|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:STAT3-NOS2 (FusionGDB2 ID:86643) |
Fusion Gene Summary for STAT3-NOS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STAT3-NOS2 | Fusion gene ID: 86643 | Hgene | Tgene | Gene symbol | STAT3 | NOS2 | Gene ID | 6774 | 339345 |
| Gene name | signal transducer and activator of transcription 3 | nanos C2HC-type zinc finger 2 | |
| Synonyms | ADMIO|ADMIO1|APRF|HIES | NOS2|ZC2HC12B | |
| Cytomap | 17q21.2 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor | nanos homolog 2NOS-2 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | P35228 | |
| Ensembl transtripts involved in fusion gene | ENST00000264657, ENST00000585517, ENST00000389272, ENST00000588969, ENST00000404395, ENST00000590776, | ENST00000313735, | |
| Fusion gene scores | * DoF score | 18 X 20 X 10=3600 | 5 X 4 X 3=60 |
| # samples | 23 | 4 | |
| ** MAII score | log2(23/3600*10)=-3.96829114027266 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STAT3 [Title/Abstract] AND NOS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | STAT3(40540297)-NOS2(26116714), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STAT3 | GO:0006355 | regulation of transcription, DNA-templated | 15664994|17344214 |
| Hgene | STAT3 | GO:0006606 | protein import into nucleus | 18234692 |
| Hgene | STAT3 | GO:0010507 | negative regulation of autophagy | 26962683 |
| Hgene | STAT3 | GO:0010628 | positive regulation of gene expression | 23820254 |
| Hgene | STAT3 | GO:0030522 | intracellular receptor signaling pathway | 17324931 |
| Hgene | STAT3 | GO:0032355 | response to estradiol | 12552091 |
| Hgene | STAT3 | GO:0032870 | cellular response to hormone stimulus | 12552091 |
| Hgene | STAT3 | GO:0033210 | leptin-mediated signaling pathway | 17344214 |
| Hgene | STAT3 | GO:0035278 | miRNA mediated inhibition of translation | 23820254 |
| Hgene | STAT3 | GO:0044320 | cellular response to leptin stimulus | 17344214 |
| Hgene | STAT3 | GO:0044321 | response to leptin | 17344214 |
| Hgene | STAT3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19390056 |
| Hgene | STAT3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17324931|27050391|31462771 |
| Hgene | STAT3 | GO:0051726 | regulation of cell cycle | 17344214 |
| Hgene | STAT3 | GO:0060396 | growth hormone receptor signaling pathway | 10925297 |
| Hgene | STAT3 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
| Hgene | STAT3 | GO:0070102 | interleukin-6-mediated signaling pathway | 12359225|12552091|17324931|24429361 |
| Hgene | STAT3 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19390056|23820254 |
| Hgene | STAT3 | GO:2000637 | positive regulation of gene silencing by miRNA | 23820254 |
| Tgene | NOS2 | GO:0017148 | negative regulation of translation | 24736845 |
| Tgene | NOS2 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 24736845 |
| Fusion gene breakpoints across STAT3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across NOS2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-L5-A4OW-01A | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW-01A | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
Top |
