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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRGAP3-RAF1 (FusionGDB2 ID:85798)

Fusion Gene Summary for SRGAP3-RAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SRGAP3-RAF1
Fusion gene ID: 85798
HgeneTgene
Gene symbol

SRGAP3

RAF1

Gene ID

23380

6037

Gene nameSLIT-ROBO Rho GTPase activating protein 2ribonuclease A family member 3
SynonymsARHGAP34|FNBP2|SRGAP2A|SRGAP3ECP|RAF1|RNS3
Cytomap

1q32.1

14q11.2

Type of geneprotein-codingprotein-coding
DescriptionSLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34eosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3
Modification date2020031320200313
UniProtAcc.

P04049

Ensembl transtripts involved in fusion geneENST00000383836, ENST00000360413, 
ENST00000433332, 		ENST00000251849, 
ENST00000442415, ENST00000534997, 
ENST00000542177, 
Fusion gene scores* DoF score12 X 10 X 10=120019 X 16 X 7=2128
# samples 1818
** MAII scorelog2(18/1200*10)=-2.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2128*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRGAP3 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRGAP3(9290737)-RAF1(12625108), # samples:1
SRGAP3(9074334)-RAF1(12641309), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRGAP3

GO:0043547

positive regulation of GTPase activity

21148482

HgeneSRGAP3

GO:0046847

filopodium assembly

22559944

HgeneSRGAP3

GO:0051014

actin filament severing

21148482

HgeneSRGAP3

GO:0060996

dendritic spine development

22559944

HgeneSRGAP3

GO:2001223

negative regulation of neuron migration

22559944

TgeneRAF1

GO:0002227

innate immune response in mucosa

12860195

TgeneRAF1

GO:0019731

antibacterial humoral response

12860195

TgeneRAF1

GO:0043152

induction of bacterial agglutination

23992292

TgeneRAF1

GO:0045087

innate immune response

23992292

TgeneRAF1

GO:0050829

defense response to Gram-negative bacterium

23992292

TgeneRAF1

GO:0050830

defense response to Gram-positive bacterium

12860195|23992292

TgeneRAF1

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195


check buttonFusion gene breakpoints across SRGAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4astrocytomaFM209427SRGAP3chr3

9290737

RAF1chr3

12625108

ChiTaRS5.0N/AFM209427SRGAP3chr3

9074334

-RAF1chr3

12641309

-


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Fusion Gene ORF analysis for SRGAP3-RAF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000383836ENST00000251849SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000383836ENST00000442415SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000383836ENST00000534997SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000383836ENST00000542177SRGAP3chr3

9290737

RAF1chr3

12625108

intron-3UTRENST00000360413ENST00000251849SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000360413ENST00000442415SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000360413ENST00000534997SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000360413ENST00000542177SRGAP3chr3

9290737

RAF1chr3

12625108

intron-3UTRENST00000433332ENST00000251849SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000433332ENST00000442415SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000433332ENST00000534997SRGAP3chr3

9290737

RAF1chr3

12625108

intron-intronENST00000433332ENST00000542177SRGAP3chr3

9290737

RAF1chr3

12625108

In-frameENST00000383836ENST00000251849SRGAP3chr3

9074334

-RAF1chr3

12641309

-
In-frameENST00000383836ENST00000442415SRGAP3chr3

9074334

-RAF1chr3

12641309

-
In-frameENST00000383836ENST00000534997SRGAP3chr3

9074334

-RAF1chr3

12641309

-
In-frameENST00000383836ENST00000542177SRGAP3chr3

9074334

-RAF1chr3

12641309

-
intron-3CDSENST00000360413ENST00000251849SRGAP3chr3

9074334

-RAF1chr3

12641309

-
intron-3CDSENST00000360413ENST00000442415SRGAP3chr3

9074334

-RAF1chr3

12641309

-
intron-3CDSENST00000360413ENST00000534997SRGAP3chr3

9074334

-RAF1chr3

12641309

-
intron-3CDSENST00000360413ENST00000542177SRGAP3chr3

9074334

-RAF1chr3

12641309

-
5UTR-3CDSENST00000433332ENST00000251849SRGAP3chr3

9074334

-RAF1chr3

12641309

-
5UTR-3CDSENST00000433332ENST00000442415SRGAP3chr3

9074334

-RAF1chr3

12641309

-
5UTR-3CDSENST00000433332ENST00000534997SRGAP3chr3

9074334

-RAF1chr3

12641309

-
5UTR-3CDSENST00000433332ENST00000542177SRGAP3chr3

9074334

-RAF1chr3

12641309

-
5UTR-3CDSENST00000433332ENST00000251849SRGAP3chr3

9079746

-RAF1chr3

12641914

-
5UTR-3CDSENST00000433332ENST00000442415SRGAP3chr3

9079746

-RAF1chr3

12641914

-
5UTR-3CDSENST00000433332ENST00000534997SRGAP3chr3

9079746

-RAF1chr3

12641914

-
5UTR-3CDSENST00000433332ENST00000542177SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000360413ENST00000251849SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000360413ENST00000442415SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000360413ENST00000534997SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000360413ENST00000542177SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000383836ENST00000251849SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000383836ENST00000442415SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000383836ENST00000534997SRGAP3chr3

9079746

-RAF1chr3

12641914

-
Frame-shiftENST00000383836ENST00000542177SRGAP3chr3

9079746

-RAF1chr3

12641914

-
intron-3UTRENST00000360413ENST00000251849SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-3UTRENST00000383836ENST00000251849SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-3UTRENST00000433332ENST00000251849SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000360413ENST00000442415SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000360413ENST00000534997SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000360413ENST00000542177SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000383836ENST00000442415SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000383836ENST00000534997SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000383836ENST00000542177SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000433332ENST00000442415SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000433332ENST00000534997SRGAP3chr3

9290737

-RAF1chr3

12625108

-
intron-intronENST00000433332ENST00000542177SRGAP3chr3

9290737

-RAF1chr3

12625108

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000383836SRGAP3chr39074334-ENST00000251849RAF1chr312641309-383719673382923861
ENST00000383836SRGAP3chr39074334-ENST00000442415RAF1chr312641309-364019673382923861
ENST00000383836SRGAP3chr39074334-ENST00000534997RAF1chr312641309-317119673382923861
ENST00000383836SRGAP3chr39074334-ENST00000542177RAF1chr312641309-310519673382923861

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000383836ENST00000251849SRGAP3chr39074334-RAF1chr312641309-0.0029715990.9970284
ENST00000383836ENST00000442415SRGAP3chr39074334-RAF1chr312641309-0.0046868190.99531317
ENST00000383836ENST00000534997SRGAP3chr39074334-RAF1chr312641309-0.0043996660.99560034
ENST00000383836ENST00000542177SRGAP3chr39074334-RAF1chr312641309-0.0045025350.99549747

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Fusion Genomic Features for SRGAP3-RAF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SRGAP3-RAF1


check button Go to

FGviewer for the breakpoints of chr3:9074334-chr3:12641309

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RAF1

P04049

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000383836-1222352_392513.01100.0Coiled coilOntology_term=ECO:0000255
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000383836-122219_314513.01100.0DomainF-BAR
TgeneRAF1chr3:9074334chr3:12641309ENST00000251849817349_609330.0649.0DomainProtein kinase
TgeneRAF1chr3:9074334chr3:12641309ENST00000442415918349_609350.0669.0DomainProtein kinase
TgeneRAF1chr3:9074334chr3:12641309ENST00000251849817355_363330.0649.0Nucleotide bindingATP
TgeneRAF1chr3:9074334chr3:12641309ENST00000442415918355_363350.0669.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000360413-122352_39201076.0Coiled coilOntology_term=ECO:0000255
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000360413-122952_98701076.0Coiled coilOntology_term=ECO:0000255
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000383836-1222952_987513.01100.0Coiled coilOntology_term=ECO:0000255
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000360413-12219_31401076.0DomainF-BAR
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000360413-122482_67001076.0DomainRho-GAP
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000360413-122744_80301076.0DomainSH3
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000383836-1222482_670513.01100.0DomainRho-GAP
HgeneSRGAP3chr3:9074334chr3:12641309ENST00000383836-1222744_803513.01100.0DomainSH3
TgeneRAF1chr3:9074334chr3:12641309ENST0000025184981756_131330.0649.0DomainRBD
TgeneRAF1chr3:9074334chr3:12641309ENST0000044241591856_131350.0669.0DomainRBD
TgeneRAF1chr3:9074334chr3:12641309ENST00000251849817138_184330.0649.0Zinc fingerPhorbol-ester/DAG-type
TgeneRAF1chr3:9074334chr3:12641309ENST00000442415918138_184350.0669.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for SRGAP3-RAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000383836_ENST00000251849_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(transcript)=3837nt_BP=1967nt
GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG
TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG
TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA
GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA
GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA
AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC
AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG
AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT
GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC
TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA
ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG
AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA
TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG
CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG
CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA
ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA
TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA
CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG
TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA
GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG
CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC
AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC
AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA
AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG
CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG
AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG
GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG
GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG
AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG
AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA
AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT
CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA
ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC
AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA
GGGCCTTAACTTCATGTTGCCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCC
CCACATTCCCCATGCTCAAGGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTG
TTGGCTACATGAGTATTTAGAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGA
GGAATGCATGTCACAGGCGGGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCG
AGACTCTGGCCGCCCGAAGGAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAG
TGCATTGGGATGGTTTTCCAGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTC
TTCCAGGAGCTGCCCCTATGGGGCGGGGCCGCAGGGCCAGCCTTGTTTCTCTAACAAACAAACAAACAAACAGCCTTGTTTCTCTAGTCA
CATCATGTGTATACAAGGAAGCCAGGAATACAGGTTTTCTTGATGATTTGGGTTTTAATTTTGTTTTTATTGCACCTGACAAAATACAGT

>In-frame_ENST00000383836_ENST00000251849_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(amino acids)=861AA_start in transcript=338_stop in transcript=2923
MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH
EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL
KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA
FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL
AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG
SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP

--------------------------------------------------------------
>In-frame_ENST00000383836_ENST00000442415_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(transcript)=3640nt_BP=1967nt
GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG
TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG
TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA
GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA
GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA
AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC
AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG
AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT
GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC
TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA
ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG
AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA
TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG
CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG
CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA
ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA
TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA
CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG
TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA
GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG
CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC
AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC
AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA
AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG
CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG
AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG
GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG
GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG
AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG
AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA
AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT
CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA
ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC
AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA
GGGCCTTAACTTCATGTTGCCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCC
CCACATTCCCCATGCTCAAGGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTG
TTGGCTACATGAGTATTTAGAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGA
GGAATGCATGTCACAGGCGGGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCG
AGACTCTGGCCGCCCGAAGGAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAG
TGCATTGGGATGGTTTTCCAGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTC

>In-frame_ENST00000383836_ENST00000442415_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(amino acids)=861AA_start in transcript=338_stop in transcript=2923
MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH
EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL
KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA
FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL
AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG
SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP

--------------------------------------------------------------
>In-frame_ENST00000383836_ENST00000534997_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(transcript)=3171nt_BP=1967nt
GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG
TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG
TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA
GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA
GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA
AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC
AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG
AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT
GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC
TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA
ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG
AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA
TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG
CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG
CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA
ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA
TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA
CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG
TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA
GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG
CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC
AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC
AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA
AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG
CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG
AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG
GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG
GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG
AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG
AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA
AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT
CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA
ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC
AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA
GGGCCTTAACTTCATGTTGCCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCC

>In-frame_ENST00000383836_ENST00000534997_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(amino acids)=861AA_start in transcript=338_stop in transcript=2923
MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH
EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL
KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA
FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL
AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG
SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP

--------------------------------------------------------------
>In-frame_ENST00000383836_ENST00000542177_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(transcript)=3105nt_BP=1967nt
GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG
TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG
TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA
GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA
GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA
AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC
AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG
AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT
GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC
TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA
ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG
AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA
TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG
CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG
CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA
ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA
TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA
CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG
TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA
GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG
CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC
AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC
AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA
AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG
CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG
AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG
GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG
GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG
AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG
AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA
AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT
CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA
ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC
AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA

>In-frame_ENST00000383836_ENST00000542177_FM209427_SRGAP3_chr3_9074334_-_RAF1_chr3_12641309_length(amino acids)=861AA_start in transcript=338_stop in transcript=2923
MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH
EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL
KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA
FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL
AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG
SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SRGAP3-RAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRAF1chr3:9074334chr3:12641309ENST00000251849817331_349330.0649.0PEBP1/RKIP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRAF1chr3:9074334chr3:12641309ENST00000442415918331_349350.0669.0PEBP1/RKIP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRGAP3-RAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRAF1P04049DB08896RegorafenibInhibitorSmall moleculeApproved
TgeneRAF1P04049DB08896RegorafenibInhibitorSmall moleculeApproved
TgeneRAF1P04049DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08862CholecystokininAgonistSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08862CholecystokininAgonistSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneRAF1P04049DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

Top

Related Diseases for SRGAP3-RAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRGAP3C1519086Pilomyxoid astrocytoma2ORPHANET
HgeneSRGAP3C0020796Profound Mental Retardation1CTD_human
HgeneSRGAP3C0025363Mental Retardation, Psychosocial1CTD_human
HgeneSRGAP3C0036341Schizophrenia1PSYGENET
HgeneSRGAP3C0795806Chromosome 3, monosomy 3p1GENOMICS_ENGLAND
HgeneSRGAP3C0917816Mental deficiency1CTD_human
HgeneSRGAP3C1535926Neurodevelopmental Disorders1CTD_human
HgeneSRGAP3C2931337Chromosome 3, monosomy 3p251CTD_human
HgeneSRGAP3C3714756Intellectual Disability1CTD_human
TgeneRAF1C0028326Noonan Syndrome10CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRAF1C0175704LEOPARD Syndrome7CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneRAF1C1969057Noonan Syndrome 54CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRAF1C1969056LEOPARD SYNDROME 23CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRAF1C0007194Hypertrophic Cardiomyopathy2CTD_human
TgeneRAF1C0041409Turner Syndrome, Male2CTD_human
TgeneRAF1C1519086Pilomyxoid astrocytoma2ORPHANET
TgeneRAF1C1527404Female Pseudo-Turner Syndrome2CTD_human
TgeneRAF1C4551472Hypertrophic obstructive cardiomyopathy2CTD_human
TgeneRAF1C4551602Noonan Syndrome 12CTD_human
TgeneRAF1C0006142Malignant neoplasm of breast1CTD_human
TgeneRAF1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneRAF1C0007193Cardiomyopathy, Dilated1CTD_human
TgeneRAF1C0017638Glioma1CTD_human
TgeneRAF1C0020429Hyperalgesia1CTD_human
TgeneRAF1C0022665Kidney Neoplasm1CTD_human
TgeneRAF1C0023903Liver neoplasms1CTD_human
TgeneRAF1C0024121Lung Neoplasms1CTD_human
TgeneRAF1C0242379Malignant neoplasm of lung1CTD_human
TgeneRAF1C0259783mixed gliomas1CTD_human
TgeneRAF1C0340427Familial dilated cardiomyopathy1ORPHANET
TgeneRAF1C0345904Malignant neoplasm of liver1CTD_human
TgeneRAF1C0345967Malignant mesothelioma1CTD_human
TgeneRAF1C0458247Allodynia1CTD_human
TgeneRAF1C0555198Malignant Glioma1CTD_human
TgeneRAF1C0587248Costello syndrome (disorder)1CLINGEN
TgeneRAF1C0678222Breast Carcinoma1CTD_human
TgeneRAF1C0740457Malignant neoplasm of kidney1CTD_human
TgeneRAF1C0751211Hyperalgesia, Primary1CTD_human
TgeneRAF1C0751212Hyperalgesia, Secondary1CTD_human
TgeneRAF1C0751213Tactile Allodynia1CTD_human
TgeneRAF1C0751214Hyperalgesia, Thermal1CTD_human
TgeneRAF1C1257931Mammary Neoplasms, Human1CTD_human
TgeneRAF1C1275081Cardio-facio-cutaneous syndrome1CLINGEN
TgeneRAF1C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneRAF1C1458155Mammary Neoplasms1CTD_human
TgeneRAF1C2936719Mechanical Allodynia1CTD_human
TgeneRAF1C4014656CARDIOMYOPATHY, DILATED, 1NN1CTD_human;UNIPROT
TgeneRAF1C4551484Leopard Syndrome 11CTD_human;GENOMICS_ENGLAND
TgeneRAF1C4704874Mammary Carcinoma, Human1CTD_human
TgeneRAF1C4721610Carcinoma, Ovarian Epithelial1CTD_human