FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SRSF5-CCT5 (FusionGDB2 ID:86031)

Fusion Gene Summary for SRSF5-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: SRSF5-CCT5
Fusion gene ID: 86031
HgeneTgene
Gene symbol

SRSF5

CCT5

Gene ID

6430

22948

Gene nameserine and arginine rich splicing factor 5chaperonin containing TCP1 subunit 5
SynonymsHRS|SFRS5|SRP40CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

14q24.1

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine-rich splicing factor 5SR splicing factor 5delayed-early protein HRSpre-mRNA-splicing factor SRP40splicing factor, arginine/serine-rich 5T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020032020200313
UniProtAcc.

P48643

Ensembl transtripts involved in fusion geneENST00000553521, ENST00000394366, 
ENST00000553548, ENST00000557154, 
ENST00000451983, ENST00000553635, 
ENST00000556587, ENST00000555349, 
ENST00000554021, 		ENST00000280326, 
ENST00000503026, ENST00000515390, 
ENST00000515676, ENST00000506600, 
Fusion gene scores* DoF score12 X 8 X 6=57658 X 14 X 17=13804
# samples 1161
** MAII scorelog2(11/576*10)=-2.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRSF5 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRSF5(70238721)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SRSF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A905-01ASRSF5chr14

70238721

-CCT5chr5

10250033

+


Top

Fusion Gene ORF analysis for SRSF5-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000553521ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000553521ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000553521ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000553521ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000553521ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-3CDSENST00000394366ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000394366ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000394366ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000394366ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000394366ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-3CDSENST00000553548ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553548ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553548ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553548ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553548ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-3CDSENST00000557154ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000557154ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000557154ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000557154ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000557154ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-3CDSENST00000451983ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000451983ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000451983ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000451983ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000451983ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-3CDSENST00000553635ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553635ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553635ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553635ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000553635ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
In-frameENST00000556587ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000556587ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000556587ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000556587ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
5CDS-intronENST00000556587ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-3CDSENST00000555349ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000555349ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000555349ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000555349ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000555349ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-3CDSENST00000554021ENST00000280326SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000554021ENST00000503026SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000554021ENST00000515390SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000554021ENST00000515676SRSF5chr14

70238721

-CCT5chr5

10250033

+
intron-intronENST00000554021ENST00000506600SRSF5chr14

70238721

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000553521SRSF5chr1470238721-ENST00000280326CCT5chr510250033+6490281532054860551
ENST00000556587SRSF5chr1470238721-ENST00000280326CCT5chr510250033+5538186322533908551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000553521ENST00000280326SRSF5chr1470238721-CCT5chr510250033+0.0006010710.99939895
ENST00000556587ENST00000280326SRSF5chr1470238721-CCT5chr510250033+0.0005033720.9994966

Top

Fusion Genomic Features for SRSF5-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SRSF5-CCT5


check button Go to

FGviewer for the breakpoints of chr14:70238721-chr5:10250033

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCT5

P48643

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553521-99182_267454.0273.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553521-9978_83454.0273.0Compositional biasNote=Gly-rich (hinge region)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553521-99108_181454.0273.0DomainRRM 2
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553521-994_74454.0273.0DomainRRM 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRSF5chr14:70238721chr5:10250033ENST00000394366-18182_2670273.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000394366-1878_830273.0Compositional biasNote=Gly-rich (hinge region)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553635-18182_2670270.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553635-1878_830270.0Compositional biasNote=Gly-rich (hinge region)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000557154-18182_2670273.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000557154-1878_830273.0Compositional biasNote=Gly-rich (hinge region)
HgeneSRSF5chr14:70238721chr5:10250033ENST00000394366-18108_1810273.0DomainRRM 2
HgeneSRSF5chr14:70238721chr5:10250033ENST00000394366-184_740273.0DomainRRM 1
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553635-18108_1810270.0DomainRRM 2
HgeneSRSF5chr14:70238721chr5:10250033ENST00000553635-184_740270.0DomainRRM 1
HgeneSRSF5chr14:70238721chr5:10250033ENST00000557154-18108_1810273.0DomainRRM 2
HgeneSRSF5chr14:70238721chr5:10250033ENST00000557154-184_740273.0DomainRRM 1


