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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SREBF1-DHRS4 (FusionGDB2 ID:85685)

Fusion Gene Summary for SREBF1-DHRS4

check button Fusion gene summary
Fusion gene informationFusion gene name: SREBF1-DHRS4
Fusion gene ID: 85685
HgeneTgene
Gene symbol

SREBF1

DHRS4

Gene ID

6720

10901

Gene namesterol regulatory element binding transcription factor 1dehydrogenase/reductase 4
SynonymsSREBP1|bHLHd1CR|NRDR|PHCR|PSCD|SCAD-SRL|SDR-SRL|SDR25C1|SDR25C2
Cytomap

17p11.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionsterol regulatory element-binding protein 1class D basic helix-loop-helix protein 1dehydrogenase/reductase SDR family member 4NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenaseNADPH-dependent retinol dehydrogenase/reductasedehydrogenase/reductase (SDR family) member 4 like 2Aperoxisomal short-chain alcohol dehydrogenases
Modification date2020032920200313
UniProtAcc.

Q6PKH6

Ensembl transtripts involved in fusion geneENST00000338854, ENST00000395757, 
ENST00000355815, ENST00000261646, 
ENST00000435530, ENST00000583732, 
ENST00000313250, ENST00000558263, 
ENST00000543741, ENST00000382761, 
ENST00000397073, ENST00000308178, 
ENST00000421831, ENST00000397075, 
ENST00000397074, ENST00000559632, 
ENST00000558581, 
Fusion gene scores* DoF score10 X 9 X 6=5404 X 4 X 4=64
# samples 145
** MAII scorelog2(14/540*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SREBF1 [Title/Abstract] AND DHRS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSREBF1(17740041)-DHRS4(24424244), # samples:1
Anticipated loss of major functional domain due to fusion event.SREBF1-DHRS4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SREBF1-DHRS4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SREBF1-DHRS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SREBF1-DHRS4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSREBF1

GO:0032933

SREBP signaling pathway

27614840

HgeneSREBF1

GO:0045944

positive regulation of transcription by RNA polymerase II

26437365

TgeneDHRS4

GO:0006066

alcohol metabolic process

18571493

TgeneDHRS4

GO:0008202

steroid metabolic process

18571493

TgeneDHRS4

GO:0042180

cellular ketone metabolic process

18571493

TgeneDHRS4

GO:0055114

oxidation-reduction process

19442656


check buttonFusion gene breakpoints across SREBF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DHRS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-CC-A7IK-01ASREBF1chr17

17740041

-DHRS4chr14

24424244

+


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Fusion Gene ORF analysis for SREBF1-DHRS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000338854ENST00000313250SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000558263SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000543741SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000382761SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000397073SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000308178SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000421831SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000397075SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000397074SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000559632SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000338854ENST00000558581SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000313250SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000558263SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000543741SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000382761SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000397073SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000308178SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000421831SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000397075SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000397074SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000559632SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000395757ENST00000558581SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000313250SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000558263SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000543741SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000382761SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000397073SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000308178SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000421831SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000397075SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000397074SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000559632SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000355815ENST00000558581SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000313250SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000558263SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000543741SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000382761SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000397073SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000308178SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000421831SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000397075SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000397074SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000559632SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000261646ENST00000558581SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000313250SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000558263SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000543741SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000382761SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000397073SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000308178SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000421831SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000397075SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000397074SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000559632SREBF1chr17

17740041

-DHRS4chr14

24424244

+
Frame-shiftENST00000435530ENST00000558581SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000313250SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000558263SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000543741SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000382761SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000397073SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000308178SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000421831SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000397075SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000397074SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000559632SREBF1chr17

17740041

-DHRS4chr14

24424244

+
intron-3CDSENST00000583732ENST00000558581SREBF1chr17

17740041

-DHRS4chr14

24424244

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SREBF1-DHRS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SREBF1chr1717740040-DHRS4chr1424424243+1.50E-070.9999999
SREBF1chr1717740040-DHRS4chr1424424243+1.50E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SREBF1-DHRS4


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DHRS4

Q6PKH6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Probable oxidoreductase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SREBF1-DHRS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SREBF1-DHRS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SREBF1-DHRS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SREBF1-DHRS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSREBF1C0002152Alloxan Diabetes2CTD_human
HgeneSREBF1C0011853Diabetes Mellitus, Experimental2CTD_human
HgeneSREBF1C0038433Streptozotocin Diabetes2CTD_human
HgeneSREBF1C0400966Non-alcoholic Fatty Liver Disease2CTD_human
HgeneSREBF1C2239176Liver carcinoma2CTD_human
HgeneSREBF1C3241937Nonalcoholic Steatohepatitis2CTD_human
HgeneSREBF1C0015695Fatty Liver1CTD_human
HgeneSREBF1C0021655Insulin Resistance1CTD_human
HgeneSREBF1C0022661Kidney Failure, Chronic1CTD_human
HgeneSREBF1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSREBF1C0028754Obesity1CTD_human
HgeneSREBF1C0036341Schizophrenia1PSYGENET
HgeneSREBF1C0920563Insulin Sensitivity1CTD_human
HgeneSREBF1C2711227Steatohepatitis1CTD_human