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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SSBP1-PON1 (FusionGDB2 ID:86106)

Fusion Gene Summary for SSBP1-PON1

check button Fusion gene summary
Fusion gene informationFusion gene name: SSBP1-PON1
Fusion gene ID: 86106
HgeneTgene
Gene symbol

SSBP1

PON1

Gene ID

6742

5444

Gene namesingle stranded DNA binding protein 1paraoxonase 1
SynonymsMt-SSB|SOSS-B1|SSBP|mtSSBESA|MVCD5|PON
Cytomap

7q34

7q21.3

Type of geneprotein-codingprotein-coding
Descriptionsingle-stranded DNA-binding protein, mitochondrialPWP1-interacting protein 17single-stranded DNA binding protein 1, mitochondrialserum paraoxonase/arylesterase 1A-esterase 1K-45PON 1aromatic esterase 1arylesterase 1arylesterase B-typeesterase Aparaoxonase B-typeserum aryldiakylphosphataseserum aryldialkylphosphatase 1
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265304, ENST00000498107, 
ENST00000469123, ENST00000465582, 
ENST00000484178, ENST00000481508, 
ENST00000222381, ENST00000542556, 
Fusion gene scores* DoF score6 X 6 X 3=1083 X 3 X 3=27
# samples 63
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SSBP1 [Title/Abstract] AND PON1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSBP1(141438210)-PON1(94947705), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSSBP1

GO:0006268

DNA unwinding involved in DNA replication

26446790

HgeneSSBP1

GO:0051096

positive regulation of helicase activity

12975372

HgeneSSBP1

GO:1905776

positive regulation of DNA helicase activity

15167897

TgenePON1

GO:0010875

positive regulation of cholesterol efflux

15721011

TgenePON1

GO:0019439

aromatic compound catabolic process

15772423

TgenePON1

GO:0032411

positive regulation of transporter activity

15721011

TgenePON1

GO:0034445

negative regulation of plasma lipoprotein oxidation

15342686

TgenePON1

GO:0046395

carboxylic acid catabolic process

7638166

TgenePON1

GO:0046434

organophosphate catabolic process

7638166

TgenePON1

GO:0046470

phosphatidylcholine metabolic process

15721011

TgenePON1

GO:0051099

positive regulation of binding

15721011


check buttonFusion gene breakpoints across SSBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PON1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A8FN-01ASSBP1chr7

141438210

+PON1chr7

94947705

-
ChimerDB4PRADTCGA-EJ-A8FNSSBP1chr7

141438210

+PON1chr7

94947705

-


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Fusion Gene ORF analysis for SSBP1-PON1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000265304ENST00000222381SSBP1chr7

141438210

+PON1chr7

94947705

-
5UTR-intronENST00000265304ENST00000542556SSBP1chr7

141438210

+PON1chr7

94947705

-
5UTR-3CDSENST00000498107ENST00000222381SSBP1chr7

141438210

+PON1chr7

94947705

-
5UTR-intronENST00000498107ENST00000542556SSBP1chr7

141438210

+PON1chr7

94947705

-
3UTR-3CDSENST00000469123ENST00000222381SSBP1chr7

141438210

+PON1chr7

94947705

-
3UTR-intronENST00000469123ENST00000542556SSBP1chr7

141438210

+PON1chr7

94947705

-
5UTR-3CDSENST00000465582ENST00000222381SSBP1chr7

141438210

+PON1chr7

94947705

-
5UTR-intronENST00000465582ENST00000542556SSBP1chr7

141438210

+PON1chr7

94947705

-
intron-3CDSENST00000484178ENST00000222381SSBP1chr7

141438210

+PON1chr7

94947705

-
intron-intronENST00000484178ENST00000542556SSBP1chr7

141438210

+PON1chr7

94947705

-
intron-3CDSENST00000481508ENST00000222381SSBP1chr7

141438210

+PON1chr7

94947705

-
intron-intronENST00000481508ENST00000542556SSBP1chr7

141438210

+PON1chr7

94947705

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SSBP1-PON1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SSBP1-PON1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SSBP1-PON1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SSBP1-PON1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SSBP1-PON1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SSBP1-PON1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSSBP1C0037274Dermatologic disorders1CTD_human
HgeneSSBP1C0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneSSBP1C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneSSBP1C0311375Arsenic Poisoning1CTD_human
HgeneSSBP1C0751851Arsenic Encephalopathy1CTD_human
HgeneSSBP1C0751852Arsenic Induced Polyneuropathy1CTD_human
TgenePON1C0353676Organophosphorus Poisoning7CTD_human
TgenePON1C0700359Organophosphate poisoning7CTD_human
TgenePON1C3494247Organothiophosphonate Poisoning7CTD_human
TgenePON1C3494248Organothiophosphate Poisoning7CTD_human
TgenePON1C0004153Atherosclerosis6CTD_human
TgenePON1C1563937Atherogenesis6CTD_human
TgenePON1C0002736Amyotrophic Lateral Sclerosis3CTD_human;ORPHANET
TgenePON1C0004352Autistic Disorder3CTD_human
TgenePON1C0005586Bipolar Disorder3PSYGENET
TgenePON1C0010054Coronary Arteriosclerosis3CTD_human
TgenePON1C0033578Prostatic Neoplasms3CTD_human
TgenePON1C0376358Malignant neoplasm of prostate3CTD_human
TgenePON1C1956346Coronary Artery Disease3CTD_human
TgenePON1C0001828Agricultural Workers' Diseases2CTD_human
TgenePON1C0007222Cardiovascular Diseases2CTD_human
TgenePON1C0010068Coronary heart disease2CTD_human
TgenePON1C0011849Diabetes Mellitus2CTD_human
TgenePON1C0011884Diabetic Retinopathy2CTD_human
TgenePON1C0020445Hypercholesterolemia, Familial2CTD_human
TgenePON1C0021364Male infertility2CTD_human
TgenePON1C0033054Prenatal Exposure Delayed Effects2CTD_human
TgenePON1C0036341Schizophrenia2PSYGENET
TgenePON1C0598608Hyperhomocysteinemia2CTD_human
TgenePON1C0687132heavy drinking2PSYGENET
TgenePON1C0745103Hyperlipoproteinemia Type IIa2CTD_human
TgenePON1C0848676Subfertility, Male2CTD_human
TgenePON1C0917731Male sterility2CTD_human
TgenePON1C1704417Hyperlipoproteinemia Type IIb2CTD_human
TgenePON1C0001969Alcoholic Intoxication1PSYGENET
TgenePON1C0003860Arteritis1CTD_human
TgenePON1C0003873Rheumatoid Arthritis1CTD_human
TgenePON1C0005612Birth Weight1CTD_human
TgenePON1C0006118Brain Neoplasms1CTD_human
TgenePON1C0008370Cholestasis1CTD_human
TgenePON1C0009806Constipation1CTD_human
TgenePON1C0010073Coronary Artery Vasospasm1CTD_human
TgenePON1C0011573Endogenous depression1CTD_human
TgenePON1C0011581Depressive disorder1CTD_human
TgenePON1C0011881Diabetic Nephropathy1CTD_human
TgenePON1C0015695Fatty Liver1CTD_human
TgenePON1C0017662Glomerulonephritis, Membranoproliferative1CTD_human
TgenePON1C0017667Nodular glomerulosclerosis1CTD_human
TgenePON1C0018799Heart Diseases1CTD_human
TgenePON1C0018801Heart failure1CTD_human
TgenePON1C0018802Congestive heart failure1CTD_human
TgenePON1C0019112Hemorrhoids1CTD_human
TgenePON1C0019193Hepatitis, Toxic1CTD_human
TgenePON1C0020443Hypercholesterolemia1CTD_human
TgenePON1C0020476Hyperlipoproteinemias1CTD_human
TgenePON1C0020550Hyperthyroidism1CTD_human
TgenePON1C0023212Left-Sided Heart Failure1CTD_human
TgenePON1C0024121Lung Neoplasms1CTD_human
TgenePON1C0024299Lymphoma1CTD_human
TgenePON1C0025193Melancholia1CTD_human
TgenePON1C0025517Metabolic Diseases1CTD_human
TgenePON1C0028797Occupational Diseases1CTD_human
TgenePON1C0030569Secondary Parkinson Disease1CTD_human
TgenePON1C0031090Periodontal Diseases1CTD_human
TgenePON1C0034219Alveolar pyorrhea1CTD_human
TgenePON1C0038219Status Dysraphicus1CTD_human
TgenePON1C0041696Unipolar Depression1CTD_human
TgenePON1C0080178Spina Bifida1CTD_human
TgenePON1C0086133Depressive Syndrome1CTD_human
TgenePON1C0149504Encephalopathy, Toxic1CTD_human
TgenePON1C0153633Malignant neoplasm of brain1CTD_human
TgenePON1C0154659Toxic Encephalitis1CTD_human
TgenePON1C0206663Neuroectodermal Tumor, Primitive1CTD_human
TgenePON1C0235032Neurotoxicity Syndromes1CTD_human
TgenePON1C0235527Heart Failure, Right-Sided1CTD_human
TgenePON1C0237326Dyschezia1CTD_human
TgenePON1C0242379Malignant neoplasm of lung1CTD_human
TgenePON1C0266508Rachischisis1CTD_human
TgenePON1C0268742Membranoproliferative Glomerulonephritis, Type I1CTD_human
TgenePON1C0268743Membranoproliferative Glomerulonephritis, Type II1CTD_human
TgenePON1C0282126Depression, Neurotic1CTD_human
TgenePON1C0282550Persian Gulf Syndrome1CTD_human
TgenePON1C0334584Spongioblastoma1CTD_human
TgenePON1C0334596Medulloepithelioma1CTD_human
TgenePON1C0342257Complications of Diabetes Mellitus1CTD_human
TgenePON1C0376544Hematopoietic Neoplasms1CTD_human
TgenePON1C0376545Hematologic Neoplasms1CTD_human
TgenePON1C0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgenePON1C0496899Benign neoplasm of brain, unspecified1CTD_human
TgenePON1C0524620Metabolic Syndrome X1CTD_human
TgenePON1C0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgenePON1C0700367Ependymoblastoma1CTD_human
TgenePON1C0750974Brain Tumor, Primary1CTD_human
TgenePON1C0750977Recurrent Brain Neoplasm1CTD_human
TgenePON1C0750979Primary malignant neoplasm of brain1CTD_human
TgenePON1C0751414Parkinson Disease, Secondary Vascular1CTD_human
TgenePON1C0751415Atherosclerotic Parkinsonism1CTD_human
TgenePON1C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
TgenePON1C0853193Bipolar I disorder1PSYGENET
TgenePON1C0860207Drug-Induced Liver Disease1CTD_human
TgenePON1C0948089Acute Coronary Syndrome1CTD_human
TgenePON1C1257861Colonic Inertia1CTD_human
TgenePON1C1262760Hepatitis, Drug-Induced1CTD_human
TgenePON1C1449861Micronuclei, Chromosome-Defective1CTD_human
TgenePON1C1449862Micronuclei, Genotoxicant-Induced1CTD_human
TgenePON1C1527390Neoplasms, Intracranial1CTD_human
TgenePON1C1720821Membranoproliferative Glomerulonephritis, Type III1CTD_human
TgenePON1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgenePON1C1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgenePON1C1959583Myocardial Failure1CTD_human
TgenePON1C1961112Heart Decompensation1CTD_human
TgenePON1C2711227Steatohepatitis1CTD_human
TgenePON1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgenePON1C3714618Primary Hyperthyroidism1CTD_human
TgenePON1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgenePON1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgenePON1C4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human