Top

Fusion Gene Sequence for SRSF5-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000553521_ENST00000280326_TCGA-C5-A905-01A_SRSF5_chr14_70238721_-_CCT5_chr5_10250033_length(transcript)=6490nt_BP=2815nt
GCCGGAGGAAGCGCCACGGGCGGCTCAGACCTGAGGCCGCAAGGGCGCGCCGGGCGGGCAGGGCGGAGGGTCCGATTTCCTCCCTCTGAA
CGGAAAAAAAGCCACTTTCCCTGGGAAGAACTCGAAGAAGTTGGATGTCTGATCTTCACCTTGGATTTGTGGTCTCGGCCCGCGGGCGAC
TCACCCCACCCACCAGGATCCCACGAAGCCGGGCCGGCTCAGCCCGCTGGCGCCATCTAGTGTCGAATGAGGAGGCGGCCCTCTGCGGCT
GGAGGGGACGCTTGGGCGTGTGAAATCTGAACGGAGAGGATTAACCAAATACCATTTGGACTTAAAAGCAGCTTGAGGCCGGGCGCGGTG
GCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCCGATCACGAGGTCAGGAGATCGAGACCATCCCGGCTAACACGGTGAA
ACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCGGTGTGGTGGCGGGCGCCTGTAGTCGCAGCTACTCGGGAGGCTGAGGCAGAAGAA
TGGCGTGAACCCGGGAGGCGGAGCCCAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTGTCTCAAAAAAAACAACAAAA
AACAGCTTGAAACCTCTTCCAGCCACTCTCCCAGAGTGACGGACATGCAGAAATCTGTATTCCAGCCTCAATTCAAGACAGCCTTCTAGC
TGCAGTCCCATTTTCAACATTTCATCAGTGAAAATCCTTTCATTTAAAAAATACTTCAGTGCCTTAGTCTTCTCACCACAACAAAACCAC
ACAGCTGTGGCATGGTTGAAAAAAGAACTCGAACATCTAGGAGCTCCCTGCTTTGAGGGCAAATTTAAATTGCAAGCAGCAAGAGCTAAG
GAAAGGCCAGGTATTTCTGCAAAGCTAAGTTTCTCCTAATTAGTAATCTTCTGGGTGTCTAAGAAAAACTTTAGATACAAGAAGGGTTGC
CACTTTTCTCAGGAGACTCTTCTGGGAGAGATGATGATGAACCGAACGCCAAGGACTTAGCAGGGGCGAACGACGTCAACAGATGTCCCT
CCAGACTCCGGCACCAGCCGGCCGAGCCCAAACGAGTTCTCGCCCCCGACCCCACCCACCGCGGGAGCAGGGTTCGGTCACTCGCAGTGT
CAGAGAGGCCCACATCCTCCTAAATTTCCGGCCCTCCCAAAACTTCCGTCTTCCCTAGGTCCAACGGGGTGGACCCAAGGCCCAGGGGCG
TCCCCGGAAGTGACGTAGGACGCGCCCTCCATTTTGTGGAGCGCCAGAGCTGCTAAGTGCGTCAGTTGTGGAGTGGCGTAGACGAGTTAA
GTCCTGGTCTGCGTGGAGGTCGACGACTCCGTCGCAGACTACGGACCTGTCTGGGTCTCAGCCGCCAAAGACCCCGTCCGGTAGGAAGTA
CTAGCCGGACATCATGAGTGGCTGTCGGGTATTCATCGGGAGACTAAATCCAGCGGCCAGGGAGAAGGACGTGGAAAGATTCTTCAAGGG
ATATGGACGGATAAGAGATATTGATCTGAAAAGAGGCTTTGGTTTTGTGGAATTTGAGGATCCAAGGGATGCAGATGATGCTGTGTATGA
GCTTGATGGAAAAGAACTCTGTAGTGAAAGGGTTACTATTGAACATGCTAGGGCTCGGTCACGAGGTGGAAGAGGTAGAGGACGATACTC
TGACCGTTTTAGTAGTCGCAGACCTCGAAATGATAGACGAAATGCTCCACCTGTAAGAACAGAAAATCGTCTTATAGTTGAGAATTTATC
CTCAAGAGTCAGCTGGCAGGATCTCAAAGATTTCATGAGACAAGCTGGGGAAGTAACGTTTGCGGATGCACACCGACCTAAATTAAATGA
AGGGGTGGTTGAGTTTGCCTCTTATGGTGACTTAAAGAATGCTATTGAAAAACTTTCTGGAAAGGAAATAAATGGGAGAAAAATAAAATT
AATTGAAGGCAGCAAAAGGCACAGTAGGTCAAGAAGCAGGTCTCGATCCCGGACCAGAAGTTCCTCTAGGTCTCGTAGCCGATCCCGTTC
CCGTAGTCGCAAATCTTACAGCCGGTCAAGAAGCAGGAGCAGGAGCCGGAGCCGGAGCAAGTCCCGTTCTGTTAGTAGGTCTCCCGTGCC
TGAGAAGAGCCAGAAACGTGGTTCTTCAAGTAGATCTAAGTCTCCAGCATCTGTGGATCGCCAGAGGTCCCGGTCCCGATCAAGGTCCAG
ATCAGTTGACAGTGGCAATTAAACTGTAAATAACTTGCCCTGGGGGCCTTTTTTTAAAAAACAAAAACCACAAAAATTCCCAAACCATAC
TTGCTAAAAATTCTGGTAAGTATGTGCTTTTCTGTGGGGGTGGGATTTGGAAGGGGGGTTGGGTTGGGCTGGATATCTTTGTAGATGTGG
ACCACCAAGGGGTTGTTGAAAACTAATTGTATTAAATGTCTTTTGATAAGCCTTCTGCTCACATTTTTGTGAATGTCTGAAGTATATAGT
TTGTGTATATTGACAGAGCTCTTTTATAACTAAAGCAAATTTAATTTTTTTGTACTAGAAAAAAATTTGAACATTTTAGTTCTTGGTTAT
AAAAATGTTAATTCAGAATTAGTTTAATGCCTTAATTAAACTAATTAATAGCTTTGGACACTTAAAAGAGCTCTAAATTTGCTTGTACAT
AAAGGCTTAATTTGTTTTCCTTGTTAGGGTCAAGGGTGTCCTCCACTCTTTAACAGCTGCTGGACAGACACATTAGAGCAGCTGTTTGTT
ATTGATAATAAAATATTATAAAACTAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAG
AAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATC
TGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGC
CGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTT
TGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGC
GTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGA
GGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGT
GGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGT
GGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCA
ATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAG
CGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCA
CCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGA
AGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAA
AGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGA
AGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTG
TCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCT
GATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGAT
CTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAA
GATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGG
AGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGC
CGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGT
GAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGG
CAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATG
AAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACA
TCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTA
CCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTA
ACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAAC
AGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGG
TCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCA
TGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCA
GCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGG
GAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAG
ACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTAC
TCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCT
ACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATC
ACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTA
CCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATA
ACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTA
AACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGG
TTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAAT
GAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAATAAACCTCTTCCACGTGATGTCTTTTATTTT