Fusion Gene ORF analysis for STAT3-NOS2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000264657 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000585517 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000389272 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000588969 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000404395 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| intron-3CDS | ENST00000590776 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000264657 | ENST00000313735 | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000585517 | ENST00000313735 | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000389272 | ENST00000313735 | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000588969 | ENST00000313735 | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000404395 | ENST00000313735 | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| intron-3CDS | ENST00000590776 | ENST00000313735 | STAT3 | chr17 | 40540296 | - | NOS2 | chr17 | 26116714 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for STAT3-NOS2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for STAT3-NOS2 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | NOS2 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). {ECO:0000250|UniProtKB:P29477, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:7531687, ECO:0000269|PubMed:7544004}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for STAT3-NOS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for STAT3-NOS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for STAT3-NOS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NOS2 | P35228 | DB11327 | Dipyrithione | Antagonist | Small molecule | Approved |
| Tgene | NOS2 | P35228 | DB11327 | Dipyrithione | Antagonist | Small molecule | Approved |
| Tgene | NOS2 | P35228 | DB01017 | Minocycline | Inhibitor | Small molecule | Approved|Investigational |
| Tgene | NOS2 | P35228 | DB01017 | Minocycline | Inhibitor | Small molecule | Approved|Investigational |
| Tgene | NOS2 | P35228 | DB08814 | Triflusal | Agonist | Small molecule | Approved|Investigational |
| Tgene | NOS2 | P35228 | DB08814 | Triflusal | Agonist | Small molecule | Approved|Investigational |
| Tgene | NOS2 | P35228 | DB09237 | Levamlodipine | Agonist | Small molecule | Approved|Investigational |
| Tgene | NOS2 | P35228 | DB09237 | Levamlodipine | Agonist | Small molecule | Approved|Investigational |
| Tgene | NOS2 | P35228 | DB01110 | Miconazole | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
| Tgene | NOS2 | P35228 | DB01110 | Miconazole | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
| Tgene | NOS2 | P35228 | DB01234 | Dexamethasone | Negative modulator | Small molecule | Approved|Investigational|Vet_approved |
| Tgene | NOS2 | P35228 | DB01234 | Dexamethasone | Negative modulator | Small molecule | Approved|Investigational|Vet_approved |
| Tgene | NOS2 | P35228 | DB14649 | Dexamethasone acetate | Negative modulator | Small molecule | Approved|Investigational|Vet_approved |
| Tgene | NOS2 | P35228 | DB14649 | Dexamethasone acetate | Negative modulator | Small molecule | Approved|Investigational|Vet_approved |
Top |
Related Diseases for STAT3-NOS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STAT3 | C4721531 | HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT | 7 | GENOMICS_ENGLAND;UNIPROT |
| Hgene | STAT3 | C0018800 | Cardiomegaly | 3 | CTD_human |
| Hgene | STAT3 | C0021368 | Inflammation | 3 | CTD_human |
| Hgene | STAT3 | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
| Hgene | STAT3 | C0376358 | Malignant neoplasm of prostate | 3 | CTD_human |
| Hgene | STAT3 | C1383860 | Cardiac Hypertrophy | 3 | CTD_human |
| Hgene | STAT3 | C2936739 | Hyper-Immunoglobulin E Syndrome, Autosomal Dominant | 3 | CTD_human;ORPHANET |
| Hgene | STAT3 | C3887645 | Job Syndrome | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | STAT3 | C4014795 | AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | STAT3 | C0001418 | Adenocarcinoma | 2 | CTD_human |
| Hgene | STAT3 | C0003865 | Arthritis, Adjuvant-Induced | 2 | CTD_human |
| Hgene | STAT3 | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
| Hgene | STAT3 | C0009324 | Ulcerative Colitis | 2 | CTD_human |
| Hgene | STAT3 | C0019207 | Hepatoma, Morris | 2 | CTD_human |
| Hgene | STAT3 | C0019208 | Hepatoma, Novikoff | 2 | CTD_human |
| Hgene | STAT3 | C0023904 | Liver Neoplasms, Experimental | 2 | CTD_human |
| Hgene | STAT3 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Hgene | STAT3 | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
| Hgene | STAT3 | C0033141 | Cardiomyopathies, Primary | 2 | CTD_human |
| Hgene | STAT3 | C0036529 | Myocardial Diseases, Secondary | 2 | CTD_human |
| Hgene | STAT3 | C0086404 | Experimental Hepatoma | 2 | CTD_human |
| Hgene | STAT3 | C0205641 | Adenocarcinoma, Basal Cell | 2 | CTD_human |
| Hgene | STAT3 | C0205642 | Adenocarcinoma, Oxyphilic | 2 | CTD_human |
| Hgene | STAT3 | C0205643 | Carcinoma, Cribriform | 2 | CTD_human |
| Hgene | STAT3 | C0205644 | Carcinoma, Granular Cell | 2 | CTD_human |
| Hgene | STAT3 | C0205645 | Adenocarcinoma, Tubular | 2 | CTD_human |
| Hgene | STAT3 | C0346647 | Malignant neoplasm of pancreas | 2 | CTD_human |
| Hgene | STAT3 | C0878544 | Cardiomyopathies | 2 | CTD_human |
| Hgene | STAT3 | C0971858 | Arthritis, Collagen-Induced | 2 | CTD_human |
| Hgene | STAT3 | C0993582 | Arthritis, Experimental | 2 | CTD_human |
| Hgene | STAT3 | C1955861 | T-Cell Large Granular Lymphocyte Leukemia | 2 | CGI;ORPHANET |
| Hgene | STAT3 | C2930809 | Neutropenia and hyperlymphocytosis with large granular lymphocytes | 2 | ORPHANET |
| Hgene | STAT3 | C3489795 | Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant | 2 | CTD_human;ORPHANET |
| Hgene | STAT3 | C0004153 | Atherosclerosis | 1 | CTD_human |
| Hgene | STAT3 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
| Hgene | STAT3 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Hgene | STAT3 | C0007097 | Carcinoma | 1 | CTD_human |
| Hgene | STAT3 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| Hgene | STAT3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | STAT3 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | STAT3 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Hgene | STAT3 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Hgene | STAT3 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | STAT3 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Hgene | STAT3 | C0015967 | Fever | 1 | CTD_human |
| Hgene | STAT3 | C0016059 | Fibrosis | 1 | CTD_human |
| Hgene | STAT3 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
| Hgene | STAT3 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | STAT3 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
| Hgene | STAT3 | C0023487 | Acute Promyelocytic Leukemia | 1 | ORPHANET |
| Hgene | STAT3 | C0023492 | Leukemia, T-Cell | 1 | CTD_human |
| Hgene | STAT3 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Hgene | STAT3 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
| Hgene | STAT3 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| Hgene | STAT3 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | STAT3 | C0025149 | Medulloblastoma | 1 | CTD_human |
| Hgene | STAT3 | C0025261 | Memory Disorders | 1 | CTD_human |
| Hgene | STAT3 | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| Hgene | STAT3 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| Hgene | STAT3 | C0030246 | Pustulosis of Palms and Soles | 1 | CTD_human |
| Hgene | STAT3 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | STAT3 | C0033860 | Psoriasis | 1 | CTD_human |
| Hgene | STAT3 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Hgene | STAT3 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | STAT3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Hgene | STAT3 | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
| Hgene | STAT3 | C0149519 | Chronic Persistent Hepatitis | 1 | CTD_human |
| Hgene | STAT3 | C0158981 | Neonatal diabetes mellitus | 1 | GENOMICS_ENGLAND |
| Hgene | STAT3 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| Hgene | STAT3 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| Hgene | STAT3 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| Hgene | STAT3 | C0205699 | Carcinomatosis | 1 | CTD_human |
| Hgene | STAT3 | C0205734 | Diabetes, Autoimmune | 1 | CTD_human |
| Hgene | STAT3 | C0205833 | Medullomyoblastoma | 1 | CTD_human |
| Hgene | STAT3 | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | CTD_human |
| Hgene | STAT3 | C0233794 | Memory impairment | 1 | CTD_human |
| Hgene | STAT3 | C0235833 | Congenital diaphragmatic hernia | 1 | CTD_human |
| Hgene | STAT3 | C0238281 | Middle Cerebral Artery Syndrome | 1 | CTD_human |
| Hgene | STAT3 | C0265699 | Congenital hernia of foramen of Morgagni | 1 | CTD_human |
| Hgene | STAT3 | C0265700 | Congenital hernia of foramen of Bochdalek | 1 | CTD_human |
| Hgene | STAT3 | C0278510 | Childhood Medulloblastoma | 1 | CTD_human |
| Hgene | STAT3 | C0278876 | Adult Medulloblastoma | 1 | CTD_human |
| Hgene | STAT3 | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
| Hgene | STAT3 | C0333641 | Atrophic | 1 | CTD_human |
| Hgene | STAT3 | C0342302 | Brittle diabetes | 1 | CTD_human |
| Hgene | STAT3 | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
| Hgene | STAT3 | C0520463 | Chronic active hepatitis | 1 | CTD_human |
| Hgene | STAT3 | C0524611 | Cryptogenic Chronic Hepatitis | 1 | CTD_human |
| Hgene | STAT3 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Hgene | STAT3 | C0740376 | Middle Cerebral Artery Thrombosis | 1 | CTD_human |
| Hgene | STAT3 | C0740391 | Middle Cerebral Artery Occlusion | 1 | CTD_human |
| Hgene | STAT3 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
| Hgene | STAT3 | C0751291 | Desmoplastic Medulloblastoma | 1 | CTD_human |
| Hgene | STAT3 | C0751292 | Age-Related Memory Disorders | 1 | CTD_human |
| Hgene | STAT3 | C0751293 | Memory Disorder, Semantic | 1 | CTD_human |
| Hgene | STAT3 | C0751294 | Memory Disorder, Spatial | 1 | CTD_human |
| Hgene | STAT3 | C0751295 | Memory Loss | 1 | CTD_human |
| Hgene | STAT3 | C0751845 | Middle Cerebral Artery Embolus | 1 | CTD_human |
| Hgene | STAT3 | C0751846 | Left Middle Cerebral Artery Infarction | 1 | CTD_human |
| Hgene | STAT3 | C0751847 | Embolic Infarction, Middle Cerebral Artery | 1 | CTD_human |
| Hgene | STAT3 | C0751848 | Thrombotic Infarction, Middle Cerebral Artery | 1 | CTD_human |
| Hgene | STAT3 | C0751849 | Right Middle Cerebral Artery Infarction | 1 | CTD_human |
| Hgene | STAT3 | C0917798 | Cerebral Ischemia | 1 | CTD_human |
| Hgene | STAT3 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Hgene | STAT3 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
| Hgene | STAT3 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
| Hgene | STAT3 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
| Hgene | STAT3 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Hgene | STAT3 | C1275668 | Melanotic medulloblastoma | 1 | CTD_human |
| Hgene | STAT3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C1512709 | Chronic Lymphoproliferative Disorder of NK-Cells | 1 | ORPHANET |
| Hgene | STAT3 | C1563937 | Atherogenesis | 1 | CTD_human |
| Hgene | STAT3 | C1623038 | Cirrhosis | 1 | CTD_human |
| Hgene | STAT3 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| Hgene | STAT3 | C1800706 | Idiopathic Pulmonary Fibrosis | 1 | CTD_human |
| Hgene | STAT3 | C1833104 | DIABETES MELLITUS, PERMANENT NEONATAL | 1 | ORPHANET |
| Hgene | STAT3 | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
| Hgene | STAT3 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
| Hgene | STAT3 | C1968689 | Hyper-Immunoglobulin E Syndrome, Autosomal Recessive | 1 | CTD_human |
| Hgene | STAT3 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | STAT3 | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
| Hgene | STAT3 | C3837958 | Diabetes Mellitus, Ketosis-Prone | 1 | CTD_human |
| Hgene | STAT3 | C4048328 | cervical cancer | 1 | CTD_human |
| Hgene | STAT3 | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
| Hgene | STAT3 | C4554117 | Diabetes Mellitus, Sudden-Onset | 1 | CTD_human |
| Hgene | STAT3 | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
| Hgene | STAT3 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Hgene | STAT3 | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |
| Hgene | STAT3 | C4721508 | Hamman-Rich Disease | 1 | CTD_human |
| Hgene | STAT3 | C4721509 | Usual Interstitial Pneumonia | 1 | CTD_human |
| Hgene | STAT3 | C4721952 | Familial Idiopathic Pulmonary Fibrosis | 1 | CTD_human |
| Tgene | NOS2 | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | NOS2 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | NOS2 | C0027055 | Myocardial Reperfusion Injury | 5 | CTD_human |
| Tgene | NOS2 | C0035126 | Reperfusion Injury | 4 | CTD_human |
| Tgene | NOS2 | C0020538 | Hypertensive disease | 3 | CTD_human |
| Tgene | NOS2 | C0038358 | Gastric ulcer | 3 | CTD_human |
| Tgene | NOS2 | C0002152 | Alloxan Diabetes | 2 | CTD_human |
| Tgene | NOS2 | C0007102 | Malignant tumor of colon | 2 | CTD_human |
| Tgene | NOS2 | C0007786 | Brain Ischemia | 2 | CTD_human |
| Tgene | NOS2 | C0008370 | Cholestasis | 2 | CTD_human |
| Tgene | NOS2 | C0009319 | Colitis | 2 | CTD_human |
| Tgene | NOS2 | C0009375 | Colonic Neoplasms | 2 | CTD_human |
| Tgene | NOS2 | C0010474 | Curling Ulcer | 2 | CTD_human |
| Tgene | NOS2 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
| Tgene | NOS2 | C0013295 | Duodenal Ulcer | 2 | CTD_human |
| Tgene | NOS2 | C0020429 | Hyperalgesia | 2 | CTD_human |
| Tgene | NOS2 | C0021368 | Inflammation | 2 | CTD_human |
| Tgene | NOS2 | C0024121 | Lung Neoplasms | 2 | CTD_human |
| Tgene | NOS2 | C0027051 | Myocardial Infarction | 2 | CTD_human |
| Tgene | NOS2 | C0027540 | Necrosis | 2 | CTD_human |
| Tgene | NOS2 | C0034189 | Pyemia | 2 | CTD_human |
| Tgene | NOS2 | C0036690 | Septicemia | 2 | CTD_human |
| Tgene | NOS2 | C0038433 | Streptozotocin Diabetes | 2 | CTD_human |
| Tgene | NOS2 | C0242379 | Malignant neoplasm of lung | 2 | CTD_human |
| Tgene | NOS2 | C0243026 | Sepsis | 2 | CTD_human |
| Tgene | NOS2 | C0458247 | Allodynia | 2 | CTD_human |
| Tgene | NOS2 | C0677050 | Manganese Poisoning | 2 | CTD_human |
| Tgene | NOS2 | C0751211 | Hyperalgesia, Primary | 2 | CTD_human |
| Tgene | NOS2 | C0751212 | Hyperalgesia, Secondary | 2 | CTD_human |
| Tgene | NOS2 | C0751213 | Tactile Allodynia | 2 | CTD_human |
| Tgene | NOS2 | C0751214 | Hyperalgesia, Thermal | 2 | CTD_human |
| Tgene | NOS2 | C0917798 | Cerebral Ischemia | 2 | CTD_human |
| Tgene | NOS2 | C1719672 | Severe Sepsis | 2 | CTD_human |
| Tgene | NOS2 | C2936719 | Mechanical Allodynia | 2 | CTD_human |
| Tgene | NOS2 | C0003510 | Aortitis Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C0003872 | Arthritis, Psoriatic | 1 | CTD_human |
| Tgene | NOS2 | C0003949 | Asbestosis | 1 | CTD_human |
| Tgene | NOS2 | C0004096 | Asthma | 1 | CTD_human |
| Tgene | NOS2 | C0004153 | Atherosclerosis | 1 | CTD_human |
| Tgene | NOS2 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | NOS2 | C0005398 | Cholestasis, Extrahepatic | 1 | CTD_human |
| Tgene | NOS2 | C0006114 | Cerebral Edema | 1 | CTD_human |
| Tgene | NOS2 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human;UNIPROT |
| Tgene | NOS2 | C0006261 | Bronchial Diseases | 1 | CTD_human |
| Tgene | NOS2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | NOS2 | C0008312 | Primary biliary cirrhosis | 1 | CTD_human |
| Tgene | NOS2 | C0008313 | Cholangitis, Sclerosing | 1 | CTD_human |
| Tgene | NOS2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Tgene | NOS2 | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
| Tgene | NOS2 | C0014476 | Eperythrozoonosis | 1 | CTD_human |
| Tgene | NOS2 | C0014518 | Toxic Epidermal Necrolysis | 1 | CTD_human |
| Tgene | NOS2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Tgene | NOS2 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
| Tgene | NOS2 | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | NOS2 | C0018802 | Congestive heart failure | 1 | CTD_human |
| Tgene | NOS2 | C0019209 | Hepatomegaly | 1 | CTD_human |
| Tgene | NOS2 | C0020452 | Hyperemia | 1 | CTD_human |
| Tgene | NOS2 | C0020672 | Hypothermia, natural | 1 | CTD_human |
| Tgene | NOS2 | C0021831 | Intestinal Diseases | 1 | CTD_human |
| Tgene | NOS2 | C0022333 | Jacksonian Seizure | 1 | CTD_human |
| Tgene | NOS2 | C0022658 | Kidney Diseases | 1 | CTD_human |
| Tgene | NOS2 | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
| Tgene | NOS2 | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
| Tgene | NOS2 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
| Tgene | NOS2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | NOS2 | C0023895 | Liver diseases | 1 | CTD_human |
| Tgene | NOS2 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
| Tgene | NOS2 | C0024796 | Marfan Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C0026936 | Mycoplasma Infections | 1 | CTD_human |
| Tgene | NOS2 | C0030246 | Pustulosis of Palms and Soles | 1 | CTD_human |
| Tgene | NOS2 | C0030569 | Secondary Parkinson Disease | 1 | CTD_human |
| Tgene | NOS2 | C0032290 | Aspiration Pneumonia | 1 | CTD_human |
| Tgene | NOS2 | C0033860 | Psoriasis | 1 | CTD_human |
| Tgene | NOS2 | C0035309 | Retinal Diseases | 1 | CTD_human |
| Tgene | NOS2 | C0036330 | Schistosomiasis mansoni | 1 | CTD_human |
| Tgene | NOS2 | C0036572 | Seizures | 1 | CTD_human |
| Tgene | NOS2 | C0036981 | Endotoxic shock | 1 | CTD_human |
| Tgene | NOS2 | C0036983 | Septic Shock | 1 | CTD_human |
| Tgene | NOS2 | C0037116 | Silicosis | 1 | CTD_human |
| Tgene | NOS2 | C0038220 | Status Epilepticus | 1 | CTD_human |
| Tgene | NOS2 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| Tgene | NOS2 | C0038525 | Subarachnoid Hemorrhage | 1 | CTD_human |
| Tgene | NOS2 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C0039263 | Takayasu Arteritis | 1 | CTD_human |
| Tgene | NOS2 | C0041408 | Turner Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C0041956 | Ureteral obstruction | 1 | CTD_human |
| Tgene | NOS2 | C0042029 | Urinary tract infection | 1 | CTD_human |
| Tgene | NOS2 | C0042484 | Venous Engorgement | 1 | CTD_human |
| Tgene | NOS2 | C0085740 | Mendelson Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C0086189 | Drug Withdrawal Symptoms | 1 | CTD_human |
| Tgene | NOS2 | C0086432 | Hyalinosis, Segmental Glomerular | 1 | CTD_human |
| Tgene | NOS2 | C0086565 | Liver Dysfunction | 1 | CTD_human |
| Tgene | NOS2 | C0087169 | Withdrawal Symptoms | 1 | CTD_human |
| Tgene | NOS2 | C0149958 | Complex partial seizures | 1 | CTD_human |
| Tgene | NOS2 | C0178540 | Cerebral Hypoxia-Ischemia | 1 | CTD_human |
| Tgene | NOS2 | C0178824 | Reactive Hyperemia | 1 | CTD_human |
| Tgene | NOS2 | C0206145 | Stunned Myocardium | 1 | CTD_human |
| Tgene | NOS2 | C0206146 | Myocardial Stunning | 1 | CTD_human |
| Tgene | NOS2 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
| Tgene | NOS2 | C0234533 | Generalized seizures | 1 | CTD_human |
| Tgene | NOS2 | C0234535 | Clonic Seizures | 1 | CTD_human |
| Tgene | NOS2 | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
| Tgene | NOS2 | C0238065 | Secondary Biliary Cholangitis | 1 | CTD_human |
| Tgene | NOS2 | C0242497 | Intestinal schistosomiasis | 1 | CTD_human |
| Tgene | NOS2 | C0242526 | Gonadal Dysgenesis, 45,X | 1 | CTD_human |
| Tgene | NOS2 | C0243050 | Cardiovascular Abnormalities | 1 | CTD_human |
| Tgene | NOS2 | C0270192 | Perinatal Subarachnoid Hemorrhage | 1 | CTD_human |
| Tgene | NOS2 | C0270823 | Petit mal status | 1 | CTD_human |
| Tgene | NOS2 | C0270824 | Visual seizure | 1 | CTD_human |
| Tgene | NOS2 | C0270844 | Tonic Seizures | 1 | CTD_human |
| Tgene | NOS2 | C0270846 | Epileptic drop attack | 1 | CTD_human |
| Tgene | NOS2 | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human |
| Tgene | NOS2 | C0333233 | Active Hyperemia | 1 | CTD_human |
| Tgene | NOS2 | C0345905 | Intrahepatic Cholangiocarcinoma | 1 | CTD_human |
| Tgene | NOS2 | C0376416 | Hibernation, Myocardial | 1 | CTD_human |
| Tgene | NOS2 | C0376618 | Endotoxemia | 1 | CTD_human |
| Tgene | NOS2 | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human |
| Tgene | NOS2 | C0422850 | Seizures, Somatosensory | 1 | CTD_human |
| Tgene | NOS2 | C0422852 | Seizures, Auditory | 1 | CTD_human |
| Tgene | NOS2 | C0422853 | Olfactory seizure | 1 | CTD_human |
| Tgene | NOS2 | C0422854 | Gustatory seizure | 1 | CTD_human |
| Tgene | NOS2 | C0422855 | Vertiginous seizure | 1 | CTD_human |
| Tgene | NOS2 | C0472383 | Subarachnoid Hemorrhage, Spontaneous | 1 | CTD_human |
| Tgene | NOS2 | C0472387 | Vasogenic Cerebral Edema | 1 | CTD_human |
| Tgene | NOS2 | C0472388 | Cytotoxic Cerebral Edema | 1 | CTD_human |
| Tgene | NOS2 | C0494475 | Tonic - clonic seizures | 1 | CTD_human |
| Tgene | NOS2 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
| Tgene | NOS2 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
| Tgene | NOS2 | C0566602 | Primary sclerosing cholangitis | 1 | CTD_human |
| Tgene | NOS2 | C0600327 | Toxic Shock Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Tgene | NOS2 | C0750969 | Vasogenic Brain Edema | 1 | CTD_human |
| Tgene | NOS2 | C0750970 | Cytotoxic Brain Edema | 1 | CTD_human |
| Tgene | NOS2 | C0751056 | Non-epileptic convulsion | 1 | CTD_human |
| Tgene | NOS2 | C0751110 | Single Seizure | 1 | CTD_human |
| Tgene | NOS2 | C0751123 | Atonic Absence Seizures | 1 | CTD_human |
| Tgene | NOS2 | C0751414 | Parkinson Disease, Secondary Vascular | 1 | CTD_human |
| Tgene | NOS2 | C0751415 | Atherosclerotic Parkinsonism | 1 | CTD_human |
| Tgene | NOS2 | C0751494 | Convulsive Seizures | 1 | CTD_human |
| Tgene | NOS2 | C0751495 | Seizures, Focal | 1 | CTD_human |
| Tgene | NOS2 | C0751496 | Seizures, Sensory | 1 | CTD_human |
| Tgene | NOS2 | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human |
| Tgene | NOS2 | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human |
| Tgene | NOS2 | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human |
| Tgene | NOS2 | C0751530 | Subarachnoid Hemorrhage, Aneurysmal | 1 | CTD_human |
| Tgene | NOS2 | C0751651 | Mitochondrial Diseases | 1 | CTD_human |
| Tgene | NOS2 | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
| Tgene | NOS2 | C0752304 | Hypoxic-Ischemic Encephalopathy | 1 | CTD_human |
| Tgene | NOS2 | C0752305 | Anoxic-Ischemic Encephalopathy | 1 | CTD_human |
| Tgene | NOS2 | C0752306 | Anoxia-Ischemia, Brain | 1 | CTD_human |
| Tgene | NOS2 | C0752307 | Anoxia-Ischemia, Cerebral | 1 | CTD_human |
| Tgene | NOS2 | C0752308 | Hypoxia-Ischemia, Brain | 1 | CTD_human |
| Tgene | NOS2 | C0795688 | Subarachnoid Hemorrhage, Intracranial | 1 | CTD_human |
| Tgene | NOS2 | C0949855 | Electron Transport Chain Deficiencies, Mitochondrial | 1 | CTD_human |
| Tgene | NOS2 | C0949856 | Oxidative Phosphorylation Deficiencies | 1 | CTD_human |
| Tgene | NOS2 | C0949857 | Mitochondrial Respiratory Chain Deficiencies | 1 | CTD_human |
| Tgene | NOS2 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Tgene | NOS2 | C1274933 | Drug-Induced Stevens Johnson Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C1306571 | Hepatic Insufficiency | 1 | CTD_human |
| Tgene | NOS2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | NOS2 | C1527168 | Bonnevie-Ullrich Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C1527303 | Chronic Airflow Obstruction | 1 | CTD_human |
| Tgene | NOS2 | C1527311 | Brain Edema | 1 | CTD_human |
| Tgene | NOS2 | C1563937 | Atherogenesis | 1 | CTD_human |
| Tgene | NOS2 | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
| Tgene | NOS2 | C1959583 | Myocardial Failure | 1 | CTD_human |
| Tgene | NOS2 | C1961112 | Heart Decompensation | 1 | CTD_human |
| Tgene | NOS2 | C2609414 | Acute kidney injury | 1 | CTD_human |
| Tgene | NOS2 | C2930617 | Pulmonary Fibrosis - from Asbestos Exposure | 1 | CTD_human |
| Tgene | NOS2 | C3495874 | Nonepileptic Seizures | 1 | CTD_human |
| Tgene | NOS2 | C3658301 | Mycoplasma-Induced Stevens-Johnson Syndrome | 1 | CTD_human |
| Tgene | NOS2 | C3658302 | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | 1 | CTD_human |
| Tgene | NOS2 | C3805278 | Extrahepatic Cholangiocarcinoma | 1 | CTD_human |
| Tgene | NOS2 | C4048158 | Convulsions | 1 | CTD_human |
| Tgene | NOS2 | C4316903 | Absence Seizures | 1 | CTD_human |
| Tgene | NOS2 | C4317109 | Epileptic Seizures | 1 | CTD_human |
| Tgene | NOS2 | C4317123 | Myoclonic Seizures | 1 | CTD_human |
| Tgene | NOS2 | C4505436 | Generalized Absence Seizures | 1 | CTD_human |
| Tgene | NOS2 | C4551595 | Biliary Cirrhosis, Primary, 1 | 1 | CTD_human |
| Tgene | NOS2 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Tgene | NOS2 | C4721845 | Marfan Syndrome, Type I | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies