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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRFBP1-HSD17B4 (FusionGDB2 ID:85729)

Fusion Gene Summary for SRFBP1-HSD17B4

check button Fusion gene summary
Fusion gene informationFusion gene name: SRFBP1-HSD17B4
Fusion gene ID: 85729
HgeneTgene
Gene symbol

SRFBP1

HSD17B4

Gene ID

153443

3295

Gene nameserum response factor binding protein 1hydroxysteroid 17-beta dehydrogenase 4
SynonymsBUD22|P49|Rlb1|STRAP|p49/STRAPDBP|MFE-2|MPF-2|PRLTS1|SDR8C1
Cytomap

5q23.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionserum response factor-binding protein 1BUD22 homologSRF-dependent transcription regulation-associated proteinperoxisomal multifunctional enzyme type 217-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydratase
Modification date2020031320200327
UniProtAcc.

P51659

Ensembl transtripts involved in fusion geneENST00000504881, ENST00000339397, 
ENST00000256216, ENST00000515320, 
ENST00000510025, ENST00000504811, 
ENST00000414835, ENST00000513628, 
ENST00000509514, ENST00000522415, 
Fusion gene scores* DoF score5 X 3 X 6=9016 X 15 X 12=2880
# samples 619
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2880*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRFBP1 [Title/Abstract] AND HSD17B4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRFBP1(121297763)-HSD17B4(118860910), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSD17B4

GO:0006635

fatty acid beta-oxidation

10400999

TgeneHSD17B4

GO:0008209

androgen metabolic process

7487879

TgeneHSD17B4

GO:0008210

estrogen metabolic process

7487879

TgeneHSD17B4

GO:0036111

very long-chain fatty-acyl-CoA metabolic process

9482850

TgeneHSD17B4

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

9089413


check buttonFusion gene breakpoints across SRFBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HSD17B4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A1M7SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+


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Fusion Gene ORF analysis for SRFBP1-HSD17B4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000504881ENST00000256216SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
intron-3CDSENST00000504881ENST00000515320SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
intron-3CDSENST00000504881ENST00000510025SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
intron-3CDSENST00000504881ENST00000504811SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
intron-3CDSENST00000504881ENST00000414835SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
intron-3CDSENST00000504881ENST00000513628SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
intron-3CDSENST00000504881ENST00000509514SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
intron-3UTRENST00000504881ENST00000522415SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
In-frameENST00000339397ENST00000256216SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
In-frameENST00000339397ENST00000515320SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
In-frameENST00000339397ENST00000510025SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
In-frameENST00000339397ENST00000504811SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
In-frameENST00000339397ENST00000414835SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
In-frameENST00000339397ENST00000513628SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
In-frameENST00000339397ENST00000509514SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+
5CDS-3UTRENST00000339397ENST00000522415SRFBP1chr5

121297763

+HSD17B4chr5

118860910

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339397SRFBP1chr5121297763+ENST00000256216HSD17B4chr5118860910+115510872815247
ENST00000339397SRFBP1chr5121297763+ENST00000515320HSD17B4chr5118860910+107410872815247
ENST00000339397SRFBP1chr5121297763+ENST00000510025HSD17B4chr5118860910+109110872815247
ENST00000339397SRFBP1chr5121297763+ENST00000504811HSD17B4chr5118860910+108610872815247
ENST00000339397SRFBP1chr5121297763+ENST00000414835HSD17B4chr5118860910+115410872815247
ENST00000339397SRFBP1chr5121297763+ENST00000513628HSD17B4chr5118860910+99610872815247
ENST00000339397SRFBP1chr5121297763+ENST00000509514HSD17B4chr5118860910+107410872815247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339397ENST00000256216SRFBP1chr5121297763+HSD17B4chr5118860910+0.0022674220.9977325
ENST00000339397ENST00000515320SRFBP1chr5121297763+HSD17B4chr5118860910+0.0021036330.9978963
ENST00000339397ENST00000510025SRFBP1chr5121297763+HSD17B4chr5118860910+0.0019677390.9980323
ENST00000339397ENST00000504811SRFBP1chr5121297763+HSD17B4chr5118860910+0.0021213180.9978787
ENST00000339397ENST00000414835SRFBP1chr5121297763+HSD17B4chr5118860910+0.0022233870.99777657
ENST00000339397ENST00000513628SRFBP1chr5121297763+HSD17B4chr5118860910+0.0025191840.9974808
ENST00000339397ENST00000509514SRFBP1chr5121297763+HSD17B4chr5118860910+0.0021036330.9978963

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Fusion Genomic Features for SRFBP1-HSD17B4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SRFBP1chr5121297763+HSD17B4chr5118860910+0.0009122480.9990878
SRFBP1chr5121297763+HSD17B4chr5118860910+0.0009122480.9990878

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SRFBP1-HSD17B4


check button Go to

FGviewer for the breakpoints of chr5:121297763-chr5:118860910

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HSD17B4

P51659

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:10671535). {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624624_736501.0737.0DomainNote=SCP2
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725624_736526.0762.0DomainNote=SCP2
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523484_600483.0719.0DomainNote=MaoC-like
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523624_736483.0719.0DomainNote=SCP2
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624734_736501.0737.0MotifMicrobody targeting signal
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725734_736526.0762.0MotifMicrobody targeting signal
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523734_736483.0719.0MotifMicrobody targeting signal
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624510_515501.0737.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523510_515483.0719.0Region(3R)-3-hydroxydecanoyl-CoA binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRFBP1chr5:121297763chr5:118860910ENST00000339397+18108_14612.0430.0Coiled coilOntology_term=ECO:0000255
HgeneSRFBP1chr5:121297763chr5:118860910ENST00000339397+1842_6712.0430.0Coiled coilOntology_term=ECO:0000255
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624484_600501.0737.0DomainNote=MaoC-like
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725484_600526.0762.0DomainNote=MaoC-like
TgeneHSD17B4chr5:121297763chr5:118860910ENST00000256216162413_37501.0737.0Nucleotide bindingNAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624164_168501.0737.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624196_199501.0737.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST00000256216162475_76501.0737.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST00000504811172513_37526.0762.0Nucleotide bindingNAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725164_168526.0762.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725196_199526.0762.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST00000504811172575_76526.0762.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST00000515320152313_37483.0719.0Nucleotide bindingNAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523164_168483.0719.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523196_199483.0719.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST00000515320152375_76483.0719.0Nucleotide bindingNote=NAD
TgeneHSD17B4chr5:121297763chr5:118860910ENST0000025621616241_305501.0737.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624322_622501.0737.0RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr5:121297763chr5:118860910ENST000002562161624406_407501.0737.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr5:121297763chr5:118860910ENST0000050481117251_305526.0762.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725322_622526.0762.0RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725406_407526.0762.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005048111725510_515526.0762.0Region(3R)-3-hydroxydecanoyl-CoA binding
TgeneHSD17B4chr5:121297763chr5:118860910ENST0000051532015231_305483.0719.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523322_622483.0719.0RegionNote=Enoyl-CoA hydratase 2
TgeneHSD17B4chr5:121297763chr5:118860910ENST000005153201523406_407483.0719.0Region(3R)-3-hydroxydecanoyl-CoA binding


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Fusion Gene Sequence for SRFBP1-HSD17B4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000339397_ENST00000256216_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(transcript)=1155nt_BP=108nt
GTGGCGACGCAGCCGCGGTCTGAGAGACCGGTTCACGTGCAGGCAGCGGCGGATCATATTCCTTCATCTACCATGGCTCAGCCGGGAACT
CTGAACCTCAATAACGAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGT
TTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA
TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCAT
TTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA
CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAA
GTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG
TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCT
CAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG
CTCTGAAGGGCACACTACACTATTAATAAAAATGGAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATT
AGAACTAAGATGCAGGGGAAATTGCTTAACATTTTCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTA
TTTTTACAAGGAACTATATATAAGCTAGCACATAATTATCCTTCTGTTCTTAGATCTGTATCTTCATAATAAAAAATTTTGCCCAAGTCC

