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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:SSR3-CLU (FusionGDB2 ID:86243)

Fusion Gene Summary for SSR3-CLU

Fusion gene summary

Fusion gene information	Fusion gene name: SSR3-CLU
	Fusion gene ID: 86243
		Hgene	Tgene
	Gene symbol	SSR3	CLU
	Gene ID	6747	1191
	Gene name	signal sequence receptor subunit 3	clusterin
	Synonyms	TRAPG	AAG4\|APO-J\|APOJ\|CLI\|CLU1\|CLU2\|KUB1\|NA1/NA2\|SGP-2\|SGP2\|SP-40\|TRPM-2\|TRPM2
	Cytomap	3q25.31	8p21.1
	Type of gene	protein-coding	protein-coding
	Description	translocon-associated protein subunit gammaSSR gammaTRAP-complex gamma subunitTRAP-gammasignal sequence receptor subunit gammasignal sequence receptor, gamma (translocon-associated protein gamma)translocon-associated protein gamma subunit	clusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40epididymis secretory sperm binding proteinku70-binding protein 1sulfated glycoprotein 2testosterone-r
	Modification date	20200313	20200327
	UniProtAcc	.	Q15846
	Ensembl transtripts involved in fusion gene	ENST00000265044, ENST00000467789, ENST00000476217, ENST00000478842, ENST00000463503, ENST00000496050,	ENST00000316403, ENST00000546343, ENST00000560366, ENST00000405140, ENST00000523500,
Fusion gene scores	* DoF score	7 X 7 X 4=196	23 X 24 X 12=6624
	# samples	7	30
	** MAII score	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/6624*10)=-4.46466826700344 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SSR3 [Title/Abstract] AND CLU [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SSR3(156271443)-CLU(27455767), # samples:1
Anticipated loss of major functional domain due to fusion event.	SSR3-CLU seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. SSR3-CLU seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SSR3-CLU seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CLU	GO:0000902	cell morphogenesis	15857407
Tgene	CLU	GO:0001774	microglial cell activation	15857407
Tgene	CLU	GO:0017038	protein import	24446231
Tgene	CLU	GO:0031333	negative regulation of protein complex assembly	22179788\|23106396
Tgene	CLU	GO:0031334	positive regulation of protein complex assembly	22179788
Tgene	CLU	GO:0032760	positive regulation of tumor necrosis factor production	15857407
Tgene	CLU	GO:0045429	positive regulation of nitric oxide biosynthetic process	15857407
Tgene	CLU	GO:0050821	protein stabilization	11123922\|12176985
Tgene	CLU	GO:0051131	chaperone-mediated protein complex assembly	17412999
Tgene	CLU	GO:0051788	response to misfolded protein	19996109
Tgene	CLU	GO:0061077	chaperone-mediated protein folding	11123922
Tgene	CLU	GO:0061518	microglial cell proliferation	15857407
Tgene	CLU	GO:1900221	regulation of amyloid-beta clearance	24446231
Tgene	CLU	GO:1901214	regulation of neuron death	17412999
Tgene	CLU	GO:1901216	positive regulation of neuron death	15857407
Tgene	CLU	GO:1902430	negative regulation of amyloid-beta formation	12047389\|17412999
Tgene	CLU	GO:1905907	negative regulation of amyloid fibril formation	22179788

Fusion gene breakpoints across SSR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CLU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-04-1536	SSR3	chr3	156271443	-	CLU	chr8	27455767	-

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Fusion Gene ORF analysis for SSR3-CLU

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000265044	ENST00000316403	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000265044	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000265044	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000265044	ENST00000405140	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000265044	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000467789	ENST00000316403	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000467789	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000467789	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000467789	ENST00000405140	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000467789	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000476217	ENST00000316403	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000476217	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000476217	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000476217	ENST00000405140	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000476217	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
intron-3CDS	ENST00000478842	ENST00000316403	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
intron-3CDS	ENST00000478842	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
intron-3CDS	ENST00000478842	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
intron-3CDS	ENST00000478842	ENST00000405140	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
intron-3CDS	ENST00000478842	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000463503	ENST00000316403	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000463503	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000463503	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000463503	ENST00000405140	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000463503	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000496050	ENST00000316403	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
In-frame	ENST00000496050	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000496050	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000496050	ENST00000405140	SSR3	chr3	156271443	-	CLU	chr8	27455767	-
Frame-shift	ENST00000496050	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265044	SSR3	chr3	156271443	-	ENST00000560366	CLU	chr8	27455767	-	1671	355	41	364	107
ENST00000265044	SSR3	chr3	156271443	-	ENST00000523500	CLU	chr8	27455767	-	610	355	41	364	107
ENST00000467789	SSR3	chr3	156271443	-	ENST00000560366	CLU	chr8	27455767	-	1636	320	6	329	107
ENST00000467789	SSR3	chr3	156271443	-	ENST00000523500	CLU	chr8	27455767	-	575	320	6	329	107
ENST00000476217	SSR3	chr3	156271443	-	ENST00000560366	CLU	chr8	27455767	-	1612	296	1078	764	104
ENST00000476217	SSR3	chr3	156271443	-	ENST00000523500	CLU	chr8	27455767	-	551	296	36	305	89
ENST00000463503	SSR3	chr3	156271443	-	ENST00000546343	CLU	chr8	27455767	-	1552	236	1018	704	104
ENST00000496050	SSR3	chr3	156271443	-	ENST00000546343	CLU	chr8	27455767	-	1576	260	1042	728	104

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265044	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.04776907	0.95223093
ENST00000265044	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.03637703	0.963623
ENST00000467789	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.087736584	0.91226345
ENST00000467789	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.036879756	0.9631203
ENST00000476217	ENST00000560366	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.11446705	0.885533
ENST00000476217	ENST00000523500	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.06140884	0.9385912
ENST00000463503	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.8258694	0.1741306
ENST00000496050	ENST00000546343	SSR3	chr3	156271443	-	CLU	chr8	27455767	-	0.73279744	0.2672026

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Fusion Genomic Features for SSR3-CLU

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SSR3-CLU

Go to
FGviewer for the breakpoints of chr3:156271443-chr8:27455767
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CLU Q15846
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

1_27

86.66666666666667

186.0

Topological domain

Lumenal

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

49_54

86.66666666666667

186.0

Topological domain

Cytoplasmic

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

28_48

86.66666666666667

186.0

Transmembrane

Helical

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

55_76

86.66666666666667

186.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

158_163

86.66666666666667

186.0

Topological domain

Cytoplasmic

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

77_135

86.66666666666667

186.0

Topological domain

Lumenal

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

136_157

86.66666666666667

186.0

Transmembrane

Helical

Hgene

SSR3

chr3:156271443

chr8:27455767

ENST00000265044

164_184

86.66666666666667

186.0

Transmembrane

Helical

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000316403

443_447

446.6666666666667

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000316403

78_81

446.6666666666667

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000405140

443_447

446.6666666666667

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000405140

78_81

446.6666666666667

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000523500

443_447

446.6666666666667

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000523500

78_81

446.6666666666667

450.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000546343

443_447

457.6666666666667

461.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000546343

78_81

457.6666666666667

461.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000560366

443_447

498.6666666666667

502.0

Motif

Nuclear localization signal

Tgene

CLU

chr3:156271443

chr8:27455767

ENST00000560366

78_81

498.6666666666667

502.0

Motif

Nuclear localization signal

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Fusion Gene Sequence for SSR3-CLU

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000265044_ENST00000560366_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=1671nt_BP=355nt
GTTAGCGGATACGGCGGCCGCAGGGGCGGAGTCAAGGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCT
CCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCT
CCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTGGTTATACTGGCGAATATGGCATATGGATCTTATTCAGTCTG
CTGTTTTGTATAGTGTGATGACCCTAGTAAGCACATATTTGGTAGCCTTTGCATACAAGAATGTGAAATTTGTTCTCAAGCACAAGGAGG
AGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTG
CACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACT
CTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTT
TTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAG
TGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTCAA
GAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAA
ACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACT
TGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTG
CTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCC
TGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGT
ACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGAT
AGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAG
CTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATT
TTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTATTT

>In-frame_ENST00000265044_ENST00000560366_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=107AA_start in transcript=41_stop in transcript=364
MPALAAGSTFPVLACSSAMAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYL

--------------------------------------------------------------
>In-frame_ENST00000265044_ENST00000523500_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=610nt_BP=355nt
GTTAGCGGATACGGCGGCCGCAGGGGCGGAGTCAAGGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCT
CCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCT
CCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTGGTTATACTGGCGAATATGGCATATGGATCTTATTCAGTCTG
CTGTTTTGTATAGTGTGATGACCCTAGTAAGCACATATTTGGTAGCCTTTGCATACAAGAATGTGAAATTTGTTCTCAAGCACAAGGAGG
AGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTG
CACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACT

>In-frame_ENST00000265044_ENST00000523500_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=107AA_start in transcript=41_stop in transcript=364
MPALAAGSTFPVLACSSAMAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYL

--------------------------------------------------------------
>In-frame_ENST00000467789_ENST00000560366_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=1636nt_BP=320nt
GGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAG
TCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCT
GCCATCCCCATCTGGTTATACTGGCGAATATGGCATATGGATCTTATTCAGTCTGCTGTTTTGTATAGTGTGATGACCCTAGTAAGCACA
TATTTGGTAGCCTTTGCATACAAGAATGTGAAATTTGTTCTCAAGCACAAGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGG
GCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGC
CCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCA
TGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCAT
TTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGA
AGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCA
ACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCT
CCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATG
AAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGAT
TTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTT
CCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCG
TGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACA
AAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCT
CTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTC
AGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTATTTGCTTAAGTGATCATAATTGTAAAGTATATGTCACA

>In-frame_ENST00000467789_ENST00000560366_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=107AA_start in transcript=6_stop in transcript=329
MPALAAGSTFPVLACSSAMAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYL

--------------------------------------------------------------
>In-frame_ENST00000467789_ENST00000523500_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=575nt_BP=320nt
GGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAG
TCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCT
GCCATCCCCATCTGGTTATACTGGCGAATATGGCATATGGATCTTATTCAGTCTGCTGTTTTGTATAGTGTGATGACCCTAGTAAGCACA
TATTTGGTAGCCTTTGCATACAAGAATGTGAAATTTGTTCTCAAGCACAAGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGG
GCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGC
CCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCA

>In-frame_ENST00000467789_ENST00000523500_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=107AA_start in transcript=6_stop in transcript=329
MPALAAGSTFPVLACSSAMAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYL

--------------------------------------------------------------
>In-frame_ENST00000476217_ENST00000560366_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=1612nt_BP=296nt
GGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAG
GATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTGGTTATACTGG
CGAATATGGCATATGGATCTTATTCAGTCTGCTGTTTTGTATAGTGTGATGACCCTAGTAAGCACATATTTGGTAGCCTTTGCATACAAG
AATGTGAAATTTGTTCTCAAGCACAAGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAA
GATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCC
CGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTC
TTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGG
GGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAA
GGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCT
GCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTA
AGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCC
AAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATC
CCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGG
CTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGC
TCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGG
TGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACT
TAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATAC

>In-frame_ENST00000476217_ENST00000560366_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=104AA_start in transcript=1078_stop in transcript=764
MLSSYNSKSTAFTNKTAAKAIALTNKTDNLDFWAPNVFITKTSIMHYNTKYTLHLLILLLNFQCIPLGDCRTLVRIHRQFYNRTEKLPFA

--------------------------------------------------------------
>In-frame_ENST00000476217_ENST00000523500_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=551nt_BP=296nt
GGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAG
GATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTGGTTATACTGG
CGAATATGGCATATGGATCTTATTCAGTCTGCTGTTTTGTATAGTGTGATGACCCTAGTAAGCACATATTTGGTAGCCTTTGCATACAAG
AATGTGAAATTTGTTCTCAAGCACAAGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAA
GATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCC
CGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTC

>In-frame_ENST00000476217_ENST00000523500_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=89AA_start in transcript=36_stop in transcript=305

--------------------------------------------------------------
>In-frame_ENST00000463503_ENST00000546343_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=1552nt_BP=236nt
AATCTCTCCAGCTCCCCTGAGCTCGGGGAGGCACGGAGCCTCTTCTTTGGGCACAGTGTTGTCGCTTGGGATTGTCCTGTGCAGCACTCG
GGGAGGTCACTTGTTAAAAGGTTATACTGGCGAATATGGCATATGGATCTTATTCAGTCTGCTGTTTTGTATAGTGTGATGACCCTAGTA
AGCACATATTTGGTAGCCTTTGCATACAAGAATGTGAAATTTGTTCTCAAGCACAAGGAGGAGTGAGATGTGGATGTTGCTTTTGCACCT
ACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGTCACCAAGTAACCAGGCCCCAGCCT
CCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCTGCTCATGGGAAGAACAGAATTGCT
CCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATGTTGAGTTGCTGCTTCCCGGCATGC
CTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCTAAGATGGTATAGGGACTGTCATAC
CAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATTGCTTGCTTTCAGGAAGAGAGATGT
GTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGTCGATGTATTCTGACCAAGGTGCGA
CAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTATTATAATGCATAATTGATGTTTTC
GTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTTGCAGCGGTTTTATTTGTAAAAGCT
GTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCCACCGCCGGTTTATATGATCTTCAT
ACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCTACGCTGCCAGCAGGTGGCCATGAC
TACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAATTCTGGTCATCAGATGTACTGCAAT
GGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAGAATATTCTTAAGTCACTGTCCCTT
GTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGCATGGCTGTCAAGGAAATTCAGAGT
AAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTATTTGCTTAAGTGATCATAATTGTAAAGTATAT

