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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST3GAL3-TAL1 (FusionGDB2 ID:86342)

Fusion Gene Summary for ST3GAL3-TAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST3GAL3-TAL1
Fusion gene ID: 86342
HgeneTgene
Gene symbol

ST3GAL3

TAL1

Gene ID

6487

6886

Gene nameST3 beta-galactoside alpha-2,3-sialyltransferase 3TAL bHLH transcription factor 1, erythroid differentiation factor
SynonymsEIEE15|MRT12|SIAT6|ST3GALII|ST3Gal III|ST3GalIII|ST3NSCL|TCL5|bHLHa17|tal-1
Cytomap

1p34.1

1p33

Type of geneprotein-codingprotein-coding
DescriptionCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseGal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferasealpha 2,3-ST 3alpha 2,3-sialyltransferase IIIalpha-2,3-sialyltransferase IIsialyltransferase 6 (N-acetyllacosaminide alpha 2,3-siT-cell acute lymphocytic leukemia protein 1T-cell acute lymphocytic leukemia 1T-cell leukemia/lymphoma protein 5class A basic helix-loop-helix protein 17stem cell proteintal-1 product
Modification date2020031320200313
UniProtAcc.

P17542

Ensembl transtripts involved in fusion geneENST00000262915, ENST00000372375, 
ENST00000351035, ENST00000372374, 
ENST00000353126, ENST00000545417, 
ENST00000330208, ENST00000335430, 
ENST00000372377, ENST00000361392, 
ENST00000361400, ENST00000347631, 
ENST00000361812, ENST00000372362, 
ENST00000531451, ENST00000372366, 
ENST00000372365, ENST00000372368, 
ENST00000332628, ENST00000372372, 
ENST00000531816, ENST00000528371, 
ENST00000372369, ENST00000531993, 
ENST00000361746, ENST00000533933, 
ENST00000372367, ENST00000461375, 
ENST00000371884, ENST00000371883, 
ENST00000294339, ENST00000459729, 
Fusion gene scores* DoF score11 X 9 X 8=7923 X 3 X 3=27
# samples 123
** MAII scorelog2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ST3GAL3 [Title/Abstract] AND TAL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointST3GAL3(44303983)-TAL1(47685846), # samples:3
Anticipated loss of major functional domain due to fusion event.ST3GAL3-TAL1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ST3GAL3-TAL1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
ST3GAL3-TAL1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAL1

GO:0031334

positive regulation of protein complex assembly

20855495

TgeneTAL1

GO:0045648

positive regulation of erythrocyte differentiation

20028976

TgeneTAL1

GO:0045893

positive regulation of transcription, DNA-templated

20028976

TgeneTAL1

GO:0045944

positive regulation of transcription by RNA polymerase II

20855495


check buttonFusion gene breakpoints across ST3GAL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TAL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FC-01AST3GAL3chr1

44303983

+TAL1chr1

47685846

-
ChimerDB4BRCATCGA-BH-A1FC-01AST3GAL3chr1

44303983

+TAL1chr1

47685846

-
ChimerDB4BRCATCGA-BH-A1FC-01AST3GAL3chr1

44345179

+TAL1chr1

47685846

-
ChimerDB4BRCATCGA-BH-A1FC-01AST3GAL3chr1

44303983

-TAL1chr1

47685846

-


Top

Fusion Gene ORF analysis for ST3GAL3-TAL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262915ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000262915ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000262915ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000262915ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372375ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372375ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372375ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372375ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000351035ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000351035ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000351035ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000351035ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-5UTRENST00000372374ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000353126ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000353126ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000353126ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000353126ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000545417ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000545417ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000545417ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000545417ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000330208ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000330208ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000330208ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000330208ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000335430ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000335430ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000335430ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000335430ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372377ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372377ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372377ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372377ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361392ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361392ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361392ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361392ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361400ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361400ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361400ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361400ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000347631ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000347631ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000347631ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000347631ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361812ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361812ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361812ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361812ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372362ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372362ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372362ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372362ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531451ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531451ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531451ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000531451ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372366ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372366ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372366ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372366ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372365ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372365ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372365ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372365ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372368ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372368ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372368ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372368ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-5UTRENST00000332628ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372372ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372372ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372372ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372372ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531816ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531816ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531816ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000531816ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000528371ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000528371ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000528371ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000528371ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372369ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372369ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372369ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372369ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531993ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531993ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000531993ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000531993ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361746ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361746ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000361746ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000361746ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000533933ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000533933ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000533933ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000533933ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372367ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372367ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
Frame-shiftENST00000372367ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
5CDS-5UTRENST00000372367ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-3CDSENST00000461375ENST00000371884ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-3CDSENST00000461375ENST00000371883ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-3CDSENST00000461375ENST00000294339ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
3UTR-5UTRENST00000461375ENST00000459729ST3GAL3chr1

44303983

+TAL1chr1

47685846

-
intron-3CDSENST00000262915ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000262915ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000262915ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000262915ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372375ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372375ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372375ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372375ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000351035ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000351035ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000351035ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000351035ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372374ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372374ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000353126ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000353126ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000353126ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000353126ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000545417ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000545417ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000545417ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000545417ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000330208ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000330208ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000330208ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000330208ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000335430ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000335430ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000335430ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000335430ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372377ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372377ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372377ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372377ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361392ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361392ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361392ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000361392ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361400ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361400ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361400ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000361400ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000347631ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000347631ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000347631ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000347631ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361812ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361812ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361812ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000361812ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372362ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372362ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372362ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372362ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531451ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531451ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531451ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000531451ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372366ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372366ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372366ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372366ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372365ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372365ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372365ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372365ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372368ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372368ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372368ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372368ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000332628ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000332628ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372372ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372372ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372372ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372372ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531816ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531816ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531816ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000531816ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000528371ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000528371ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000528371ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000528371ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372369ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372369ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372369ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372369ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531993ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531993ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000531993ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000531993ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361746ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361746ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000361746ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000361746ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000533933ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000533933ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000533933ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000533933ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372367ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372367ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000372367ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000372367ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000461375ENST00000371884ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000461375ENST00000371883ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-3CDSENST00000461375ENST00000294339ST3GAL3chr1

44345179

+TAL1chr1

47685846

-
intron-5UTRENST00000461375ENST00000459729ST3GAL3chr1

44345179

+TAL1chr1

47685846

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ST3GAL3-TAL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ST3GAL3-TAL1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TAL1

P17542

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ST3GAL3-TAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ST3GAL3-TAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST3GAL3-TAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST3GAL3-TAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneST3GAL3C1970200MENTAL RETARDATION, AUTOSOMAL RECESSIVE 122CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneST3GAL3C3554316EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 152GENOMICS_ENGLAND;UNIPROT
HgeneST3GAL3C0037769West Syndrome1ORPHANET
HgeneST3GAL3C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneTAL1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human;ORPHANET