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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:STK11-GPX4 (FusionGDB2 ID:86844) |
Fusion Gene Summary for STK11-GPX4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STK11-GPX4 | Fusion gene ID: 86844 | Hgene | Tgene | Gene symbol | STK11 | GPX4 | Gene ID | 6794 | 2879 |
| Gene name | serine/threonine kinase 11 | glutathione peroxidase 4 | |
| Synonyms | LKB1|PJS|hLKB1 | GPx-4|GSHPx-4|MCSP|PHGPx|SMDS|snGPx|snPHGPx | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1 | phospholipid hydroperoxide glutathione peroxidaseepididymis secretory sperm binding proteinphospholipid hydroperoxidasephospholipid hydroperoxide glutathione peroxidase, mitochondrialsperm nucleus glutathione peroxidase | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | P36969 | |
| Ensembl transtripts involved in fusion gene | ENST00000585748, ENST00000326873, | ENST00000354171, ENST00000589115, | |
| Fusion gene scores | * DoF score | 13 X 3 X 8=312 | 5 X 4 X 3=60 |
| # samples | 17 | 5 | |
| ** MAII score | log2(17/312*10)=-0.876011282724546 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STK11 [Title/Abstract] AND GPX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | STK11(1222005)-GPX4(1105185), # samples:2 GPX4(1106458)-STK11(1226453), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | STK11-GPX4 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. STK11-GPX4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. STK11-GPX4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. STK11-GPX4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. STK11-GPX4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. STK11-GPX4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. STK11-GPX4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK11 | GO:0006468 | protein phosphorylation | 12805220|25329316 |
| Hgene | STK11 | GO:0007050 | cell cycle arrest | 12805220|17216128 |
| Hgene | STK11 | GO:0046777 | protein autophosphorylation | 11430832 |
| Hgene | STK11 | GO:0071493 | cellular response to UV-B | 25329316 |
| Hgene | STK11 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11430832 |
| Fusion gene breakpoints across STK11 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GPX4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-C8-A26X-01A | STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105185 | + |
| ChimerDB4 | BRCA | TCGA-C8-A26X-01A | STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105185 | + |
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Fusion Gene ORF analysis for STK11-GPX4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000585748 | ENST00000354171 | STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105185 | + |
| intron-3CDS | ENST00000585748 | ENST00000589115 | STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105185 | + |
| Frame-shift | ENST00000326873 | ENST00000354171 | STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105185 | + |
| Frame-shift | ENST00000326873 | ENST00000589115 | STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105185 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for STK11-GPX4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105184 | + | 9.55E-07 | 0.99999905 |
| STK11 | chr19 | 1222005 | + | GPX4 | chr19 | 1105184 | + | 9.55E-07 | 0.99999905 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for STK11-GPX4 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GPX4 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). {ECO:0000250|UniProtKB:O70325, ECO:0000250|UniProtKB:P36968, ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:24439385}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for STK11-GPX4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for STK11-GPX4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for STK11-GPX4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | GPX4 | P36969 | DB00143 | Glutathione | Cofactor | Small molecule | Approved|Investigational|Nutraceutical |
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Related Diseases for STK11-GPX4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STK11 | C0031269 | Peutz-Jeghers Syndrome | 19 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | STK11 | C1336708 | Testicular Germ Cell Tumor | 2 | CTD_human;UNIPROT |
| Hgene | STK11 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | STK11 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | STK11 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | STK11 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | STK11 | C0030297 | Pancreatic Neoplasm | 1 | CGI;CTD_human |
| Hgene | STK11 | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
| Hgene | STK11 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CGI;CTD_human |
| Hgene | STK11 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
| Hgene | STK11 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
| Hgene | STK11 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
| Hgene | STK11 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
| Hgene | STK11 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
| Hgene | STK11 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human;UNIPROT |
| Hgene | STK11 | C0282207 | Cronkhite-Canada Syndrome | 1 | CTD_human |
| Hgene | STK11 | C0346647 | Malignant neoplasm of pancreas | 1 | CGI;CTD_human |
| Hgene | STK11 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
| Hgene | STK11 | C1257915 | Intestinal Polyposis | 1 | CTD_human |
| Tgene | GPX4 | C0021364 | Male infertility | 2 | CTD_human |
| Tgene | GPX4 | C0848676 | Subfertility, Male | 2 | CTD_human |
| Tgene | GPX4 | C0917731 | Male sterility | 2 | CTD_human |
| Tgene | GPX4 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Tgene | GPX4 | C0006635 | Cadmium poisoning | 1 | CTD_human |
| Tgene | GPX4 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| Tgene | GPX4 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | GPX4 | C0010417 | Cryptorchidism | 1 | CTD_human |
| Tgene | GPX4 | C0012684 | Blastocyst Disintegration | 1 | CTD_human |
| Tgene | GPX4 | C0013937 | Embryo Resorption | 1 | CTD_human |
| Tgene | GPX4 | C0015695 | Fatty Liver | 1 | CTD_human |
| Tgene | GPX4 | C0016059 | Fibrosis | 1 | CTD_human |
| Tgene | GPX4 | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | GPX4 | C0018802 | Congestive heart failure | 1 | CTD_human |
| Tgene | GPX4 | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
| Tgene | GPX4 | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
| Tgene | GPX4 | C0271650 | Impaired glucose tolerance | 1 | CTD_human |
| Tgene | GPX4 | C0431663 | Bilateral Cryptorchidism | 1 | CTD_human |
| Tgene | GPX4 | C0431664 | Unilateral Cryptorchidism | 1 | CTD_human |
| Tgene | GPX4 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Tgene | GPX4 | C0752350 | Embryo Death | 1 | CTD_human |
| Tgene | GPX4 | C0752351 | Embryo Loss | 1 | CTD_human |
| Tgene | GPX4 | C1136082 | Embryo Disintegration | 1 | CTD_human |
| Tgene | GPX4 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Tgene | GPX4 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | GPX4 | C1563730 | Abdominal Cryptorchidism | 1 | CTD_human |
| Tgene | GPX4 | C1563731 | Inguinal Cryptorchidism | 1 | CTD_human |
| Tgene | GPX4 | C1623038 | Cirrhosis | 1 | CTD_human |
| Tgene | GPX4 | C1855229 | Spondylometaphyseal dysplasia, Sedaghatian type | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | GPX4 | C1959583 | Myocardial Failure | 1 | CTD_human |
| Tgene | GPX4 | C1961112 | Heart Decompensation | 1 | CTD_human |
| Tgene | GPX4 | C2711227 | Steatohepatitis | 1 | CTD_human |
| Tgene | GPX4 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
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