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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STRADA-LYZ (FusionGDB2 ID:87076)

Fusion Gene Summary for STRADA-LYZ

check button Fusion gene summary
Fusion gene informationFusion gene name: STRADA-LYZ
Fusion gene ID: 87076
HgeneTgene
Gene symbol

STRADA

LYZ

Gene ID

92335

4069

Gene nameSTE20 related adaptor alphalysozyme
SynonymsLYK5|NY-BR-96|PMSE|STRAD|STRAD alpha|StlkLYZF1|LZM
Cytomap

17q23.3

12q15

Type of geneprotein-codingprotein-coding
DescriptionSTE20-related kinase adapter protein alphaSTE20-like pseudokinaseSTE20-related kinase adaptor alphaprotein kinase LYK5serologically defined breast cancer antigen NY-BR-96lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1
Modification date2020031320200313
UniProtAcc.

P61626

Ensembl transtripts involved in fusion geneENST00000245865, ENST00000375840, 
ENST00000392950, ENST00000336174, 
ENST00000447001, ENST00000582137, 
ENST00000580039, ENST00000579340, 
ENST00000261267, ENST00000549690, 
ENST00000548839, 
Fusion gene scores* DoF score6 X 8 X 5=24051 X 27 X 13=17901
# samples 960
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(60/17901*10)=-4.89893387178018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STRADA [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTRADA(61805694)-LYZ(69743888), # samples:2
Anticipated loss of major functional domain due to fusion event.STRADA-LYZ seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
STRADA-LYZ seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
STRADA-LYZ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
STRADA-LYZ seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTRADA

GO:0006468

protein phosphorylation

12805220

HgeneSTRADA

GO:0006611

protein export from nucleus

12805220

HgeneSTRADA

GO:0032147

activation of protein kinase activity

12805220

TgeneLYZ

GO:0031640

killing of cells of other organism

9727055

TgeneLYZ

GO:0042742

defense response to bacterium

21093056

TgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056


check buttonFusion gene breakpoints across STRADA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LYZ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-5898-01ASTRADAchr17

61805694

-LYZchr12

69743888

+
ChimerDB4LUSCTCGA-56-5898STRADAchr17

61805693

-LYZchr12

69743887

+
ChimerDB4LUSCTCGA-56-5898STRADAchr17

61805694

-LYZchr12

69743888

+
ChimerDB4LUSCTCGA-56-5898STRADAchr17

61803998

-LYZchr12

69743888

+


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Fusion Gene ORF analysis for STRADA-LYZ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000245865ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000245865ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000245865ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000375840ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000375840ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000375840ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
intron-3CDSENST00000392950ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
intron-3CDSENST00000392950ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
intron-3CDSENST00000392950ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000336174ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000336174ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
In-frameENST00000336174ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000447001ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000447001ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000447001ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000582137ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000582137ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
Frame-shiftENST00000582137ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
intron-3CDSENST00000580039ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
intron-3CDSENST00000580039ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
intron-3CDSENST00000580039ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000579340ENST00000261267STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000579340ENST00000549690STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000579340ENST00000548839STRADAchr17

61805694

-LYZchr12

69743888

+
5UTR-3CDSENST00000245865ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000245865ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000245865ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000375840ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000375840ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000375840ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
intron-3CDSENST00000392950ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
intron-3CDSENST00000392950ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
intron-3CDSENST00000392950ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000336174ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000336174ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
In-frameENST00000336174ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000447001ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000447001ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000447001ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000582137ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000582137ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
Frame-shiftENST00000582137ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
intron-3CDSENST00000580039ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
intron-3CDSENST00000580039ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
intron-3CDSENST00000580039ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000579340ENST00000261267STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000579340ENST00000549690STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000579340ENST00000548839STRADAchr17

61805693

-LYZchr12

69743887

+
5UTR-3CDSENST00000245865ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000245865ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000245865ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000375840ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000375840ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000375840ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000392950ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000392950ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000392950ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+
Frame-shiftENST00000336174ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
Frame-shiftENST00000336174ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
Frame-shiftENST00000336174ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+
Frame-shiftENST00000447001ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
Frame-shiftENST00000447001ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
In-frameENST00000447001ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000582137ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000582137ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000582137ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000580039ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000580039ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
intron-3CDSENST00000580039ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000579340ENST00000261267STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000579340ENST00000549690STRADAchr17

61803998

-LYZchr12

69743888

+
5UTR-3CDSENST00000579340ENST00000548839STRADAchr17

61803998

-LYZchr12

69743888

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336174STRADAchr1761805694-ENST00000548839LYZchr1269743888+5481493001100
ENST00000336174STRADAchr1761805693-ENST00000548839LYZchr1269743887+5481493001100
ENST00000447001STRADAchr1761803998-ENST00000548839LYZchr1269743888+67527618245490

