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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STIM1-WT1 (FusionGDB2 ID:86806)

Fusion Gene Summary for STIM1-WT1

check button Fusion gene summary
Fusion gene informationFusion gene name: STIM1-WT1
Fusion gene ID: 86806
HgeneTgene
Gene symbol

STIM1

WT1

Gene ID

6786

7490

Gene namestromal interaction molecule 1WT1 transcription factor
SynonymsD11S4896E|GOK|IMD10|STRMK|TAM|TAM1AWT1|GUD|NPHS4|WAGR|WIT-2|WT33
Cytomap

11p15.4

11p13

Type of geneprotein-codingprotein-coding
Descriptionstromal interaction molecule 1Wilms tumor proteinWilms tumor 1
Modification date2020032920200320
UniProtAcc.

P19544

Ensembl transtripts involved in fusion geneENST00000300737, ENST00000527651, 
ENST00000527484, ENST00000533977, 
ENST00000379079, ENST00000332351, 
ENST00000530998, ENST00000448076, 
Fusion gene scores* DoF score21 X 13 X 12=32763 X 6 X 5=90
# samples 234
** MAII scorelog2(23/3276*10)=-3.83222959069663
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/90*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STIM1 [Title/Abstract] AND WT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTIM1(4076867)-WT1(32421590), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTIM1

GO:0002115

store-operated calcium entry

28219928

HgeneSTIM1

GO:0005513

detection of calcium ion

16005298

HgeneSTIM1

GO:0032237

activation of store-operated calcium channel activity

16005298|26322679|28219928

HgeneSTIM1

GO:0045762

positive regulation of adenylate cyclase activity

19171672

HgeneSTIM1

GO:0051924

regulation of calcium ion transport

16005298

TgeneWT1

GO:0000122

negative regulation of transcription by RNA polymerase II

7585606

TgeneWT1

GO:0007530

sex determination

9815658

TgeneWT1

GO:0008285

negative regulation of cell proliferation

9553041|9765217

TgeneWT1

GO:0030308

negative regulation of cell growth

9553041|9765217

TgeneWT1

GO:0045892

negative regulation of transcription, DNA-templated

1332065|7585606|7720589|8119964|12802290|14701728|19050011

TgeneWT1

GO:0045893

positive regulation of transcription, DNA-templated

8132626|9178767|9553041|9765217|12802290|14701728|16467207|21390327

TgeneWT1

GO:0045944

positive regulation of transcription by RNA polymerase II

23042785

TgeneWT1

GO:0071371

cellular response to gonadotropin stimulus

15961562


check buttonFusion gene breakpoints across STIM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1028STIM1chr11

4076867

+WT1chr11

32421590

-


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Fusion Gene ORF analysis for STIM1-WT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000300737ENST00000379079STIM1chr11

4076867

+WT1chr11

32421590

-
In-frameENST00000300737ENST00000332351STIM1chr11

4076867

+WT1chr11

32421590

-
In-frameENST00000300737ENST00000530998STIM1chr11

4076867

+WT1chr11

32421590

-
In-frameENST00000300737ENST00000448076STIM1chr11

4076867

+WT1chr11

32421590

-
In-frameENST00000527651ENST00000379079STIM1chr11

4076867

+WT1chr11

32421590

-
In-frameENST00000527651ENST00000332351STIM1chr11

4076867

+WT1chr11

32421590

-
In-frameENST00000527651ENST00000530998STIM1chr11

4076867

+WT1chr11

32421590

-
In-frameENST00000527651ENST00000448076STIM1chr11

4076867

+WT1chr11

32421590

-
3UTR-3CDSENST00000527484ENST00000379079STIM1chr11

4076867

+WT1chr11

32421590

-
3UTR-3CDSENST00000527484ENST00000332351STIM1chr11

4076867

+WT1chr11

32421590

-
3UTR-3CDSENST00000527484ENST00000530998STIM1chr11

4076867

+WT1chr11

32421590

-
3UTR-3CDSENST00000527484ENST00000448076STIM1chr11

4076867

+WT1chr11

32421590

-
intron-3CDSENST00000533977ENST00000379079STIM1chr11

4076867

+WT1chr11

32421590

-
intron-3CDSENST00000533977ENST00000332351STIM1chr11

4076867

+WT1chr11

32421590

-
intron-3CDSENST00000533977ENST00000530998STIM1chr11

4076867

+WT1chr11

32421590

-
intron-3CDSENST00000533977ENST00000448076STIM1chr11

4076867

+WT1chr11

32421590

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000300737STIM1chr114076867+ENST00000379079WT1chr1132421590-289310665541609351
ENST00000300737STIM1chr114076867+ENST00000332351WT1chr1132421590-290210665541618354
ENST00000300737STIM1chr114076867+ENST00000530998WT1chr1132421590-289910665541618354
ENST00000300737STIM1chr114076867+ENST00000448076WT1chr1132421590-198910665541609351
ENST00000527651STIM1chr114076867+ENST00000379079WT1chr1132421590-2413586741129351
ENST00000527651STIM1chr114076867+ENST00000332351WT1chr1132421590-2422586741138354
ENST00000527651STIM1chr114076867+ENST00000530998WT1chr1132421590-2419586741138354
ENST00000527651STIM1chr114076867+ENST00000448076WT1chr1132421590-1509586741129351

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000300737ENST00000379079STIM1chr114076867+WT1chr1132421590-0.002818950.99718106
ENST00000300737ENST00000332351STIM1chr114076867+WT1chr1132421590-0.0025800130.99741995
ENST00000300737ENST00000530998STIM1chr114076867+WT1chr1132421590-0.0026143670.9973857
ENST00000300737ENST00000448076STIM1chr114076867+WT1chr1132421590-0.0232392420.97676075
ENST00000527651ENST00000379079STIM1chr114076867+WT1chr1132421590-0.0013813080.9986187
ENST00000527651ENST00000332351STIM1chr114076867+WT1chr1132421590-0.0013047960.9986952
ENST00000527651ENST00000530998STIM1chr114076867+WT1chr1132421590-0.0013091070.9986909
ENST00000527651ENST00000448076STIM1chr114076867+WT1chr1132421590-0.0086016010.99139833

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Fusion Genomic Features for STIM1-WT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STIM1-WT1


check button Go to

FGviewer for the breakpoints of chr11:4076867-chr11:32421590

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.WT1

P19544

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269|PubMed:15520190, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17716689, ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:7862533}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+41276_87165.66666666666666686.0Calcium binding.
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+41263_98165.66666666666666686.0DomainNote=EF-hand
TgeneWT1chr11:4076867chr11:32421590ENST00000379079410236_244121.66666666666667303.0Motif9aaTAD
TgeneWT1chr11:4076867chr11:32421590ENST0000053099839236_244104.66666666666667289.0Motif9aaTAD
TgeneWT1chr11:4076867chr11:32421590ENST00000379079410323_347121.66666666666667303.0Zinc fingerC2H2-type 1
TgeneWT1chr11:4076867chr11:32421590ENST00000379079410353_377121.66666666666667303.0Zinc fingerC2H2-type 2
TgeneWT1chr11:4076867chr11:32421590ENST00000379079410383_405121.66666666666667303.0Zinc fingerC2H2-type 3
TgeneWT1chr11:4076867chr11:32421590ENST00000379079410414_438121.66666666666667303.0Zinc fingerC2H2-type 4
TgeneWT1chr11:4076867chr11:32421590ENST0000053099839323_347104.66666666666667289.0Zinc fingerC2H2-type 1
TgeneWT1chr11:4076867chr11:32421590ENST0000053099839353_377104.66666666666667289.0Zinc fingerC2H2-type 2
TgeneWT1chr11:4076867chr11:32421590ENST0000053099839383_405104.66666666666667289.0Zinc fingerC2H2-type 3
TgeneWT1chr11:4076867chr11:32421590ENST0000053099839414_438104.66666666666667289.0Zinc fingerC2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412248_442165.66666666666666686.0Coiled coilOntology_term=ECO:0000269,ECO:0000269,ECO:0000269
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412270_336165.66666666666666686.0Compositional biasNote=Glu-rich
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412600_629165.66666666666666686.0Compositional biasNote=Pro/Ser-rich
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412672_685165.66666666666666686.0Compositional biasNote=Lys-rich
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412132_200165.66666666666666686.0DomainSAM
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412642_645165.66666666666666686.0MotifNote=Microtubule tip localization signal
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412334_444165.66666666666666686.0RegionNote=SOAR/CAD
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412235_685165.66666666666666686.0Topological domainCytoplasmic
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+41223_213165.66666666666666686.0Topological domainExtracellular
HgeneSTIM1chr11:4076867chr11:32421590ENST00000300737+412214_234165.66666666666666686.0TransmembraneHelical
TgeneWT1chr11:4076867chr11:32421590ENST0000037907941027_83121.66666666666667303.0Compositional biasNote=Pro-rich
TgeneWT1chr11:4076867chr11:32421590ENST000005309983927_83104.66666666666667289.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for STIM1-WT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000300737_ENST00000379079_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=2893nt_BP=1066nt
GCTGGACCTGGGCACCGCCAGCCGCCTGGGCACGGGACTGGGCGGGGGCGCTGACCTCGGCCTAGGAGGCCCAGGATCCCGGAGACGCCC
GCGCCCTCAGGACCCTGCGGGTCGCACGCCCTCCCCAGCTTCTGCTGCTCGCCGCTCTTCGGCAGGGCGAGGTCAGGTGCCCCCTTCTCG
CCTCTCTTCTCTTCTCTTCTCTTCCTCCTCCACTTCTGTGCCCGCGGAGACTCCGGCCGCCCCCTTCCGCAGGGGTGTAGTAATCTGCGG
AGCTGACAGCAGCCCCGCAGCCACCCTGCCCGAAGTCTCCGGAAGCGGCACGAGCTCAGGCCGCCGCAGCCCCGGCGGACCCACTGTTGG
ACCTGAGGAGCCAGCCCTCCTCCCGCACCCAAACTTGGAGCACTTGACCTTTGGCTGTTGGAGGGGGCAGGCTCGCGGGTGGCTGGACAG
CTGCGGAGCCGCGAGGGCATCTTGCCTGGAGACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACAT
CAGACGCATGTTGACTGAGACCTAGAGTCATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCC
AGAGCCTCAGCCATAGTCACAGTGAGAAGGCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAA
TTGACAAGCCCCTGTGTCACAGTGAGGATGAGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATG
GTGATGTGGATGTGGAAGAAAGTGATGAGTTCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTG
AGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGC
TGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGT
ACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGC
GACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCA
ATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTG
AACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAA
AGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAA
AGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCC
TCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCA
GTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCC
TACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACT
GTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATT
TTCTATCATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGC
AAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGT
AGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAA
AGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTTT
TGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCATCACTGGGAG
TGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGA
TCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAA
TCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTAT
TATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAG
ATGCATCACTGGGTGTTGATCTTACAAGATATTGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTTTGCTCTCAATTAAAGTCT

>In-frame_ENST00000300737_ENST00000379079_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=351AA_start in transcript=554_stop in transcript=1609
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------
>In-frame_ENST00000300737_ENST00000332351_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=2902nt_BP=1066nt
GCTGGACCTGGGCACCGCCAGCCGCCTGGGCACGGGACTGGGCGGGGGCGCTGACCTCGGCCTAGGAGGCCCAGGATCCCGGAGACGCCC
GCGCCCTCAGGACCCTGCGGGTCGCACGCCCTCCCCAGCTTCTGCTGCTCGCCGCTCTTCGGCAGGGCGAGGTCAGGTGCCCCCTTCTCG
CCTCTCTTCTCTTCTCTTCTCTTCCTCCTCCACTTCTGTGCCCGCGGAGACTCCGGCCGCCCCCTTCCGCAGGGGTGTAGTAATCTGCGG
AGCTGACAGCAGCCCCGCAGCCACCCTGCCCGAAGTCTCCGGAAGCGGCACGAGCTCAGGCCGCCGCAGCCCCGGCGGACCCACTGTTGG
ACCTGAGGAGCCAGCCCTCCTCCCGCACCCAAACTTGGAGCACTTGACCTTTGGCTGTTGGAGGGGGCAGGCTCGCGGGTGGCTGGACAG
CTGCGGAGCCGCGAGGGCATCTTGCCTGGAGACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACAT
CAGACGCATGTTGACTGAGACCTAGAGTCATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCC
AGAGCCTCAGCCATAGTCACAGTGAGAAGGCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAA
TTGACAAGCCCCTGTGTCACAGTGAGGATGAGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATG
GTGATGTGGATGTGGAAGAAAGTGATGAGTTCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTG
AGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGC
TGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGT
ACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGC
GACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCA
ATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTG
AACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAA
AGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTAAAACAAGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTT
GTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAG
GGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAG
GAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTC
TGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGA
TTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTAT
TGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAAC
AGCAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAA
GCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAG
AAATCTAAAAGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGT
GTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCAT
CACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGAT
GGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGG
GTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAG
GGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTAT
AAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGATATTGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTTTGCTCTCAA

>In-frame_ENST00000300737_ENST00000332351_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=354AA_start in transcript=554_stop in transcript=1618
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------
>In-frame_ENST00000300737_ENST00000530998_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=2899nt_BP=1066nt
GCTGGACCTGGGCACCGCCAGCCGCCTGGGCACGGGACTGGGCGGGGGCGCTGACCTCGGCCTAGGAGGCCCAGGATCCCGGAGACGCCC
GCGCCCTCAGGACCCTGCGGGTCGCACGCCCTCCCCAGCTTCTGCTGCTCGCCGCTCTTCGGCAGGGCGAGGTCAGGTGCCCCCTTCTCG
CCTCTCTTCTCTTCTCTTCTCTTCCTCCTCCACTTCTGTGCCCGCGGAGACTCCGGCCGCCCCCTTCCGCAGGGGTGTAGTAATCTGCGG
AGCTGACAGCAGCCCCGCAGCCACCCTGCCCGAAGTCTCCGGAAGCGGCACGAGCTCAGGCCGCCGCAGCCCCGGCGGACCCACTGTTGG
ACCTGAGGAGCCAGCCCTCCTCCCGCACCCAAACTTGGAGCACTTGACCTTTGGCTGTTGGAGGGGGCAGGCTCGCGGGTGGCTGGACAG
CTGCGGAGCCGCGAGGGCATCTTGCCTGGAGACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACAT
CAGACGCATGTTGACTGAGACCTAGAGTCATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCC
AGAGCCTCAGCCATAGTCACAGTGAGAAGGCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAA
TTGACAAGCCCCTGTGTCACAGTGAGGATGAGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATG
GTGATGTGGATGTGGAAGAAAGTGATGAGTTCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTG
AGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGC
TGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGT
ACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGC
GACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCA
ATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTG
AACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAA
AGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTAAAACAAGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTT
GTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAG
GGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAG
GAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTC
TGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGA
TTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTAT
TGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAAC
AGCAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAA
GCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAG
AAATCTAAAAGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGT
GTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCAT
CACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGAT
GGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGG
GTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAG
GGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTAT
AAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGATATTGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTTTGCTCTCAA

>In-frame_ENST00000300737_ENST00000530998_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=354AA_start in transcript=554_stop in transcript=1618
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------
>In-frame_ENST00000300737_ENST00000448076_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=1989nt_BP=1066nt
GCTGGACCTGGGCACCGCCAGCCGCCTGGGCACGGGACTGGGCGGGGGCGCTGACCTCGGCCTAGGAGGCCCAGGATCCCGGAGACGCCC
GCGCCCTCAGGACCCTGCGGGTCGCACGCCCTCCCCAGCTTCTGCTGCTCGCCGCTCTTCGGCAGGGCGAGGTCAGGTGCCCCCTTCTCG
CCTCTCTTCTCTTCTCTTCTCTTCCTCCTCCACTTCTGTGCCCGCGGAGACTCCGGCCGCCCCCTTCCGCAGGGGTGTAGTAATCTGCGG
AGCTGACAGCAGCCCCGCAGCCACCCTGCCCGAAGTCTCCGGAAGCGGCACGAGCTCAGGCCGCCGCAGCCCCGGCGGACCCACTGTTGG
ACCTGAGGAGCCAGCCCTCCTCCCGCACCCAAACTTGGAGCACTTGACCTTTGGCTGTTGGAGGGGGCAGGCTCGCGGGTGGCTGGACAG
CTGCGGAGCCGCGAGGGCATCTTGCCTGGAGACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACAT
CAGACGCATGTTGACTGAGACCTAGAGTCATGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCC
AGAGCCTCAGCCATAGTCACAGTGAGAAGGCGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAA
TTGACAAGCCCCTGTGTCACAGTGAGGATGAGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATG
GTGATGTGGATGTGGAAGAAAGTGATGAGTTCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTG
AGGATAAGCTCATCAGCGTGGAGGACCTGTGGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGC
TGATCACATATGTGGAGCTGCCTCAGTATGAGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGT
ACGAGAGCGATAACCACACAACGCCCATCCTCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGC
GACGTGTGCCTGGAGTAGCCCCGACTCTTGTACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCA
ATAAGAGATATTTTAAGCTGTCCCACTTACAGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTG
AACGAAGGTTTTCTCGTTCAGACCAGCTCAAAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAA
AGTTCTCCCGGTCCGACCACCTGAAGACCCACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAA
AGTTTGCCCGGTCAGATGAATTAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCC
TCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCA
GTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCC
TACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACT
GTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATT

>In-frame_ENST00000300737_ENST00000448076_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=351AA_start in transcript=554_stop in transcript=1609
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------
>In-frame_ENST00000527651_ENST00000379079_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=2413nt_BP=586nt
GACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACATCAGACGCATGTTGACTGAGACCTAGAGTCA
TGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAGG
CGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAATTGACAAGCCCCTGTGTCACAGTGAGGATG
AGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATGGTGATGTGGATGTGGAAGAAAGTGATGAGT
TCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGT
GGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATG
AGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCC
TCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTG
TACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTAC
AGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCA
AAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCC
ACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCC
ATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCAC
AGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACA
AGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGA
AGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCC
CTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGC
ATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGG
GGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATG
CATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAATTCAATGTG
AACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTC
TTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTA
TATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAAC
TTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAA
ATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGAT

>In-frame_ENST00000527651_ENST00000379079_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=351AA_start in transcript=74_stop in transcript=1129
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------
>In-frame_ENST00000527651_ENST00000332351_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=2422nt_BP=586nt
GACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACATCAGACGCATGTTGACTGAGACCTAGAGTCA
TGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAGG
CGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAATTGACAAGCCCCTGTGTCACAGTGAGGATG
AGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATGGTGATGTGGATGTGGAAGAAAGTGATGAGT
TCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGT
GGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATG
AGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCC
TCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTG
TACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTAC
AGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCA
AAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCC
ACACCAGGACTCATACAGGTAAAACAAGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAAT
TAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCC
AGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACT
TCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGG
CCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGAT
CATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATA
GGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAA
GGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTA
AAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAA
TTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATC
ATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACC
ATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTT
TTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCG
TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATT
ACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATC

>In-frame_ENST00000527651_ENST00000332351_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=354AA_start in transcript=74_stop in transcript=1138
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------
>In-frame_ENST00000527651_ENST00000530998_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=2419nt_BP=586nt
GACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACATCAGACGCATGTTGACTGAGACCTAGAGTCA
TGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAGG
CGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAATTGACAAGCCCCTGTGTCACAGTGAGGATG
AGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATGGTGATGTGGATGTGGAAGAAAGTGATGAGT
TCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGT
GGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATG
AGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCC
TCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTG
TACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTAC
AGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCA
AAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCC
ACACCAGGACTCATACAGGTAAAACAAGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAAT
TAGTCCGCCATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCC
AGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACT
TCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGG
CCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGAT
CATGTCCCCCTGACCCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATA
GGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCAA
GGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTA
AAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTAA
TTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTTTTGACTCTTTTGAGTGGTAATC
ATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACC
ATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTT
TTAAGTAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCG
TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATT
ACTGTGTAAATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATC

>In-frame_ENST00000527651_ENST00000530998_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=354AA_start in transcript=74_stop in transcript=1138
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

--------------------------------------------------------------
>In-frame_ENST00000527651_ENST00000448076_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(transcript)=1509nt_BP=586nt
GACCGTCGGCTGCACTCCCGGGCTCCTGGCTTTGCCTCTGGGATCCCGAGGTGTCCACATCAGACGCATGTTGACTGAGACCTAGAGTCA
TGGATGTATGCGTCCGTCTTGCCCTGTGGCTCCTCTGGGGACTCCTCCTGCACCAGGGCCAGAGCCTCAGCCATAGTCACAGTGAGAAGG
CGACAGGAACCAGCTCGGGGGCCAACTCTGAGGAGTCCACTGCAGCAGAGTTTTGCCGAATTGACAAGCCCCTGTGTCACAGTGAGGATG
AGAAACTCAGCTTCGAGGCAGTCCGTAACATCCACAAACTGATGGACGATGATGCCAATGGTGATGTGGATGTGGAAGAAAGTGATGAGT
TCCTGAGGGAAGACCTCAATTACCATGACCCAACAGTGAAACACAGCACCTTCCATGGTGAGGATAAGCTCATCAGCGTGGAGGACCTGT
GGAAGGCATGGAAGTCATCAGAAGTATACAATTGGACCGTGGATGAGGTGGTACAGTGGCTGATCACATATGTGGAGCTGCCTCAGTATG
AGGAGACCTTCCGGAAGCTGCAGCTCAGTGGCCATGCCATGCCAAGCCACAGCACAGGGTACGAGAGCGATAACCACACAACGCCCATCC
TCTGCGGAGCCCAATACAGAATACACACGCACGGTGTCTTCAGAGGCATTCAGGATGTGCGACGTGTGCCTGGAGTAGCCCCGACTCTTG
TACGGTCGGCATCTGAGACCAGTGAGAAACGCCCCTTCATGTGTGCTTACCCAGGCTGCAATAAGAGATATTTTAAGCTGTCCCACTTAC
AGATGCACAGCAGGAAGCACACTGGTGAGAAACCATACCAGTGTGACTTCAAGGACTGTGAACGAAGGTTTTCTCGTTCAGACCAGCTCA
AAAGACACCAAAGGAGACATACAGGTGTGAAACCATTCCAGTGTAAAACTTGTCAGCGAAAGTTCTCCCGGTCCGACCACCTGAAGACCC
ACACCAGGACTCATACAGGTGAAAAGCCCTTCAGCTGTCGGTGGCCAAGTTGTCAGAAAAAGTTTGCCCGGTCAGATGAATTAGTCCGCC
ATCACAACATGCATCAGAGAAACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCAC
AGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACA
AGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGA
AGCAGCTAACAATGTCTGGTTAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCC

>In-frame_ENST00000527651_ENST00000448076_TCGA-23-1028_STIM1_chr11_4076867_+_WT1_chr11_32421590_length(amino acids)=351AA_start in transcript=74_stop in transcript=1129
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDV
EESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPSHSTGYESDN
HTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFS

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Fusion Gene PPI Analysis for STIM1-WT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STIM1-WT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STIM1-WT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTIM1C1861451Stormorken Syndrome5GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneSTIM1C4011726MYOPATHY, TUBULAR AGGREGATE, 14GENOMICS_ENGLAND;UNIPROT
HgeneSTIM1C2748557Immune dysfunction with T-cell inactivation due to calcium entry defect 23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneSTIM1C0020538Hypertensive disease1CTD_human
HgeneSTIM1C0024121Lung Neoplasms1CTD_human
HgeneSTIM1C0027659Neoplasms, Experimental1CTD_human
HgeneSTIM1C0087031Juvenile-Onset Still Disease1CTD_human
HgeneSTIM1C0242379Malignant neoplasm of lung1CTD_human
HgeneSTIM1C0410207Tubular Aggregate Myopathy1CTD_human;ORPHANET
HgeneSTIM1C0494261Combined immunodeficiency1GENOMICS_ENGLAND
HgeneSTIM1C3495559Juvenile arthritis1CTD_human
HgeneSTIM1C3495676Anorectal Malformations1GENOMICS_ENGLAND
HgeneSTIM1C3714758Juvenile psoriatic arthritis1CTD_human
HgeneSTIM1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneSTIM1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneWT1C0950121Denys-Drash Syndrome20CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneWT1C0027708Nephroblastoma8CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneWT1C3151568NEPHROTIC SYNDROME, TYPE 46CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneWT1C0950122Frasier Syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneWT1C1837026MEACHAM SYNDROME (disorder)3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneWT1C0023467Leukemia, Myelocytic, Acute2CGI;CTD_human
TgeneWT1C0026998Acute Myeloid Leukemia, M12CTD_human
TgeneWT1C0345967Malignant mesothelioma2CTD_human;GENOMICS_ENGLAND
TgeneWT1C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneWT1C2930471Bilateral Wilms Tumor2CTD_human
TgeneWT1C0006142Malignant neoplasm of breast1CTD_human
TgeneWT1C0007102Malignant tumor of colon1CTD_human
TgeneWT1C0009375Colonic Neoplasms1CTD_human
TgeneWT1C0017636Glioblastoma1CTD_human
TgeneWT1C0017658Glomerulonephritis1CTD_human
TgeneWT1C0018054Gonadal Dysgenesis, 46,XY1ORPHANET
TgeneWT1C0019284Diaphragmatic Hernia1CTD_human
TgeneWT1C0023418leukemia1CTD_human
TgeneWT1C0023473Myeloid Leukemia, Chronic1CTD_human
TgeneWT1C0023487Acute Promyelocytic Leukemia1CTD_human
TgeneWT1C0024121Lung Neoplasms1CTD_human
TgeneWT1C0027809Neurilemmoma1CTD_human
TgeneWT1C0029463Osteosarcoma1CTD_human
TgeneWT1C0030297Pancreatic Neoplasm1CTD_human
TgeneWT1C0031149Peritoneal Neoplasms1CTD_human
TgeneWT1C0085215Ovarian Failure, Premature1CTD_human
TgeneWT1C0086367Gonadotropin-Resistant Ovary Syndrome1CTD_human
TgeneWT1C0206115WAGR Syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneWT1C0235833Congenital diaphragmatic hernia1CTD_human
TgeneWT1C0242379Malignant neoplasm of lung1CTD_human
TgeneWT1C0265699Congenital hernia of foramen of Morgagni1CTD_human
TgeneWT1C0265700Congenital hernia of foramen of Bochdalek1CTD_human
TgeneWT1C0334588Giant Cell Glioblastoma1CTD_human
TgeneWT1C0346647Malignant neoplasm of pancreas1CTD_human
TgeneWT1C0346990Carcinomatosis of peritoneal cavity1CTD_human
TgeneWT1C0678222Breast Carcinoma1CTD_human
TgeneWT1C0751374Schwannomatosis, Plexiform1CTD_human
TgeneWT1C1257931Mammary Neoplasms, Human1CTD_human
TgeneWT1C1458155Mammary Neoplasms1CTD_human
TgeneWT1C1621958Glioblastoma Multiforme1CTD_human
TgeneWT1C1704377Bright Disease1CTD_human
TgeneWT1C1840452Hyaloideoretinal degeneration of Wagner1GENOMICS_ENGLAND
TgeneWT1C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
TgeneWT1C2931803Deletion 11p131ORPHANET
TgeneWT1C2936694Swyer Syndrome1ORPHANET
TgeneWT1C3494522Hypergonadotropic Ovarian Failure, X-Linked1CTD_human
TgeneWT1C451074446,XY partial gonadal dysgenesis1ORPHANET
TgeneWT1C4552079Premature Ovarian Failure 11CTD_human
TgeneWT1C4704874Mammary Carcinoma, Human1CTD_human