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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SSBP4-SLC5A5 (FusionGDB2 ID:86141)

Fusion Gene Summary for SSBP4-SLC5A5

Fusion gene summary

Fusion gene information	Fusion gene name: SSBP4-SLC5A5
	Fusion gene ID: 86141
		Hgene	Tgene
	Gene symbol	SSBP4	SLC5A5
	Gene ID	170463	6528
	Gene name	single stranded DNA binding protein 4	solute carrier family 5 member 5
	Synonyms	-	NIS\|TDH1
	Cytomap	19p13.11	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	single-stranded DNA-binding protein 4	sodium/iodide cotransporterNa(+)/I(-) cotransporterNa(+)/I(-) symportersolute carrier family 5 (sodium iodide symporter), member 5solute carrier family 5 (sodium/iodide cotransporter), member 5
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000348495, ENST00000270061, ENST00000598159, ENST00000599699,	ENST00000222248,
Fusion gene scores	* DoF score	5 X 4 X 4=80	4 X 4 X 2=32
	# samples	5	4
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SSBP4 [Title/Abstract] AND SLC5A5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SSBP4(18544627)-SLC5A5(17994659), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SLC5A5	GO:1904200	iodide transmembrane transport	21988488\|26599396

Fusion gene breakpoints across SSBP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC5A5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AJ-A3QS-01A	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+
ChimerDB4	UCEC	TCGA-AJ-A3QS-01A	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+

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Fusion Gene ORF analysis for SSBP4-SLC5A5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000348495	ENST00000222248	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+
In-frame	ENST00000270061	ENST00000222248	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+
intron-3CDS	ENST00000598159	ENST00000222248	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+
In-frame	ENST00000599699	ENST00000222248	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000348495

SSBP4

chr19

18544627

ENST00000222248

SLC5A5

chr19

17994659

3275

1375

313

1977

554

ENST00000270061

SSBP4

chr19

18544627

ENST00000222248

SLC5A5

chr19

17994659

3322

1422

294

2024

576

ENST00000599699

SSBP4

chr19

18544627

ENST00000222248

SLC5A5

chr19

17994659

2347

447

192

1049

285

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000348495	ENST00000222248	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+	0.042115673	0.9578844
ENST00000270061	ENST00000222248	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+	0.05255261	0.94744736
ENST00000599699	ENST00000222248	SSBP4	chr19	18544627	+	SLC5A5	chr19	17994659	+	0.027695432	0.9723045

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Fusion Genomic Features for SSBP4-SLC5A5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SSBP4	chr19	18544627	+	SLC5A5	chr19	17994658	+	1.53E-07	0.9999999
SSBP4	chr19	18544627	+	SLC5A5	chr19	17994658	+	1.53E-07	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SSBP4-SLC5A5

Go to
FGviewer for the breakpoints of chr19:18544627-chr19:17994659
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SSBP4