>In-frame_ENST00000553521_ENST00000280326_TCGA-C5-A905-01A_SRSF5_chr14_70238721_-_CCT5_chr5_10250033_length(amino acids)=551AA_start in transcript=3205_stop in transcript=4860
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------
>In-frame_ENST00000556587_ENST00000280326_TCGA-C5-A905-01A_SRSF5_chr14_70238721_-_CCT5_chr5_10250033_length(transcript)=5538nt_BP=1863nt
GCGTGGAGGTCGACGACTCCGTCGCAGACTACGGACCTGTCTGGGTCTCAGCCGCCAAAGACCCCGTCCGGTAGGTGAGTGGCTCACTTT
GAGGGCAAGCCTTCTCGGATCGAGGCTTCTTCATGGCCGCTCAGATCGTGAGCGGCCGGGGCTGCTCTCTTTGCGGAGGATGGCGTCTAA
TGAGCGCAGTTGATTCGAGGAAGTACTAGCCGGACATCATGAGTGGCTGTCGGGTATTCATCGGGAGACTAAATCCAGCGGCCAGGGAGA
AGGACGTGGAAAGATTCTTCAAGGGATATGGACGGATAAGAGATATTGATCTGAAAAGAGGCTTTGGTTTTGTGGAATTTGAGGATCCAA
GGGATGCAGATGATGCTGTGTATGAGCTTGATGGAAAAGAACTCTGTAGTGAAAGGGTTACTATTGAACATGCTAGGGCTCGGTCACGAG
GTGGAAGAGGTAGAGGACGATACTCTGACCGTTTTAGTAGTCGCAGACCTCGAAATGATAGACGGTATGTGAAGGGTGGATGGCTGCATT
GAACAATTATTGTAGGGGTAGCATTTAAGATTCAGGAGTCATTAGCAGTGATGATTTTGGGTCCTGCCGTATAATCTGTTCTTCTATTCC
CACGTTAGCCAGTTGTTCTTGATGAATCTATATGAGTCATAGAACACAAATCTATTGACGGAAGTCATTAGAATGGCTTGTGATATCTGA
TGGCTTGAACTTGCCCACAGTTGAACACAAGTGCTGTCATTGCATTTCTTCCATTGTGAATACGAATTTTCTTCCTCAGAAATGCTCCAC
CTGTAAGAACAGAAAATCGTCTTATAGTTGAGAATTTATCCTCAAGAGTCAGCTGGCAGGATCTCAAAGATTTCATGAGACAAGCTGGGG
AAGTAACGTTTGCGGATGCACACCGACCTAAATTAAATGAAGGGGTGGTTGAGTTTGCCTCTTATGGTGACTTAAAGAATGCTATTGAAA
AACTTTCTGGAAAGGAAATAAATGGGAGAAAAATAAAATTAATTGAAGGCAGCAAAAGGCACAGGTCAAGAAGCAGGTCTCGATCCCGGA
CCAGAAGTTCCTCTAGGTCTCGTAGCCGATCCCGTTCCCGTAGTCGCAAATCTTACAGCCGGTCAAGAAGCAGGAGCAGGAGCCGGAGCC
GGAGCAAGTCCCGTTCTGTTAGTAGGTCTCCCGTGCCTGAGAAGAGCCAGAAACGTGGTTCTTCAAGTAGATCTAAGTCTCCAGCATCTG
TGGATCGCCAGAGGTCCCGGTCCCGATCAAGGTCCAGATCAGTTGACAGTGGCAATTAAACTGTAAATAACTTGCCCTGGGGGCCTTTTT
TTAAAAAACAAAAACCACAAAAATTCCCAAACCATACTTGCTAAAAATTCTGGTAAGTATGTGCTTTTCTGTGGGGGTGGGATTTGGAAG
GGGGGTTGGGTTGGGCTGGATATCTTTGTAGATGTGGACCACCAAGGGGTTGTTGAAAACTAATTGTATTAAATGTCTTTTGATAAGCCT
TCTGCTCACATTTTTGTGAATGTCTGAAGTATATAGTTTGTGTATATTGACAGAGCTCTTTTATAACTAAAGCAAATTTAATTTTTTTGT
ACTAGAAAAAAATTTGAACATTTTAGTTCTTGGTTATAAAAATGTTAATTCAGAATTAGTTTAATGCCTTAATTAAACTAATTAATAGCT
TTGGACACTTAAAAGAGCTCTAAATTTGCTTGTACATAAAGGCTTAATTTGTTTTCCTTGTTAGGGTCAAGGGTGTCCTCCACTCTTTAA
CAGCTGCTGGACAGACACATTAGAGCAGCTGTTTGTTATTGATAATAAAATATTATAAAACTAAAAAAAAAAAAAAACCGGAAATGGGTC
CTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAAC
TATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCC
CCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACAT
AAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGC
CGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATC
AAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGA
ACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGC
ATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTG
GTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAG
GCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCA
AAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATG
GAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATT
GTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAA
CCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATT
CAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTG
CCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACA
GCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAAC
TCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATC
CGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAG
TGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAAT
CCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAAT
GATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAG
ATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATG
GATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCA
TAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAAC
CTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTC
TCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTC
TTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAG
CCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATA
CACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACAC
AGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTAC
TTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAG
ATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCC
CAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTC
TTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGA
CTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTG
TTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATG
TTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAG
CCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCAC
AGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTA

>In-frame_ENST00000556587_ENST00000280326_TCGA-C5-A905-01A_SRSF5_chr14_70238721_-_CCT5_chr5_10250033_length(amino acids)=551AA_start in transcript=2253_stop in transcript=3908
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SRSF5-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SRSF5-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SRSF5-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRSF5C0023895Liver diseases1CTD_human
HgeneSRSF5C0086565Liver Dysfunction1CTD_human
HgeneSRSF5C0149504Encephalopathy, Toxic1CTD_human
HgeneSRSF5C0154659Toxic Encephalitis1CTD_human
HgeneSRSF5C0235032Neurotoxicity Syndromes1CTD_human
TgeneCCT5C1850395Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCCT5C0006142Malignant neoplasm of breast1CTD_human
TgeneCCT5C0019193Hepatitis, Toxic1CTD_human
TgeneCCT5C0019693HIV Infections1CTD_human
TgeneCCT5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCCT5C0678222Breast Carcinoma1CTD_human
TgeneCCT5C0860207Drug-Induced Liver Disease1CTD_human
TgeneCCT5C1257931Mammary Neoplasms, Human1CTD_human
TgeneCCT5C1262760Hepatitis, Drug-Induced1CTD_human
TgeneCCT5C1458155Mammary Neoplasms1CTD_human
TgeneCCT5C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCCT5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCCT5C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCCT5C4505456HIV Coinfection1CTD_human
TgeneCCT5C4704874Mammary Carcinoma, Human1CTD_human