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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STEAP4-CTNND1 (FusionGDB2 ID:86782)

Fusion Gene Summary for STEAP4-CTNND1

check button Fusion gene summary
Fusion gene informationFusion gene name: STEAP4-CTNND1
Fusion gene ID: 86782
HgeneTgene
Gene symbol

STEAP4

CTNND1

Gene ID

79689

100528016

Gene nameSTEAP4 metalloreductaseTMX2-CTNND1 readthrough (NMD candidate)
SynonymsSTAMP2|SchLAH|TIARP|TNFAIP9CAS|CTNND1|p120(cas)|p120(ctn)
Cytomap

7q21.12

11q12.1

Type of geneprotein-codingncRNA
Descriptionmetalloreductase STEAP4STEAP family member 4seven chromosome locus associated with HCCsix transmembrane prostate protein 2six-transmembrane epithelial antigen of prostate 4sixTransMembrane protein of prostate 2tumor necrosis factor, alpha-induced prCadherin-associated Src substrateCatenin delta-1TMX2-CTNND1 readthrough (non-protein coding)p120 catenin
Modification date2020031320200313
UniProtAcc.

O60716

Ensembl transtripts involved in fusion geneENST00000380079, ENST00000301959, 
ENST00000414498, 		ENST00000524630, 
ENST00000529919, ENST00000399039, 
ENST00000360682, ENST00000361796, 
ENST00000361391, ENST00000530094, 
ENST00000428599, ENST00000361332, 
ENST00000527467, ENST00000415361, 
ENST00000532245, ENST00000532463, 
ENST00000528232, ENST00000529986, 
ENST00000531014, ENST00000358694, 
ENST00000526772, ENST00000532787, 
ENST00000533667, ENST00000529873, 
ENST00000525902, ENST00000529526, 
ENST00000532649, ENST00000426142, 
ENST00000532844, ENST00000528621, 
ENST00000399050, ENST00000526357, 
ENST00000530748, ENST00000534579, 
ENST00000526938, 
Fusion gene scores* DoF score2 X 2 X 2=817 X 21 X 10=3570
# samples 225
** MAII scorelog2(2/8*10)=1.32192809488736log2(25/3570*10)=-3.83592407425437
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STEAP4 [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTEAP4(87912372)-CTNND1(57569332), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTEAP4

GO:0070207

protein homotrimerization

30337524


check buttonFusion gene breakpoints across STEAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CTNND1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF987948STEAP4chr7

87912372

-CTNND1chr11

57569332

+


Top

Fusion Gene ORF analysis for STEAP4-CTNND1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380079ENST00000524630STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529919STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000399039STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000360682STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000361796STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000361391STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000530094STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000428599STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000361332STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000527467STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000415361STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532245STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532463STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000528232STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529986STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000531014STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000358694STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000526772STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532787STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000533667STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529873STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000525902STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529526STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532649STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000426142STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532844STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000528621STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000399050STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000526357STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000530748STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000534579STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000526938STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000524630STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529919STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000399039STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000360682STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000361796STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000361391STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000530094STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000428599STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000361332STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000527467STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000415361STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532245STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532463STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000528232STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529986STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000531014STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000358694STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000526772STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532787STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000533667STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529873STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000525902STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529526STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532649STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000426142STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532844STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000528621STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000399050STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000526357STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000530748STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000534579STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000526938STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000524630STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529919STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000399039STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000360682STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000361796STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000361391STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000530094STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000428599STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000361332STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000527467STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000415361STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532245STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532463STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000528232STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529986STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000531014STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000358694STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000526772STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532787STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000533667STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529873STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000525902STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529526STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532649STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000426142STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532844STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000528621STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000399050STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000526357STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000530748STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000534579STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000526938STEAP4chr7

87912372

-CTNND1chr11

57569332

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for STEAP4-CTNND1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STEAP4-CTNND1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTNND1

O60716

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for STEAP4-CTNND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for STEAP4-CTNND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STEAP4-CTNND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STEAP4-CTNND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTEAP4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSTEAP4C0033578Prostatic Neoplasms1CTD_human
HgeneSTEAP4C0376358Malignant neoplasm of prostate1CTD_human
TgeneCTNND1C0008925Cleft Palate1GENOMICS_ENGLAND
TgeneCTNND1C1861536Blepharo-cheilo-dontic syndrome1ORPHANET