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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SSH2-VMP1 (FusionGDB2 ID:86201)

Fusion Gene Summary for SSH2-VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SSH2-VMP1
Fusion gene ID: 86201
HgeneTgene
Gene symbol

SSH2

VMP1

Gene ID

85464

81671

Gene nameslingshot protein phosphatase 2vacuole membrane protein 1
SynonymsSSH-2|SSH-2LEPG3|TANGO5|TMEM49
Cytomap

17q11.2

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase Slingshot homolog 2SSH-like protein 2vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000269033, ENST00000540801, 
ENST00000324677, ENST00000582084, 
ENST00000590153, ENST00000579954, 
ENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
Fusion gene scores* DoF score39 X 23 X 10=897042 X 34 X 19=27132
# samples 48151
** MAII scorelog2(48/8970*10)=-4.22400167419811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(151/27132*10)=-4.16737494326024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSH2 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSH2(28256956)-VMP1(57915656), # samples:1
Anticipated loss of major functional domain due to fusion event.SSH2-VMP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SSH2-VMP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SSH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VMP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A275-01ASSH2chr17

28256956

-VMP1chr17

57915656

+


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Fusion Gene ORF analysis for SSH2-VMP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000269033ENST00000262291SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000269033ENST00000537567SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000269033ENST00000539763SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000269033ENST00000536180SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000269033ENST00000545362SSH2chr17

28256956

-VMP1chr17

57915656

+
5CDS-intronENST00000269033ENST00000588617SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000540801ENST00000262291SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000540801ENST00000537567SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000540801ENST00000539763SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000540801ENST00000536180SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000540801ENST00000545362SSH2chr17

28256956

-VMP1chr17

57915656

+
5CDS-intronENST00000540801ENST00000588617SSH2chr17

28256956

-VMP1chr17

57915656

+
intron-3CDSENST00000324677ENST00000262291SSH2chr17

28256956

-VMP1chr17

57915656

+
intron-3CDSENST00000324677ENST00000537567SSH2chr17

28256956

-VMP1chr17

57915656

+
intron-3CDSENST00000324677ENST00000539763SSH2chr17

28256956

-VMP1chr17

57915656

+
intron-3CDSENST00000324677ENST00000536180SSH2chr17

28256956

-VMP1chr17

57915656

+
intron-3CDSENST00000324677ENST00000545362SSH2chr17

28256956

-VMP1chr17

57915656

+
intron-intronENST00000324677ENST00000588617SSH2chr17

28256956

-VMP1chr17

57915656

+
In-frameENST00000582084ENST00000262291SSH2chr17

28256956

-VMP1chr17

57915656

+
In-frameENST00000582084ENST00000537567SSH2chr17

28256956

-VMP1chr17

57915656

+
In-frameENST00000582084ENST00000539763SSH2chr17

28256956

-VMP1chr17

57915656

+
In-frameENST00000582084ENST00000536180SSH2chr17

28256956

-VMP1chr17

57915656

+
In-frameENST00000582084ENST00000545362SSH2chr17

28256956

-VMP1chr17

57915656

+
5CDS-intronENST00000582084ENST00000588617SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000590153ENST00000262291SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000590153ENST00000537567SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000590153ENST00000539763SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000590153ENST00000536180SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000590153ENST00000545362SSH2chr17

28256956

-VMP1chr17

57915656

+
5CDS-intronENST00000590153ENST00000588617SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000579954ENST00000262291SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000579954ENST00000537567SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000579954ENST00000539763SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000579954ENST00000536180SSH2chr17

28256956

-VMP1chr17

57915656

+
Frame-shiftENST00000579954ENST00000545362SSH2chr17

28256956

-VMP1chr17

57915656

+
5CDS-intronENST00000579954ENST00000588617SSH2chr17

28256956

-VMP1chr17

57915656

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000582084SSH2chr1728256956-ENST00000262291VMP1chr1757915656+164922115467150
ENST00000582084SSH2chr1728256956-ENST00000537567VMP1chr1757915656+72822115467150
ENST00000582084SSH2chr1728256956-ENST00000539763VMP1chr1757915656+68822115467150
ENST00000582084SSH2chr1728256956-ENST00000536180VMP1chr1757915656+56022115467150
ENST00000582084SSH2chr1728256956-ENST00000545362VMP1chr1757915656+72022115467150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000582084ENST00000262291SSH2chr1728256956-VMP1chr1757915656+0.508837760.49116224
ENST00000582084ENST00000537567SSH2chr1728256956-VMP1chr1757915656+0.293295470.7067045
ENST00000582084ENST00000539763SSH2chr1728256956-VMP1chr1757915656+0.340867340.6591326
ENST00000582084ENST00000536180SSH2chr1728256956-VMP1chr1757915656+0.329253520.6707465
ENST00000582084ENST00000545362SSH2chr1728256956-VMP1chr1757915656+0.31221640.6877836

