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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRSF11-C11orf49 (FusionGDB2 ID:85996)

Fusion Gene Summary for SRSF11-C11orf49

check button Fusion gene summary
Fusion gene informationFusion gene name: SRSF11-C11orf49
Fusion gene ID: 85996
HgeneTgene
Gene symbol

SRSF11

C11orf49

Gene ID

9295

79096

Gene nameserine and arginine rich splicing factor 11chromosome 11 open reading frame 49
SynonymsNET2|SFRS11|dJ677H15.2|p54-
Cytomap

1p31.1

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine-rich splicing factor 11SR splicing factor 11arginine-rich 54 kDa nuclear proteinsplicing factor p54splicing factor, arginine/serine-rich 11UPF0705 protein C11orf49
Modification date2020031320200313
UniProtAcc.

Q9H6J7

Ensembl transtripts involved in fusion geneENST00000370951, ENST00000405432, 
ENST00000370950, ENST00000454435, 
ENST00000436161, ENST00000484162, 
ENST00000370949, 		ENST00000378618, 
ENST00000536126, ENST00000278460, 
ENST00000395460, ENST00000378615, 
ENST00000543718, ENST00000527268, 
Fusion gene scores* DoF score13 X 13 X 6=101417 X 14 X 6=1428
# samples 1618
** MAII scorelog2(16/1014*10)=-2.66391384211598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1428*10)=-2.98792716769943
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRSF11 [Title/Abstract] AND C11orf49 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRSF11(70694238)-C11orf49(47008758), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SRSF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across C11orf49 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2033SRSF11chr1

70694238

+C11orf49chr11

47008758

+


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Fusion Gene ORF analysis for SRSF11-C11orf49

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000370951ENST00000378618SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370951ENST00000536126SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370951ENST00000278460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370951ENST00000395460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370951ENST00000378615SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370951ENST00000543718SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-intronENST00000370951ENST00000527268SRSF11chr1

70694238

+C11orf49chr11

47008758

+
In-frameENST00000405432ENST00000378618SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000405432ENST00000536126SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000405432ENST00000278460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000405432ENST00000395460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000405432ENST00000378615SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000405432ENST00000543718SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-intronENST00000405432ENST00000527268SRSF11chr1

70694238

+C11orf49chr11

47008758

+
In-frameENST00000370950ENST00000378618SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370950ENST00000536126SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370950ENST00000278460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370950ENST00000395460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370950ENST00000378615SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000370950ENST00000543718SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-intronENST00000370950ENST00000527268SRSF11chr1

70694238

+C11orf49chr11

47008758

+
In-frameENST00000454435ENST00000378618SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000454435ENST00000536126SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000454435ENST00000278460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000454435ENST00000395460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000454435ENST00000378615SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000454435ENST00000543718SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-intronENST00000454435ENST00000527268SRSF11chr1

70694238

+C11orf49chr11

47008758

+
In-frameENST00000436161ENST00000378618SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000436161ENST00000536126SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000436161ENST00000278460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000436161ENST00000395460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000436161ENST00000378615SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-5UTRENST00000436161ENST00000543718SRSF11chr1

70694238

+C11orf49chr11

47008758

+
5CDS-intronENST00000436161ENST00000527268SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-3CDSENST00000484162ENST00000378618SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000484162ENST00000536126SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000484162ENST00000278460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000484162ENST00000395460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000484162ENST00000378615SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000484162ENST00000543718SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-intronENST00000484162ENST00000527268SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-3CDSENST00000370949ENST00000378618SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000370949ENST00000536126SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000370949ENST00000278460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000370949ENST00000395460SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000370949ENST00000378615SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-5UTRENST00000370949ENST00000543718SRSF11chr1

70694238

+C11orf49chr11

47008758

+
intron-intronENST00000370949ENST00000527268SRSF11chr1

70694238

+C11orf49chr11

47008758

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370951SRSF11chr170694238+ENST00000378618C11orf49chr1147008758+15264581211392423
ENST00000405432SRSF11chr170694238+ENST00000378618C11orf49chr1147008758+1484416791350423
ENST00000370950SRSF11chr170694238+ENST00000378618C11orf49chr1147008758+1487419821353423
ENST00000454435SRSF11chr170694238+ENST00000378618C11orf49chr1147008758+1473405681339423
ENST00000436161SRSF11chr170694238+ENST00000378618C11orf49chr1147008758+15805121751446423

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370951ENST00000378618SRSF11chr170694238+C11orf49chr1147008758+0.0147197450.9852802
ENST00000405432ENST00000378618SRSF11chr170694238+C11orf49chr1147008758+0.0144115440.9855884
ENST00000370950ENST00000378618SRSF11chr170694238+C11orf49chr1147008758+0.0141944080.9858056
ENST00000454435ENST00000378618SRSF11chr170694238+C11orf49chr1147008758+0.013739420.9862606
ENST00000436161ENST00000378618SRSF11chr170694238+C11orf49chr1147008758+0.0128849580.987115

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Fusion Genomic Features for SRSF11-C11orf49


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SRSF11chr170694238+C11orf49chr1147008758+2.20E-091
SRSF11chr170694238+C11orf49chr1147008758+2.20E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SRSF11-C11orf49


check button Go to

FGviewer for the breakpoints of chr1:70694238-chr11:47008758

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.C11orf49

Q9H6J7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+31317_31112.33333333333333485.0Compositional biasNote=Poly-Gly
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+31317_31112.33333333333333484.0Compositional biasNote=Poly-Gly
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+31317_31112.33333333333333485.0Compositional biasNote=Poly-Gly
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+31333_113112.33333333333333485.0DomainRRM
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+31333_113112.33333333333333484.0DomainRRM
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+31333_113112.33333333333333485.0DomainRRM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313252_259112.33333333333333485.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313291_294112.33333333333333485.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313341_349112.33333333333333485.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313397_404112.33333333333333485.0Compositional biasNote=Poly-Lys
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313252_259112.33333333333333484.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313291_294112.33333333333333484.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313341_349112.33333333333333484.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313397_404112.33333333333333484.0Compositional biasNote=Poly-Lys
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313252_259112.33333333333333485.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313291_294112.33333333333333485.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313341_349112.33333333333333485.0Compositional biasNote=Poly-Arg
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313397_404112.33333333333333485.0Compositional biasNote=Poly-Lys
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313247_353112.33333333333333485.0RegionNote=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313247_353112.33333333333333484.0RegionNote=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313247_353112.33333333333333485.0RegionNote=10 X 8 AA approximate repeats of R-R-S-R-S-R-S-R
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313247_255112.33333333333333485.0RepeatNote=1
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313258_265112.33333333333333485.0RepeatNote=2
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313267_274112.33333333333333485.0RepeatNote=3
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313275_282112.33333333333333485.0RepeatNote=4
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313285_292112.33333333333333485.0RepeatNote=5
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313293_300112.33333333333333485.0RepeatNote=6
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313302_309112.33333333333333485.0RepeatNote=7
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313321_328112.33333333333333485.0RepeatNote=8
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313334_341112.33333333333333485.0RepeatNote=9
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370950+313346_353112.33333333333333485.0RepeatNote=10
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313247_255112.33333333333333484.0RepeatNote=1
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313258_265112.33333333333333484.0RepeatNote=2
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313267_274112.33333333333333484.0RepeatNote=3
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313275_282112.33333333333333484.0RepeatNote=4
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313285_292112.33333333333333484.0RepeatNote=5
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313293_300112.33333333333333484.0RepeatNote=6
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313302_309112.33333333333333484.0RepeatNote=7
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313321_328112.33333333333333484.0RepeatNote=8
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313334_341112.33333333333333484.0RepeatNote=9
HgeneSRSF11chr1:70694238chr11:47008758ENST00000370951+313346_353112.33333333333333484.0RepeatNote=10
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313247_255112.33333333333333485.0RepeatNote=1
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313258_265112.33333333333333485.0RepeatNote=2
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313267_274112.33333333333333485.0RepeatNote=3
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313275_282112.33333333333333485.0RepeatNote=4
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313285_292112.33333333333333485.0RepeatNote=5
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313293_300112.33333333333333485.0RepeatNote=6
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313302_309112.33333333333333485.0RepeatNote=7
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313321_328112.33333333333333485.0RepeatNote=8
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313334_341112.33333333333333485.0RepeatNote=9
HgeneSRSF11chr1:70694238chr11:47008758ENST00000405432+313346_353112.33333333333333485.0RepeatNote=10


