGAGCAGACCCTGGCGCCAGGAAGGAGCATGTGTTAGCGTCTCGTCCCACC

>In-frame_ENST00000538824_ENST00000345167_TCGA-L5-A8NW_SRD5A1_chr5_6663079_+_GRK4_chr4_3024140_length(amino acids)=458AA_start in transcript=83_stop in transcript=1459
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRAIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAA
RPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFC
FLSGRAKEHHEDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYK
EKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SRD5A1-GRK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRD5A1-GRK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SRD5A1-GRK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRD5A1C0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneSRD5A1C0014175Endometriosis2CTD_human
HgeneSRD5A1C0032460Polycystic Ovary Syndrome2CTD_human
HgeneSRD5A1C0033578Prostatic Neoplasms2CTD_human
HgeneSRD5A1C0269102Endometrioma2CTD_human
HgeneSRD5A1C0376358Malignant neoplasm of prostate2CTD_human
HgeneSRD5A1C1136382Sclerocystic Ovaries2CTD_human
HgeneSRD5A1C0011570Mental Depression1PSYGENET
HgeneSRD5A1C0011581Depressive disorder1PSYGENET
HgeneSRD5A1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGRK4C0019193Hepatitis, Toxic1CTD_human
TgeneGRK4C0860207Drug-Induced Liver Disease1CTD_human
TgeneGRK4C1262760Hepatitis, Drug-Induced1CTD_human
TgeneGRK4C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneGRK4C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneGRK4C4279912Chemically-Induced Liver Toxicity1CTD_human