FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SRSF5-MEAF6 (FusionGDB2 ID:86036)

Fusion Gene Summary for SRSF5-MEAF6

check button Fusion gene summary
Fusion gene informationFusion gene name: SRSF5-MEAF6
Fusion gene ID: 86036
HgeneTgene
Gene symbol

SRSF5

MEAF6

Gene ID

6430

64769

Gene nameserine and arginine rich splicing factor 5MYST/Esa1 associated factor 6
SynonymsHRS|SFRS5|SRP40C1orf149|CENP-28|EAF6|NY-SAR-91
Cytomap

14q24.1

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine-rich splicing factor 5SR splicing factor 5delayed-early protein HRSpre-mRNA-splicing factor SRP40splicing factor, arginine/serine-rich 5chromatin modification-related protein MEAF6Esa1p-associated factor 6 homologcentromere protein 28protein EAF6 homologsarcoma antigen NY-SAR-91
Modification date2020032020200313
UniProtAcc.

Q9HAF1

Ensembl transtripts involved in fusion geneENST00000553521, ENST00000394366, 
ENST00000553548, ENST00000557154, 
ENST00000451983, ENST00000553635, 
ENST00000556587, ENST00000555349, 
ENST00000554021, 		ENST00000373075, 
ENST00000296214, ENST00000373074, 
ENST00000475828, ENST00000373073, 
ENST00000448519, 
Fusion gene scores* DoF score12 X 8 X 6=5766 X 5 X 5=150
# samples 116
** MAII scorelog2(11/576*10)=-2.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRSF5 [Title/Abstract] AND MEAF6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRSF5(70235968)-MEAF6(37961519), # samples:1
Anticipated loss of major functional domain due to fusion event.SRSF5-MEAF6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SRSF5-MEAF6 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMEAF6

GO:0043968

histone H2A acetylation

14966270

TgeneMEAF6

GO:0043981

histone H4-K5 acetylation

16387653

TgeneMEAF6

GO:0043982

histone H4-K8 acetylation

16387653

TgeneMEAF6

GO:0043983

histone H4-K12 acetylation

16387653

TgeneMEAF6

GO:0043984

histone H4-K16 acetylation

16387653

TgeneMEAF6

GO:0044154

histone H3-K14 acetylation

16387653


check buttonFusion gene breakpoints across SRSF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MEAF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-27-1831-01ASRSF5chr14

70235968

+MEAF6chr1

37961519

-


Top

Fusion Gene ORF analysis for SRSF5-MEAF6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000553521ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000553521ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000553521ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-5UTRENST00000553521ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-intronENST00000553521ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-3UTRENST00000553521ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000394366ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000394366ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000394366ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-5UTRENST00000394366ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-intronENST00000394366ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-3UTRENST00000394366ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
intron-3CDSENST00000553548ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
intron-3CDSENST00000553548ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
intron-3CDSENST00000553548ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
intron-5UTRENST00000553548ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
intron-intronENST00000553548ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
intron-3UTRENST00000553548ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000557154ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000557154ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000557154ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-5UTRENST00000557154ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-intronENST00000557154ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-3UTRENST00000557154ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000451983ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000451983ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000451983ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-5UTRENST00000451983ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-intronENST00000451983ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-3UTRENST00000451983ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000553635ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000553635ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000553635ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-5UTRENST00000553635ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-intronENST00000553635ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-3UTRENST00000553635ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
3UTR-3CDSENST00000556587ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
3UTR-3CDSENST00000556587ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
3UTR-3CDSENST00000556587ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
3UTR-5UTRENST00000556587ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
3UTR-intronENST00000556587ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
3UTR-3UTRENST00000556587ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000555349ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000555349ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000555349ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-5UTRENST00000555349ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-intronENST00000555349ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-3UTRENST00000555349ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000554021ENST00000373075SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000554021ENST00000296214SRSF5chr14

70235968

+MEAF6chr1

37961519

-
Frame-shiftENST00000554021ENST00000373074SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-5UTRENST00000554021ENST00000475828SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-intronENST00000554021ENST00000373073SRSF5chr14

70235968

+MEAF6chr1

37961519

-
5CDS-3UTRENST00000554021ENST00000448519SRSF5chr14

70235968

+MEAF6chr1

37961519

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SRSF5-MEAF6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SRSF5-MEAF6


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MEAF6

Q9HAF1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358). {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for SRSF5-MEAF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for SRSF5-MEAF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SRSF5-MEAF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SRSF5-MEAF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSRSF5C0023895Liver diseases1CTD_human
HgeneSRSF5C0086565Liver Dysfunction1CTD_human
HgeneSRSF5C0149504Encephalopathy, Toxic1CTD_human
HgeneSRSF5C0154659Toxic Encephalitis1CTD_human
HgeneSRSF5C0235032Neurotoxicity Syndromes1CTD_human