chr19:18544627

chr19:17994659

ENST00000270061

125_279

376.0

386.0

Compositional bias

Note=Pro-rich

Hgene

SSBP4

chr19:18544627

chr19:17994659

ENST00000270061

17_49

376.0

386.0

Domain

LisH

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

466_525

443.0

644.0

Topological domain

Extracellular

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

547_643

443.0

644.0

Topological domain

Cytoplasmic

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

445_465

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

526_546

443.0

644.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

110_136

443.0

644.0

Topological domain

Cytoplasmic

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

158_163

443.0

644.0

Topological domain

Extracellular

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

185_186

443.0

644.0

Topological domain

Cytoplasmic

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

1_16

443.0

644.0

Topological domain

Extracellular

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

208_241

443.0

644.0

Topological domain

Extracellular

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

263_286

443.0

644.0

Topological domain

Cytoplasmic

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

308_326

443.0

644.0

Topological domain

Extracellular

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

348_391

443.0

644.0

Topological domain

Cytoplasmic

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

38_53

443.0

644.0

Topological domain

Cytoplasmic

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

413_416

443.0

644.0

Topological domain

Extracellular

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

438_444

443.0

644.0

Topological domain

Cytoplasmic

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

75_88

443.0

644.0

Topological domain

Extracellular

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

137_157

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

164_184

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

17_37

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

187_207

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

242_262

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

287_307

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

327_347

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

392_412

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

417_437

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

54_74

443.0

644.0

Transmembrane

Helical

Tgene

SLC5A5

chr19:18544627

chr19:17994659

ENST00000222248

89_109

443.0

644.0

Transmembrane

Helical

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Fusion Gene Sequence for SSBP4-SLC5A5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000348495_ENST00000222248_TCGA-AJ-A3QS-01A_SSBP4_chr19_18544627_+_SLC5A5_chr19_17994659_length(transcript)=3275nt_BP=1375nt
CGCCCGCGGGCGGCGTAGAGGCAGCGGGCGGGGGCGCGCGCGGCGGGAGGAGGGGAGCGCGCGTTTCCCGGAACAGCCCGCGCGGAGGAA
AGGGAGGAAAAAAAGCCACCCTGCGGCCGGGGCCGGAGCTGGAGCCGCCGCTGCCGCCGCCGCCGCGGCCGTCTGGAGCTCCCCCGCGCG
GACGATGCCTGCCGTGCCCGCCTGGGGCTCGGGGCGGTGAGGCCCGGGGCGCGGGGTAGCTATGGCGACGGCAAGCGCGGCCCGCGGCGC
CGCCTGACAGGTGTGGGCCCCGGCGGCGGCGGCGTGGAGCAGCATGTACGCCAAGGGGGGCAAGGGTTCGGCCGTGCCCTCCGACAGCCA
GGCCCGCGAGAAGTTGGCGCTGTACGTTTATGAGTACCTGCTGCACATCGGTGCCCAGAAGTCAGCCCAGACCTTCCTGTCTGAGATCCG
ATGGGAGAAGAACATCACGCTGGGGGAGCCCCCTGGGTTCCTGCACTCCTGGTGGTGCGTCTTCTGGGACCTGTACTGCGCGGCGCCTGA
CAGAAGAGAGGCCTGCGAGCACTCCGGCGAGGCCAAGGCCTTCCAGGACTATAGTGCTGCAGCCGCCCCCAGCCCCGTTATGGGGAGTAT
GGCCCCAGGTGACACAATGGCCGCAGGCTCCATGGCGGCTGGCTTCTTCCAGCCCTTCATGTCACCGCGCTTCCCAGGGGGCCCCCGGCC
CACCCTGCGGATGCCGAGTCAGCCTCCCGCAGGCCTCCCTGGCTCCCAGCCCCTCCTCCCTGGCGCCATGGAGCCCTCCCCACGAGCCCA
GGGGCATCCGAGCATGGGCGGCCCAATGCAGAGGGTGACGCCTCCTCGTGGCATGGCCAGCGTGGGGCCCCAGAGCTATGGAGGTGGCAT
GCGACCCCCACCCAACTCCCTCGCCGGCCCAGGCCTGCCTGCCATGAACATGGGCCCAGGAGTTCGTGGCCCGTGGGCCAGCCCCAGTGG
AAACTCGATCCCCTACTCCTCCTCATCCCCCGGCAGCTACACCGGACCCCCAGGAGGAGGTGGGCCCCCTGGAACACCCATCATGCCTAG
CCCTGGAGATTCCACCAACTCCAGCGAAAACATGTACACTATCATGAACCCCATCGGGCAGGGCGCCGGCAGGGCTAATTTCCCGCTCGG
CCCTGGCCCGGAGGGCCCCATGGCCGCCATGAGCGCGATGGAGCCTCACCACGTGAACGGATCCCTGGGCTCGGGCGACATGGACGGGTT
GCCGAAGAGTTCCCCCGGCGCCGTGGCCGGCCTGAGCAACGCCCCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTT
CCTGCACCCGTTCCCGAGCGAAAGCGGCGTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCT
GTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGA
CCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGCTCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGC
CATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCG
CAGCACCCTGGCCCCGGGATTGTTGTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGA
CAACTTGGTCAAGGGTCCTGAAGAACTCCCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTT
GGGGCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAGGAGACAAACCTCTGAGG
ACAGGGCCAGCCGCGGGACTGACACCCTGGGATGGAACCTCAGGATGGGCCAAACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTG
GCTGGATTGCCTTGTATGCAAATGAGTTCAGGACTACAATACCCTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCC
AGCCCCTTGCTTCAACCGTCCCCAGTATTAGACGCTGCAGCCCTGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCTCTTTTTT
TTTTTTTTTTTTTTTTGAGACAGGGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCC
CAGGCTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGGGATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTA
GTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGG
TTACAGGCGTAAGCTACCATGCCCAGCCTACCGTTTTTCTCAATCTATAATAGAAAGCCACCACGCCCAGGTAATTTTTGTAATTTTGTA
TTTTTGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGG
CTGGGATTACAGGGGTGAGCCACCGCGCCCCACCTCTTTCTTATTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCC
TCCAACCTTGGCCCACACACCTGCCATGGCTCCCATCATCCTGAGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTCTCGAATT
GGGTTGTGTCCCCCCAAAATTTATGTCTACCCAGAACCTCAGAACATGAGCTTACTTGGAAATAGGGTCTTTGCAGGTGTAACTGGTTAA
ATTAAAAGAGGTATTACTGGAGGAGGATGGATGAATCCAGTGACTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGG
GAAGATGCCACGTGAAGACAGAGGCAGTGGTTGGATCAATGCATCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCA
GGAGGGGGGCATGAGATGCATTATTTCTTAGAGCCTTTAGAGGGAACATGGCCCTACTGACACCTTGATGTCAGACTTCTGGCTGCTAGA

>In-frame_ENST00000348495_ENST00000222248_TCGA-AJ-A3QS-01A_SSBP4_chr19_18544627_+_SLC5A5_chr19_17994659_length(amino acids)=554AA_start in transcript=313_stop in transcript=1977
MYAKGGKGSAVPSDSQAREKLALYVYEYLLHIGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPDRREACEHSGEAKAF
QDYSAAAAPSPVMGSMAPGDTMAAGSMAAGFFQPFMSPRFPGGPRPTLRMPSQPPAGLPGSQPLLPGAMEPSPRAQGHPSMGGPMQRVTP
PRGMASVGPQSYGGGMRPPPNSLAGPGLPAMNMGPGVRGPWASPSGNSIPYSSSSPGSYTGPPGGGGPPGTPIMPSPGDSTNSSENMYTI
MNPIGQGAGRANFPLGPGPEGPMAAMSAMEPHHVNGSLGSGDMDGLPKSSPGAVAGLSNAPGTPRDDGEMAAAGTFLHPFPSESGVLAGL
GAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTT
VLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTPC

--------------------------------------------------------------
>In-frame_ENST00000270061_ENST00000222248_TCGA-AJ-A3QS-01A_SSBP4_chr19_18544627_+_SLC5A5_chr19_17994659_length(transcript)=3322nt_BP=1422nt
GGCAGCGGGCGGGGGCGCGCGCGGCGGGAGGAGGGGAGCGCGCGTTTCCCGGAACAGCCCGCGCGGAGGAAAGGGAGGAAAAAAAGCCAC
CCTGCGGCCGGGGCCGGAGCTGGAGCCGCCGCTGCCGCCGCCGCCGCGGCCGTCTGGAGCTCCCCCGCGCGGACGATGCCTGCCGTGCCC
GCCTGGGGCTCGGGGCGGTGAGGCCCGGGGCGCGGGGTAGCTATGGCGACGGCAAGCGCGGCCCGCGGCGCCGCCTGACAGGTGTGGGCC
CCGGCGGCGGCGGCGTGGAGCAGCATGTACGCCAAGGGGGGCAAGGGTTCGGCCGTGCCCTCCGACAGCCAGGCCCGCGAGAAGTTGGCG
CTGTACGTTTATGAGTACCTGCTGCACATCGGTGCCCAGAAGTCAGCCCAGACCTTCCTGTCTGAGATCCGATGGGAGAAGAACATCACG
CTGGGGGAGCCCCCTGGGTTCCTGCACTCCTGGTGGTGCGTCTTCTGGGACCTGTACTGCGCGGCGCCTGACAGAAGAGAGGCCTGCGAG
CACTCCGGCGAGGCCAAGGCCTTCCAGGACTATAGTGCTGCAGCCGCCCCCAGCCCCGTTATGGGGAGTATGGCCCCAGGTGACACAATG
GCCGCAGGCTCCATGGCGGCTGGCTTCTTCCAGGGCCCCCCCGGCTCCCAGCCGTCCCCCCACAACCCCAACGCCCCCATGATGGGGCCT
CACGGTCAGCCCTTCATGTCACCGCGCTTCCCAGGGGGCCCCCGGCCCACCCTGCGGATGCCGAGTCAGCCTCCCGCAGGCCTCCCTGGC
TCCCAGCCCCTCCTCCCTGGCGCCATGGAGCCCTCCCCACGAGCCCAGGGGCATCCGAGCATGGGCGGCCCAATGCAGAGGGTGACGCCT
CCTCGTGGCATGGCCAGCGTGGGGCCCCAGAGCTATGGAGGTGGCATGCGACCCCCACCCAACTCCCTCGCCGGCCCAGGCCTGCCTGCC
ATGAACATGGGCCCAGGAGTTCGTGGCCCGTGGGCCAGCCCCAGTGGAAACTCGATCCCCTACTCCTCCTCATCCCCCGGCAGCTACACC
GGACCCCCAGGAGGAGGTGGGCCCCCTGGAACACCCATCATGCCTAGCCCTGGAGATTCCACCAACTCCAGCGAAAACATGTACACTATC
ATGAACCCCATCGGGCAGGGCGCCGGCAGGGCTAATTTCCCGCTCGGCCCTGGCCCGGAGGGCCCCATGGCCGCCATGAGCGCGATGGAG
CCTCACCACGTGAACGGATCCCTGGGCTCGGGCGACATGGACGGGTTGCCGAAGAGTTCCCCCGGCGCCGTGGCCGGCCTGAGCAACGCC
CCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTTCCTGCACCCGTTCCCGAGCGAAAGCGGCGTCCTCGCGGGACTA
GGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCG
GCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCCAGCAGGGCCCCCAGC
TCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACT
GTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTTGTGGTGGGACCTCGCACGG
CAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAACTTGGTCAAGGGTCCTGAAGAACTCCCCACTGGAAACAAG
AAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTGGAGGGGGCTGGCTCTTGGACCCCCTGT
GTTGGACATGATGGTGGTCGAGACCAGCAGGAGACAAACCTCTGAGGACAGGGCCAGCCGCGGGACTGACACCCTGGGATGGAACCTCAG
GATGGGCCAAACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTGGCTGGATTGCCTTGTATGCAAATGAGTTCAGGACTACAATACC
CTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCCAGCCCCTTGCTTCAACCGTCCCCAGTATTAGACGCTGCAGCCC
TGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCATGCTCTGTCACCCAG
GCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGG
GATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAAC
TCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGTTACAGGCGTAAGCTACCATGCCCAGCCTACCGTTTTTCTCAA
TCTATAATAGAAAGCCACCACGCCCAGGTAATTTTTGTAATTTTGTATTTTTGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCT
CAAACTCCTGATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGGCTGGGATTACAGGGGTGAGCCACCGCGCCCCACCTCTTTCTTA
TTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCCTCCAACCTTGGCCCACACACCTGCCATGGCTCCCATCATCCTG
AGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTCTCGAATTGGGTTGTGTCCCCCCAAAATTTATGTCTACCCAGAACCTCAGA
ACATGAGCTTACTTGGAAATAGGGTCTTTGCAGGTGTAACTGGTTAAATTAAAAGAGGTATTACTGGAGGAGGATGGATGAATCCAGTGA
CTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGGGAAGATGCCACGTGAAGACAGAGGCAGTGGTTGGATCAATGCA
TCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCAGGAGGGGGGCATGAGATGCATTATTTCTTAGAGCCTTTAGAGG

>In-frame_ENST00000270061_ENST00000222248_TCGA-AJ-A3QS-01A_SSBP4_chr19_18544627_+_SLC5A5_chr19_17994659_length(amino acids)=576AA_start in transcript=294_stop in transcript=2024
MYAKGGKGSAVPSDSQAREKLALYVYEYLLHIGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPDRREACEHSGEAKAF
QDYSAAAAPSPVMGSMAPGDTMAAGSMAAGFFQGPPGSQPSPHNPNAPMMGPHGQPFMSPRFPGGPRPTLRMPSQPPAGLPGSQPLLPGA
MEPSPRAQGHPSMGGPMQRVTPPRGMASVGPQSYGGGMRPPPNSLAGPGLPAMNMGPGVRGPWASPSGNSIPYSSSSPGSYTGPPGGGGP
PGTPIMPSPGDSTNSSENMYTIMNPIGQGAGRANFPLGPGPEGPMAAMSAMEPHHVNGSLGSGDMDGLPKSSPGAVAGLSNAPGTPRDDG
EMAAAGTFLHPFPSESGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRP
ALADSFYAISYLYYGALGTLTTVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPT

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>In-frame_ENST00000599699_ENST00000222248_TCGA-AJ-A3QS-01A_SSBP4_chr19_18544627_+_SLC5A5_chr19_17994659_length(transcript)=2347nt_BP=447nt
TTCCCCCTGCCGTCAGCCCGCCTGCCGGGTGGAGGCGTCTAGTGGCGTCCTGAGCCCCCCGGGGGCCGCTCAGTGACAGGGGCTGCCCCG
AGCTGGAGGGGGATCCAGCGACCAAACCAGAGGATGCACTGACCGCCCCTCCCCCCCAGGCCCAACCCTCCACCTGGCCTCAGTCCCGGG
GTTCCTGGCGGGCTGTGCGGGGCGGGGGCGCGTCGGCGGGGGCAGCTTGCGAGGGTCGTTGGCCCCTGGAGGCCGAGGGGCATGGCGCCA
GCACGTCTGAGCCGGTGCCCGTGTCTGTCCGTGTCTGTAGGCTCGGGCGACATGGACGGGTTGCCGAAGAGTTCCCCCGGCGCCGTGGCC
GGCCTGAGCAACGCCCCGGGCACCCCGCGGGACGACGGCGAGATGGCGGCCGCCGGGACCTTCCTGCACCCGTTCCCGAGCGAAAGCGGC
GTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCCTTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGG
GTCCTGCCATCGTCGGCTGCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCTGCTAACGACTCC
AGCAGGGCCCCCAGCTCAGGAATGGACGCCAGCCGACCCGCCTTAGCTGACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTG
GGCACGCTGACCACTGTGCTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCGGGATTGTTGTGG
TGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTGGCCATCCTGGATGACAACTTGGTCAAGGGTCCTGAAGAACTC
CCCACTGGAAACAAGAAGCCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTGGAGGGGGCTGGC
TCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAGGAGACAAACCTCTGAGGACAGGGCCAGCCGCGGGACTGACACCCT
GGGATGGAACCTCAGGATGGGCCAAACCCAGACAACGGGCCCATGGCCTTGGGCTCTGATTGGCTGGATTGCCTTGTATGCAAATGAGTT
CAGGACTACAATACCCTACCCTATGGGGAGGCCCTGCCTCCGGGAGGTCATTTTTTAAATCCAGCCCCTTGCTTCAACCGTCCCCAGTAT
TAGACGCTGCAGCCCTGACGGCTCCCCCCAAATAAGGCTGGGTTTTTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCA
TGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGCTCAAGTGATTCTCCTGCCTCAGC
CTCTTGAGTAGCTGGGATTGTAGGTGCCCACCACCATGCCCAGCCAACTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTC
AGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGTTACAGGCGTAAGCTACCATGCCCAGCC
TACCGTTTTTCTCAATCTATAATAGAAAGCCACCACGCCCAGGTAATTTTTGTAATTTTGTATTTTTGTAGAGACGGGGTTTTGCCATGT
TGGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCCTCCTGCCTTGGCCTCCCAAAGGGCTGGGATTACAGGGGTGAGCCACCGCGC
CCCACCTCTTTCTTATTTTCTTCCTGGGATTGGGGAGGGGATGATTCAGACCCCACATGGCCTCCAACCTTGGCCCACACACCTGCCATG
GCTCCCATCATCCTGAGCATGCTAGCGTCCCCTCCTCACCTGACAATGGAGGCTCTCGAATTGGGTTGTGTCCCCCCAAAATTTATGTCT
ACCCAGAACCTCAGAACATGAGCTTACTTGGAAATAGGGTCTTTGCAGGTGTAACTGGTTAAATTAAAAGAGGTATTACTGGAGGAGGAT
GGATGAATCCAGTGACTGGTTCCTCATATGAAGTAGAGAAGAGATGCAGAGAAACACATGGGGAAGATGCCACGTGAAGACAGAGGCAGT
GGTTGGATCAATGCATCTACGAGTCGGAGAACCCAAGGATTGCCAGCAACAACCAGAAATCAGGAGGGGGGCATGAGATGCATTATTTCT
TAGAGCCTTTAGAGGGAACATGGCCCTACTGACACCTTGATGTCAGACTTCTGGCTGCTAGAACTGTCAGAGAATAAATTTCTGTTGTTT

>In-frame_ENST00000599699_ENST00000222248_TCGA-AJ-A3QS-01A_SSBP4_chr19_18544627_+_SLC5A5_chr19_17994659_length(amino acids)=285AA_start in transcript=192_stop in transcript=1049
MCGAGARRRGQLARVVGPWRPRGMAPARLSRCPCLSVSVGSGDMDGLPKSSPGAVAGLSNAPGTPRDDGEMAAAGTFLHPFPSESGVLAG
LGAGLALSLWVALGATLYPPSEQTMRVLPSSAARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLT
TVLCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKKPPGFLPTNEDRLFFLGQKELEGAGSWTP

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Fusion Gene PPI Analysis for SSBP4-SLC5A5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SSBP4-SLC5A5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SSBP4-SLC5A5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SLC5A5	C1848805	Thyroid Dyshormonogenesis 1	8	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	SLC5A5	C0033578	Prostatic Neoplasms	2	CTD_human
Tgene	SLC5A5	C0040136	Thyroid Neoplasm	2	CTD_human
Tgene	SLC5A5	C0151468	Thyroid Gland Follicular Adenoma	2	CTD_human
Tgene	SLC5A5	C0376358	Malignant neoplasm of prostate	2	CTD_human
Tgene	SLC5A5	C0549473	Thyroid carcinoma	2	CTD_human
Tgene	SLC5A5	C2239176	Liver carcinoma	2	CTD_human
Tgene	SLC5A5	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	SLC5A5	C0006826	Malignant Neoplasms	1	CTD_human
Tgene	SLC5A5	C0017638	Glioma	1	CTD_human
Tgene	SLC5A5	C0018021	Goiter	1	GENOMICS_ENGLAND
Tgene	SLC5A5	C0022665	Kidney Neoplasm	1	CTD_human
Tgene	SLC5A5	C0025202	melanoma	1	CTD_human
Tgene	SLC5A5	C0027651	Neoplasms	1	CTD_human
Tgene	SLC5A5	C0086692	Benign Neoplasm	1	CTD_human
Tgene	SLC5A5	C0206698	Cholangiocarcinoma	1	CTD_human
Tgene	SLC5A5	C0259783	mixed gliomas	1	CTD_human
Tgene	SLC5A5	C0345905	Intrahepatic Cholangiocarcinoma	1	CTD_human
Tgene	SLC5A5	C0555198	Malignant Glioma	1	CTD_human
Tgene	SLC5A5	C0678222	Breast Carcinoma	1	CTD_human
Tgene	SLC5A5	C0740457	Malignant neoplasm of kidney	1	CTD_human
Tgene	SLC5A5	C0919267	ovarian neoplasm	1	CTD_human
Tgene	SLC5A5	C1140680	Malignant neoplasm of ovary	1	CTD_human
Tgene	SLC5A5	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	SLC5A5	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	SLC5A5	C3805278	Extrahepatic Cholangiocarcinoma	1	CTD_human
Tgene	SLC5A5	C4704874	Mammary Carcinoma, Human	1	CTD_human