>In-frame_ENST00000463503_ENST00000546343_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=104AA_start in transcript=1018_stop in transcript=704
MLSSYNSKSTAFTNKTAAKAIALTNKTDNLDFWAPNVFITKTSIMHYNTKYTLHLLILLLNFQCIPLGDCRTLVRIHRQFYNRTEKLPFA

--------------------------------------------------------------
>In-frame_ENST00000496050_ENST00000546343_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(transcript)=1576nt_BP=260nt
ATTTTGGAATGGCCTGTGTTTCGCATGCTAGTACCCTGATGAATGAAATTTGAAGTCTGACTTGTGATTACGTTGAGCCAGAGTTTGTTC
TCATTTTAGAAGTTGAAATCTCATCTGGACTAGTAATAGGAAGGGTTATACTGGCGAATATGGCATATGGATCTTATTCAGTCTGCTGTT
TTGTATAGTGTGATGACCCTAGTAAGCACATATTTGGTAGCCTTTGCATACAAGAATGTGAAATTTGTTCTCAAGCACAAGGAGGAGTGA
GATGTGGATGTTGCTTTTGCACCTACGGGGGCATCTGAGTCCAGCTCCCCCCAAGATGAGCTGCAGCCCCCCAGAGAGAGCTCTGCACGT
CACCAAGTAACCAGGCCCCAGCCTCCAGGCCCCCAACTCCGCCCAGCCTCTCCCCGCTCTGGATCCTGCACTCTAACACTCGACTCTGCT
GCTCATGGGAAGAACAGAATTGCTCCTGCATGCAACTAATTCAATAAAACTGTCTTGTGAGCTGATCGCTTGGAGGGTCCTCTTTTTATG
TTGAGTTGCTGCTTCCCGGCATGCCTTCATTTTGCTATGGGGGGCAGGCAGGGGGGATGGAAAATAAGTAGAAACAAAAAAGCAGTGGCT
AAGATGGTATAGGGACTGTCATACCAGTGAAGAATAAAAGGGTGAAGAATAAAAGGGATATGATGACAAGGTTGATCCACTTCAAGAATT
GCTTGCTTTCAGGAAGAGAGATGTGTTTCAACAAGCCAACTAAAATATATTGCTGCAAATGGAAGCTTTTCTGTTCTATTATAAAACTGT
CGATGTATTCTGACCAAGGTGCGACAATCTCCTAAAGGAATACACTGAAAGTTAAGGAGAAGAATCAGTAAGTGTAAGGTGTACTTGGTA
TTATAATGCATAATTGATGTTTTCGTTATGAAAACATTTGGTGCCCAGAAGTCCAAATTATCAGTTTTATTTGTAAGAGCTATTGCTTTT
GCAGCGGTTTTATTTGTAAAAGCTGTTGATTTCGAGTTGTAAGAGCTCAGCATCCCAGGGGCATCTTCTTGACTGTGGCATTTCCTGTCC
ACCGCCGGTTTATATGATCTTCATACCTTTCCCTGGACCACAGGCGTTTCTCGGCTTTTAGTCTGAACCATAGCTGGGCTGCAGTACCCT
ACGCTGCCAGCAGGTGGCCATGACTACCCGTGGTACCAATCTCAGTCTTAAAGCTCAGGCTTTTCGTTCATTAACATTCTCTGATAGAAT
TCTGGTCATCAGATGTACTGCAATGGAACAAAACTCATCTGGCTGCATCCCAGGTGTGTAGCAAAGTCCACATGTAAATTTATAGCTTAG
AATATTCTTAAGTCACTGTCCCTTGTCTCTCTTTGAAGTTATAAACAACAAACTTAAAGCTTAGCTTATGTCCAAGGTAAGTATTTTAGC
ATGGCTGTCAAGGAAATTCAGAGTAAAGTCAGTGTGATTCACTTAATGATATACATTAATTAGAATTATGGGGTCAGAGGTATTTGCTTA

>In-frame_ENST00000496050_ENST00000546343_TCGA-04-1536_SSR3_chr3_156271443_-_CLU_chr8_27455767_length(amino acids)=104AA_start in transcript=1042_stop in transcript=728
MLSSYNSKSTAFTNKTAAKAIALTNKTDNLDFWAPNVFITKTSIMHYNTKYTLHLLILLLNFQCIPLGDCRTLVRIHRQFYNRTEKLPFA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SSR3-CLU

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SSR3-CLU

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SSR3-CLU

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	CLU	C0022660	Kidney Failure, Acute	6	CTD_human
Tgene	CLU	C1565662	Acute Kidney Insufficiency	6	CTD_human
Tgene	CLU	C2609414	Acute kidney injury	6	CTD_human
Tgene	CLU	C0002395	Alzheimer's Disease	3	CTD_human
Tgene	CLU	C0011265	Presenile dementia	3	CTD_human
Tgene	CLU	C0022658	Kidney Diseases	3	CTD_human
Tgene	CLU	C0276496	Familial Alzheimer Disease (FAD)	3	CTD_human
Tgene	CLU	C0494463	Alzheimer Disease, Late Onset	3	CTD_human
Tgene	CLU	C0546126	Acute Confusional Senile Dementia	3	CTD_human
Tgene	CLU	C0750900	Alzheimer's Disease, Focal Onset	3	CTD_human
Tgene	CLU	C0750901	Alzheimer Disease, Early Onset	3	CTD_human
Tgene	CLU	C0013221	Drug toxicity	2	CTD_human
Tgene	CLU	C0029408	Degenerative polyarthritis	2	CTD_human
Tgene	CLU	C0041755	Adverse reaction to drug	2	CTD_human
Tgene	CLU	C0086743	Osteoarthrosis Deformans	2	CTD_human
Tgene	CLU	C0019193	Hepatitis, Toxic	1	CTD_human
Tgene	CLU	C0022333	Jacksonian Seizure	1	CTD_human
Tgene	CLU	C0024141	Lupus Erythematosus, Systemic	1	CTD_human
Tgene	CLU	C0025202	melanoma	1	CTD_human
Tgene	CLU	C0027686	Pathologic Neovascularization	1	CTD_human
Tgene	CLU	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	CLU	C0036341	Schizophrenia	1	PSYGENET
Tgene	CLU	C0036572	Seizures	1	CTD_human
Tgene	CLU	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene	CLU	C0149958	Complex partial seizures	1	CTD_human
Tgene	CLU	C0234533	Generalized seizures	1	CTD_human
Tgene	CLU	C0234535	Clonic Seizures	1	CTD_human
Tgene	CLU	C0234985	Mental deterioration	1	CTD_human
Tgene	CLU	C0242380	Libman-Sacks Disease	1	CTD_human
Tgene	CLU	C0270824	Visual seizure	1	CTD_human
Tgene	CLU	C0270844	Tonic Seizures	1	CTD_human
Tgene	CLU	C0270846	Epileptic drop attack	1	CTD_human
Tgene	CLU	C0333641	Atrophic	1	CTD_human
Tgene	CLU	C0338656	Impaired cognition	1	CTD_human
Tgene	CLU	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	CLU	C0422850	Seizures, Somatosensory	1	CTD_human
Tgene	CLU	C0422852	Seizures, Auditory	1	CTD_human
Tgene	CLU	C0422853	Olfactory seizure	1	CTD_human
Tgene	CLU	C0422854	Gustatory seizure	1	CTD_human
Tgene	CLU	C0422855	Vertiginous seizure	1	CTD_human
Tgene	CLU	C0494475	Tonic - clonic seizures	1	CTD_human
Tgene	CLU	C0751056	Non-epileptic convulsion	1	CTD_human
Tgene	CLU	C0751110	Single Seizure	1	CTD_human
Tgene	CLU	C0751123	Atonic Absence Seizures	1	CTD_human
Tgene	CLU	C0751494	Convulsive Seizures	1	CTD_human
Tgene	CLU	C0751495	Seizures, Focal	1	CTD_human
Tgene	CLU	C0751496	Seizures, Sensory	1	CTD_human
Tgene	CLU	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene	CLU	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene	CLU	C1270972	Mild cognitive disorder	1	CTD_human
Tgene	CLU	C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
Tgene	CLU	C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
Tgene	CLU	C3495559	Juvenile arthritis	1	CTD_human
Tgene	CLU	C3495874	Nonepileptic Seizures	1	CTD_human
Tgene	CLU	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene	CLU	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene	CLU	C4048158	Convulsions	1	CTD_human
Tgene	CLU	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene	CLU	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene	CLU	C4316903	Absence Seizures	1	CTD_human
Tgene	CLU	C4317109	Epileptic Seizures	1	CTD_human
Tgene	CLU	C4317123	Myoclonic Seizures	1	CTD_human
Tgene	CLU	C4505436	Generalized Absence Seizures	1	CTD_human
Tgene	CLU	C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human
Tgene	CLU	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene	CLU	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human