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336174ENST00000548839STRADAchr1761805694-LYZchr1269743888+0.337525520.66247445
ENST00000336174ENST00000548839STRADAchr1761805693-LYZchr1269743887+0.337525520.66247445
ENST00000447001ENST00000548839STRADAchr1761803998-LYZchr1269743888+0.195562560.80443746

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Fusion Genomic Features for STRADA-LYZ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STRADAchr1761805693-LYZchr1269743887+3.96E-050.9999604
STRADAchr1761805693-LYZchr1269743887+3.96E-050.9999604
STRADAchr1761803997-LYZchr1269743887+1.18E-070.9999999
STRADAchr1761805693-LYZchr1269743887+3.96E-050.9999604
STRADAchr1761805693-LYZchr1269743887+3.96E-050.9999604
STRADAchr1761803997-LYZchr1269743887+1.18E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STRADA-LYZ


check button Go to

FGviewer for the breakpoints of chr17:61805694-chr12:69743888

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LYZ

P61626

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTRADAchr17:61803998chr12:69743888ENST00000336174-31369_37931.333333333333332432.0DomainProtein kinase
HgeneSTRADAchr17:61803998chr12:69743888ENST00000375840-31269_3790374.0DomainProtein kinase
HgeneSTRADAchr17:61803998chr12:69743888ENST00000392950-1969_3790349.0DomainProtein kinase
HgeneSTRADAchr17:61803998chr12:69743888ENST00000447001-31169_37931.333333333333332340.3333333333333DomainProtein kinase
HgeneSTRADAchr17:61803998chr12:69743888ENST00000582137-11169_3790315.3333333333333DomainProtein kinase
HgeneSTRADAchr17:61805693chr12:69743887ENST00000336174-21369_37912.0432.0DomainProtein kinase
HgeneSTRADAchr17:61805693chr12:69743887ENST00000375840-21269_3790374.0DomainProtein kinase
HgeneSTRADAchr17:61805693chr12:69743887ENST00000392950-1969_3790349.0DomainProtein kinase
HgeneSTRADAchr17:61805693chr12:69743887ENST00000447001-21169_37912.0340.3333333333333DomainProtein kinase
HgeneSTRADAchr17:61805693chr12:69743887ENST00000582137-21169_37912.0315.3333333333333DomainProtein kinase
HgeneSTRADAchr17:61805694chr12:69743888ENST00000336174-21369_37912.0432.0DomainProtein kinase
HgeneSTRADAchr17:61805694chr12:69743888ENST00000375840-21269_3790374.0DomainProtein kinase
HgeneSTRADAchr17:61805694chr12:69743888ENST00000392950-1969_3790349.0DomainProtein kinase
HgeneSTRADAchr17:61805694chr12:69743888ENST00000447001-21169_37912.0340.3333333333333DomainProtein kinase
HgeneSTRADAchr17:61805694chr12:69743888ENST00000582137-21169_37912.0315.3333333333333DomainProtein kinase
TgeneLYZchr17:61803998chr12:69743888ENST000002612670419_14845.333333333333336149.0DomainC-type lysozyme
TgeneLYZchr17:61805693chr12:69743887ENST000002612670419_14845.333333333333336149.0DomainC-type lysozyme
TgeneLYZchr17:61805694chr12:69743888ENST000002612670419_14845.333333333333336149.0DomainC-type lysozyme


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Fusion Gene Sequence for STRADA-LYZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000336174_ENST00000548839_TCGA-56-5898-01A_STRADA_chr17_61805694_-_LYZ_chr12_69743888_length(transcript)=548nt_BP=149nt
GCGGCGCGGCAGTAAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAA
GTAGGCCTACACAGTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGGGATGTGTTTGGCCAAATGGGAGAGTGGTTA
CAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGG
CAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGTAAGACAAGCTAATATTTGACCAATCTGGTTATACTTACAAGAAT
TGAGACTCAATACAAATGAAAAAGCCTTGAAAGGTTCATGAGGGACCTAGAAAAACTACATCTCAACTTCCAGAAAGTCATTATTATTTT
CCTCATAATTCCCTGAGTAAGAAATTAAAGAAGTGGTATCATAAAAGGTTGATGTTTTTTAATATACAGAAGTTTCTGGAATGACCTATT

>In-frame_ENST00000336174_ENST00000548839_TCGA-56-5898-01A_STRADA_chr17_61805694_-_LYZ_chr12_69743888_length(amino acids)=100AA_start in transcript=300_stop in transcript=1
MTGINCSWGFAIITPVAAIDLKYPIISASVSSIVVCSSCVVTTLPFGQTHPLIRSGLLTRNDMSSYCVGLLQFQKLKPVPGVSKQPRPSW

--------------------------------------------------------------
>In-frame_ENST00000336174_ENST00000548839_TCGA-56-5898_STRADA_chr17_61805693_-_LYZ_chr12_69743887_length(transcript)=548nt_BP=149nt
GCGGCGCGGCAGTAAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAA
GTAGGCCTACACAGTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGGGATGTGTTTGGCCAAATGGGAGAGTGGTTA
CAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGG
CAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGTAAGACAAGCTAATATTTGACCAATCTGGTTATACTTACAAGAAT
TGAGACTCAATACAAATGAAAAAGCCTTGAAAGGTTCATGAGGGACCTAGAAAAACTACATCTCAACTTCCAGAAAGTCATTATTATTTT
CCTCATAATTCCCTGAGTAAGAAATTAAAGAAGTGGTATCATAAAAGGTTGATGTTTTTTAATATACAGAAGTTTCTGGAATGACCTATT

>In-frame_ENST00000336174_ENST00000548839_TCGA-56-5898_STRADA_chr17_61805693_-_LYZ_chr12_69743887_length(amino acids)=100AA_start in transcript=300_stop in transcript=1
MTGINCSWGFAIITPVAAIDLKYPIISASVSSIVVCSSCVVTTLPFGQTHPLIRSGLLTRNDMSSYCVGLLQFQKLKPVPGVSKQPRPSW

--------------------------------------------------------------
>In-frame_ENST00000447001_ENST00000548839_TCGA-56-5898_STRADA_chr17_61803998_-_LYZ_chr12_69743888_length(transcript)=675nt_BP=276nt
ATCAGTCCTCCCGGTCGCCCCACTGCGCATGGCACGTTGCGTACTCCCCTCCCAGCAACCGGTCTGGCGGCGGCGCGGCAGTAAAACTGA
GGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACAGTAGGAAC
TCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTAT
TTGGAGGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACAGAAGCACTGATTATGGGA
TATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGGTAAGACAA
GCTAATATTTGACCAATCTGGTTATACTTACAAGAATTGAGACTCAATACAAATGAAAAAGCCTTGAAAGGTTCATGAGGGACCTAGAAA
AACTACATCTCAACTTCCAGAAAGTCATTATTATTTTCCTCATAATTCCCTGAGTAAGAAATTAAAGAAGTGGTATCATAAAAGGTTGAT

>In-frame_ENST00000447001_ENST00000548839_TCGA-56-5898_STRADA_chr17_61803998_-_LYZ_chr12_69743888_length(amino acids)=90AA_start in transcript=182_stop in transcript=454
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSGKTS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for STRADA-LYZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STRADA-LYZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLYZP61626DB03175Propyl alcoholSmall moleculeApproved
TgeneLYZP61626DB03175Propyl alcoholSmall moleculeApproved
TgeneLYZP61626DB02772SucroseSmall moleculeApproved|Experimental|Investigational
TgeneLYZP61626DB02772SucroseSmall moleculeApproved|Experimental|Investigational
TgeneLYZP61626DB00128Aspartic acidSmall moleculeApproved|Nutraceutical
TgeneLYZP61626DB00128Aspartic acidSmall moleculeApproved|Nutraceutical
TgeneLYZP61626DB03006Arsanilic acidSmall moleculeExperimental|Vet_approved
TgeneLYZP61626DB03006Arsanilic acidSmall moleculeExperimental|Vet_approved

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Related Diseases for STRADA-LYZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTRADAC1970203Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneSTRADAC0025149Medulloblastoma1CTD_human
HgeneSTRADAC0205833Medullomyoblastoma1CTD_human
HgeneSTRADAC0278510Childhood Medulloblastoma1CTD_human
HgeneSTRADAC0278876Adult Medulloblastoma1CTD_human
HgeneSTRADAC0751291Desmoplastic Medulloblastoma1CTD_human
HgeneSTRADAC1275668Melanotic medulloblastoma1CTD_human
HgeneSTRADAC1854919Severe psychomotor retardation1GENOMICS_ENGLAND
TgeneLYZC0268389Amyloidosis, familial visceral4CTD_human;GENOMICS_ENGLAND;UNIPROT