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Fusion Gene Sequence for SRSF11-C11orf49


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000370951_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(transcript)=1526nt_BP=458nt
GCAGTCCAGATGTCGTCAGCACCAGCGCCTGGGCTGGAGGACAGAGAAGCCTTTTCCGTTGCCGGTGCCGGCCTAGCGTCCTGGAATTAC
TTCAATCAAGAGCGAGAACCCGAGCAGCGCCATGAGCAACACTACCGTCGTCCCCAGCACTGCAGGTCCGGGCCCCAGCGGCGGGCCCGG
TGGCGGAGGTGGTGGTGGCGGCGGAGGCGGCGGCACCGAGGTAATCCAGGTGACTAATGTCTCCCCGAGCGCTAGCTCTGAGCAGATGCG
GACTCTCTTCGGTTTCCTAGGCAAGATCGACGAACTGCGCCTCTTCCCGCCGGATGATTCGCCTTTGCCAGTCTCATCTCGTGTCTGCTT
TGTTAAGTTCCATGATCCAGACTCAGCAGTTGTGGCACAGCATCTGACAAACACTGTATTCGTTGACAGAGCTTTGATAGTCGTACCATA
TGCAGAAGCTCAGCGACATGTCCTCACCTACATGGAGGATGCAGTGTGCCAGCTGCTAGAAAACAGGGAAGATATTAGCCAATATGGAAT
TGCCAGGTTCTTCACTGAATATTTTAACAGTGTATGCCAGGGAACACACATTCTCTTTCGAGAATTCAGCTTCGTCCAAGCCACCCCCCA
CAATAGGGTATCATTTTTACGGGCCTTCTGGAGATGCTTCCGAACTGTGGGCAAAAATGGCGATTTGCTGACCATGAAAGAATATCACTG
TTTGCTGCAATTACTGTGTCCTGATTTCCCGCTGGAGCTCACTCAGAAAGCAGCCAGGATTGTGCTCATGGACGATGCCATGGACTGCTT
GATGTCTTTTTCAGATTTCCTCTTTGCCTTCCAGATCCAGTTTTACTACTCAGAATTCCTGGACAGTGTGGCTGCCATCTATGAGGACCT
GCTGTCAGGCAAGAACCCCAACACAGTGATTGTGCCGACGTCGTCCAGTGGGCAGCACCGCCAACGACCTGCCTTGGGCGGGGCCGGCAC
GCTGGAGGGCGTGGAGGCGTCGCTGTTCTACCAGTGTCTGGAAAACCTGTGTGATCGGCACAAGTACAGCTGCCCACCCCCAGCACTTGT
CAAAGAGGCCCTCAGCAATGTTCAGAGACTGACCTTCTATGGATTCCTCATGGCTCTCTCAAAGCACCGTGGAATCAACCAAGCCCTCGG
AGCTTTGCCTGACAAGGGGGATCTGATGCACGACCCAGCAATGGATGAAGAGCTGGAACGGCTGGTGGTGAGGTCGAAGCTGCACCGGAC
CTCACGGCAGCACAGAGCCAAGGAGCCAGGGGCCTTTGGCTTTCAGAGAAGAGAGAAGCAGGAGGCCCTGGAGAGAGTGTCCTCAGCTTC
GGTACCGACGCCCTACCATTACCGGTGGGAGCCCAGAGAGTGAGGCCAGGGGCCGGCACTGGGCAGGGAGGCAGGATCCAGAGGACACTG

>In-frame_ENST00000370951_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(amino acids)=423AA_start in transcript=121_stop in transcript=1392
MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAV
VAQHLTNTVFVDRALIVVPYAEAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFW
RCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVI
VPTSSSGQHRQRPALGGAGTLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHRGINQALGALPDKGDLMH

--------------------------------------------------------------
>In-frame_ENST00000405432_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(transcript)=1484nt_BP=416nt
AGAGAAGCCTTTTCCGTTGCCGGTGCCGGCCTAGCGTCCTGGAATTACTTCAATCAAGAGCGAGAACCCGAGCAGCGCCATGAGCAACAC
TACCGTCGTCCCCAGCACTGCAGGTCCGGGCCCCAGCGGCGGGCCCGGTGGCGGAGGTGGTGGTGGCGGCGGAGGCGGCGGCACCGAGGT
AATCCAGGTGACTAATGTCTCCCCGAGCGCTAGCTCTGAGCAGATGCGGACTCTCTTCGGTTTCCTAGGCAAGATCGACGAACTGCGCCT
CTTCCCGCCGGATGATTCGCCTTTGCCAGTCTCATCTCGTGTCTGCTTTGTTAAGTTCCATGATCCAGACTCAGCAGTTGTGGCACAGCA
TCTGACAAACACTGTATTCGTTGACAGAGCTTTGATAGTCGTACCATATGCAGAAGCTCAGCGACATGTCCTCACCTACATGGAGGATGC
AGTGTGCCAGCTGCTAGAAAACAGGGAAGATATTAGCCAATATGGAATTGCCAGGTTCTTCACTGAATATTTTAACAGTGTATGCCAGGG
AACACACATTCTCTTTCGAGAATTCAGCTTCGTCCAAGCCACCCCCCACAATAGGGTATCATTTTTACGGGCCTTCTGGAGATGCTTCCG
AACTGTGGGCAAAAATGGCGATTTGCTGACCATGAAAGAATATCACTGTTTGCTGCAATTACTGTGTCCTGATTTCCCGCTGGAGCTCAC
TCAGAAAGCAGCCAGGATTGTGCTCATGGACGATGCCATGGACTGCTTGATGTCTTTTTCAGATTTCCTCTTTGCCTTCCAGATCCAGTT
TTACTACTCAGAATTCCTGGACAGTGTGGCTGCCATCTATGAGGACCTGCTGTCAGGCAAGAACCCCAACACAGTGATTGTGCCGACGTC
GTCCAGTGGGCAGCACCGCCAACGACCTGCCTTGGGCGGGGCCGGCACGCTGGAGGGCGTGGAGGCGTCGCTGTTCTACCAGTGTCTGGA
AAACCTGTGTGATCGGCACAAGTACAGCTGCCCACCCCCAGCACTTGTCAAAGAGGCCCTCAGCAATGTTCAGAGACTGACCTTCTATGG
ATTCCTCATGGCTCTCTCAAAGCACCGTGGAATCAACCAAGCCCTCGGAGCTTTGCCTGACAAGGGGGATCTGATGCACGACCCAGCAAT
GGATGAAGAGCTGGAACGGCTGGTGGTGAGGTCGAAGCTGCACCGGACCTCACGGCAGCACAGAGCCAAGGAGCCAGGGGCCTTTGGCTT
TCAGAGAAGAGAGAAGCAGGAGGCCCTGGAGAGAGTGTCCTCAGCTTCGGTACCGACGCCCTACCATTACCGGTGGGAGCCCAGAGAGTG
AGGCCAGGGGCCGGCACTGGGCAGGGAGGCAGGATCCAGAGGACACTGCTTCACTCAGACCAACAGGGAGCCAGGCCCTGCAGGGGCTTT

>In-frame_ENST00000405432_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(amino acids)=423AA_start in transcript=79_stop in transcript=1350
MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAV
VAQHLTNTVFVDRALIVVPYAEAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFW
RCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVI
VPTSSSGQHRQRPALGGAGTLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHRGINQALGALPDKGDLMH

--------------------------------------------------------------
>In-frame_ENST00000370950_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(transcript)=1487nt_BP=419nt
AGAGAAGCCTTTTCCGTTGCCGGTGCCGGCCTAGCGTCCTGGAATTACTTCAATCAACAGGAGCGAGAACCCGAGCAGCGCCATGAGCAA
CACTACCGTCGTCCCCAGCACTGCAGGTCCGGGCCCCAGCGGCGGGCCCGGTGGCGGAGGTGGTGGTGGCGGCGGAGGCGGCGGCACCGA
GGTAATCCAGGTGACTAATGTCTCCCCGAGCGCTAGCTCTGAGCAGATGCGGACTCTCTTCGGTTTCCTAGGCAAGATCGACGAACTGCG
CCTCTTCCCGCCGGATGATTCGCCTTTGCCAGTCTCATCTCGTGTCTGCTTTGTTAAGTTCCATGATCCAGACTCAGCAGTTGTGGCACA
GCATCTGACAAACACTGTATTCGTTGACAGAGCTTTGATAGTCGTACCATATGCAGAAGCTCAGCGACATGTCCTCACCTACATGGAGGA
TGCAGTGTGCCAGCTGCTAGAAAACAGGGAAGATATTAGCCAATATGGAATTGCCAGGTTCTTCACTGAATATTTTAACAGTGTATGCCA
GGGAACACACATTCTCTTTCGAGAATTCAGCTTCGTCCAAGCCACCCCCCACAATAGGGTATCATTTTTACGGGCCTTCTGGAGATGCTT
CCGAACTGTGGGCAAAAATGGCGATTTGCTGACCATGAAAGAATATCACTGTTTGCTGCAATTACTGTGTCCTGATTTCCCGCTGGAGCT
CACTCAGAAAGCAGCCAGGATTGTGCTCATGGACGATGCCATGGACTGCTTGATGTCTTTTTCAGATTTCCTCTTTGCCTTCCAGATCCA
GTTTTACTACTCAGAATTCCTGGACAGTGTGGCTGCCATCTATGAGGACCTGCTGTCAGGCAAGAACCCCAACACAGTGATTGTGCCGAC
GTCGTCCAGTGGGCAGCACCGCCAACGACCTGCCTTGGGCGGGGCCGGCACGCTGGAGGGCGTGGAGGCGTCGCTGTTCTACCAGTGTCT
GGAAAACCTGTGTGATCGGCACAAGTACAGCTGCCCACCCCCAGCACTTGTCAAAGAGGCCCTCAGCAATGTTCAGAGACTGACCTTCTA
TGGATTCCTCATGGCTCTCTCAAAGCACCGTGGAATCAACCAAGCCCTCGGAGCTTTGCCTGACAAGGGGGATCTGATGCACGACCCAGC
AATGGATGAAGAGCTGGAACGGCTGGTGGTGAGGTCGAAGCTGCACCGGACCTCACGGCAGCACAGAGCCAAGGAGCCAGGGGCCTTTGG
CTTTCAGAGAAGAGAGAAGCAGGAGGCCCTGGAGAGAGTGTCCTCAGCTTCGGTACCGACGCCCTACCATTACCGGTGGGAGCCCAGAGA
GTGAGGCCAGGGGCCGGCACTGGGCAGGGAGGCAGGATCCAGAGGACACTGCTTCACTCAGACCAACAGGGAGCCAGGCCCTGCAGGGGC

>In-frame_ENST00000370950_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(amino acids)=423AA_start in transcript=82_stop in transcript=1353
MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAV
VAQHLTNTVFVDRALIVVPYAEAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFW
RCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVI
VPTSSSGQHRQRPALGGAGTLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHRGINQALGALPDKGDLMH

--------------------------------------------------------------
>In-frame_ENST00000454435_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(transcript)=1473nt_BP=405nt
TTCCGTTGCCGGTGCCGGCCTAGCGTCCTGGAATTACTTCAATCAAGAGCGAGAACCCGAGCAGCGCCATGAGCAACACTACCGTCGTCC
CCAGCACTGCAGGTCCGGGCCCCAGCGGCGGGCCCGGTGGCGGAGGTGGTGGTGGCGGCGGAGGCGGCGGCACCGAGGTAATCCAGGTGA
CTAATGTCTCCCCGAGCGCTAGCTCTGAGCAGATGCGGACTCTCTTCGGTTTCCTAGGCAAGATCGACGAACTGCGCCTCTTCCCGCCGG
ATGATTCGCCTTTGCCAGTCTCATCTCGTGTCTGCTTTGTTAAGTTCCATGATCCAGACTCAGCAGTTGTGGCACAGCATCTGACAAACA
CTGTATTCGTTGACAGAGCTTTGATAGTCGTACCATATGCAGAAGCTCAGCGACATGTCCTCACCTACATGGAGGATGCAGTGTGCCAGC
TGCTAGAAAACAGGGAAGATATTAGCCAATATGGAATTGCCAGGTTCTTCACTGAATATTTTAACAGTGTATGCCAGGGAACACACATTC
TCTTTCGAGAATTCAGCTTCGTCCAAGCCACCCCCCACAATAGGGTATCATTTTTACGGGCCTTCTGGAGATGCTTCCGAACTGTGGGCA
AAAATGGCGATTTGCTGACCATGAAAGAATATCACTGTTTGCTGCAATTACTGTGTCCTGATTTCCCGCTGGAGCTCACTCAGAAAGCAG
CCAGGATTGTGCTCATGGACGATGCCATGGACTGCTTGATGTCTTTTTCAGATTTCCTCTTTGCCTTCCAGATCCAGTTTTACTACTCAG
AATTCCTGGACAGTGTGGCTGCCATCTATGAGGACCTGCTGTCAGGCAAGAACCCCAACACAGTGATTGTGCCGACGTCGTCCAGTGGGC
AGCACCGCCAACGACCTGCCTTGGGCGGGGCCGGCACGCTGGAGGGCGTGGAGGCGTCGCTGTTCTACCAGTGTCTGGAAAACCTGTGTG
ATCGGCACAAGTACAGCTGCCCACCCCCAGCACTTGTCAAAGAGGCCCTCAGCAATGTTCAGAGACTGACCTTCTATGGATTCCTCATGG
CTCTCTCAAAGCACCGTGGAATCAACCAAGCCCTCGGAGCTTTGCCTGACAAGGGGGATCTGATGCACGACCCAGCAATGGATGAAGAGC
TGGAACGGCTGGTGGTGAGGTCGAAGCTGCACCGGACCTCACGGCAGCACAGAGCCAAGGAGCCAGGGGCCTTTGGCTTTCAGAGAAGAG
AGAAGCAGGAGGCCCTGGAGAGAGTGTCCTCAGCTTCGGTACCGACGCCCTACCATTACCGGTGGGAGCCCAGAGAGTGAGGCCAGGGGC
CGGCACTGGGCAGGGAGGCAGGATCCAGAGGACACTGCTTCACTCAGACCAACAGGGAGCCAGGCCCTGCAGGGGCTTTATTTTGACACC

>In-frame_ENST00000454435_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(amino acids)=423AA_start in transcript=68_stop in transcript=1339
MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAV
VAQHLTNTVFVDRALIVVPYAEAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFW
RCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVI
VPTSSSGQHRQRPALGGAGTLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHRGINQALGALPDKGDLMH

--------------------------------------------------------------
>In-frame_ENST00000436161_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(transcript)=1580nt_BP=512nt
GGCGTGCGGCGGGGCGGAGAAACGGCGGCGGCGGCGGCGGCATCGGCAGCAGTAGCAGAGGCTGTAGCATCGGACACCCTCCTCTCTCCC
GCAATCCGGTTCCTCTTCCCCCTCCTTCTCACTGTTTGTTGTGTGTTTGATGTGTTAAAGCAGGAGCGAGAACCCGAGCAGCGCCATGAG
CAACACTACCGTCGTCCCCAGCACTGCAGGTCCGGGCCCCAGCGGCGGGCCCGGTGGCGGAGGTGGTGGTGGCGGCGGAGGCGGCGGCAC
CGAGGTAATCCAGGTGACTAATGTCTCCCCGAGCGCTAGCTCTGAGCAGATGCGGACTCTCTTCGGTTTCCTAGGCAAGATCGACGAACT
GCGCCTCTTCCCGCCGGATGATTCGCCTTTGCCAGTCTCATCTCGTGTCTGCTTTGTTAAGTTCCATGATCCAGACTCAGCAGTTGTGGC
ACAGCATCTGACAAACACTGTATTCGTTGACAGAGCTTTGATAGTCGTACCATATGCAGAAGCTCAGCGACATGTCCTCACCTACATGGA
GGATGCAGTGTGCCAGCTGCTAGAAAACAGGGAAGATATTAGCCAATATGGAATTGCCAGGTTCTTCACTGAATATTTTAACAGTGTATG
CCAGGGAACACACATTCTCTTTCGAGAATTCAGCTTCGTCCAAGCCACCCCCCACAATAGGGTATCATTTTTACGGGCCTTCTGGAGATG
CTTCCGAACTGTGGGCAAAAATGGCGATTTGCTGACCATGAAAGAATATCACTGTTTGCTGCAATTACTGTGTCCTGATTTCCCGCTGGA
GCTCACTCAGAAAGCAGCCAGGATTGTGCTCATGGACGATGCCATGGACTGCTTGATGTCTTTTTCAGATTTCCTCTTTGCCTTCCAGAT
CCAGTTTTACTACTCAGAATTCCTGGACAGTGTGGCTGCCATCTATGAGGACCTGCTGTCAGGCAAGAACCCCAACACAGTGATTGTGCC
GACGTCGTCCAGTGGGCAGCACCGCCAACGACCTGCCTTGGGCGGGGCCGGCACGCTGGAGGGCGTGGAGGCGTCGCTGTTCTACCAGTG
TCTGGAAAACCTGTGTGATCGGCACAAGTACAGCTGCCCACCCCCAGCACTTGTCAAAGAGGCCCTCAGCAATGTTCAGAGACTGACCTT
CTATGGATTCCTCATGGCTCTCTCAAAGCACCGTGGAATCAACCAAGCCCTCGGAGCTTTGCCTGACAAGGGGGATCTGATGCACGACCC
AGCAATGGATGAAGAGCTGGAACGGCTGGTGGTGAGGTCGAAGCTGCACCGGACCTCACGGCAGCACAGAGCCAAGGAGCCAGGGGCCTT
TGGCTTTCAGAGAAGAGAGAAGCAGGAGGCCCTGGAGAGAGTGTCCTCAGCTTCGGTACCGACGCCCTACCATTACCGGTGGGAGCCCAG
AGAGTGAGGCCAGGGGCCGGCACTGGGCAGGGAGGCAGGATCCAGAGGACACTGCTTCACTCAGACCAACAGGGAGCCAGGCCCTGCAGG

>In-frame_ENST00000436161_ENST00000378618_TCGA-24-2033_SRSF11_chr1_70694238_+_C11orf49_chr11_47008758_length(amino acids)=423AA_start in transcript=175_stop in transcript=1446
MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAV
VAQHLTNTVFVDRALIVVPYAEAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFW
RCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVI
VPTSSSGQHRQRPALGGAGTLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHRGINQALGALPDKGDLMH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SRSF11-C11orf49


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRSF11-C11orf49


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SRSF11-C11orf49


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource