FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SSR1-CAGE1 (FusionGDB2 ID:86219)

Fusion Gene Summary for SSR1-CAGE1

check button Fusion gene summary
Fusion gene informationFusion gene name: SSR1-CAGE1
Fusion gene ID: 86219
HgeneTgene
Gene symbol

SSR1

CAGE1

Gene ID

6745

285782

Gene namesignal sequence receptor subunit 1cancer antigen 1
SynonymsTRAPACT3|CT95|CTAG3|bA69L16.7
Cytomap

6p24.3

6p24.3

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunitcancer-associated gene 1 proteincancer/testis antigen 3cancer/testis antigen 95cancer/testis antigen gene 1
Modification date2020031320200313
UniProtAcc.

Q8TC20

Ensembl transtripts involved in fusion geneENST00000488834, ENST00000474597, 
ENST00000244763, ENST00000397511, 
ENST00000534851, ENST00000489567, 
ENST00000479365, ENST00000462112, 
ENST00000379918, ENST00000502583, 
ENST00000296742, ENST00000512086, 
ENST00000338150, ENST00000509324, 
Fusion gene scores* DoF score15 X 18 X 8=21605 X 8 X 3=120
# samples 188
** MAII scorelog2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSR1 [Title/Abstract] AND CAGE1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSR1(7301543)-CAGE1(7330121), # samples:2
Anticipated loss of major functional domain due to fusion event.SSR1-CAGE1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAGE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CX-01ASSR1chr6

7301543

-CAGE1chr6

7330121

-
ChimerDB4BRCATCGA-A2-A0CX-01ASSR1chr6

7301543

-CAGE1chr6

7330121

-
ChimerDB4BRCATCGA-A2-A0CX-01ASSR1chr6

7301542

-CAGE1chr6

7330120

-


Top

Fusion Gene ORF analysis for SSR1-CAGE1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000488834ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
intron-3CDSENST00000488834ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
intron-3CDSENST00000488834ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
intron-3CDSENST00000488834ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
intron-3CDSENST00000488834ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
intron-intronENST00000488834ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000474597ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000474597ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000474597ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000474597ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000474597ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
5CDS-intronENST00000474597ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000244763ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000244763ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000244763ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000244763ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000244763ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
5CDS-intronENST00000244763ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000397511ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000397511ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000397511ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000397511ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000397511ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
5CDS-intronENST00000397511ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000534851ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000534851ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000534851ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000534851ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000534851ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
5CDS-intronENST00000534851ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000489567ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000489567ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000489567ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000489567ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000489567ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
5CDS-intronENST00000489567ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000479365ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000479365ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000479365ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000479365ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000479365ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
5CDS-intronENST00000479365ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000462112ENST00000379918SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000462112ENST00000502583SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000462112ENST00000296742SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000462112ENST00000512086SSR1chr6

7301543

-CAGE1chr6

7330121

-
Frame-shiftENST00000462112ENST00000338150SSR1chr6

7301543

-CAGE1chr6

7330121

-
5CDS-intronENST00000462112ENST00000509324SSR1chr6

7301543

-CAGE1chr6

7330121

-
intron-3CDSENST00000488834ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
intron-3CDSENST00000488834ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
intron-3CDSENST00000488834ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
intron-3CDSENST00000488834ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
intron-3CDSENST00000488834ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
intron-intronENST00000488834ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000474597ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000474597ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000474597ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000474597ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000474597ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
5CDS-intronENST00000474597ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000244763ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000244763ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000244763ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000244763ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000244763ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
5CDS-intronENST00000244763ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000397511ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000397511ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000397511ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000397511ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000397511ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
5CDS-intronENST00000397511ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000534851ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000534851ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000534851ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000534851ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000534851ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
5CDS-intronENST00000534851ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000489567ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000489567ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000489567ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000489567ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000489567ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
5CDS-intronENST00000489567ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000479365ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000479365ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000479365ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000479365ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000479365ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
5CDS-intronENST00000479365ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000462112ENST00000379918SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000462112ENST00000502583SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000462112ENST00000296742SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000462112ENST00000512086SSR1chr6

7301542

-CAGE1chr6

7330120

-
Frame-shiftENST00000462112ENST00000338150SSR1chr6

7301542

-CAGE1chr6

7330120

-
5CDS-intronENST00000462112ENST00000509324SSR1chr6

7301542

-CAGE1chr6

7330120

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SSR1-CAGE1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SSR1-CAGE1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAGE1

Q8TC20

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for SSR1-CAGE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for SSR1-CAGE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SSR1-CAGE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SSR1-CAGE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource