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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:STAT3-RAB5C (FusionGDB2 ID:86647)

Fusion Gene Summary for STAT3-RAB5C

Fusion gene summary

Fusion gene information	Fusion gene name: STAT3-RAB5C
	Fusion gene ID: 86647
		Hgene	Tgene
	Gene symbol	STAT3	RAB5C
	Gene ID	6774	5878
	Gene name	signal transducer and activator of transcription 3	RAB5C, member RAS oncogene family
	Synonyms	ADMIO\|ADMIO1\|APRF\|HIES	L1880\|RAB5CL\|RAB5L\|RABL
	Cytomap	17q21.2	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor	ras-related protein Rab-5CRAB5C, member of RAS oncogene family
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000264657, ENST00000585517, ENST00000389272, ENST00000588969, ENST00000404395, ENST00000590776,	ENST00000346213, ENST00000393860, ENST00000547517,
Fusion gene scores	* DoF score	18 X 20 X 10=3600	8 X 7 X 6=336
	# samples	23	10
	** MAII score	log2(23/3600*10)=-3.96829114027266 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STAT3 [Title/Abstract] AND RAB5C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	STAT3(40475022)-RAB5C(40278866), # samples:1
Anticipated loss of major functional domain due to fusion event.	STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. STAT3-RAB5C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STAT3	GO:0006355	regulation of transcription, DNA-templated	15664994\|17344214
Hgene	STAT3	GO:0006606	protein import into nucleus	18234692
Hgene	STAT3	GO:0010507	negative regulation of autophagy	26962683
Hgene	STAT3	GO:0010628	positive regulation of gene expression	23820254
Hgene	STAT3	GO:0030522	intracellular receptor signaling pathway	17324931
Hgene	STAT3	GO:0032355	response to estradiol	12552091
Hgene	STAT3	GO:0032870	cellular response to hormone stimulus	12552091
Hgene	STAT3	GO:0033210	leptin-mediated signaling pathway	17344214
Hgene	STAT3	GO:0035278	miRNA mediated inhibition of translation	23820254
Hgene	STAT3	GO:0044320	cellular response to leptin stimulus	17344214
Hgene	STAT3	GO:0044321	response to leptin	17344214
Hgene	STAT3	GO:0045893	positive regulation of transcription, DNA-templated	19390056
Hgene	STAT3	GO:0045944	positive regulation of transcription by RNA polymerase II	17324931\|27050391\|31462771
Hgene	STAT3	GO:0051726	regulation of cell cycle	17344214
Hgene	STAT3	GO:0060396	growth hormone receptor signaling pathway	10925297
Hgene	STAT3	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	12552091
Hgene	STAT3	GO:0070102	interleukin-6-mediated signaling pathway	12359225\|12552091\|17324931\|24429361
Hgene	STAT3	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	19390056\|23820254
Hgene	STAT3	GO:2000637	positive regulation of gene silencing by miRNA	23820254

Fusion gene breakpoints across STAT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAB5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7820	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-

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Fusion Gene ORF analysis for STAT3-RAB5C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000264657	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
In-frame	ENST00000264657	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
In-frame	ENST00000264657	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
In-frame	ENST00000585517	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
In-frame	ENST00000585517	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
In-frame	ENST00000585517	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000389272	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000389272	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000389272	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000588969	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000588969	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000588969	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000404395	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000404395	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
Frame-shift	ENST00000404395	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
intron-3CDS	ENST00000590776	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
intron-3CDS	ENST00000590776	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-
intron-3CDS	ENST00000590776	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264657	STAT3	chr17	40475022	-	ENST00000346213	RAB5C	chr17	40278866	-	3218	2201	313	2298	661
ENST00000264657	STAT3	chr17	40475022	-	ENST00000393860	RAB5C	chr17	40278866	-	3214	2201	313	2298	661
ENST00000264657	STAT3	chr17	40475022	-	ENST00000547517	RAB5C	chr17	40278866	-	2527	2201	313	2298	661
ENST00000585517	STAT3	chr17	40475022	-	ENST00000346213	RAB5C	chr17	40278866	-	3070	2053	30	2150	706
ENST00000585517	STAT3	chr17	40475022	-	ENST00000393860	RAB5C	chr17	40278866	-	3066	2053	30	2150	706
ENST00000585517	STAT3	chr17	40475022	-	ENST00000547517	RAB5C	chr17	40278866	-	2379	2053	30	2150	706

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264657	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020193728	0.97980624
ENST00000264657	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020207101	0.97979295
ENST00000264657	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020764273	0.9792357
ENST00000585517	ENST00000346213	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020494651	0.9795053
ENST00000585517	ENST00000393860	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.020526294	0.97947377
ENST00000585517	ENST00000547517	STAT3	chr17	40475022	-	RAB5C	chr17	40278866	-	0.021547657	0.9784524

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Fusion Genomic Features for STAT3-RAB5C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STAT3-RAB5C

Go to
FGviewer for the breakpoints of chr17:40475022-chr17:40278866
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000264657

150_162

629.3333333333334

771.0

Motif

Note=Essential for nuclear import

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000404395

150_162

629.3333333333334

770.0

Motif

Note=Essential for nuclear import

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000588969

150_162

629.3333333333334

771.0

Motif

Note=Essential for nuclear import

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

164_166

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

164_166

147.0

217.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000264657

580_670

629.3333333333334

771.0

Domain

SH2

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000404395

580_670

629.3333333333334

770.0

Domain

SH2

Hgene

STAT3

chr17:40475022

chr17:40278866

ENST00000588969

580_670

629.3333333333334

771.0

Domain

SH2

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

50_58

147.0

217.0

Motif

Effector region

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

50_58

147.0

217.0

Motif

Effector region

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

50_58

180.0

250.0

Motif

Effector region

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

134_137

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

28_36

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

47_53

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000346213

76_80

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

134_137

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

28_36

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

47_53

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000393860

76_80

147.0

217.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

134_137

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

164_166

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

28_36

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

47_53

180.0

250.0

Nucleotide binding

GTP

Tgene

RAB5C

chr17:40475022

chr17:40278866

ENST00000547517

76_80

180.0

250.0

Nucleotide binding

GTP

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Fusion Gene Sequence for STAT3-RAB5C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000264657_ENST00000346213_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(transcript)=3218nt_BP=2201nt
GAATTATGCATGACGGCGTGCCTCGGCCAGGCTGGGGCTGGGCGAGGATTGGCTGAAGGGGCTGTAATTCAGCGGTTTCCGGAGCTGCGG
CGGCGCAGACTGGGAGGGGGAGCCGGGGGTTCCGACGTCGCAGCCGAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTG
GCGCTGTCTCTCCCCCTCGGCTCGGAGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTC
GGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGGATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGA
GCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGGCATATGC
GGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAA
TGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGC
CCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGT
GGTGACGGAGAAGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAGAAAATGAAAGTGGTAGA
GAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGAC
CAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTC
AGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCC
CAACATCTGCCTAGATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAAATTAAGAAACTGGAGGA
GTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAAACTT
AATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAGACCGGCGTCCAGTTCAC
TACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGC
AGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAACAACGGCAGCCTCTCTGC
AGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCT
GCACCTGATCACCTTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCAGTTGTGGTGATCTCCAA
CATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAACAATCCCAAGAATGTAAACTTTTTTACCAAGCC
CCCAATTGGAACCTGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTGAGCATCGAGCAGCTGAC
TACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACATGGGCTAAATTTTGCAAAGAAAACATGGCTGG
CAAGGGCTTCTCCTTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACGAAGGGTACATCAT
GGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTTCCTGCTAAGATTCAGTGAAAGCAGCAAAGA
AGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGAAGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACAT
CAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTC
CAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGC
TGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGG
GGAGGGGTCCACCATGATTTCTCCATATAATTTTGATCATAGGCCGGAGTGAGTCATTCCACCTGCACCTTTCTGTACAAATACTAATTC
AATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCTGCTCTTCCCACTTCCTCCCCTTTCTACTGCTCTCCCATTTTCCCTTG
CTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCTTGTATATGGGGACAGTGGGGTCAGTGCAGCTACCCTTTCTTTCCCTCCTGCGGAA
CAGCGGACCCAGCAAGAGCATCCACATCCTCACTTTGTTCGGAGTGGTCTTTGGTTTGGGCGGTGGGGCAGACCTTGGGAAGGGGCTTAG
GAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTCATCAGGCTGCAGCCCCCTCCCCGCTCCCACCTCCCTGCTGGGAAACCACAGCATT
ATCACAGCATTATTGTGACAGCCACGAACCCATTGCCCACAACCCCTCCACCCTCGGTCACCCCAACCTCTGGCTCTGAGCCCTGTTCTG
ACCAAATCATGATGATGAGTATTTGGGGGTGGGTGGGTAAGGGGGGGAGTGGGAGGGGACGGAACCAACTTTTTCTGTATTTTGTATTGT

>In-frame_ENST00000264657_ENST00000346213_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(amino acids)=661AA_start in transcript=313_stop in transcript=2298
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFL
QSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSL
AESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISG

--------------------------------------------------------------
>In-frame_ENST00000264657_ENST00000393860_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(transcript)=3214nt_BP=2201nt
GAATTATGCATGACGGCGTGCCTCGGCCAGGCTGGGGCTGGGCGAGGATTGGCTGAAGGGGCTGTAATTCAGCGGTTTCCGGAGCTGCGG
CGGCGCAGACTGGGAGGGGGAGCCGGGGGTTCCGACGTCGCAGCCGAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTG
GCGCTGTCTCTCCCCCTCGGCTCGGAGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTC
GGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGGATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGA
GCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGGCATATGC
GGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAA
TGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGC
CCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGT
GGTGACGGAGAAGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAGAAAATGAAAGTGGTAGA
GAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGAC
CAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTC
AGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCC
CAACATCTGCCTAGATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAAATTAAGAAACTGGAGGA
GTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAAACTT
AATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAGACCGGCGTCCAGTTCAC
TACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGC
AGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAACAACGGCAGCCTCTCTGC
AGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCT
GCACCTGATCACCTTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCAGTTGTGGTGATCTCCAA
CATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAACAATCCCAAGAATGTAAACTTTTTTACCAAGCC
CCCAATTGGAACCTGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTGAGCATCGAGCAGCTGAC
TACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACATGGGCTAAATTTTGCAAAGAAAACATGGCTGG
CAAGGGCTTCTCCTTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACGAAGGGTACATCAT
GGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTTCCTGCTAAGATTCAGTGAAAGCAGCAAAGA
AGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGAAGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACAT
CAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTC
CAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGC
TGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGG
GGAGGGGTCCACCATGATTTCTCCATATAATTTTGATCATAGGCCGGAGTGAGTCATTCCACCTGCACCTTTCTGTACAAATACTAATTC
AATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCTGCTCTTCCCACTTCCTCCCCTTTCTACTGCTCTCCCATTTTCCCTTG
CTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCTTGTATATGGGGACAGTGGGGTCAGTGCAGCTACCCTTTCTTTCCCTCCTGCGGAA
CAGCGGACCCAGCAAGAGCATCCACATCCTCACTTTGTTCGGAGTGGTCTTTGGTTTGGGCGGTGGGGCAGACCTTGGGAAGGGGCTTAG
GAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTCATCAGGCTGCAGCCCCCTCCCCGCTCCCACCTCCCTGCTGGGAAACCACAGCATT
ATCACAGCATTATTGTGACAGCCACGAACCCATTGCCCACAACCCCTCCACCCTCGGTCACCCCAACCTCTGGCTCTGAGCCCTGTTCTG
ACCAAATCATGATGATGAGTATTTGGGGGTGGGTGGGTAAGGGGGGGAGTGGGAGGGGACGGAACCAACTTTTTCTGTATTTTGTATTGT

>In-frame_ENST00000264657_ENST00000393860_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(amino acids)=661AA_start in transcript=313_stop in transcript=2298
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFL
QSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSL
AESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISG

--------------------------------------------------------------
>In-frame_ENST00000264657_ENST00000547517_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(transcript)=2527nt_BP=2201nt
GAATTATGCATGACGGCGTGCCTCGGCCAGGCTGGGGCTGGGCGAGGATTGGCTGAAGGGGCTGTAATTCAGCGGTTTCCGGAGCTGCGG
CGGCGCAGACTGGGAGGGGGAGCCGGGGGTTCCGACGTCGCAGCCGAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTG
GCGCTGTCTCTCCCCCTCGGCTCGGAGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTC
GGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGGATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGA
GCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGGCATATGC
GGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAA
TGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGC
CCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGT
GGTGACGGAGAAGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAGAAAATGAAAGTGGTAGA
GAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGAC
CAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTC
AGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCC
CAACATCTGCCTAGATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAAATTAAGAAACTGGAGGA
GTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAAACTT
AATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAGACCGGCGTCCAGTTCAC
TACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGC
AGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAACAACGGCAGCCTCTCTGC
AGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCT
GCACCTGATCACCTTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCAGTTGTGGTGATCTCCAA
CATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAACAATCCCAAGAATGTAAACTTTTTTACCAAGCC
CCCAATTGGAACCTGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTGAGCATCGAGCAGCTGAC
TACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACATGGGCTAAATTTTGCAAAGAAAACATGGCTGG
CAAGGGCTTCTCCTTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACGAAGGGTACATCAT
GGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTTCCTGCTAAGATTCAGTGAAAGCAGCAAAGA
AGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGAAGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACAT
CAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTC
CAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGC
TGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGG

>In-frame_ENST00000264657_ENST00000547517_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(amino acids)=661AA_start in transcript=313_stop in transcript=2298
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFL
QSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSL
AESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISG

--------------------------------------------------------------
>In-frame_ENST00000585517_ENST00000346213_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(transcript)=3070nt_BP=2053nt
GCAGCCGAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTCGGAGAGGCCCTTCGGC
CTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTCGGCCTCTGCCGGAGAAACAGCAGGATGGCCCAATGGAAT
CAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCC
CCTTGGATTGAGAGTCAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGAC
CAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTT
GAGAAGCCAATGGAGATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAA
GGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTG
CAGGATCTAGAACAGAAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATG
CAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGA
AGCATCGTGAGTGAGCTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGG
CGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTAGATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTT
CAGACCCGTCAACAAATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTG
GAGGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGG
CCCCTCGTCATCAAGACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAA
GTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAAC
ATGGAAGAATCCAACAACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAAT
TGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACCTTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAG
ACCCACTCCTTGCCAGTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAAC
AATCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACC
ACCAAGCGAGGACTGAGCATCGAGCAGCTGACTACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACA
TGGGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCCTTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTAC
ATCCTGGCCCTTTGGAACGAAGGGTACATCATGGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACC
TTCCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGAAGCACAAGCCTATGC
AGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAATAGCTAAGAAGCTTCC
CAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGCCAGCCGGAGCCAGTG
CTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAACCAATCGCACT
TAACGACTCGGGCCACCACTGGGGGGGCAGGGGGAGGGGTCCACCATGATTTCTCCATATAATTTTGATCATAGGCCGGAGTGAGTCATT
CCACCTGCACCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCTGCTCTTCCCACTTCC
TCCCCTTTCTACTGCTCTCCCATTTTCCCTTGCTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCTTGTATATGGGGACAGTGGGGTCA
GTGCAGCTACCCTTTCTTTCCCTCCTGCGGAACAGCGGACCCAGCAAGAGCATCCACATCCTCACTTTGTTCGGAGTGGTCTTTGGTTTG
GGCGGTGGGGCAGACCTTGGGAAGGGGCTTAGGAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTCATCAGGCTGCAGCCCCCTCCCCG
CTCCCACCTCCCTGCTGGGAAACCACAGCATTATCACAGCATTATTGTGACAGCCACGAACCCATTGCCCACAACCCCTCCACCCTCGGT
CACCCCAACCTCTGGCTCTGAGCCCTGTTCTGACCAAATCATGATGATGAGTATTTGGGGGTGGGTGGGTAAGGGGGGGAGTGGGAGGGG
ACGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTATCTTGTCAATATAGTCAGCCGATCGATC

>In-frame_ENST00000585517_ENST00000346213_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(amino acids)=706AA_start in transcript=30_stop in transcript=2150
MDRHPGLALSLPLGSERPFGLREPRRPSPAHAQPRPLGLCRRNSRMAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAY
AASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAA
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLL
SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRN
LMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLS
AEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTK
PPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYI

--------------------------------------------------------------
>In-frame_ENST00000585517_ENST00000393860_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(transcript)=3066nt_BP=2053nt
GCAGCCGAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTCGGAGAGGCCCTTCGGC
CTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTCGGCCTCTGCCGGAGAAACAGCAGGATGGCCCAATGGAAT
CAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCC
CCTTGGATTGAGAGTCAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGAC
CAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTT
GAGAAGCCAATGGAGATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAA
GGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTG
CAGGATCTAGAACAGAAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATG
CAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGA
AGCATCGTGAGTGAGCTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGG
CGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTAGATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTT
CAGACCCGTCAACAAATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTG
GAGGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGG
CCCCTCGTCATCAAGACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAA
GTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAAC
ATGGAAGAATCCAACAACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAAT
TGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACCTTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAG
ACCCACTCCTTGCCAGTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAAC
AATCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACC
ACCAAGCGAGGACTGAGCATCGAGCAGCTGACTACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACA
TGGGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCCTTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTAC
ATCCTGGCCCTTTGGAACGAAGGGTACATCATGGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACC
TTCCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGAAGCACAAGCCTATGC
AGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAATAGCTAAGAAGCTTCC
CAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGCCAGCCGGAGCCAGTG
CTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAACCAATCGCACT
TAACGACTCGGGCCACCACTGGGGGGGCAGGGGGAGGGGTCCACCATGATTTCTCCATATAATTTTGATCATAGGCCGGAGTGAGTCATT
CCACCTGCACCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCTGCTCTTCCCACTTCC
TCCCCTTTCTACTGCTCTCCCATTTTCCCTTGCTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCTTGTATATGGGGACAGTGGGGTCA
GTGCAGCTACCCTTTCTTTCCCTCCTGCGGAACAGCGGACCCAGCAAGAGCATCCACATCCTCACTTTGTTCGGAGTGGTCTTTGGTTTG
GGCGGTGGGGCAGACCTTGGGAAGGGGCTTAGGAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTCATCAGGCTGCAGCCCCCTCCCCG
CTCCCACCTCCCTGCTGGGAAACCACAGCATTATCACAGCATTATTGTGACAGCCACGAACCCATTGCCCACAACCCCTCCACCCTCGGT
CACCCCAACCTCTGGCTCTGAGCCCTGTTCTGACCAAATCATGATGATGAGTATTTGGGGGTGGGTGGGTAAGGGGGGGAGTGGGAGGGG
ACGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTATCTTGTCAATATAGTCAGCCGATCGATC

>In-frame_ENST00000585517_ENST00000393860_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(amino acids)=706AA_start in transcript=30_stop in transcript=2150
MDRHPGLALSLPLGSERPFGLREPRRPSPAHAQPRPLGLCRRNSRMAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAY
AASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAA
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLL
SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRN
LMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLS
AEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTK
PPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYI

--------------------------------------------------------------
>In-frame_ENST00000585517_ENST00000547517_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(transcript)=2379nt_BP=2053nt
GCAGCCGAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTCGGAGAGGCCCTTCGGC
CTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTCGGCCTCTGCCGGAGAAACAGCAGGATGGCCCAATGGAAT
CAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCC
CCTTGGATTGAGAGTCAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGAC
CAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTT
GAGAAGCCAATGGAGATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAA
GGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTG
CAGGATCTAGAACAGAAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATG
CAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGA
AGCATCGTGAGTGAGCTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGG
CGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTAGATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTT
CAGACCCGTCAACAAATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTG
GAGGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCCTTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGG
CCCCTCGTCATCAAGACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAA
GTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGATCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAAC
ATGGAAGAATCCAACAACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAAT
TGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACCTTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAG
ACCCACTCCTTGCCAGTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAAC
AATCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACC
ACCAAGCGAGGACTGAGCATCGAGCAGCTGACTACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACA
TGGGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCCTTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTAC
ATCCTGGCCCTTTGGAACGAAGGGTACATCATGGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACC
TTCCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAAGGACATCAGCGGAAGCACAAGCCTATGC
AGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAATAGCTAAGAAGCTTCC
CAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGCCAGCCGGAGCCAGTG
CTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAACCAATCGCACT

>In-frame_ENST00000585517_ENST00000547517_TCGA-HC-7820_STAT3_chr17_40475022_-_RAB5C_chr17_40278866_length(amino acids)=706AA_start in transcript=30_stop in transcript=2150
MDRHPGLALSLPLGSERPFGLREPRRPSPAHAQPRPLGLCRRNSRMAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAY
AASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAA
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLL
SAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRN
LMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLS
AEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTK
PPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for STAT3-RAB5C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for STAT3-RAB5C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for STAT3-RAB5C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	STAT3	C4721531	HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT	7	GENOMICS_ENGLAND;UNIPROT
Hgene	STAT3	C0018800	Cardiomegaly	3	CTD_human
Hgene	STAT3	C0021368	Inflammation	3	CTD_human
Hgene	STAT3	C0033578	Prostatic Neoplasms	3	CTD_human
Hgene	STAT3	C0376358	Malignant neoplasm of prostate	3	CTD_human
Hgene	STAT3	C1383860	Cardiac Hypertrophy	3	CTD_human
Hgene	STAT3	C2936739	Hyper-Immunoglobulin E Syndrome, Autosomal Dominant	3	CTD_human;ORPHANET
Hgene	STAT3	C3887645	Job Syndrome	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	STAT3	C4014795	AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	STAT3	C0001418	Adenocarcinoma	2	CTD_human
Hgene	STAT3	C0003865	Arthritis, Adjuvant-Induced	2	CTD_human
Hgene	STAT3	C0007137	Squamous cell carcinoma	2	CTD_human
Hgene	STAT3	C0009324	Ulcerative Colitis	2	CTD_human
Hgene	STAT3	C0019207	Hepatoma, Morris	2	CTD_human
Hgene	STAT3	C0019208	Hepatoma, Novikoff	2	CTD_human
Hgene	STAT3	C0023904	Liver Neoplasms, Experimental	2	CTD_human
Hgene	STAT3	C0027627	Neoplasm Metastasis	2	CTD_human
Hgene	STAT3	C0030297	Pancreatic Neoplasm	2	CTD_human
Hgene	STAT3	C0033141	Cardiomyopathies, Primary	2	CTD_human
Hgene	STAT3	C0036529	Myocardial Diseases, Secondary	2	CTD_human
Hgene	STAT3	C0086404	Experimental Hepatoma	2	CTD_human
Hgene	STAT3	C0205641	Adenocarcinoma, Basal Cell	2	CTD_human
Hgene	STAT3	C0205642	Adenocarcinoma, Oxyphilic	2	CTD_human
Hgene	STAT3	C0205643	Carcinoma, Cribriform	2	CTD_human
Hgene	STAT3	C0205644	Carcinoma, Granular Cell	2	CTD_human
Hgene	STAT3	C0205645	Adenocarcinoma, Tubular	2	CTD_human
Hgene	STAT3	C0346647	Malignant neoplasm of pancreas	2	CTD_human
Hgene	STAT3	C0878544	Cardiomyopathies	2	CTD_human
Hgene	STAT3	C0971858	Arthritis, Collagen-Induced	2	CTD_human
Hgene	STAT3	C0993582	Arthritis, Experimental	2	CTD_human
Hgene	STAT3	C1955861	T-Cell Large Granular Lymphocyte Leukemia	2	CGI;ORPHANET
Hgene	STAT3	C2930809	Neutropenia and hyperlymphocytosis with large granular lymphocytes	2	ORPHANET
Hgene	STAT3	C3489795	Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant	2	CTD_human;ORPHANET
Hgene	STAT3	C0004153	Atherosclerosis	1	CTD_human
Hgene	STAT3	C0004364	Autoimmune Diseases	1	CTD_human
Hgene	STAT3	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	STAT3	C0007097	Carcinoma	1	CTD_human
Hgene	STAT3	C0007102	Malignant tumor of colon	1	CTD_human
Hgene	STAT3	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Hgene	STAT3	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	STAT3	C0007786	Brain Ischemia	1	CTD_human
Hgene	STAT3	C0007873	Uterine Cervical Neoplasm	1	CTD_human
Hgene	STAT3	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	STAT3	C0011581	Depressive disorder	1	PSYGENET
Hgene	STAT3	C0011854	Diabetes Mellitus, Insulin-Dependent	1	CTD_human
Hgene	STAT3	C0015967	Fever	1	CTD_human
Hgene	STAT3	C0016059	Fibrosis	1	CTD_human
Hgene	STAT3	C0019189	Hepatitis, Chronic	1	CTD_human
Hgene	STAT3	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
Hgene	STAT3	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1	CTD_human
Hgene	STAT3	C0023487	Acute Promyelocytic Leukemia	1	ORPHANET
Hgene	STAT3	C0023492	Leukemia, T-Cell	1	CTD_human
Hgene	STAT3	C0023493	Adult T-Cell Lymphoma/Leukemia	1	CTD_human
Hgene	STAT3	C0023903	Liver neoplasms	1	CTD_human
Hgene	STAT3	C0024232	Lymphatic Metastasis	1	CTD_human
Hgene	STAT3	C0024623	Malignant neoplasm of stomach	1	CTD_human
Hgene	STAT3	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	STAT3	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	STAT3	C0025149	Medulloblastoma	1	CTD_human
Hgene	STAT3	C0025261	Memory Disorders	1	CTD_human
Hgene	STAT3	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Hgene	STAT3	C0027659	Neoplasms, Experimental	1	CTD_human
Hgene	STAT3	C0030246	Pustulosis of Palms and Soles	1	CTD_human
Hgene	STAT3	C0032927	Precancerous Conditions	1	CTD_human
Hgene	STAT3	C0033860	Psoriasis	1	CTD_human
Hgene	STAT3	C0034069	Pulmonary Fibrosis	1	CTD_human
Hgene	STAT3	C0035126	Reperfusion Injury	1	CTD_human
Hgene	STAT3	C0038356	Stomach Neoplasms	1	CTD_human
Hgene	STAT3	C0079772	T-Cell Lymphoma	1	CTD_human
Hgene	STAT3	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	STAT3	C0149519	Chronic Persistent Hepatitis	1	CTD_human
Hgene	STAT3	C0158981	Neonatal diabetes mellitus	1	GENOMICS_ENGLAND
Hgene	STAT3	C0205696	Anaplastic carcinoma	1	CTD_human
Hgene	STAT3	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Hgene	STAT3	C0205698	Undifferentiated carcinoma	1	CTD_human
Hgene	STAT3	C0205699	Carcinomatosis	1	CTD_human
Hgene	STAT3	C0205734	Diabetes, Autoimmune	1	CTD_human
Hgene	STAT3	C0205833	Medullomyoblastoma	1	CTD_human
Hgene	STAT3	C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	1	CTD_human
Hgene	STAT3	C0233794	Memory impairment	1	CTD_human
Hgene	STAT3	C0235833	Congenital diaphragmatic hernia	1	CTD_human
Hgene	STAT3	C0238281	Middle Cerebral Artery Syndrome	1	CTD_human
Hgene	STAT3	C0265699	Congenital hernia of foramen of Morgagni	1	CTD_human
Hgene	STAT3	C0265700	Congenital hernia of foramen of Bochdalek	1	CTD_human
Hgene	STAT3	C0278510	Childhood Medulloblastoma	1	CTD_human
Hgene	STAT3	C0278876	Adult Medulloblastoma	1	CTD_human
Hgene	STAT3	C0282313	Condition, Preneoplastic	1	CTD_human
Hgene	STAT3	C0333641	Atrophic	1	CTD_human
Hgene	STAT3	C0342302	Brittle diabetes	1	CTD_human
Hgene	STAT3	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	STAT3	C0520463	Chronic active hepatitis	1	CTD_human
Hgene	STAT3	C0524611	Cryptogenic Chronic Hepatitis	1	CTD_human
Hgene	STAT3	C0678222	Breast Carcinoma	1	CTD_human
Hgene	STAT3	C0740376	Middle Cerebral Artery Thrombosis	1	CTD_human
Hgene	STAT3	C0740391	Middle Cerebral Artery Occlusion	1	CTD_human
Hgene	STAT3	C0740392	Infarction, Middle Cerebral Artery	1	CTD_human
Hgene	STAT3	C0751291	Desmoplastic Medulloblastoma	1	CTD_human
Hgene	STAT3	C0751292	Age-Related Memory Disorders	1	CTD_human
Hgene	STAT3	C0751293	Memory Disorder, Semantic	1	CTD_human
Hgene	STAT3	C0751294	Memory Disorder, Spatial	1	CTD_human
Hgene	STAT3	C0751295	Memory Loss	1	CTD_human
Hgene	STAT3	C0751845	Middle Cerebral Artery Embolus	1	CTD_human
Hgene	STAT3	C0751846	Left Middle Cerebral Artery Infarction	1	CTD_human
Hgene	STAT3	C0751847	Embolic Infarction, Middle Cerebral Artery	1	CTD_human
Hgene	STAT3	C0751848	Thrombotic Infarction, Middle Cerebral Artery	1	CTD_human
Hgene	STAT3	C0751849	Right Middle Cerebral Artery Infarction	1	CTD_human
Hgene	STAT3	C0917798	Cerebral Ischemia	1	CTD_human
Hgene	STAT3	C0919267	ovarian neoplasm	1	CTD_human
Hgene	STAT3	C1140680	Malignant neoplasm of ovary	1	CTD_human
Hgene	STAT3	C1168401	Squamous cell carcinoma of the head and neck	1	CTD_human
Hgene	STAT3	C1257925	Mammary Carcinoma, Animal	1	CTD_human
Hgene	STAT3	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	STAT3	C1275668	Melanotic medulloblastoma	1	CTD_human
Hgene	STAT3	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	STAT3	C1512709	Chronic Lymphoproliferative Disorder of NK-Cells	1	ORPHANET
Hgene	STAT3	C1563937	Atherogenesis	1	CTD_human
Hgene	STAT3	C1623038	Cirrhosis	1	CTD_human
Hgene	STAT3	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Hgene	STAT3	C1800706	Idiopathic Pulmonary Fibrosis	1	CTD_human
Hgene	STAT3	C1833104	DIABETES MELLITUS, PERMANENT NEONATAL	1	ORPHANET
Hgene	STAT3	C1876165	Copper-Overload Cirrhosis	1	CTD_human
Hgene	STAT3	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Hgene	STAT3	C1968689	Hyper-Immunoglobulin E Syndrome, Autosomal Recessive	1	CTD_human
Hgene	STAT3	C3495559	Juvenile arthritis	1	CTD_human
Hgene	STAT3	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	STAT3	C3837958	Diabetes Mellitus, Ketosis-Prone	1	CTD_human
Hgene	STAT3	C4048328	cervical cancer	1	CTD_human
Hgene	STAT3	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	STAT3	C4554117	Diabetes Mellitus, Sudden-Onset	1	CTD_human
Hgene	STAT3	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Hgene	STAT3	C4704874	Mammary Carcinoma, Human	1	CTD_human
Hgene	STAT3	C4721507	Alveolitis, Fibrosing	1	CTD_human
Hgene	STAT3	C4721508	Hamman-Rich Disease	1	CTD_human
Hgene	STAT3	C4721509	Usual Interstitial Pneumonia	1	CTD_human
Hgene	STAT3	C4721952	Familial Idiopathic Pulmonary Fibrosis	1	CTD_human