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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ST8SIA1-FTO (FusionGDB2 ID:86441) |
Fusion Gene Summary for ST8SIA1-FTO |
Fusion gene summary |
Fusion gene information | Fusion gene name: ST8SIA1-FTO | Fusion gene ID: 86441 | Hgene | Tgene | Gene symbol | ST8SIA1 | FTO | Gene ID | 6489 | 79068 |
Gene name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | FTO alpha-ketoglutarate dependent dioxygenase | |
Synonyms | GD3S|SIAT8|SIAT8-A|SIAT8A|ST8SiaI | ALKBH9|BMIQ14|GDFD | |
Cytomap | 12p12.1 | 16q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-N-acetylneuraminide alpha-2,8-sialyltransferaseST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1alpha-2,8-sialyltransferase 8Adisialoganglioside (GD3) synthaseganglioside GD3 synthaseganglioside GT3 synthaseganglioside-specific alpha | alpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTOU6 small nuclear RNA N(6)-methyladenosine-demethylase FTOfat mass and obesity associatedfat mass and obesity-associated protei | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | Q9C0B1 | |
Ensembl transtripts involved in fusion gene | ENST00000396037, ENST00000539510, ENST00000536558, ENST00000404299, ENST00000381424, | ENST00000471389, ENST00000394647, ENST00000431610, ENST00000460382, ENST00000463855, ENST00000472835, | |
Fusion gene scores | * DoF score | 10 X 7 X 6=420 | 12 X 10 X 7=840 |
# samples | 11 | 15 | |
** MAII score | log2(11/420*10)=-1.93288580414146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/840*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ST8SIA1 [Title/Abstract] AND FTO [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ST8SIA1(22401940)-FTO(54145674), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | ST8SIA1-FTO seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FTO | GO:0006307 | DNA dealkylation involved in DNA repair | 18775698|20376003 |
Tgene | FTO | GO:0035552 | oxidative single-stranded DNA demethylation | 18775698|20376003 |
Tgene | FTO | GO:0035553 | oxidative single-stranded RNA demethylation | 18775698|22002720|25452335|26457839|28002401|30197295 |
Tgene | FTO | GO:0042245 | RNA repair | 18775698 |
Tgene | FTO | GO:0061157 | mRNA destabilization | 28002401|30197295 |
Tgene | FTO | GO:0070989 | oxidative demethylation | 18775698 |
Tgene | FTO | GO:0080111 | DNA demethylation | 18775698 |
Fusion gene breakpoints across ST8SIA1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across FTO (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LGG | TCGA-TM-A84I-01A | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
ChimerDB4 | LGG | TCGA-TM-A84I | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
ChimerDB4 | LGG | TCGA-TM-A84I-01A | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
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Fusion Gene ORF analysis for ST8SIA1-FTO |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000396037 | ENST00000471389 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
In-frame | ENST00000396037 | ENST00000394647 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
In-frame | ENST00000396037 | ENST00000431610 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
In-frame | ENST00000396037 | ENST00000460382 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
In-frame | ENST00000396037 | ENST00000463855 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
5CDS-3UTR | ENST00000396037 | ENST00000472835 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
In-frame | ENST00000539510 | ENST00000471389 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
Frame-shift | ENST00000539510 | ENST00000394647 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
Frame-shift | ENST00000539510 | ENST00000431610 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
Frame-shift | ENST00000539510 | ENST00000460382 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
Frame-shift | ENST00000539510 | ENST00000463855 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
5CDS-3UTR | ENST00000539510 | ENST00000472835 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000536558 | ENST00000471389 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000536558 | ENST00000394647 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000536558 | ENST00000431610 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000536558 | ENST00000460382 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000536558 | ENST00000463855 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3UTR | ENST00000536558 | ENST00000472835 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000404299 | ENST00000471389 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000404299 | ENST00000394647 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000404299 | ENST00000431610 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000404299 | ENST00000460382 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000404299 | ENST00000463855 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3UTR | ENST00000404299 | ENST00000472835 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000381424 | ENST00000471389 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000381424 | ENST00000394647 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000381424 | ENST00000431610 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000381424 | ENST00000460382 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3CDS | ENST00000381424 | ENST00000463855 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
intron-3UTR | ENST00000381424 | ENST00000472835 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000396037 | ST8SIA1 | chr12 | 22401940 | - | ENST00000394647 | FTO | chr16 | 54145674 | + | 1392 | 1066 | 482 | 1219 | 245 |
ENST00000396037 | ST8SIA1 | chr12 | 22401940 | - | ENST00000431610 | FTO | chr16 | 54145674 | + | 1443 | 1066 | 482 | 1219 | 245 |
ENST00000396037 | ST8SIA1 | chr12 | 22401940 | - | ENST00000460382 | FTO | chr16 | 54145674 | + | 2292 | 1066 | 482 | 1219 | 245 |
ENST00000396037 | ST8SIA1 | chr12 | 22401940 | - | ENST00000463855 | FTO | chr16 | 54145674 | + | 3768 | 1066 | 482 | 1219 | 245 |
ENST00000539510 | ST8SIA1 | chr12 | 22401940 | - | ENST00000471389 | FTO | chr16 | 54145674 | + | 10619 | 439 | 8984 | 8571 | 137 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000396037 | ENST00000394647 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + | 0.04120939 | 0.95879066 |
ENST00000396037 | ENST00000431610 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + | 0.03735236 | 0.9626477 |
ENST00000396037 | ENST00000460382 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + | 0.023370882 | 0.9766291 |
ENST00000396037 | ENST00000463855 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + | 0.010381733 | 0.98961824 |
ENST00000539510 | ENST00000471389 | ST8SIA1 | chr12 | 22401940 | - | FTO | chr16 | 54145674 | + | 0.120198086 | 0.8798019 |
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Fusion Genomic Features for ST8SIA1-FTO |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ST8SIA1 | chr12 | 22401939 | - | FTO | chr16 | 54145673 | + | 3.82E-05 | 0.99996185 |
ST8SIA1 | chr12 | 22401939 | - | FTO | chr16 | 54145673 | + | 3.82E-05 | 0.99996185 |
ST8SIA1 | chr12 | 22401939 | - | FTO | chr16 | 54145673 | + | 3.82E-05 | 0.99996185 |
ST8SIA1 | chr12 | 22401939 | - | FTO | chr16 | 54145673 | + | 3.82E-05 | 0.99996185 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ST8SIA1-FTO |
Go to FGviewer for the breakpoints of chr12:22401940-chr16:54145674 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | FTO |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ST8SIA1 | chr12:22401940 | chr16:54145674 | ENST00000396037 | - | 4 | 5 | 188_190 | 194.66666666666666 | 357.0 | Region | Substrate binding |
Hgene | ST8SIA1 | chr12:22401940 | chr16:54145674 | ENST00000396037 | - | 4 | 5 | 1_29 | 194.66666666666666 | 357.0 | Topological domain | Cytoplasmic |
Hgene | ST8SIA1 | chr12:22401940 | chr16:54145674 | ENST00000396037 | - | 4 | 5 | 30_48 | 194.66666666666666 | 357.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000431610 | 3 | 5 | 213_224 | 55.666666666666664 | 107.0 | Region | Loop L1%3B predicted to block binding of double-stranded DNA or RNA | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000431610 | 3 | 5 | 231_234 | 55.666666666666664 | 107.0 | Region | Substrate binding | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000431610 | 3 | 5 | 316_318 | 55.666666666666664 | 107.0 | Region | Alpha-ketoglutarate binding | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000460382 | 2 | 4 | 213_224 | 55.666666666666664 | 107.0 | Region | Loop L1%3B predicted to block binding of double-stranded DNA or RNA | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000460382 | 2 | 4 | 231_234 | 55.666666666666664 | 107.0 | Region | Substrate binding | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000460382 | 2 | 4 | 316_318 | 55.666666666666664 | 107.0 | Region | Alpha-ketoglutarate binding | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000463855 | 1 | 3 | 213_224 | 76.66666666666667 | 128.0 | Region | Loop L1%3B predicted to block binding of double-stranded DNA or RNA | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000463855 | 1 | 3 | 231_234 | 76.66666666666667 | 128.0 | Region | Substrate binding | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000463855 | 1 | 3 | 316_318 | 76.66666666666667 | 128.0 | Region | Alpha-ketoglutarate binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ST8SIA1 | chr12:22401940 | chr16:54145674 | ENST00000396037 | - | 4 | 5 | 274_276 | 194.66666666666666 | 357.0 | Region | Substrate binding |
Hgene | ST8SIA1 | chr12:22401940 | chr16:54145674 | ENST00000396037 | - | 4 | 5 | 49_356 | 194.66666666666666 | 357.0 | Topological domain | Lumenal |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000431610 | 3 | 5 | 32_327 | 55.666666666666664 | 107.0 | Region | Fe2OG dioxygenase domain | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000460382 | 2 | 4 | 32_327 | 55.666666666666664 | 107.0 | Region | Fe2OG dioxygenase domain | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000463855 | 1 | 3 | 32_327 | 76.66666666666667 | 128.0 | Region | Fe2OG dioxygenase domain | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000471389 | 7 | 9 | 213_224 | 454.6666666666667 | 506.0 | Region | Loop L1%3B predicted to block binding of double-stranded DNA or RNA | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000471389 | 7 | 9 | 231_234 | 454.6666666666667 | 506.0 | Region | Substrate binding | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000471389 | 7 | 9 | 316_318 | 454.6666666666667 | 506.0 | Region | Alpha-ketoglutarate binding | |
Tgene | FTO | chr12:22401940 | chr16:54145674 | ENST00000471389 | 7 | 9 | 32_327 | 454.6666666666667 | 506.0 | Region | Fe2OG dioxygenase domain |
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Fusion Gene Sequence for ST8SIA1-FTO |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000396037_ENST00000394647_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(transcript)=1392nt_BP=1066nt GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA >In-frame_ENST00000396037_ENST00000394647_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(amino acids)=245AA_start in transcript=482_stop in transcript=1219 MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS -------------------------------------------------------------- >In-frame_ENST00000396037_ENST00000431610_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(transcript)=1443nt_BP=1066nt GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA AACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTC >In-frame_ENST00000396037_ENST00000431610_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(amino acids)=245AA_start in transcript=482_stop in transcript=1219 MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS -------------------------------------------------------------- >In-frame_ENST00000396037_ENST00000460382_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(transcript)=2292nt_BP=1066nt GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA AACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTC CCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGC CTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAG TTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAA AAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATG GAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGC TTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGC CTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGA TCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATG TAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTA >In-frame_ENST00000396037_ENST00000460382_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(amino acids)=245AA_start in transcript=482_stop in transcript=1219 MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS -------------------------------------------------------------- >In-frame_ENST00000396037_ENST00000463855_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(transcript)=3768nt_BP=1066nt GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA AACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTC CCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGC CTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAG TTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAA AAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATG GAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGC TTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGC CTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGA TCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATG TAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTA AAACCTGAGCTTTAAGACTCCCACTAGCTTCGTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATATGA AAGGCACCAGTCCTAAGGTGAACATTAAGTGAGATGATTCTAGTTACAGACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGGAAA TTCTGGTACTGTTATGTGTGGGTGAGCTGACCTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTGATG CCATTAACACATCTCTCCCTTTCTGACCTGGCTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCCAGC CTGTTGCTTTCTCGTGTAGTTGTTCACAGTAGTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTCCTG CCACCAGAATTGCAGTGGTTCACGGCCTGCACTCATTCCCATGAATGCAGTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGCCAG GGTCTCATCGTGTTGAGACTCGAGTCTCTCAGACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGAGAA GTGAAGCAGTGTCTCACAGGGTCATTACAGAGATTAAATGAAATAAATGAAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTCACA GATGGGGCACCCTCGGGCCATCCAGCCCAGTGTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATATTT AAAAATTGGGAGATTTCACATAAAATTAAAAGGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACTCTG TCACCAGGCTAGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCCAAG TAGCTGGGACTACAGGCACGTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATGGTC TCGATCTCAACCTCGTGATCCACCCACCTCGGTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGCATT TTTCTTTAGAACTCAGAACACCCAATAGTCCTAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTTGGG GCATGACCCAGCCTATGGTTTGCCATACTCCCTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCTGACCTGCATCACCCTTTCATGTCA GTGCTCTCCAAACCTGCTTGCTTGCACCCCTCTAGTCGAAATATTTTGTGCTTACCCCAATATATGTGTGTGACTATTGAACTCTATTCG >In-frame_ENST00000396037_ENST00000463855_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(amino acids)=245AA_start in transcript=482_stop in transcript=1219 MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS -------------------------------------------------------------- >In-frame_ENST00000539510_ENST00000471389_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(transcript)=10619nt_BP=439nt CAGAGGGGCCATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTG GCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCA GACCGCGGCCAGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGG GAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGATGCAATCTCCCTC CTTTGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCAC GAATTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACC TCACAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGAT CGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATC CAAAACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTC TTCCCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAA AGCCTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCC CAGTTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAAT TAAAAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGAT ATGGAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGT AGCTTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAA AGCCTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCT TGATCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTT ATGTAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGT TTAAAACCTGAGCTTTAAGACTCCCACTAGCTTCGTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATA TGAAAGGCACCAGTCCTAAGGTGAACATTAAGTGAGATGATTCTAGTTACAGACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGG AAATTCTGGTACTGTTATGTGTGGGTGAGCTGACCTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTG ATGCCATTAACACATCTCTCCCTTTCTGACCTGGCTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCC AGCCTGTTGCTTTCTCGTGTAGTTGTTCACAGTAGTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTC CTGCCACCAGAATTGCAGTGGTTCACGGCCTGCACTCATTCCCATGAATGCAGTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGC CAGGGTCTCATCGTGTTGAGACTCGAGTCTCTCAGACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGA GAAGTGAAGCAGTGTCTCACAGGGTCATTACAGAGATTAAATGAAATAAATGAAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTC ACAGATGGGGCACCCTCGGGCCATCCAGCCCAGTGTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATA TTTAAAAATTGGGAGATTTCACATAAAATTAAAAGGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACT CTGTCACCAGGCTAGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCC AAGTAGCTGGGACTACAGGCACGTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATG GTCTCGATCTCAACCTCGTGATCCACCCACCTCGGTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGC ATTTTTCTTTAGAACTCAGAACACCCAATAGTCCTAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTT GGGGCATGACCCAGCCTATGGTTTGCCATACTCCCTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCTGACCTGCATCACCCTTTCATG TCAGTGCTCTCCAAACCTGCTTGCTTGCACCCCTCTAGTCGAAATATTTTGTGCTTACCCCAATATATGTGTGTGACTATTGAACTCTAT TCGTAGACTGCTTGTACTAATGTCATTTGCATCATAAAATATTCATATCCAATAAACATATTAAAAGGATGAGATAAGAAACCGAGAGAT TTTGCTGTTTTTTTCCTTTTGCATGGATGAGCCAGCTTCACTGTCCTGGGTGGGGCCCAGGTGGAATTAGTTCTCAAAGTCCTCCAGGTG GAGTCAGGGAATGTGCAACAGGGTTGGAGAAATCACTACTTTAAGTGAATCCGAAAGGTGAGATCACATTTGCTCTAAAGAAATGGTGAT CCCAGCACTTTGGGAGGCTGAGGCAGCAGATCACTGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACACGGTGAAACCCCGTCTCTACT GAAAACACAAAAATTAGCTGGGTGTGGTGGTGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGCAAATCGCTTGGCCCGGGA GGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAGAGAAGAAAGAAATGGTGACTTTCATTGAT CATGTGTTTGAGGATTTCATGTGCTCTCCAGGGAGGTTTCAGGTGGGTAGAAGGAGGTGGGCAAGACCCAATAAAAAAGCAGCTGGTGCG GGCAATGACAATGAACTCGTATCCTGCAGGGTCAAAGGAAGGCTTGCTTCTGCTGTGAATTGGAGAAGGACTTTCCTGGAAGCACAGGCC CAGAAATCGCACCCTTCTCCCCATGTGTGCGGATAAGGGACCACTTCCATCAGCAGCAGCCCCCTCCTGCTTTCCTGCCAGTCCTCCCTG TGGTCCCAGGTCTCTTGAGAAAAGTGATCTAAGAGATCCCTTTGCAATGAGGTGCTACTGACTGCCCTACCTCCCTCCCTTCCTCCCATG AATGTTTCTTGGTGCTGACCACAGCCTCAGCAATGAGGCAAGCCTGGGGACCCAAGACAGATCTCTGCCTCCCAGGCTAGTGGATGCCCT GGGATATGTAGTCACCAAAATAGGAACTTACCCCATAGTGGGGAAATAGACAGTAAGCAGCAAATCAATAACAAGAGTGTTCCAGATGGT TGTAAGTGCCAGGAAGGGAACCAACTGGGAGAGGGACAAGAGGAGATGGTGACTGACCAAGGGGACCTTGATCAGGCTGTGGGGAAGGGA GGTGGTTGGGAAGAGCTTCCCAGGAAAGGGGACGGCGGGCCCAGGCAGGAGAGCCTTGGGAGGGGGTGCCCAAGGAAGGAAAAGGGCCCT GAGCCTGAAGCCGAGAAGACCAGGAGGGGAGAAGGGGAGATGTAGGGCAGAGCAGACGGGAGCCGCTCGGGTTTTATTCCACACACCCCA GGAAGCATGAGAGGGTTTCAAGCAGCAAGGGCATGGAAGTAACTTGGTGAGATATTTTTATGCATTAGATCATCGCTCTATCTGGATTCC AGAGGGTCTCTGAGAGAGCAAACAGCTTAATCCAAAGGAGCGGCTTTCCAACTGGGAATGTCCCCCTGGCTGGGTGAGATCTCAAGATGG CCTGCGGCCCCTCTAGATTGCCTGCCTACAGAGTTCACTCTAAACAGCCCCTCCCCTCCACACCCCAGCAGATCCATTCCTGACGCCCTC ACTGGCAGGCTCCAGCCCCACAGAGCTTTCTAGACATAAAAGAGCAGGGTCATGGCATCATTGGTGACACAATTTTAGTAATAAGCTTCA AAACCCATCACTCCACTGAATCCAGGGATGCCAGAATTGAGAGTCCATAGGACCCGTTTAACGGATCCCACATTCAGTAGACGGTTTTTT GTATGCTTCGAGGGAAGGAAGGTATTTTCAAATGCAACTTCTTTTTTTTTTTTCTTGCTCTAGTTAGGGCTGATTTTACCACTGGGCAAA TTGCATACATTTGGATCCATGCCACGCTAAAAACTGTTTATTTTGGAGATCTGTCAGAGGCAAGCACATGGAAGACAAGGGGATTCTGGT TTGAAAAGGCAATTCTCATCCAGACAGATTCAGATGGAGAGGAGCGGTGTGGATTAAAATGCGCCGAAGTGGTAATGCCGTTTATCCCGT TTGCCTTTGTTACTCTGTGATTAAATGGTATTTTTAATTAAGTTTCATTGGGAGCCATAGGTATCGCGGTGGTGAAATCAATTTGACAAC CATAAAGGGGAGAGACGGCACAGGCGTGTTGTGATGATTGCGGCTGTAGGGAAAGCCGGGCAGCTTGCAGAGGATGGGTGGGAGGAGGGG AAGCCGGCTAAGAATGACTTCCTGCAAGACAGCAAGGGCACCCCTGGGCCACTGCTGTGTTTGGGAGGCAGGTTTTGGGGGTTGTCAGAA GGCATTCACCTGGTTCTCTCGCTCACCTGAGACACCCGATAGATTCCTGGAAACTCCAGGAAAGTATCTGAAGATCTGGTTCTCCATTCT CTCTTATTAACAAGGAGAACCACAAGTGCCCCCCAGATCCCGGCTAGAAGGACCAGACAGCTTTCCACCCCGGTTCCCAGGCAGCCCTGC TCCCATAGTCCTGTGTCCCATCGGCCCCATGCTCCCAGGACAGTCCTAATTCCCACCTCTCAGAACCTTGTCAGCCAAGTTCTTCCTGCT CTCTGGCCCAAATCCTCCTCCTACATTGGAAACTGAGCCTCTCTGCATCCTCTGCTCTTTCTATCCCGCTGTCATTCATCAGATTTTCCA AATCTTTGGATTCCTGAGTGGCAGAAGAGGTTTTCTGAGTTTAAGTTCTGATTCTGTGTGTGATTCTCACTCTACCACCTCTTCAAACCT TTGTTGTCTTATCTACAAAATAGAATAGTAGTAATCCATCACCTAAGGTTGTTGTGAAGGTTCAATAAGTTAATGCGTATTTAAAATGCC TCCCACAGTACCTGACATATACTGGGCTTCAGTGAGGTACTAGCTATTATTATTAACCAAGTTTCCTGTGGTAACAGTTGTAGCTTTGTG ACTGGGCCAAATCACTTAACCCCTCTGCGCTCCAGTCTTTGTTTCTATAATGGGGATGATGATAATGCCTAGCTCATTGGATTGTTCTGT CCCCTACGATCAGCCATGTTAAGTGATTCATATCATGTCTGGTACTTAAAAATCACGCCACGCATGTACATTATTATGATGAAAAATATG ATCCGTGATATCCTGACCAAAATATTAAAGGGACTAAAGATAGCTGTGGCTTGTTCAAGAAGAATATTGTGTCACTATCCCATATATTAT CCCATTTGCTCTTCACAGCTTCCATTTTTCGCTAGGCGGATGGCATGGAACTTTTTATAAATGAGATATTATGAAAAATGATGTTTTAGG ACTCTCATTTCTACAGTGGGAGTAGGTCACCCATTGCAATTTTGGATTTGCTTAAAAAAATTCTTGCCATCACCTTCTAATGGATGATCT GTGTACAACAATTGTTTATTGACTCTGAATGTCTAAGTACCAGGGTCAGTCTATTTCAAGGGGAGGGAAGCATTAATTAACCTCCAGCAT TAGATTCAGTGATTCTTTTCCAATGATGCAGTTCATGACTTTGCTCGCATTTACTTTTCATCAATCCTGAAAGAATTGAGGTAAAATAGT TCCTCTGCACATGTGTGTCAAGCTAAATGGATAACAGCAGATACAGATCTGTTTGCCTGTCTGCACTTGCCTTTAGACAAAATTCATCAA TTTTACAAAAGCCACTGACTAAACATGGCACCAATACAAATGAAGCACTTCTAGCAGGCGGAGATTCCCTTTGTTTCTGATCTGGTAAAT GCGGTAGTTTCCTGCTGAGAGATGGGAAGTGCTGGCCTAGGACAGCAAGGTGCCCTACAGGTGGGGCCAAAAGGGTCAAGACCGTTCTAC AGGAAGTTTAGGAGAAGTTCAATGGTTCCAGATCCTGTGTGCTTCGGGTAATTCTGACCCTCTTCATTAGTGATAATGGCATGAAGCTCT TTCACACAGTCTTTTTTTTTTTTCTTTTTTTTTTTCAGACAGGGTCTCACCCTGTCACGTAGGCTGGAGTGCAGTGGTGAGATCACGGCT CACTGCAGCCTCGACTTCATGGGCTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGTAGTCGGGATCATAGGCACTTGCCACCACATCCGG CTAATTTTTTTGTAGAGACAGGATTTCACCACATTACACAGGCTGGTTTCAAACTCCGAGGCTCAAGTGATCTGCCTGCATCGGCCTCCC AAAGCGCTGAGATTACAAGCGTGAGCCACTACGCCTTGCCCTCCACACAGCCTTGCTTGGTGTTAAAGATTAAACAAAGACCACAGGTGA TCACTGTCTTCGTGGTGCCAGTTTCAAGGGCACCCTTCTTCCCTTCCCAGCCTCCGAGAGAAGGAGAGAGGGTCCACAAGCCAGATCCAT CCCCATCCACACAGGTAAAACCACGACTGTGCAGCTAGCAGGTGGAGATAACATTTGGAAAAAGGCTTTGTAAATGCTAAAGTCCTACTC AAGTCCAAGGGAGAGAAATTATTATTATTCGTTTTGTGAAACCAATTTAGTTTGGCTGGGTAATGGAAGAATTTCTACATACATTCATTA CTTCTGATCAGGCAAGACCAGTCTGACACAGGAACAGTCTATGGCTCACTCTTAAAGCCACAGCAGGCTGCCAGGGCTTGGAGAAATAGA AACCTCTCTTGCACAAGAATAGTCTCAATGAATCATGTTAAGGCCTCTTTAGGTTTTTCAGACTCCATGCACCCTGTGGAAACTGCCTTT CTTGAGTAGAGGTACGTTCAGCACTTCATAAAATAATCTTGGAGCCTCCAGACACACGGATGGAGGAGCATGATTTCATTTGTTTCTTTG CAAAACTGCTGTCCCCAACTGAAAAACCTGATTATCCTTTCAAATAGGGAATTCGGCTTTCCACGTTGGAACCAGAACAGTTAACCTTCA AACCCCCAAGGCTTGCAAGAGATGAATCAGTTTCTCAGACAGCCAAAGCCGTGGCTTATAACTCATCCAACCCAGAAAACTGGACCGCTG GTCACCTTCCTTCCCCCTGCCCCCAACTCTGCAGACAGAGGTTTCCCGTTGATTATGCCTTGATTAGAGTCAGGAGAGAAGCAAACCAGG TATATAGGATTCCATTATCCTTCCCTCCTCTGCTCCCAACCAGGGTCACGCTGAGAGGGATCTCGGTGAACATGTGAACAATCAAGCCAT GTTTACCATGGACGTTTAGTTTTCTTTTCTCAAAATCAAAACAGAGTTTAGTAGGCAGCGTATTTCATACATGCCCCTTGATCAATGGAA TGATCTGTCAGAAGCCATTAAAGCCCCCATTAGCTTGAATGCATTCAAAGCTAAACTATTGGATCATTTAAGGGCTGCAGTGATTGTTTT TAATATACCGTACATTGATTTCTCCCTGTGAGCAGCAACATAAGTTTGAAACTAACTGTGTATGACTAAGGCTCCATTTGCTGTCTCCAA CCCTCTGTGAGAAGCATGGTTTCACTTCGACCAGAAATGTCTGTGTATAGTTTTCAAAGAGATGCAGACCCTGTTCGATTTCCCAAGATT TAGACTGGGTCGGGTTGTTATTTCTTTTTTCCCTGAGCTTTCTCCCATTTCTTTGTGCCCATTAAGTGAGCTGTGCGTGCAGAATGGGAG AGGCATCCCTGCCAAGGACTTCAAGTGAAAGGCGGTGGGAGAAATTGTTCTGAAAGCATGAAGCCCAGCTGAGGCCAAAATCAAAGTGAA TTTGACAGCCTTGGGCCAGCAAAACTCTGTACCCAGCAGAAAACAATAGATGTGTGGCTGTGTCAGGGGCATCCTCACTGGGACATAGCT TGGGGAGCTGAAGGTACCTTGGAAGGGCCAGATGAGGAAGCTAGCCAAGGCCACAGGCCTTCCTTTGACTGCCATATTGCCAGCTCTTCA TAGTATTGACTCTTCAGTCTTAGCCAACACACACTTGTTGATTCCTTCCGGAATGTCAGACTCTGCTAGCAACACAAGGTCCCTGTCCTC AAAATCCTATTCTTAATCAGCATTTCTAATTTCTGCCCTTTGCTCATTTTAATACAGAGCCTGAGGATAGGAGAGCAGCGTGGTGAAAGA AGCAATAGTTACCACATTTGCAAAGGCACATACCCCAAAGAGAAGTTTTTAATATGTCACACCCATATTTTATAGATGGGGCAATGGAAG TCCAGATGGGAGAAGTTATTTCAGGTGAATTATAGAAACTGGATTTCAAGTTTCTGATAAGTATTGAATTTGGGAAGGCTGTGAACATTC TTGAGCCCCCCTCCCAAGTTCACCTTCAACATCCTAAAGCAGGTTGAAGAGGAAGATGGTTCCAGGTCACTTACAAGAACAGGAACAGCC CCTCCCTCCAAATTTGAGCCCAGAAAGGAGAACCTTTGTTACTCTAGAAAACAGTGTGTGTGCTATTGTTTTCTCCATAGGTCACAAACA TCCACAAGATATTGGTGATTTTACATATTATTAGAGCCACTGAAATTTATGATGCAGGATATTAACGTCAAAGAGGCCAAGATGCATCAT TCAGAACACTGGCAGGTCAAGCAGAAACCACCGTAGTAAAATTGAAAGCTGGAGTCAGCAAAGTATAGCCCACAGCCAAATCTGGCCCAT CCCCTGTTCTTATAAAGTTTTATTGGAACGCAGCCATGCTCATCGGTTTATGTATTATCTATGGCTGTTTCCAACTACAGTGGCAGAGCT GAATAGTTGCAAAGGACCATAGGGCTATCAAAGCCCCAAATAGTCATTGTCTGACCCTTCATAGAAAAATTTTGCTGAACTGTAGTCTAG CTCCAAGGATTGTTGTATCACCTGTGATCGTGCCTATTAAGCAATTAACGTCATGTCTAGTACTTAGTAATGACTCAGCATGTATCAATT ACGATGATAAATATTATCATGGCATCCAAACCAAAATACTCATGCCAACATCTCTCTGTACAGAAACATGGAAAAAGAGCGATGCTATTA AGGAGGAAAATGGAGCCAGGAGCAAAACCTAAGGCTATTTCTGAACTAAAGAGGCCTGAATAAGGTAGTGAAAGGACCAGGGAAAGCCTT CCCACGGGGATGGAGAGCCACCTCCTCCCCGGCTTTCTGGTTCAGATGTCTTGTCTCAACAGACGGCAGATTCGCAGGGAAGCAGGCCGA GCCTGATCTTTTCTCCGCTAGAACTGCTCAACAGGTGAAGAATCTTTTTCCAGCACTCCTGAGCCCTTCGGGTCGCGGAACAGTGCGAAG ATTATTCCAATGCCTCATTCGGAGAGGTGATAATCTGGTCTGTGGTTTCTTTTTCGGTGGGGCATGGGGTGGGGGTGAGTGTCATGCTTT CTAAGGCACAGGGCTGACTAAAGGGTGTCCTATTTATAAGTCAGTAAAACACAGCGGCTTCATACTCTGTGCTTATTACCCAGAAGCCCC >In-frame_ENST00000539510_ENST00000471389_TCGA-TM-A84I-01A_ST8SIA1_chr12_22401940_-_FTO_chr16_54145674_length(amino acids)=137AA_start in transcript=8984_stop in transcript=8571 MAVKGRPVALASFLIWPFQGTFSSPSYVPVRMPLTQPHIYCFLLGTEFCWPKAVKFTLILASAGLHAFRTISPTAFHLKSLAGMPLPFCT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ST8SIA1-FTO |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ST8SIA1-FTO |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ST8SIA1-FTO |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ST8SIA1 | C0023895 | Liver diseases | 1 | CTD_human |
Hgene | ST8SIA1 | C0086565 | Liver Dysfunction | 1 | CTD_human |
Hgene | ST8SIA1 | C0149504 | Encephalopathy, Toxic | 1 | CTD_human |
Hgene | ST8SIA1 | C0154659 | Toxic Encephalitis | 1 | CTD_human |
Hgene | ST8SIA1 | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
Tgene | FTO | C0028754 | Obesity | 6 | CTD_human |
Tgene | FTO | C2752001 | Growth Retardation, Developmental Delay, Coarse Facies, And Early Death | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | FTO | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Tgene | FTO | C0011581 | Depressive disorder | 3 | PSYGENET |
Tgene | FTO | C0005910 | Body Weight | 2 | CTD_human |
Tgene | FTO | C0011570 | Mental Depression | 2 | PSYGENET |
Tgene | FTO | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Tgene | FTO | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Tgene | FTO | C0025202 | melanoma | 1 | CTD_human |
Tgene | FTO | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | FTO | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | FTO | C0678222 | Breast Carcinoma | 1 | CTD_human |
Tgene | FTO | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Tgene | FTO | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | FTO | C2362324 | Pediatric Obesity | 1 | CTD_human |
Tgene | FTO | C4317171 | Adolescent Obesity | 1 | CTD_human |
Tgene | FTO | C4521075 | Childhood Overweight | 1 | CTD_human |
Tgene | FTO | C4553478 | Infantile Obesity | 1 | CTD_human |
Tgene | FTO | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Tgene | FTO | C4704955 | Infant Overweight | 1 | CTD_human |
Tgene | FTO | C4704956 | Adolescent Overweight | 1 | CTD_human |