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Fusion Genomic Features for SSH2-VMP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SSH2chr1728256955-VMP1chr1757915655+1.85E-091
SSH2chr1728256955-VMP1chr1757915655+1.85E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SSH2-VMP1


check button Go to

FGviewer for the breakpoints of chr17:28256956-chr17:57915656

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912327_363324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912385_406324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912364_384324.6666666666667407.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSH2chr17:28256956chr17:57915656ENST00000269033-115307_44821.01424.0DomainTyrosine-protein phosphatase
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912173_316324.6666666666667407.0RegionVTT domain
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912131_250324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912272_273324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912295_305324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr17:28256956chr17:57915656ENST000002622919122_43324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr17:28256956chr17:57915656ENST0000026229191265_77324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr17:28256956chr17:57915656ENST0000026229191299_109324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912110_130324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912251_271324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912274_294324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr17:28256956chr17:57915656ENST00000262291912306_326324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr17:28256956chr17:57915656ENST0000026229191244_64324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr17:28256956chr17:57915656ENST0000026229191278_98324.6666666666667407.0TransmembraneHelical


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Fusion Gene Sequence for SSH2-VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000582084_ENST00000262291_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(transcript)=1649nt_BP=221nt
GGGGAGAGGCGGTAGCTGACAGGTGGCGCCTGCGCACTGGGAGCGCTCATTGTGCCCCGCAGCTGCGGAACCGCCCGCCCGCCGCCCGTT
CGGAGCGTCAGTCGGCGACAGTCTGGTGGACAAGAATGCCCTGCCCGGAACAACCCAGCAGCGCCTAGATGGCTTTGGTCACGGTCCAGC
GGTCACCTACCCCCAGCACCACCTCCAGCCCCTGCGCCTCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTAC
CTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTG
GTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCA
GAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGG
GAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTT
TCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGC
AACAGACTGGCCTTCTGTTTGTTACTTTCAAAAGGCCCACATGATACAATTAGAGAATTCCCACCGCACAAAAAAAGTTCCTAAGTATGT
TAAATATGTCAAGCTTTTTAGGCTTGTCACAAATGATTGCTTTGTTTTCCTAAGTCATCAAAATGTATATAAATTATCTAGATTGGATAA
CAGTCTTGCATGTTTATCATGTTACAATTTAATATTCCATCCTGCCCAACCCTTCCTCTCCCATCCTCAAAAAAGGGCCATTTTATGATG
CATTGCACACCCTCTGGGGAAATTGATCTTTAAATTTTGAGACAGTATAAGGAAAATCTGGTTGGTGTCTTACAAGTGAGCTGACACCAT
TTTTTATTCTGTGTATTTAGAATGAAGTCTTGAAAAAAACTTTATAAAGACATCTTTAATCATTCCAAAATTGTGTCCGTTTTCTTGAGC
GTTTTGATTTTTTACTTTTAGCTTATACCAGCTGAATGGCAGCCTTGCCTAATCCACCTACAACAAGAATTTCTTAAGCTTTCTTTTATT
TGCATGAGAGAGCCACTACCAAGGCATGTTTTGTTATGCTGAAACTGGGCTGCTGCATACTGCTAAATGGCACCTCTGGGATTGGCCTAC
CTGGGGATTTCTTGGTTTGTGAAAACAGGAGAGGAGAAATATCTCATACAAGTGAAAGGATACTGGAGAGAGAAATTACCCATTTCTAAA
AAAAAACCACACTCTGTCGTATCTGTGTTAATGTTTTCTAGCATGTACTCTGGTTTCAACAGACACAAATTTATATGTTAACCCAGTTTT
CTTGCCGTTCTGTAAGTGTTTTATTCTTAGTGTGATTTTTTTCCATTGGGATGTTTTTGATTGAACTTGTTCATTTTGTTTTGCTTGGGA

>In-frame_ENST00000582084_ENST00000262291_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(amino acids)=150AA_start in transcript=15_stop in transcript=467
MTGGACALGALIVPRSCGTARPPPVRSVSRRQSGGQECPARNNPAAPRWLWSRSSGHLPPAPPPAPAPRAVPGIGPSLQKPFQEYLEAQR

--------------------------------------------------------------
>In-frame_ENST00000582084_ENST00000537567_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(transcript)=728nt_BP=221nt
GGGGAGAGGCGGTAGCTGACAGGTGGCGCCTGCGCACTGGGAGCGCTCATTGTGCCCCGCAGCTGCGGAACCGCCCGCCCGCCGCCCGTT
CGGAGCGTCAGTCGGCGACAGTCTGGTGGACAAGAATGCCCTGCCCGGAACAACCCAGCAGCGCCTAGATGGCTTTGGTCACGGTCCAGC
GGTCACCTACCCCCAGCACCACCTCCAGCCCCTGCGCCTCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTAC
CTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTG
GTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCA
GAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGG
GAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTT
TCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGC

>In-frame_ENST00000582084_ENST00000537567_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(amino acids)=150AA_start in transcript=15_stop in transcript=467
MTGGACALGALIVPRSCGTARPPPVRSVSRRQSGGQECPARNNPAAPRWLWSRSSGHLPPAPPPAPAPRAVPGIGPSLQKPFQEYLEAQR

--------------------------------------------------------------
>In-frame_ENST00000582084_ENST00000539763_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(transcript)=688nt_BP=221nt
GGGGAGAGGCGGTAGCTGACAGGTGGCGCCTGCGCACTGGGAGCGCTCATTGTGCCCCGCAGCTGCGGAACCGCCCGCCCGCCGCCCGTT
CGGAGCGTCAGTCGGCGACAGTCTGGTGGACAAGAATGCCCTGCCCGGAACAACCCAGCAGCGCCTAGATGGCTTTGGTCACGGTCCAGC
GGTCACCTACCCCCAGCACCACCTCCAGCCCCTGCGCCTCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTAC
CTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTG
GTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCA
GAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGG
GAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTT

>In-frame_ENST00000582084_ENST00000539763_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(amino acids)=150AA_start in transcript=15_stop in transcript=467
MTGGACALGALIVPRSCGTARPPPVRSVSRRQSGGQECPARNNPAAPRWLWSRSSGHLPPAPPPAPAPRAVPGIGPSLQKPFQEYLEAQR

--------------------------------------------------------------
>In-frame_ENST00000582084_ENST00000536180_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(transcript)=560nt_BP=221nt
GGGGAGAGGCGGTAGCTGACAGGTGGCGCCTGCGCACTGGGAGCGCTCATTGTGCCCCGCAGCTGCGGAACCGCCCGCCCGCCGCCCGTT
CGGAGCGTCAGTCGGCGACAGTCTGGTGGACAAGAATGCCCTGCCCGGAACAACCCAGCAGCGCCTAGATGGCTTTGGTCACGGTCCAGC
GGTCACCTACCCCCAGCACCACCTCCAGCCCCTGCGCCTCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTAC
CTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTG
GTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCA
GAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGG

>In-frame_ENST00000582084_ENST00000536180_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(amino acids)=150AA_start in transcript=15_stop in transcript=467
MTGGACALGALIVPRSCGTARPPPVRSVSRRQSGGQECPARNNPAAPRWLWSRSSGHLPPAPPPAPAPRAVPGIGPSLQKPFQEYLEAQR

--------------------------------------------------------------
>In-frame_ENST00000582084_ENST00000545362_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(transcript)=720nt_BP=221nt
GGGGAGAGGCGGTAGCTGACAGGTGGCGCCTGCGCACTGGGAGCGCTCATTGTGCCCCGCAGCTGCGGAACCGCCCGCCCGCCGCCCGTT
CGGAGCGTCAGTCGGCGACAGTCTGGTGGACAAGAATGCCCTGCCCGGAACAACCCAGCAGCGCCTAGATGGCTTTGGTCACGGTCCAGC
GGTCACCTACCCCCAGCACCACCTCCAGCCCCTGCGCCTCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTAC
CTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTG
GTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCA
GAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGG
GAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTT
TCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGC

>In-frame_ENST00000582084_ENST00000545362_TCGA-C8-A275-01A_SSH2_chr17_28256956_-_VMP1_chr17_57915656_length(amino acids)=150AA_start in transcript=15_stop in transcript=467
MTGGACALGALIVPRSCGTARPPPVRSVSRRQSGGQECPARNNPAAPRWLWSRSSGHLPPAPPPAPAPRAVPGIGPSLQKPFQEYLEAQR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SSH2-VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SSH2-VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SSH2-VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource