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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STAU2-LRRC39 (FusionGDB2 ID:86727)

Fusion Gene Summary for STAU2-LRRC39

check button Fusion gene summary
Fusion gene informationFusion gene name: STAU2-LRRC39
Fusion gene ID: 86727
HgeneTgene
Gene symbol

STAU2

LRRC39

Gene ID

27067

127495

Gene namestaufen double-stranded RNA binding protein 2leucine rich repeat containing 39
Synonyms39K2|39K3-
Cytomap

8q21.11

1p21.2

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2leucine-rich repeat-containing protein 39densin hlgmyomaspmyosin-interacting M-band-associated stress-responsive protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000522695, ENST00000524300, 
ENST00000523558, ENST00000521210, 
ENST00000355780, ENST00000519961, 
ENST00000521727, ENST00000521451, 
ENST00000522509, ENST00000517542, 
ENST00000524104, ENST00000522962, 
ENST00000521419, 		ENST00000342895, 
ENST00000370138, ENST00000370137, 
Fusion gene scores* DoF score26 X 20 X 13=67603 X 4 X 2=24
# samples 344
** MAII scorelog2(34/6760*10)=-4.31341659503185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STAU2 [Title/Abstract] AND LRRC39 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTAU2(74585342)-LRRC39(100614653), # samples:1
Anticipated loss of major functional domain due to fusion event.STAU2-LRRC39 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across STAU2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LRRC39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315367STAU2chr8

74585342

-LRRC39chr1

100614653

-


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Fusion Gene ORF analysis for STAU2-LRRC39

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000522695ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000522695ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000522695ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
In-frameENST00000524300ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000524300ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000524300ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
intron-3CDSENST00000523558ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
intron-3UTRENST00000523558ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
intron-3UTRENST00000523558ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
Frame-shiftENST00000521210ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000521210ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000521210ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
In-frameENST00000355780ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000355780ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000355780ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
Frame-shiftENST00000519961ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000519961ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000519961ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
Frame-shiftENST00000521727ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000521727ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000521727ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
intron-3CDSENST00000521451ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
intron-3UTRENST00000521451ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
intron-3UTRENST00000521451ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
In-frameENST00000522509ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000522509ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000522509ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
Frame-shiftENST00000517542ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000517542ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000517542ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
In-frameENST00000524104ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000524104ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000524104ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
5UTR-3CDSENST00000522962ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5UTR-3UTRENST00000522962ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5UTR-3UTRENST00000522962ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-
In-frameENST00000521419ENST00000342895STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000521419ENST00000370138STAU2chr8

74585342

-LRRC39chr1

100614653

-
5CDS-3UTRENST00000521419ENST00000370137STAU2chr8

74585342

-LRRC39chr1

100614653

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000524300STAU2chr874585342-ENST00000342895LRRC39chr1100614653-1006761351821156
ENST00000355780STAU2chr874585342-ENST00000342895LRRC39chr1100614653-778533219593124
ENST00000522509STAU2chr874585342-ENST00000342895LRRC39chr1100614653-929684370744124
ENST00000524104STAU2chr874585342-ENST00000342895LRRC39chr1100614653-778533219593124
ENST00000521419STAU2chr874585342-ENST00000342895LRRC39chr1100614653-848603307663118

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000524300ENST00000342895STAU2chr874585342-LRRC39chr1100614653-0.0134769590.9865231
ENST00000355780ENST00000342895STAU2chr874585342-LRRC39chr1100614653-0.050772130.9492279
ENST00000522509ENST00000342895STAU2chr874585342-LRRC39chr1100614653-0.037112040.962888
ENST00000524104ENST00000342895STAU2chr874585342-LRRC39chr1100614653-0.050772130.9492279
ENST00000521419ENST00000342895STAU2chr874585342-LRRC39chr1100614653-0.024755070.9752449

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Fusion Genomic Features for STAU2-LRRC39


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STAU2-LRRC39


check button Go to

FGviewer for the breakpoints of chr8:74585342-chr1:100614653

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAU2chr8:74585342chr1:100614653ENST00000524104-568_75104.66666666666667106.0DomainDRBM 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAU2chr8:74585342chr1:100614653ENST00000524104-56207_274104.66666666666667106.0DomainDRBM 3
HgeneSTAU2chr8:74585342chr1:100614653ENST00000524104-56307_375104.66666666666667106.0DomainDRBM 4
HgeneSTAU2chr8:74585342chr1:100614653ENST00000524104-5695_181104.66666666666667106.0DomainDRBM 2
HgeneSTAU2chr8:74585342chr1:100614653ENST00000524104-56273_291104.66666666666667106.0MotifNuclear localization signal 1
HgeneSTAU2chr8:74585342chr1:100614653ENST00000524104-56373_412104.66666666666667106.0MotifNuclear localization signal 2
HgeneSTAU2chr8:74585342chr1:100614653ENST00000524104-56381_570104.66666666666667106.0RegionRequired for dendritic transport
TgeneLRRC39chr8:74585342chr1:100614653ENST000003428957910_47317.3333333333333336.0Coiled coilOntology_term=ECO:0000255
TgeneLRRC39chr8:74585342chr1:100614653ENST0000037013781010_47317.3333333333333336.0Coiled coilOntology_term=ECO:0000255
TgeneLRRC39chr8:74585342chr1:100614653ENST0000037013891110_47340.6666666666667404.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579294_299317.3333333333333336.0Compositional biasNote=Poly-Glu
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810294_299317.3333333333333336.0Compositional biasNote=Poly-Glu
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911294_299340.6666666666667404.6666666666667Compositional biasNote=Poly-Glu
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579107_128317.3333333333333336.0RepeatNote=LRR 2
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579130_151317.3333333333333336.0RepeatNote=LRR 3
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579153_176317.3333333333333336.0RepeatNote=LRR 4
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579177_197317.3333333333333336.0RepeatNote=LRR 5
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579200_221317.3333333333333336.0RepeatNote=LRR 6
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579223_244317.3333333333333336.0RepeatNote=LRR 7
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579246_267317.3333333333333336.0RepeatNote=LRR 8
TgeneLRRC39chr8:74585342chr1:100614653ENST0000034289579269_290317.3333333333333336.0RepeatNote=LRR 9
TgeneLRRC39chr8:74585342chr1:100614653ENST000003428957984_105317.3333333333333336.0RepeatNote=LRR 1
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810107_128317.3333333333333336.0RepeatNote=LRR 2
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810130_151317.3333333333333336.0RepeatNote=LRR 3
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810153_176317.3333333333333336.0RepeatNote=LRR 4
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810177_197317.3333333333333336.0RepeatNote=LRR 5
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810200_221317.3333333333333336.0RepeatNote=LRR 6
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810223_244317.3333333333333336.0RepeatNote=LRR 7
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810246_267317.3333333333333336.0RepeatNote=LRR 8
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370137810269_290317.3333333333333336.0RepeatNote=LRR 9
TgeneLRRC39chr8:74585342chr1:100614653ENST0000037013781084_105317.3333333333333336.0RepeatNote=LRR 1
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911107_128340.6666666666667404.6666666666667RepeatNote=LRR 2
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911130_151340.6666666666667404.6666666666667RepeatNote=LRR 3
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911153_176340.6666666666667404.6666666666667RepeatNote=LRR 4
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911177_197340.6666666666667404.6666666666667RepeatNote=LRR 5
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911200_221340.6666666666667404.6666666666667RepeatNote=LRR 6
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911223_244340.6666666666667404.6666666666667RepeatNote=LRR 7
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911246_267340.6666666666667404.6666666666667RepeatNote=LRR 8
TgeneLRRC39chr8:74585342chr1:100614653ENST00000370138911269_290340.6666666666667404.6666666666667RepeatNote=LRR 9
TgeneLRRC39chr8:74585342chr1:100614653ENST0000037013891184_105340.6666666666667404.6666666666667RepeatNote=LRR 1


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Fusion Gene Sequence for STAU2-LRRC39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000524300_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(transcript)=1006nt_BP=761nt
AGGGCGCGGCGGGAGCGCCGGGGAGGCGGGCGGAGGCGGGCGGAGGCGGGGGGCGGGGAGCCCGAGGGGTGGAAGCCGGCGGCGGCCGAG
CGGGGTCAGTTCTCTGTAGTGTTTGCCAATGTTGGAGCCGTCTGCAAAGTGTCCCCGGCAAGAAGAGGCTGCCTACCACAAGGACTTTAG
CTTACTTTTTAAAGATTGAAGAAAAAAAAGAAGACAGAAAAAGAAGAACTCAAAGATACACAAAGTAATTTGAACCAAGGCTCAGAAGTT
TTTGGAGCCGTGAGGGATACAGCAGTTTGGTCAATATTGTCTTAACATGCTTCAAATAAATCAGCTTCTCTCCAAGATAAAATGGCAAAC
CCAAAAGAGAAAACTGCAATGTGTCTGGTAAATGAGTTAGCCCGTTTCAATAGAGTCCAACCCCAGTATAAACTTCTGAATGAAAGAGGG
CCTGCTCATTCAAAGATGTTCTCAGTGCAGCTGAGTCTTGGTGAGCAGACATGGGAATCCGAAGGCAGCAGTATAAAGAAGGCTCAGCAG
GCTGTTGCCAATAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTTCAGAAGCCACCCAAAAGTAATGTTAACAATAACCCAGGCAGT
ATAACTCCAACTGTGGAACTGAATGGGCTTGCTATGAAAAGGGGAGAGCCTGCCATCTACAGGCCATTAGATCCAAAGCCATTCCCAAAT
TATAGAGCTAATTACAACTTTCGGGGCATGTACAATCAGAGATCACCAAGTCAACGGTTCAACTACTTTACCAATCTCCATAAATACGGA
TGGATAATATAATTCAAGATGCCCTTCTAAAGAGGATTACTTTGGTGAATTCTCTAATGTTTGGATTTCTGAAGTAAAAAGAAAAGCTAT
TACCAAAGTTTAATGAGGCCACAGCATTTTTTAAAGTTCATATTATTTGCTATTTAAAGTATATATTTTTTTGATATAAAAATATAATTA

>In-frame_ENST00000524300_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(amino acids)=156AA_start in transcript=351_stop in transcript=821
MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNN

--------------------------------------------------------------
>In-frame_ENST00000355780_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(transcript)=778nt_BP=533nt
AGTTCTCTGTAGTGTTTGCCAATGTTGGAGCCGTCTGCAAAGTGTCCCCGGCAAGAAGAGGCTGCCTACCACAAGGACTTTAGCTTACTT
TTTAAAGATTGAAGAAAAAAAAGAAGACAGAAAAAGAAGAACTCAAAGATACACAAAGTAATTTGAACCAAGGCTCAGAAGTTTTTGGAG
CCGTGAGGGATACAGCAGTTTGGTCAATATTGTCTTAACATGCTTCAAATAAATCAGATGTTCTCAGTGCAGCTGAGTCTTGGTGAGCAG
ACATGGGAATCCGAAGGCAGCAGTATAAAGAAGGCTCAGCAGGCTGTTGCCAATAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTT
CAGAAGCCACCCAAAAGTAATGTTAACAATAACCCAGGCAGTATAACTCCAACTGTGGAACTGAATGGGCTTGCTATGAAAAGGGGAGAG
CCTGCCATCTACAGGCCATTAGATCCAAAGCCATTCCCAAATTATAGAGCTAATTACAACTTTCGGGGCATGTACAATCAGAGATCACCA
AGTCAACGGTTCAACTACTTTACCAATCTCCATAAATACGGATGGATAATATAATTCAAGATGCCCTTCTAAAGAGGATTACTTTGGTGA
ATTCTCTAATGTTTGGATTTCTGAAGTAAAAAGAAAAGCTATTACCAAAGTTTAATGAGGCCACAGCATTTTTTAAAGTTCATATTATTT

>In-frame_ENST00000355780_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(amino acids)=124AA_start in transcript=219_stop in transcript=593
MLQINQMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFP

--------------------------------------------------------------
>In-frame_ENST00000522509_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(transcript)=929nt_BP=684nt
ACTCTTGCCTCATAAATCTAGGATTCAGGGCATTGTTTTCAATGGTTCTCATTTTTGGCTCCAAGGATTCTTTTTCATGTGACTAATATT
TTCGGTAGAAGAGGAGGTCTGGCCACGCCGCGGGTCTTGGCGAGCAGGTGATCACGGATCCCTGGTGTTTGCTGGGCGAGACGGTGAAGC
AACCTCCTCCCCGCCCCCTCCCCCGTCTAGAAAGGTGCAAGATCCGCTAAACCGTGCGTTGCACAGCGGCGGCCGGAGCAGACGCGGGAT
GGTCGCGCGTCCCCTGCACAGCACAGAGGGGCAGCCGGAGAGCCTGGGAAAGTTTTTGGAGCCGTGAGGGATACAGCAGTTTGGTCAATA
TTGTCTTAACATGCTTCAAATAAATCAGATGTTCTCAGTGCAGCTGAGTCTTGGTGAGCAGACATGGGAATCCGAAGGCAGCAGTATAAA
GAAGGCTCAGCAGGCTGTTGCCAATAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTTCAGAAGCCACCCAAAAGTAATGTTAACAA
TAACCCAGGCAGTATAACTCCAACTGTGGAACTGAATGGGCTTGCTATGAAAAGGGGAGAGCCTGCCATCTACAGGCCATTAGATCCAAA
GCCATTCCCAAATTATAGAGCTAATTACAACTTTCGGGGCATGTACAATCAGAGATCACCAAGTCAACGGTTCAACTACTTTACCAATCT
CCATAAATACGGATGGATAATATAATTCAAGATGCCCTTCTAAAGAGGATTACTTTGGTGAATTCTCTAATGTTTGGATTTCTGAAGTAA
AAAGAAAAGCTATTACCAAAGTTTAATGAGGCCACAGCATTTTTTAAAGTTCATATTATTTGCTATTTAAAGTATATATTTTTTTGATAT

>In-frame_ENST00000522509_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(amino acids)=124AA_start in transcript=370_stop in transcript=744
MLQINQMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFP

--------------------------------------------------------------
>In-frame_ENST00000524104_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(transcript)=778nt_BP=533nt
AGTTCTCTGTAGTGTTTGCCAATGTTGGAGCCGTCTGCAAAGTGTCCCCGGCAAGAAGAGGCTGCCTACCACAAGGACTTTAGCTTACTT
TTTAAAGATTGAAGAAAAAAAAGAAGACAGAAAAAGAAGAACTCAAAGATACACAAAGTAATTTGAACCAAGGCTCAGAAGTTTTTGGAG
CCGTGAGGGATACAGCAGTTTGGTCAATATTGTCTTAACATGCTTCAAATAAATCAGATGTTCTCAGTGCAGCTGAGTCTTGGTGAGCAG
ACATGGGAATCCGAAGGCAGCAGTATAAAGAAGGCTCAGCAGGCTGTTGCCAATAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTT
CAGAAGCCACCCAAAAGTAATGTTAACAATAACCCAGGCAGTATAACTCCAACTGTGGAACTGAATGGGCTTGCTATGAAAAGGGGAGAG
CCTGCCATCTACAGGCCATTAGATCCAAAGCCATTCCCAAATTATAGAGCTAATTACAACTTTCGGGGCATGTACAATCAGAGATCACCA
AGTCAACGGTTCAACTACTTTACCAATCTCCATAAATACGGATGGATAATATAATTCAAGATGCCCTTCTAAAGAGGATTACTTTGGTGA
ATTCTCTAATGTTTGGATTTCTGAAGTAAAAAGAAAAGCTATTACCAAAGTTTAATGAGGCCACAGCATTTTTTAAAGTTCATATTATTT

>In-frame_ENST00000524104_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(amino acids)=124AA_start in transcript=219_stop in transcript=593
MLQINQMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFP

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>In-frame_ENST00000521419_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(transcript)=848nt_BP=603nt
GGGGCGGGGAGCCCGAGGGGTGGAAGCCGGCGGCGGCCGAGCGGGGTCAGTTCTCTGTAGTGTTTGCCAATGTTGGAGCCGTCTGCAAAG
TGTCCCCGGCAAGAAGTTTTTGGAGCCGTGAGGGATACAGCAGTTTGGTCAATATTGTCTTAACATGCTTCAAATAAATCAGATTGAAGA
ACTCCCTTCAGGATTTCTTGTAGAACAAGTCTGGTGTTGATGAAATCCTTCGGCTTTTGTTTGTCTGGGAAAGACTTTATCTCTCCTTCA
TAATTAAAGGATATTTTCACCAGATATACTATTCTAGATGTTCTCAGTGCAGCTGAGTCTTGGTGAGCAGACATGGGAATCCGAAGGCAG
CAGTATAAAGAAGGCTCAGCAGGCTGTTGCCAATAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTTCAGAAGCCACCCAAAAGTAA
TGTTAACAATAACCCAGGCAGTATAACTCCAACTGTGGAACTGAATGGGCTTGCTATGAAAAGGGGAGAGCCTGCCATCTACAGGCCATT
AGATCCAAAGCCATTCCCAAATTATAGAGCTAATTACAACTTTCGGGGCATGTACAATCAGAGATCACCAAGTCAACGGTTCAACTACTT
TACCAATCTCCATAAATACGGATGGATAATATAATTCAAGATGCCCTTCTAAAGAGGATTACTTTGGTGAATTCTCTAATGTTTGGATTT
CTGAAGTAAAAAGAAAAGCTATTACCAAAGTTTAATGAGGCCACAGCATTTTTTAAAGTTCATATTATTTGCTATTTAAAGTATATATTT

>In-frame_ENST00000521419_ENST00000342895_ERR315367_STAU2_chr8_74585342_-_LRRC39_chr1_100614653_length(amino acids)=118AA_start in transcript=307_stop in transcript=663
MFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFPNYRANY

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Fusion Gene PPI Analysis for STAU2-LRRC39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STAU2-LRRC39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STAU2-LRRC39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAU2C0023893Liver Cirrhosis, Experimental1CTD_human