>In-frame_ENST00000339397_ENST00000256216_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(amino acids)=247AA_start in transcript=72_stop in transcript=815
MAQPGTLNLNNEAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWK
EGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLK

--------------------------------------------------------------
>In-frame_ENST00000339397_ENST00000515320_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(transcript)=1074nt_BP=108nt
GTGGCGACGCAGCCGCGGTCTGAGAGACCGGTTCACGTGCAGGCAGCGGCGGATCATATTCCTTCATCTACCATGGCTCAGCCGGGAACT
CTGAACCTCAATAACGAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGT
TTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA
TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCAT
TTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA
CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAA
GTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG
TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCT
CAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG
CTCTGAAGGGCACACTACACTATTAATAAAAATGGAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATT
AGAACTAAGATGCAGGGGAAATTGCTTAACATTTTCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTA

>In-frame_ENST00000339397_ENST00000515320_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(amino acids)=247AA_start in transcript=72_stop in transcript=815
MAQPGTLNLNNEAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWK
EGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLK

--------------------------------------------------------------
>In-frame_ENST00000339397_ENST00000510025_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(transcript)=1091nt_BP=108nt
GTGGCGACGCAGCCGCGGTCTGAGAGACCGGTTCACGTGCAGGCAGCGGCGGATCATATTCCTTCATCTACCATGGCTCAGCCGGGAACT
CTGAACCTCAATAACGAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGT
TTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA
TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCAT
TTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA
CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAA
GTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG
TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCT
CAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG
CTCTGAAGGGCACACTACACTATTAATAAAAATGGAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATT
AGAACTAAGATGCAGGGGAAATTGCTTAACATTTTCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTA
TTTTTACAAGGAACTATATATAAGCTAGCACATAATTATCCTTCTGTTCTTAGATCTGTATCTTCATAATAAAAAATTTTGCCCAAGTCC

>In-frame_ENST00000339397_ENST00000510025_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(amino acids)=247AA_start in transcript=72_stop in transcript=815
MAQPGTLNLNNEAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWK
EGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLK

--------------------------------------------------------------
>In-frame_ENST00000339397_ENST00000504811_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(transcript)=1086nt_BP=108nt
GTGGCGACGCAGCCGCGGTCTGAGAGACCGGTTCACGTGCAGGCAGCGGCGGATCATATTCCTTCATCTACCATGGCTCAGCCGGGAACT
CTGAACCTCAATAACGAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGT
TTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA
TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCAT
TTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA
CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAA
GTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG
TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCT
CAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG
CTCTGAAGGGCACACTACACTATTAATAAAAATGGAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATT
AGAACTAAGATGCAGGGGAAATTGCTTAACATTTTCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTA
TTTTTACAAGGAACTATATATAAGCTAGCACATAATTATCCTTCTGTTCTTAGATCTGTATCTTCATAATAAAAAATTTTGCCCAAGTCC

>In-frame_ENST00000339397_ENST00000504811_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(amino acids)=247AA_start in transcript=72_stop in transcript=815
MAQPGTLNLNNEAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWK
EGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLK

--------------------------------------------------------------
>In-frame_ENST00000339397_ENST00000414835_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(transcript)=1154nt_BP=108nt
GTGGCGACGCAGCCGCGGTCTGAGAGACCGGTTCACGTGCAGGCAGCGGCGGATCATATTCCTTCATCTACCATGGCTCAGCCGGGAACT
CTGAACCTCAATAACGAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGT
TTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA
TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCAT
TTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA
CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAA
GTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG
TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCT
CAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG
CTCTGAAGGGCACACTACACTATTAATAAAAATGGAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATT
AGAACTAAGATGCAGGGGAAATTGCTTAACATTTTCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTA
TTTTTACAAGGAACTATATATAAGCTAGCACATAATTATCCTTCTGTTCTTAGATCTGTATCTTCATAATAAAAAATTTTGCCCAAGTCC

>In-frame_ENST00000339397_ENST00000414835_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(amino acids)=247AA_start in transcript=72_stop in transcript=815
MAQPGTLNLNNEAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWK
EGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLK

--------------------------------------------------------------
>In-frame_ENST00000339397_ENST00000513628_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(transcript)=996nt_BP=108nt
GTGGCGACGCAGCCGCGGTCTGAGAGACCGGTTCACGTGCAGGCAGCGGCGGATCATATTCCTTCATCTACCATGGCTCAGCCGGGAACT
CTGAACCTCAATAACGAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGT
TTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA
TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCAT
TTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA
CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAA
GTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG
TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCT
CAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG
CTCTGAAGGGCACACTACACTATTAATAAAAATGGAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATT
AGAACTAAGATGCAGGGGAAATTGCTTAACATTTTCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTA

>In-frame_ENST00000339397_ENST00000513628_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(amino acids)=247AA_start in transcript=72_stop in transcript=815
MAQPGTLNLNNEAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWK
EGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLK

--------------------------------------------------------------
>In-frame_ENST00000339397_ENST00000509514_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(transcript)=1074nt_BP=108nt
GTGGCGACGCAGCCGCGGTCTGAGAGACCGGTTCACGTGCAGGCAGCGGCGGATCATATTCCTTCATCTACCATGGCTCAGCCGGGAACT
CTGAACCTCAATAACGAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTTGCTAGTCTAGCAGGT
TTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA
TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAAGGAAACAGAATTCAT
TTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA
CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCTGAGGTGGTGAAGAAA
GTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG
TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTGGGCAAGCTTGACCCT
CAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG
CTCTGAAGGGCACACTACACTATTAATAAAAATGGAATCATTAAATACTCTCTTCACCCAAATATGCTTGATTATTCTGCAAAAGTGATT
AGAACTAAGATGCAGGGGAAATTGCTTAACATTTTCAGATATCAGATAACTGCAGATTTTCATTTTCTACTAATTTTTCATGTATCATTA

>In-frame_ENST00000339397_ENST00000509514_TCGA-C5-A1M7_SRFBP1_chr5_121297763_+_HSD17B4_chr5_118860910_length(amino acids)=247AA_start in transcript=72_stop in transcript=815
MAQPGTLNLNNEAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWK
EGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SRFBP1-HSD17B4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRFBP1-HSD17B4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHSD17B4P51659DB00157NADHSmall moleculeApproved|Nutraceutical
TgeneHSD17B4P51659DB00157NADHSmall moleculeApproved|Nutraceutical
TgeneHSD17B4P51659DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for SRFBP1-HSD17B4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHSD17B4C0342870Bifunctional peroxisomal enzyme deficiency12CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneHSD17B4C0685838Gonadal dysgenesis XX type deafness10CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneHSD17B4C0282525Adrenoleukodystrophy, Neonatal2CTD_human
TgeneHSD17B4C0282526Hyperpipecolic Acidemia2CTD_human
TgeneHSD17B4C0282528Peroxisomal Disorders2CTD_human
TgeneHSD17B4C0751708Peroxisomal Dysfunction, General2CTD_human
TgeneHSD17B4C0751709Peroxisomal Dysfunction, Multiple2CTD_human
TgeneHSD17B4C0751710Peroxisomal Dysfunction, Single2CTD_human
TgeneHSD17B4C4551721PERRAULT SYNDROME 12GENOMICS_ENGLAND;UNIPROT
TgeneHSD17B4C0037769West Syndrome1CTD_human
TgeneHSD17B4C0043459Zellweger Syndrome1CTD_human
TgeneHSD17B4C0393698Cryptogenic Infantile Spasms1CTD_human
TgeneHSD17B4C0393699Symptomatic Infantile Spasms1CTD_human
TgeneHSD17B4C0546878Nodding spasm1CTD_human
TgeneHSD17B4C0553558Jackknife Seizures1CTD_human
TgeneHSD17B4C0684276Hypsarrhythmia1CTD_human
TgeneHSD17B4C0751594Zellweger-Like Syndrome1CTD_human
TgeneHSD17B4C1384666hearing impairment1GENOMICS_ENGLAND
TgeneHSD17B4C1527306spasmus nutans1CTD_human
TgeneHSD17B4C1527366Salaam Seizures1CTD_human
TgeneHSD17B4C3658299Zellweger Spectrum1CTD_human