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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STK11-BSG (FusionGDB2 ID:86840)

Fusion Gene Summary for STK11-BSG

check button Fusion gene summary
Fusion gene informationFusion gene name: STK11-BSG
Fusion gene ID: 86840
HgeneTgene
Gene symbol

STK11

BSG

Gene ID

6794

682

Gene nameserine/threonine kinase 11basigin (Ok blood group)
SynonymsLKB1|PJS|hLKB15F7|CD147|EMMPRIN|EMPRIN|OK|SLC7A11|TCSF
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1basiginOK blood group antigencollagenase stimulatory factorextracellular matrix metalloproteinase inducerleukocyte activation antigen M6tumor cell-derived collagenase stimulatory factor
Modification date2020032920200315
UniProtAcc.

P35613

Ensembl transtripts involved in fusion geneENST00000585748, ENST00000326873, 
ENST00000346916, ENST00000545507, 
ENST00000333511, ENST00000353555, 
ENST00000574970, 
Fusion gene scores* DoF score13 X 3 X 8=3129 X 12 X 6=648
# samples 1714
** MAII scorelog2(17/312*10)=-0.876011282724546
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/648*10)=-2.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STK11 [Title/Abstract] AND BSG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTK11(1207202)-BSG(580379), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK11

GO:0006468

protein phosphorylation

12805220|25329316

HgeneSTK11

GO:0007050

cell cycle arrest

12805220|17216128

HgeneSTK11

GO:0046777

protein autophosphorylation

11430832

HgeneSTK11

GO:0071493

cellular response to UV-B

25329316

HgeneSTK11

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

11430832


check buttonFusion gene breakpoints across STK11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BSG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8289-01ASTK11chr19

1207202

+BSGchr19

580379

+
ChimerDB4STADTCGA-BR-8289STK11chr19

1207202

+BSGchr19

579499

+
ChimerDB4STADTCGA-BR-8289-01ASTK11chr19

1207202

+BSGchr19

580379

+
ChimerDB4STADTCGA-BR-8289-01ASTK11chr19

1207202

+BSGchr19

579500

+


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Fusion Gene ORF analysis for STK11-BSG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000585748ENST00000346916STK11chr19

1207202

+BSGchr19

580379

+
intron-5UTRENST00000585748ENST00000545507STK11chr19

1207202

+BSGchr19

580379

+
intron-5UTRENST00000585748ENST00000333511STK11chr19

1207202

+BSGchr19

580379

+
intron-5UTRENST00000585748ENST00000353555STK11chr19

1207202

+BSGchr19

580379

+
intron-intronENST00000585748ENST00000574970STK11chr19

1207202

+BSGchr19

580379

+
In-frameENST00000326873ENST00000346916STK11chr19

1207202

+BSGchr19

580379

+
5CDS-5UTRENST00000326873ENST00000545507STK11chr19

1207202

+BSGchr19

580379

+
5CDS-5UTRENST00000326873ENST00000333511STK11chr19

1207202

+BSGchr19

580379

+
5CDS-5UTRENST00000326873ENST00000353555STK11chr19

1207202

+BSGchr19

580379

+
5CDS-intronENST00000326873ENST00000574970STK11chr19

1207202

+BSGchr19

580379

+
intron-intronENST00000585748ENST00000346916STK11chr19

1207202

+BSGchr19

579499

+
intron-5UTRENST00000585748ENST00000545507STK11chr19

1207202

+BSGchr19

579499

+
intron-5UTRENST00000585748ENST00000333511STK11chr19

1207202

+BSGchr19

579499

+
intron-5UTRENST00000585748ENST00000353555STK11chr19

1207202

+BSGchr19

579499

+
intron-3UTRENST00000585748ENST00000574970STK11chr19

1207202

+BSGchr19

579499

+
5CDS-intronENST00000326873ENST00000346916STK11chr19

1207202

+BSGchr19

579499

+
5CDS-5UTRENST00000326873ENST00000545507STK11chr19

1207202

+BSGchr19

579499

+
5CDS-5UTRENST00000326873ENST00000333511STK11chr19

1207202

+BSGchr19

579499

+
5CDS-5UTRENST00000326873ENST00000353555STK11chr19

1207202

+BSGchr19

579499

+
5CDS-3UTRENST00000326873ENST00000574970STK11chr19

1207202

+BSGchr19

579499

+
intron-intronENST00000585748ENST00000346916STK11chr19

1207202

+BSGchr19

579500

+
intron-5UTRENST00000585748ENST00000545507STK11chr19

1207202

+BSGchr19

579500

+
intron-5UTRENST00000585748ENST00000333511STK11chr19

1207202

+BSGchr19

579500

+
intron-5UTRENST00000585748ENST00000353555STK11chr19

1207202

+BSGchr19

579500

+
intron-3UTRENST00000585748ENST00000574970STK11chr19

1207202

+BSGchr19

579500

+
5CDS-intronENST00000326873ENST00000346916STK11chr19

1207202

+BSGchr19

579500

+
5CDS-5UTRENST00000326873ENST00000545507STK11chr19

1207202

+BSGchr19

579500

+
5CDS-5UTRENST00000326873ENST00000333511STK11chr19

1207202

+BSGchr19

579500

+
5CDS-5UTRENST00000326873ENST00000353555STK11chr19

1207202

+BSGchr19

579500

+
5CDS-3UTRENST00000326873ENST00000574970STK11chr19

1207202

+BSGchr19

579500

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000326873STK11chr191207202+ENST00000346916BSGchr19580379+2798146312762425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326873ENST00000346916STK11chr191207202+BSGchr19580379+0.0021925440.99780744

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Fusion Genomic Features for STK11-BSG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STK11chr191207202+BSGchr19579499+0.0002273140.9997727
STK11chr191207202+BSGchr19579499+0.0002273140.9997727
STK11chr191207202+BSGchr19580378+8.84E-080.9999999
STK11chr191207202+BSGchr19579499+0.0002273140.9997727
STK11chr191207202+BSGchr19579499+0.0002273140.9997727
STK11chr191207202+BSGchr19580378+8.84E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STK11-BSG


check button Go to

FGviewer for the breakpoints of chr19:1207202-chr19:580379

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BSG

P35613

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11943775, PubMed:11688976). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:12553375, PubMed:11992541, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTK11chr19:1207202chr19:580379ENST00000326873+11055_6396.66666666666667225.33333333333334Nucleotide bindingATP
TgeneBSGchr19:1207202chr19:580379ENST0000033351129356_359190.66666666666666587.3333333333334Compositional biasNote=Poly-Asp
TgeneBSGchr19:1207202chr19:580379ENST0000034691607356_35910.666666666666666359.6666666666667Compositional biasNote=Poly-Asp
TgeneBSGchr19:1207202chr19:580379ENST0000035355518356_35974.66666666666667476.6666666666667Compositional biasNote=Poly-Asp
TgeneBSGchr19:1207202chr19:580379ENST0000054550718356_3590333.3333333333333Compositional biasNote=Poly-Asp
TgeneBSGchr19:1207202chr19:580379ENST0000033351129221_315190.66666666666666587.3333333333334DomainIg-like V-type
TgeneBSGchr19:1207202chr19:580379ENST0000034691607138_21910.666666666666666359.6666666666667DomainIg-like C2-type
TgeneBSGchr19:1207202chr19:580379ENST0000034691607221_31510.666666666666666359.6666666666667DomainIg-like V-type
TgeneBSGchr19:1207202chr19:580379ENST000003469160737_12010.666666666666666359.6666666666667DomainIg-like
TgeneBSGchr19:1207202chr19:580379ENST0000035355518138_21974.66666666666667476.6666666666667DomainIg-like C2-type
TgeneBSGchr19:1207202chr19:580379ENST0000035355518221_31574.66666666666667476.6666666666667DomainIg-like V-type
TgeneBSGchr19:1207202chr19:580379ENST0000054550718138_2190333.3333333333333DomainIg-like C2-type
TgeneBSGchr19:1207202chr19:580379ENST0000054550718221_3150333.3333333333333DomainIg-like V-type
TgeneBSGchr19:1207202chr19:580379ENST000005455071837_1200333.3333333333333DomainIg-like
TgeneBSGchr19:1207202chr19:580379ENST0000033351129345_385190.66666666666666587.3333333333334Topological domainCytoplasmic
TgeneBSGchr19:1207202chr19:580379ENST0000034691607138_32310.666666666666666359.6666666666667Topological domainExtracellular
TgeneBSGchr19:1207202chr19:580379ENST0000034691607345_38510.666666666666666359.6666666666667Topological domainCytoplasmic
TgeneBSGchr19:1207202chr19:580379ENST0000035355518138_32374.66666666666667476.6666666666667Topological domainExtracellular
TgeneBSGchr19:1207202chr19:580379ENST0000035355518345_38574.66666666666667476.6666666666667Topological domainCytoplasmic
TgeneBSGchr19:1207202chr19:580379ENST0000054550718138_3230333.3333333333333Topological domainExtracellular
TgeneBSGchr19:1207202chr19:580379ENST0000054550718345_3850333.3333333333333Topological domainCytoplasmic
TgeneBSGchr19:1207202chr19:580379ENST0000033351129324_344190.66666666666666587.3333333333334TransmembraneHelical
TgeneBSGchr19:1207202chr19:580379ENST0000034691607324_34410.666666666666666359.6666666666667TransmembraneHelical
TgeneBSGchr19:1207202chr19:580379ENST0000035355518324_34474.66666666666667476.6666666666667TransmembraneHelical
TgeneBSGchr19:1207202chr19:580379ENST0000054550718324_3440333.3333333333333TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTK11chr19:1207202chr19:580379ENST00000326873+11049_30996.66666666666667225.33333333333334DomainProtein kinase
TgeneBSGchr19:1207202chr19:580379ENST0000033351129138_219190.66666666666666587.3333333333334DomainIg-like C2-type
TgeneBSGchr19:1207202chr19:580379ENST000003335112937_120190.66666666666666587.3333333333334DomainIg-like
TgeneBSGchr19:1207202chr19:580379ENST000003535551837_12074.66666666666667476.6666666666667DomainIg-like
TgeneBSGchr19:1207202chr19:580379ENST0000033351129138_323190.66666666666666587.3333333333334Topological domainExtracellular


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Fusion Gene Sequence for STK11-BSG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000326873_ENST00000346916_TCGA-BR-8289-01A_STK11_chr19_1207202_+_BSG_chr19_580379_length(transcript)=2798nt_BP=1463nt
GGCGTGCGGTGTCCGCGGCGGCGCAGGGAGGGGGAGGGAGGTAAACAAGATGGCGGCGGCGTGTCGGGCGCGGAAGGGGGAGGCGGCCCG
GGGCGCCCGCGAGTGAGGCGCGGGGCGGCGAAGGGAGCGCGGGTGGCGGCACTTGCTGCCGCGGCCTTGGATGGGCTGGGCCCCCCTCGC
CGCTCCGCCTCCTCCACACGCGCGGCGGCCGCGGCGAGGGGGACGCGCCGCCCGGGGCCCGGCACCTTCGGGAACCCCCCGGCCCGGAGC
CTGCGGCCTGCGCCGCCTCGGCCGCCGGGAGCCCCGTGGAGCCCCCGCCGCCGCGCCGCCCCGCGGACCGGACGCTGAGGGCACTCGGGG
CGGGGCGCGCGCTCGGGCAGACGTTTGCGGGGAGGGGGGCGCCTGCCGGGCCCCGGCGACCACCTTGGGGGTCGCGGGCCGGCTCGGGGG
GCGCCCAGTGCGGGCCCTCGCGGGCGCCGGGCAGCGACCAGCCCTGAGCGGAGCTGTTGGCCGCGGCGGGAGGCCTCCCGGACGCCCCCA
GCCCCCCGAACGCTCGCCCGGGCCGGCGGGAGTCGGCGCCCCCCGGGAGGTCCGCTCGGTCGTCCGCGGCGGAGCGTTTGCTCCTGGGAC
AGGCGGTGGGACCGGGGCGTCGCCGGAGACGCCCCCAGCGAAGTTGGGCTCTCCAGGTGTGGGGGTCCCGGGGGGTAGCGACGTCGCGGA
CCCGGCCTGTGGGATGGGCGGCCCGGAGAAGACTGCGCTCGGCCGTGTTCATACTTGTCCGTGGGCCTGAGGTCCCCGGAGGATGACCTA
GCACTGAAAAGCCCCGGCCGGCCTCCCCAGGGTCCCCGAGGACGAAGTTGACCCTGACCGGGCCGTCTCCCAGTTCTGAGGCCCGGGTCC
CACTGGAACTCGCGTCTGAGCCGCCGTCCCGGACCCCCGGTGCCCGCCGGTCCGCAGACCCTGCACCGGGCTTGGACTCGCAGCCGGGAC
TGACGTGTAGAACAATCGTTTCTGTTGGAAGAAGGGTTTTTCCCTTCCTTTTGGGGTTTTTGTTGCCTTTTTTTTTTCTTTTTTCTTTGT
AAAATTTTGGAGAAGGGAAGTCGGAACACAAGGAAGGACCGCTCACCCGCGGACTCAGGGCTGGCGGCGGGACTCCAGGACCCTGGGTCC
AGCATGGAGGTGGTGGACCCGCAGCAGCTGGGCATGTTCACGGAGGGCGAGCTGATGTCGGTGGGTATGGACACGTTCATCCACCGCATC
GACTCCACCGAGGTCATCTACCAGCCGCGCCGCAAGCGGGCCAAGCTCATCGGCAAGTACCTGATGGGGGACCTGCTGGGGGAAGGCTCT
TACGGCAAGGTGAAGGAGGTGCTGGACTCGGAGACGCTGTGCAGGAGGGCCGTCAAGATCCTCAAGAAGAAGAAGTTGCGAAGGATCCCC
AACGGGGAGGCCAACGTGAAGAAGGTGGACTCCGACGACCAGTGGGGAGAGTACTCCTGCGTCTTCCTCCCCGAGCCCATGGGCACGGCC
AACATCCAGCTCCACGGGCCTCCCAGAGTGAAGGCTGTGAAGTCGTCAGAACACATCAACGAGGGGGAGACGGCCATGCTGGTCTGCAAG
TCAGAGTCCGTGCCACCTGTCACTGACTGGGCCTGGTACAAGATCACTGACTCTGAGGACAAGGCCCTCATGAACGGCTCCGAGAGCAGG
TTCTTCGTGAGTTCCTCGCAGGGCCGGTCAGAGCTACACATTGAGAACCTGAACATGGAGGCCGACCCCGGCCAGTACCGGTGCAACGGC
ACCAGCTCCAAGGGCTCCGACCAGGCCATCATCACGCTCCGCGTGCGCAGCCACCTGGCCGCCCTCTGGCCCTTCCTGGGCATCGTGGCT
GAGGTGCTGGTGCTGGTCACCATCATCTTCATCTACGAGAAGCGCCGGAAGCCCGAGGACGTCCTGGATGATGACGACGCCGGCTCTGCA
CCCCTGAAGAGCAGCGGGCAGCACCAGAATGACAAAGGCAAGAACGTCCGCCAGAGGAACTCTTCCTGAGGCAGGTGGCCCGAGGACGCT
CCCTGCTCCACGTCTGCGCCGCCGCCGGAGTCCACTCCCAGTGCTTGCAAGATTCCAAGTTCTCACCTCTTAAAGAAAACCCACCCCGTA
GATTCCCATCATACACTTCCTTCTTTTTTAAAAAAGTTGGGTTTTCTCCATTCAGGATTCTGTTCCTTAGGTTTTTTTCCTTCTGAAGTG
TTTCACGAGAGCCCGGGAGCTGCTGCCCTGCGGCCCCGTCTGTGGCTTTCAGCCTCTGGGTCTGAGTCATGGCCGGGTGGGCGGCACAGC
CTTCTCCACTGGCCGGAGTCAGTGCCAGGTCCTTGCCCTTTGTGGAAAGTCACAGGTCACACGAGGGGCCCCGTGTCCTGCCTGTCTGAA
GCCAATGCTGTCTGGTTGCGCCATTTTTGTGCTTTTATGTTTAATTTTATGAGGGCCACGGGTCTGTGTTCGACTCAGCCTCAGGGACGA
CTCTGACCTCTTGGCCACAGAGGACTCACTTGCCCACACCGAGGGCGACCCCGTCACAGCCTCAAGTCACTCCCAAGCCCCCTCCTTGTC
TGTGCATCCGGGGGCAGCTCTGGAGGGGGTTTGCTGGGGAACTGGCGCCATCGCCGGGACTCCAGAACCGCAGAAGCCTCCCCAGCTCAC
CCCTGGAGGACGGCCGGCTCTCTATAGCACCAGGGCTCACGTGGGAACCCCCCTCCCACCCACCGCCACAATAAAGATCGCCCCCACCTC

>In-frame_ENST00000326873_ENST00000346916_TCGA-BR-8289-01A_STK11_chr19_1207202_+_BSG_chr19_580379_length(amino acids)=425AA_start in transcript=1276_stop in transcript=2
MTSVESMRWMNVSIPTDISSPSVNMPSCCGSTTSMLDPGSWSPAASPESAGERSFLVFRLPFSKILQRKKKKKRQQKPQKEGKNPSSNRN
DCSTRQSRLRVQARCRVCGPAGTGGPGRRLRREFQWDPGLRTGRRPGQGQLRPRGPWGGRPGLFSARSSSGDLRPTDKYEHGRAQSSPGR
PSHRPGPRRRYPPGPPHLESPTSLGASPATPRSHRLSQEQTLRRGRPSGPPGGRRLPPARASVRGAGGVREASRRGQQLRSGLVAARRPR
GPALGAPRAGPRPPRWSPGPGRRPPPRKRLPERAPRPECPQRPVRGAARRRGLHGAPGGRGGAGRRLRAGGFPKVPGPGRRVPLAAAAAR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for STK11-BSG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STK11-BSG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STK11-BSG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTK11C0031269Peutz-Jeghers Syndrome19CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneSTK11C1336708Testicular Germ Cell Tumor2CTD_human;UNIPROT
HgeneSTK11C0001418Adenocarcinoma1CTD_human
HgeneSTK11C0007137Squamous cell carcinoma1CTD_human
HgeneSTK11C0020538Hypertensive disease1CTD_human
HgeneSTK11C0024121Lung Neoplasms1CTD_human
HgeneSTK11C0030297Pancreatic Neoplasm1CGI;CTD_human
HgeneSTK11C0149721Left Ventricular Hypertrophy1CTD_human
HgeneSTK11C0152013Adenocarcinoma of lung (disorder)1CGI;CTD_human
HgeneSTK11C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneSTK11C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneSTK11C0205643Carcinoma, Cribriform1CTD_human
HgeneSTK11C0205644Carcinoma, Granular Cell1CTD_human
HgeneSTK11C0205645Adenocarcinoma, Tubular1CTD_human
HgeneSTK11C0242379Malignant neoplasm of lung1CTD_human;UNIPROT
HgeneSTK11C0282207Cronkhite-Canada Syndrome1CTD_human
HgeneSTK11C0346647Malignant neoplasm of pancreas1CGI;CTD_human
HgeneSTK11C0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneSTK11C1257915Intestinal Polyposis1CTD_human
TgeneBSGC0015697Arterial Fatty Streak1CTD_human
TgeneBSGC0027626Neoplasm Invasiveness1CTD_human
TgeneBSGC0027627Neoplasm Metastasis1CTD_human
TgeneBSGC0027659Neoplasms, Experimental1CTD_human
TgeneBSGC0264956Atheroma1CTD_human
TgeneBSGC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneBSGC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneBSGC2936350Plaque, Atherosclerotic1CTD_human
TgeneBSGC2936351Fibroatheroma1CTD_human
TgeneBSGC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human