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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STARD10-ZC3H12C (FusionGDB2 ID:86559)

Fusion Gene Summary for STARD10-ZC3H12C

check button Fusion gene summary
Fusion gene informationFusion gene name: STARD10-ZC3H12C
Fusion gene ID: 86559
HgeneTgene
Gene symbol

STARD10

ZC3H12C

Gene ID

10809

85463

Gene nameStAR related lipid transfer domain containing 10zinc finger CCCH-type containing 12C
SynonymsCGI-52|NY-CO-28|PCTP2|SDCCAG28MCPIP3
Cytomap

11q13.4

11q22.3

Type of geneprotein-codingprotein-coding
DescriptionSTART domain-containing protein 10PCTP-LPCTP-like proteinSTART domain containing 10StAR-related lipid transfer (START) domain containing 10antigen NY-CO-28serologically defined colon cancer antigen 28stAR-related lipid transfer protein 10probable ribonuclease ZC3H12CMCP-induced protein 3zinc finger CCCH domain-containing protein 12C
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000543304, ENST00000334805, 
ENST00000538536, ENST00000538437, 
ENST00000545082, 		ENST00000278590, 
ENST00000528673, ENST00000453089, 
Fusion gene scores* DoF score10 X 7 X 6=4201 X 1 X 1=1
# samples 101
** MAII scorelog2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: STARD10 [Title/Abstract] AND ZC3H12C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTARD10(72492020)-ZC3H12C(110007388), # samples:3
Anticipated loss of major functional domain due to fusion event.STARD10-ZC3H12C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across STARD10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZC3H12C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KICHTCGA-KL-8339-01ASTARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
ChimerDB4KICHTCGA-KL-8339-01ASTARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
ChimerDB4KICHTCGA-KL-8339-01ASTARD10chr11

72492020

-ZC3H12Cchr11

110007388

+


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Fusion Gene ORF analysis for STARD10-ZC3H12C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000543304ENST00000278590STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
Frame-shiftENST00000543304ENST00000528673STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
5CDS-5UTRENST00000543304ENST00000453089STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
In-frameENST00000334805ENST00000278590STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
In-frameENST00000334805ENST00000528673STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
5CDS-5UTRENST00000334805ENST00000453089STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
intron-3CDSENST00000538536ENST00000278590STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
intron-3CDSENST00000538536ENST00000528673STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
intron-5UTRENST00000538536ENST00000453089STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
5UTR-3CDSENST00000538437ENST00000278590STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
5UTR-3CDSENST00000538437ENST00000528673STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
5UTR-5UTRENST00000538437ENST00000453089STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
intron-3CDSENST00000545082ENST00000278590STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
intron-3CDSENST00000545082ENST00000528673STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+
intron-5UTRENST00000545082ENST00000453089STARD10chr11

72492020

-ZC3H12Cchr11

110007388

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334805STARD10chr1172492020-ENST00000278590ZC3H12Cchr11110007388+986211277763757993
ENST00000334805STARD10chr1172492020-ENST00000528673ZC3H12Cchr11110007388+395511277763757993

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334805ENST00000278590STARD10chr1172492020-ZC3H12Cchr11110007388+0.0005210630.999479
ENST00000334805ENST00000528673STARD10chr1172492020-ZC3H12Cchr11110007388+0.0015827850.99841726

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Fusion Genomic Features for STARD10-ZC3H12C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STARD10chr1172492019-ZC3H12Cchr11110007387+0.0209755490.9790245
STARD10chr1172492019-ZC3H12Cchr11110007387+0.0209755490.9790245

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STARD10-ZC3H12C


check button Go to

FGviewer for the breakpoints of chr11:72492020-chr11:110007388

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZC3H12Cchr11:72492020chr11:110007388ENST0000027859006245_4007.0884.0DomainRNase NYN
TgeneZC3H12Cchr11:72492020chr11:110007388ENST0000027859006410_4357.0884.0Zinc fingerC3H1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTARD10chr11:72492020chr11:110007388ENST00000334805-2714_22469.0292.0DomainSTART
HgeneSTARD10chr11:72492020chr11:110007388ENST00000543304-3814_22469.0292.0DomainSTART


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Fusion Gene Sequence for STARD10-ZC3H12C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000334805_ENST00000278590_TCGA-KL-8339-01A_STARD10_chr11_72492020_-_ZC3H12C_chr11_110007388_length(transcript)=9862nt_BP=1127nt
ACGTGGGGGCGCCTGAGCGAAGATAACCGTAATAAATAGTAACCTAACGGTCCAGTCATCGTTCTGTGGTCCTTTCTTTTATGATTCACA
AGGAATGACCCTCTTCATCGCCTCTCCTAATTCAGTCCTCACAACAGTCCTTTTACAAATGGGACAACAGGTTAGAGGAAGTCAGGCAGA
TTTCCAGCATCATAGAGAGTAAAGGACCAGGGAAGGATCAGGATTCAAGGACTGCACCCAGGCTCTGCTTCCAGCTTGCTGTGTGACTTT
GGGTAATTTTGTTCCCTTAGGGAACTGAGCTTTCTCATTTGTAAATGCAAACAGGCTGTTGGGAGGATCAAATGAGATCCAGGGGTGAAA
ACAGCTTAGTTTACTTTCAGGAATTTACCCACGCGGTATATAAAGGCAAAATATTATTATAGTCAGGTGATTGTAGATTGAGGAACCCAT
TTCCTCATTCTGCAAATTGCAAACCTGAGGGCCCAAAGAGGGACAGGGGCTTGCCCCAGGTCTCAGCAGGCTGTGAGCAAGAGCTAAAGC
CTAATCCTCCTGCCTTTGGGCCTGGAGCCCTTCCTTGTACCCCAGGGGTCAGTGTCTTTGTTGGATACAGGCTTAGATTGACTGACTGTA
CCCTGAGAACCTAGGGGAGTCCCTGTTCCCAATTCTTCTCCTACCCCCACCTTGGCCTGATGGAGGAAGACCCTGCTGTGTTGAGATGAG
CACCAGAGCCAAGAAGCTGAGGAGGATCTGGAGAATTCTGGAGGAAGAGGAGAGTGTTGCTGGAGCTGTACAGACCCTGCTTCTCAGGTC
CCAGGAAGGTGGCGTCAGCATCTGCAGCCGCGTCGACGTTGTCGGAGCCTCCGCGGAGGACCCAGGAGAGCCGGACTAGGACCAGGGCCC
TGGGCCTCCCCACACTCCCCATGGAGAAGCTGGCGGCCTCTACAGAGCCCCAAGGGCCTCGGCCGGTCCTGGGCCGTGAGAGTGTCCAGG
TGCCCGATGACCAAGACTTTCGCAGCTTCCGGTCAGAGTGTGAGGCTGAGGTGGGCTGGAACCTGACCTATAGCAGGGCTGGGGTGTCTG
TCTGGGTGCAGGCTGTGGAGATGGATCGGACGCTGCACAAGATCAAGGAATACGGGGTGCTTTGCATTCAGGAATACAGAAAAAACAGCA
AAGTGGAGTCAAGTACACGTAACAACTTCATGGGCTTGAAGGATCACCTAGGGCATGACCTCGGCCACCTTTATGTGGAGAGCACTGACC
CACAGTTAAGTCCAGCTGTACCTTGGTCAACAGTAGAAAACCCAAGTATGGATACCGTTAATGTGGGGAAGGATGAAAAAGAGGCGTCTG
AAGAGAATGCAAGCTCTGGTGACTCTGAAGAAAACACAAATTCTGATCATGAGTCAGAACAATTGGGTAGCATTTCAGTAGAGCCAGGCT
TGATAACTAAGACTCACAGACAGCTCTGCAGGTCTCCCTGTTTAGAGCCTCACATACTCAAGCGCAATGAAATTTTGCAAGACTTTAAAC
CTGAAGAGTCCCAGACTACATCCAAGGAAGCAAAGAAACCACCTGATGTGGTGCGAGAATACCAAACAAAACTGGAGTTTGCACTTAAGT
TAGGTTATTCTGAAGAACAGGTTCAGCTTGTACTAAACAAACTTGGTACTGATGCTTTAATCAATGATATTTTGGGAGAACTTGTCAAAC
TTGGAAATAAAAGTGAGGCTGATCAAACGGTTAGTACAATTAACACTATAACACGGGAAACTTCTTCCCTGGAATCTCAGAGGTCTGAAT
CTCCAATGCAAGAGATTGTAACAGATGATGGTGAAAATCTGAGACCAATAGTTATTGATGGCAGCAATGTGGCAATGAGCCATGGAAACA
AAGAAGTATTTTCCTGCAGAGGAATAAAATTGGCAGTGGATTGGTTTTTGGAAAGAGGCCACAAAGACATTACAGTTTTTGTTCCTGCTT
GGAGGAAAGAGCAATCCCGACCTGATGCTCTCATTACAGATCAGGAAATTTTACGTAAATTAGAGAAGGAGAAAATCCTGGTGTTCACGC
CATCCCGGCGAGTCCAGGGGAGGAGAGTGGTGTGCTATGACGACAGGTTCATCGTGAAGCTGGCTTTTGAGTCGGACGGTATCATTGTGT
CCAATGATAACTACAGGGACTTGGCTAATGAGAAGCCAGAATGGAAGAAGTTCATAGATGAACGATTATTAATGTATTCATTTGTCAATG
ACAAGTTCATGCCCCCTGATGACCCTCTTGGCAGACATGGCCCCAGTCTGGATAATTTTCTGAGGAAGAAACCTATTGTTCCTGAACACA
AAAAGCAGCCTTGTCCATATGGAAAGAAGTGTACCTATGGACACAAGTGCAAATATTACCATCCCGAAAGGGGCAGTCAGCCACAGCGGT
CAGTGGCTGATGAACTCCGTGCCATGTCTAGAAATACGGCAGCCAAAACTGCAAACGAAGGAGGACTGGTGAAAAGCAACAGTGTTCCTT
GTAGCACCAAGGCTGATAGCACTTCTGATGTCAAACGAGGTGCTCCAAAGAGGCAATCAGATCCAAGCATAAGGACACAAGTCTACCAAG
ACCTAGAAGAAAAGCTTCCCACCAAAAACAAATTGGAAACCAGGTCTGTACCTTCCTTAGTTAGCATCCCAGCTACTTCTACTGCAAAAC
CCCAAAGCACTACATCTTTAAGCAATGGCCTTCCATCTGGAGTTCATTTCCCACCTCAGGATCAAAGACCACAGGGACAATATCCTTCAA
TGATGATGGCAACCAAAAATCATGGAACGCCAATGCCTTATGAACAGTATCCAAAATGTGACTCACCTGTCGACATCGGATATTATTCCA
TGTTGAATGCATACTCAAATCTGAGTCTCTCAGGCCCACGAAGCCCTGAAAGGCGTTTCTCCTTAGACACAGATTATAGAATAAGTTCCG
TAGCTTCTGACTGCAGCAGTGAAGGGAGCATGAGCTGTGGGAGCAGTGACTCCTACGTGGGTTACAATGACCGGTCCTATGTCAGCTCCC
CCGACCCACAGCTAGAGGAGAATTTGAAGTGTCAACACATGCACCCTCACAGCCGCCTTAATCCTCAACCGTTCCTGCAGAATTTCCACG
ACCCCTTAACCAGAGGGCAAAGTTACAGTCACGAAGAACCAAAGTTCCATCACAAGCCTCCTCTTCCGCACCTGGCTCTGCACCTGCCGC
ACTCCGCTGTGGGCGCCCGGTCCAGCTGTCCTGGCGACTACCCCTCTCCTCCAAGTTCAGCACACTCTAAGGCACCACACCTAGGGAGGT
CCTTGGTGGCCACGAGAATAGACAGCATCTCTGACTCTCGACTTTATGACAGTTCTCCTTCACGACAAAGAAAGCCTTATTCCCGCCAGG
AAGGCCTGGGAAGCTGGGAGAGGCCAGGCTATGGGATCGACGCCTATGGGTACCGGCAGACTTATTCCTTGCCCGATAACTCCACACAGC
CGTGTTATGAGCAGTTCACCTTCCAGAGCCTCCCTGAGCAACAGGAGCCAGCCTGGCGGATCCCATACTGTGGAATGCCGCAAGATCCCC
CGAGGTATCAAGACAACCGAGAAAAGATTTATATCAATTTGTGCAACATCTTCCCCCCTGACCTTGTGAGAATTGTCATGAAAAGGAATC
CTCACATGACAGACGCCCAGCAGCTCGCCGCAGCCATTTTAGTGGAGAAATCCCAGCTGGGTTATTGAAAGATGATGCATCTTTGTGGTG
TTTAGTAGTTTTTTGTTCAGCTCAAATGCTGAGGGAGGTTTGCTACAATAGCACATGTGATCTCCTTCTCAGCAAGGAGGTTATATAGTA
TCCATTTATGTGAAATACTGTATCATGGAATCTGTATGTATAGCCCCACATGGTGGAAGTATCACGGGATTGCTTTACATTTAAACTTTT
TTTTTTTAACATTTCCTTTTTAAAGCTATATCCTTGGCTGGAAATTTTTCCAGTTTGATTTAATAGATGTATCTGTGATCTTTGATATTA
ATCTTTGGTGCATCAGGGGTTTATATGCAGCACTTTTTATCCTTGTTTTGTGTTTTATTAACTTGGTGTTTGTCTATCAATTGCAAGCAA
TTACAATACCTTCAGAATGTGGGACATTTGACTAGACCTAGCAAACTGTTTTTTCGAGCCAAGCTTAGTTAGACTCTTTTACAGCTTTTT
AAGTTATTTTTATTTGGGGAAAGTGGGCTTCTTTGTGCTATAATCATTATTTATAGAAACAAAGTTATACTACAGCACTGACTTTATATT
TTAAACAGAATGTAAGTTACCAGTTTTATGTTGAAATGTGTTACAGTATATATATATTAGAATGATTTACAATATGGCACTTTTCGATGT
GTTATTTTTGTTTGGATTTTTTTTTCTGTTAAGAAATTAGTTAATTTAATATGGTCAATTTAAAAGAAAGCAGATGCAATCAATGGAAAA
ATGTTTCCATTTTTTAAAAATGAATAAGGCAAAAGCTGTAACTGTTACAGGTTAGAGCTTTGTTATCCAGCTATGATGTGCTTCTTGACA
GTAGAAGTGGAATTGAATTCCTAGATTTCCATTAACCTGTATTTTTAATATGTCTGTCTTTTTGTTTTGGGGCACAACAATACTGGATAA
AATAACCCTTTCACAGCACTTGCCTGTTTTTAATGAATCTAATTATTCACAATGCAACTTTTATATTTAACATACTCTTTAGCTTTCCTG
CTATTTATCAAGGCTGGCCTGAGGTGGGTTTATGTGTTGAGGTTATGCAACATTTCTTGATACTGCACTATAGAGAAATGGTGATGGAGG
AGTTGTAAATGGTAACTTAAAATTTTTGTAAGATATTGTATATTTTCCATTTTCCTGAAGGTAGTTTTCTTGGGGGGGCCTGTTATATTA
TTAAGGCCAGACTCTTGCCACAAATAGTGTAGTTTTAGATACAGACTAAGGTCTGTTCTAGTATTAGTAAGGGATATTTCTGGTTTCAAA
GTCATGGGTTTTGCTAGTGGTGAATACATTTCTGCGGAGTAGAAGATAGATTTTGCAGTCAGTGGCAGACAGTTGTGTGATTGACATCAC
TTGACTGTTGCGTCCAGGTTTTGAATTGTACTTCACGTAACAGATGCATTCAGATCTTTTTCTGTAGTCTGCTTAGATGCCCTGGCTATT
CTGATTATCCTACATGCTACAGTTTGAAGTGAAGCCCTGAAAAACCAGAAAGTACCTTTTACTGTTGATACAAATTGTATCTTTTTAACT
ATAAGAACTATTTTGATTTGTAGATCTAGTTAAAACACAAGTATGTAACTATGATTAGACTTTTGGGCAACATTTTATCCCTTATTTAAA
TACAAATTTTTAAAGTAAAATTGAGGTCTAGAATAGATTAGAAAATAAAAATAACAATTTAGATAAATAGAAATGTCTGTCTTAGTTTTA
TATAATATATTAAAACACAGTAAATAAATTTATTGGCATTTTCTTTCTCCTAAAACTTACCTAGTGTGAACTTAAAATAAAGGTAAAATG
CTGCCTGAAAATAATGTCCAAGCACCTTTGACTAGGATAACATTTTCACTACTTGTGTGACACTGTGTGTTGCACGAAGTAGGATTTGGG
TATACAGTAAATGCTTCTAAAAGGCATTGTGCATATTGACATAACCAATAATCTGAACCGTGTTCAGCAAACTTAATTCAGGAAAGTGGT
ATTCTACACAATTATTGCTGTTGTGTTTGAAATGAGTGTGGCACTCATCTGTATCCAGAAATAATATGGGTGAGGCCACACAACCCATTC
TGAGTGGTGTCTGTCTGAAAGCAACCCTACTCGCATGTGAAATTGTTCTCCTTGATTTGGTCACTATAAAGCAAGTTTAAATGTAGAGGC
TAACTCAGTGCCAAAAACAGGGTTACAAATGTGTAGTATCTTTTATTTTAGTCATATTCTAAGACTTCTTTTTAGTATGAAATCACTTTT
AAATTATACATGTAGGTTTTGCTTCCATTTTCTTCATTTTACCATTTTAATTATTTGAACATTCGCCAAATTTTACATTTATTTAAATGA
GATCTTAGGTGAGATGTGTGTGACACTTTGAATTTGACCTTCTTGTGTTATTAGCTGACTATTTGTCATTGCCTCATGGATTTTAAATTA
TGGGAAAATAGTGTAGCCAGCTGCCACCTCTACTGAAGTGAGTAGCTCTGAACTACCCACACTAAATCCTTCAGTGTAATTAATTATGAG
TTTAAAAATAGCAGTTTTCTTATGTGAAGAGGACAGTTTGTCCCCTTTTTTTGAAGCACCGATGTTGCGTTCAGAGCTGTAGAATGAGAT
AATTGGCAGACTTTAGGTACAGCAAATTCTTACTTATCTAAAGCAATAAGTCAAAGGAGTCCATCATTAAATTAAATCCATAGCTGATCA
CAAGCCTTCATTTTAGCCAAAACTTTCTCTCTAACCAAATCTTTTACCAGACTTGCTAATAAATAACCAGAGAGATGTGTTAATAAGTGA
AGTTGCCAGAAATGGTCAACTGATCGGAAAAAAAAGGATTCAGACTGGAGTATTTTGCCCCTGAATAATTGACAGTTGACTGTGCTTTAC
ACAGTAACTAGCCAGTCTGTTGTCTCTGTGTCTTAGTCCAGAGGGAATAGTACCCAATTGGCCAAATACTGGCCCTTAGTATCTCCTCCT
TTCTTGCATGGGATACAGACGTTTTCAGTCTTGTTTTTATGATCTCTCTCTATATCCTGATAAGAGTTTGTCATTGACTTACACATTTGG
AAGAAATGCACACCAGTGTAATATATTTGATACTGGTGGAAACTTGAACTTTGTGTTTTTATGAAAATTCATTTATGAGAATATGTAATA
TAACTGAAGAGTATTTTATGTATATCTATATACACAAATATGTATTTGTTATGAGGTATTAAAAACAGGGGTTGGGGGGAGTGCTTCTGA
TGGCTAACTTTTCTCTAATTAAACTATGTTTCTTTGAGTTGTGAACGACCGAGTCTGGGGTCTGGACGGCCAATGATAAGATTTAGAACC
ACTTGGATGGAAAGCAGTTCTTCACTGGTTTTATTCTTGGTATTTTCAAAGAATTATTTTGATATTTTTAATAGAATGTGTAATTTTAAA
ATACACAAAAAACTTAAAGTAGTATTGATTATACAAATAATTATTTAACATGTCTTATGGATGTATCTATATGTATATAGACAGTAATAT
ATTTATAAAACAAATATACTTTGCTTATGTTATAGCTCTTAGTTTGTGACAGGTGGGAGGATGGCTCTGGGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTTTTGAAAACTCTCAAGCTGTTTTCCCTCTGATTTACAATGGTATTTACTTTAAAGTATGTTTGGTTTT
CATTATTCTTTTTGCTCTCCAACTTCCTTATTCAAGATAAAATAAGACATACAGTTTTCTGGCCATTCTGTTGGTGTGTGGTGCACCCAT
TTTATTGTCATCTAACTCCTGGAGAATTCCCACGTGACCTGAAATCAAACAGATTCTGGCTGGACATATGCTTATGTTCCAAATATATTA
AAGATGTTAATTCAGCTAACAGTTAAGTTTCCAAGGTATACACCAACAAATAAAATGAGGTATTAAAAAGAGATGGATTACACACATGCA
TTAGAATAAGAGAAAACAGTAGTGTTAATAAAAGTAAAGAAACATACACTATCTTAGCCCCCTAGGGCAGGGGTTGACTTTTTCTGTAAA
GGATCAGATAGTAAATAATACAGGAATCATATGGACTTCAAATGCCATTGTAAAAACTACTCAGCTCTGCCTTTAGAGCATAAGAACAGC
CACAGATAACATGTAAATTAGTGTGGCTGTGTTCCAATAAAACTTTATTTACAGAAACGGGAAGCCGGTCAGATTGGGCCTGTGGGCCAT
AATTTGCTGATCTCAAGCAGTAAATCCTGGTATATGTTAATAGAAGAAATCATAATTGCATTTCAGTTGACATTAAAAGAAAATCTGGTA
GTTTTTGATGTCCTTCAAAAGAGGATTGTTAGACATTGATGTTAAAGCATCTTAATTCATTTGAGTTTTCTTACCTGTTTACACCCATTA
TTTATTAGAGATATTTCTTGTGTTTAACCACAAAAAAAAGCACTCTGTTAAAATGTTTTAATATGTATTGAATTTCTTTCATAAACTTTT
CATTTCTGTTGATAAATGGGAATCCCTTACCAACCTTTTGTTTTTTAAAAGTCTCATAGACCAAAAAAAATCTGTTGCAGCATTTAATTA
GCCACAGATACATTTTGGCTGCATTTACCAGTTACATTTTTCCATTGGTTTTGGCTTCTAATAAATAACATATCTGCCATTCTTTAAAAA
TGATTTTAAAGAAGATAAATATATTGTAATTTCACATGCTATAGCTTTATTCTGTAAGATTAAAAATTGTGACTAGTATAATTGTAGCTA
TAATGTGAGTGGCATGTTACAATGTAACTCTTTATGAGAAATAAAATGTATCTCTGCTTTGTCTGTCCAGATCTTTAGGATTTTTAGATG
CCTTGGGACTGTCCTTGGTGAATGATATTCTTCATATGATCATATGTAATTTTGAATTCGTTGGAAGTACACGCTGCTGAGCATGTTTAT
TCACAGTGCTTTATACCGGGTGTTGCATCAGTAATCATTTTCATAAGAACATTTAAACAGCATGAACATCATCATCCACTTAAATAGTTA
AACTTTCTTTTAAAATTGGAATGCAACTGTAGGTTTTAACAATGTTTATTGTTTTTTAAGTGGTTACTTTGTTTTTCCTTAATACTTTCT
GTTAACTTAATTATTACTCCTGTTGCAGTGTTACTGTTATGTATTAGAAGTGGCTTTTCCCCCTAAGATCCTTAGTCTTTTAAAGACAAT
TTAAGGTATTGGCCATTTGGCAGTAGAAAATGTGCATGTTTTAACTTGGTTTTATAAAATCTGTAATGTTTCACTTCTTGAACCATGTAC
CAAATTTGCCAATTTTCTGTCCAAGTGTTTCAGATGAATAACAAAACGCTGTTCATTGAAGCTTTCGCCACCTTTCTTAAAGCAGCGTAT
GTTCCAAGGGAAAAAGGCATTGAAAAGCAATCGTTTGTTTTTATGAAGAATAGGTGTTCAGATTCCTTCAGTTTTTTTGAAATTAGAAAT
TTCTTACCTTATGTGAAATATTCACAAACGTGCACACTTCTGCAGAGACAAAGCATTTCACTGCACGTGTACCAGGTTATTGATTTTATC
TTTTCCTTTCAGGGTTTTGTCCTCCCAAACCAGAGTCATATGCTGCTAGTAGAATTTTTTATTTGATCCTGCGAACTTTTCTTATAGGAA
AAGTAAGGCAAAGGATGTGTAGTGCAACCATCTGATAAACTAGTGTGATTGTATTTATCCTCTGTTCTGTGTATTTCTGTAATGGAATCT
TTACAATTCCCAAAACGGTATTTTAGACCTACTGGAAATCTGTATCGAAACAGCTATGTGATTCTGCCACTGAGAAAAAAAAAATTTTTA
ATTCGTTTTTCTTATGCTGGTTTGTTTTTCTTTAATGAAGAAATTGATCTCATATGGCATCATAGATGCTAAATAAATAAAAGCATCATA
CTTCTCTAGTTTGCCTGCATTCAGTGGCTAACATTATGAGCATTGTGTAAGATAAACACATGGTCAGTATCAATGTAAATGTTAGAGCCA

>In-frame_ENST00000334805_ENST00000278590_TCGA-KL-8339-01A_STARD10_chr11_72492020_-_ZC3H12C_chr11_110007388_length(amino acids)=993AA_start in transcript=776_stop in transcript=3757
MLELYRPCFSGPRKVASASAAASTLSEPPRRTQESRTRTRALGLPTLPMEKLAASTEPQGPRPVLGRESVQVPDDQDFRSFRSECEAEVG
WNLTYSRAGVSVWVQAVEMDRTLHKIKEYGVLCIQEYRKNSKVESSTRNNFMGLKDHLGHDLGHLYVESTDPQLSPAVPWSTVENPSMDT
VNVGKDEKEASEENASSGDSEENTNSDHESEQLGSISVEPGLITKTHRQLCRSPCLEPHILKRNEILQDFKPEESQTTSKEAKKPPDVVR
EYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINTITRETSSLESQRSESPMQEIVTDDGENLRPIVI
DGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIV
KLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKY
YHPERGSQPQRSVADELRAMSRNTAAKTANEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPS
LVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPSMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSLSGPRSPERR
FSLDTDYRISSVASDCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEENLKCQHMHPHSRLNPQPFLQNFHDPLTRGQSYSHEEPKFHHK
PPLPHLALHLPHSAVGARSSCPGDYPSPPSSAHSKAPHLGRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWERPGYGIDAYGYR
QTYSLPDNSTQPCYEQFTFQSLPEQQEPAWRIPYCGMPQDPPRYQDNREKIYINLCNIFPPDLVRIVMKRNPHMTDAQQLAAAILVEKSQ

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>In-frame_ENST00000334805_ENST00000528673_TCGA-KL-8339-01A_STARD10_chr11_72492020_-_ZC3H12C_chr11_110007388_length(transcript)=3955nt_BP=1127nt
ACGTGGGGGCGCCTGAGCGAAGATAACCGTAATAAATAGTAACCTAACGGTCCAGTCATCGTTCTGTGGTCCTTTCTTTTATGATTCACA
AGGAATGACCCTCTTCATCGCCTCTCCTAATTCAGTCCTCACAACAGTCCTTTTACAAATGGGACAACAGGTTAGAGGAAGTCAGGCAGA
TTTCCAGCATCATAGAGAGTAAAGGACCAGGGAAGGATCAGGATTCAAGGACTGCACCCAGGCTCTGCTTCCAGCTTGCTGTGTGACTTT
GGGTAATTTTGTTCCCTTAGGGAACTGAGCTTTCTCATTTGTAAATGCAAACAGGCTGTTGGGAGGATCAAATGAGATCCAGGGGTGAAA
ACAGCTTAGTTTACTTTCAGGAATTTACCCACGCGGTATATAAAGGCAAAATATTATTATAGTCAGGTGATTGTAGATTGAGGAACCCAT
TTCCTCATTCTGCAAATTGCAAACCTGAGGGCCCAAAGAGGGACAGGGGCTTGCCCCAGGTCTCAGCAGGCTGTGAGCAAGAGCTAAAGC
CTAATCCTCCTGCCTTTGGGCCTGGAGCCCTTCCTTGTACCCCAGGGGTCAGTGTCTTTGTTGGATACAGGCTTAGATTGACTGACTGTA
CCCTGAGAACCTAGGGGAGTCCCTGTTCCCAATTCTTCTCCTACCCCCACCTTGGCCTGATGGAGGAAGACCCTGCTGTGTTGAGATGAG
CACCAGAGCCAAGAAGCTGAGGAGGATCTGGAGAATTCTGGAGGAAGAGGAGAGTGTTGCTGGAGCTGTACAGACCCTGCTTCTCAGGTC
CCAGGAAGGTGGCGTCAGCATCTGCAGCCGCGTCGACGTTGTCGGAGCCTCCGCGGAGGACCCAGGAGAGCCGGACTAGGACCAGGGCCC
TGGGCCTCCCCACACTCCCCATGGAGAAGCTGGCGGCCTCTACAGAGCCCCAAGGGCCTCGGCCGGTCCTGGGCCGTGAGAGTGTCCAGG
TGCCCGATGACCAAGACTTTCGCAGCTTCCGGTCAGAGTGTGAGGCTGAGGTGGGCTGGAACCTGACCTATAGCAGGGCTGGGGTGTCTG
TCTGGGTGCAGGCTGTGGAGATGGATCGGACGCTGCACAAGATCAAGGAATACGGGGTGCTTTGCATTCAGGAATACAGAAAAAACAGCA
AAGTGGAGTCAAGTACACGTAACAACTTCATGGGCTTGAAGGATCACCTAGGGCATGACCTCGGCCACCTTTATGTGGAGAGCACTGACC
CACAGTTAAGTCCAGCTGTACCTTGGTCAACAGTAGAAAACCCAAGTATGGATACCGTTAATGTGGGGAAGGATGAAAAAGAGGCGTCTG
AAGAGAATGCAAGCTCTGGTGACTCTGAAGAAAACACAAATTCTGATCATGAGTCAGAACAATTGGGTAGCATTTCAGTAGAGCCAGGCT
TGATAACTAAGACTCACAGACAGCTCTGCAGGTCTCCCTGTTTAGAGCCTCACATACTCAAGCGCAATGAAATTTTGCAAGACTTTAAAC
CTGAAGAGTCCCAGACTACATCCAAGGAAGCAAAGAAACCACCTGATGTGGTGCGAGAATACCAAACAAAACTGGAGTTTGCACTTAAGT
TAGGTTATTCTGAAGAACAGGTTCAGCTTGTACTAAACAAACTTGGTACTGATGCTTTAATCAATGATATTTTGGGAGAACTTGTCAAAC
TTGGAAATAAAAGTGAGGCTGATCAAACGGTTAGTACAATTAACACTATAACACGGGAAACTTCTTCCCTGGAATCTCAGAGGTCTGAAT
CTCCAATGCAAGAGATTGTAACAGATGATGGTGAAAATCTGAGACCAATAGTTATTGATGGCAGCAATGTGGCAATGAGCCATGGAAACA
AAGAAGTATTTTCCTGCAGAGGAATAAAATTGGCAGTGGATTGGTTTTTGGAAAGAGGCCACAAAGACATTACAGTTTTTGTTCCTGCTT
GGAGGAAAGAGCAATCCCGACCTGATGCTCTCATTACAGATCAGGAAATTTTACGTAAATTAGAGAAGGAGAAAATCCTGGTGTTCACGC
CATCCCGGCGAGTCCAGGGGAGGAGAGTGGTGTGCTATGACGACAGGTTCATCGTGAAGCTGGCTTTTGAGTCGGACGGTATCATTGTGT
CCAATGATAACTACAGGGACTTGGCTAATGAGAAGCCAGAATGGAAGAAGTTCATAGATGAACGATTATTAATGTATTCATTTGTCAATG
ACAAGTTCATGCCCCCTGATGACCCTCTTGGCAGACATGGCCCCAGTCTGGATAATTTTCTGAGGAAGAAACCTATTGTTCCTGAACACA
AAAAGCAGCCTTGTCCATATGGAAAGAAGTGTACCTATGGACACAAGTGCAAATATTACCATCCCGAAAGGGGCAGTCAGCCACAGCGGT
CAGTGGCTGATGAACTCCGTGCCATGTCTAGAAATACGGCAGCCAAAACTGCAAACGAAGGAGGACTGGTGAAAAGCAACAGTGTTCCTT
GTAGCACCAAGGCTGATAGCACTTCTGATGTCAAACGAGGTGCTCCAAAGAGGCAATCAGATCCAAGCATAAGGACACAAGTCTACCAAG
ACCTAGAAGAAAAGCTTCCCACCAAAAACAAATTGGAAACCAGGTCTGTACCTTCCTTAGTTAGCATCCCAGCTACTTCTACTGCAAAAC
CCCAAAGCACTACATCTTTAAGCAATGGCCTTCCATCTGGAGTTCATTTCCCACCTCAGGATCAAAGACCACAGGGACAATATCCTTCAA
TGATGATGGCAACCAAAAATCATGGAACGCCAATGCCTTATGAACAGTATCCAAAATGTGACTCACCTGTCGACATCGGATATTATTCCA
TGTTGAATGCATACTCAAATCTGAGTCTCTCAGGCCCACGAAGCCCTGAAAGGCGTTTCTCCTTAGACACAGATTATAGAATAAGTTCCG
TAGCTTCTGACTGCAGCAGTGAAGGGAGCATGAGCTGTGGGAGCAGTGACTCCTACGTGGGTTACAATGACCGGTCCTATGTCAGCTCCC
CCGACCCACAGCTAGAGGAGAATTTGAAGTGTCAACACATGCACCCTCACAGCCGCCTTAATCCTCAACCGTTCCTGCAGAATTTCCACG
ACCCCTTAACCAGAGGGCAAAGTTACAGTCACGAAGAACCAAAGTTCCATCACAAGCCTCCTCTTCCGCACCTGGCTCTGCACCTGCCGC
ACTCCGCTGTGGGCGCCCGGTCCAGCTGTCCTGGCGACTACCCCTCTCCTCCAAGTTCAGCACACTCTAAGGCACCACACCTAGGGAGGT
CCTTGGTGGCCACGAGAATAGACAGCATCTCTGACTCTCGACTTTATGACAGTTCTCCTTCACGACAAAGAAAGCCTTATTCCCGCCAGG
AAGGCCTGGGAAGCTGGGAGAGGCCAGGCTATGGGATCGACGCCTATGGGTACCGGCAGACTTATTCCTTGCCCGATAACTCCACACAGC
CGTGTTATGAGCAGTTCACCTTCCAGAGCCTCCCTGAGCAACAGGAGCCAGCCTGGCGGATCCCATACTGTGGAATGCCGCAAGATCCCC
CGAGGTATCAAGACAACCGAGAAAAGATTTATATCAATTTGTGCAACATCTTCCCCCCTGACCTTGTGAGAATTGTCATGAAAAGGAATC
CTCACATGACAGACGCCCAGCAGCTCGCCGCAGCCATTTTAGTGGAGAAATCCCAGCTGGGTTATTGAAAGATGATGCATCTTTGTGGTG
TTTAGTAGTTTTTTGTTCAGCTCAAATGCTGAGGGAGGTTTGCTACAATAGCACATGTGATCTCCTTCTCAGCAAGGAGGTTATATAGTA

>In-frame_ENST00000334805_ENST00000528673_TCGA-KL-8339-01A_STARD10_chr11_72492020_-_ZC3H12C_chr11_110007388_length(amino acids)=993AA_start in transcript=776_stop in transcript=3757
MLELYRPCFSGPRKVASASAAASTLSEPPRRTQESRTRTRALGLPTLPMEKLAASTEPQGPRPVLGRESVQVPDDQDFRSFRSECEAEVG
WNLTYSRAGVSVWVQAVEMDRTLHKIKEYGVLCIQEYRKNSKVESSTRNNFMGLKDHLGHDLGHLYVESTDPQLSPAVPWSTVENPSMDT
VNVGKDEKEASEENASSGDSEENTNSDHESEQLGSISVEPGLITKTHRQLCRSPCLEPHILKRNEILQDFKPEESQTTSKEAKKPPDVVR
EYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINTITRETSSLESQRSESPMQEIVTDDGENLRPIVI
DGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIV
KLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKY
YHPERGSQPQRSVADELRAMSRNTAAKTANEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPS
LVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPSMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSLSGPRSPERR
FSLDTDYRISSVASDCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEENLKCQHMHPHSRLNPQPFLQNFHDPLTRGQSYSHEEPKFHHK
PPLPHLALHLPHSAVGARSSCPGDYPSPPSSAHSKAPHLGRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWERPGYGIDAYGYR
QTYSLPDNSTQPCYEQFTFQSLPEQQEPAWRIPYCGMPQDPPRYQDNREKIYINLCNIFPPDLVRIVMKRNPHMTDAQQLAAAILVEKSQ

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Fusion Gene PPI Analysis for STARD10-ZC3H12C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STARD10-ZC3H12C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STARD10-ZC3H12C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTARD10C0033578Prostatic Neoplasms1CTD_human
HgeneSTARD10C0376358Malignant neoplasm of prostate1CTD_human
TgeneZC3H12CC0030246Pustulosis of Palms and Soles1CTD_human
TgeneZC3H12CC0033860Psoriasis1CTD_human