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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STRAP-MYO7A (FusionGDB2 ID:87087)

Fusion Gene Summary for STRAP-MYO7A

check button Fusion gene summary
Fusion gene informationFusion gene name: STRAP-MYO7A
Fusion gene ID: 87087
HgeneTgene
Gene symbol

STRAP

MYO7A

Gene ID

153443

4647

Gene nameserum response factor binding protein 1myosin VIIA
SynonymsBUD22|P49|Rlb1|STRAP|p49/STRAPDFNA11|DFNB2|MYOVIIA|MYU7A|NSRD2|USH1B
Cytomap

5q23.1

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionserum response factor-binding protein 1BUD22 homologSRF-dependent transcription regulation-associated proteinunconventional myosin-VIIamyosin VIIA (Usher syndrome 1B (autosomal recessive, severe))
Modification date2020031320200313
UniProtAcc.

Q13402

Ensembl transtripts involved in fusion geneENST00000538352, ENST00000025399, 
ENST00000419869, 		ENST00000409709, 
ENST00000409893, ENST00000458637, 
ENST00000409619, ENST00000605744, 
Fusion gene scores* DoF score5 X 5 X 3=759 X 9 X 4=324
# samples 510
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STRAP [Title/Abstract] AND MYO7A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTRAP(16036610)-MYO7A(76866953), # samples:1
Anticipated loss of major functional domain due to fusion event.STRAP-MYO7A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYO7A

GO:0007040

lysosome organization

16001398

TgeneMYO7A

GO:0030048

actin filament-based movement

21687988


check buttonFusion gene breakpoints across STRAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYO7A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A10A-01ASTRAPchr12

16036610

+MYO7Achr11

76866953

+


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Fusion Gene ORF analysis for STRAP-MYO7A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000538352ENST00000409709STRAPchr12

16036610

+MYO7Achr11

76866953

+
intron-3CDSENST00000538352ENST00000409893STRAPchr12

16036610

+MYO7Achr11

76866953

+
intron-3CDSENST00000538352ENST00000458637STRAPchr12

16036610

+MYO7Achr11

76866953

+
intron-3CDSENST00000538352ENST00000409619STRAPchr12

16036610

+MYO7Achr11

76866953

+
intron-intronENST00000538352ENST00000605744STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000025399ENST00000409709STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000025399ENST00000409893STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000025399ENST00000458637STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000025399ENST00000409619STRAPchr12

16036610

+MYO7Achr11

76866953

+
5CDS-intronENST00000025399ENST00000605744STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000419869ENST00000409709STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000419869ENST00000409893STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000419869ENST00000458637STRAPchr12

16036610

+MYO7Achr11

76866953

+
Frame-shiftENST00000419869ENST00000409619STRAPchr12

16036610

+MYO7Achr11

76866953

+
5CDS-intronENST00000419869ENST00000605744STRAPchr12

16036610

+MYO7Achr11

76866953

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for STRAP-MYO7A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STRAPchr1216036610+MYO7Achr1176866952+5.83E-050.9999417
STRAPchr1216036610+MYO7Achr1176866952+5.83E-050.9999417

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STRAP-MYO7A


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO7A

Q13402

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000250, ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:21493626, ECO:0000269|PubMed:21687988, ECO:0000269|PubMed:21709241}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for STRAP-MYO7A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for STRAP-MYO7A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STRAP-MYO7A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STRAP-MYO7A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTRAPC0009402Colorectal Carcinoma1CTD_human
HgeneSTRAPC0009404Colorectal Neoplasms1CTD_human
TgeneMYO7AC1568247Usher Syndrome, Type I24CLINGEN;GENOMICS_ENGLAND;UNIPROT
TgeneMYO7AC3711374Nonsyndromic Deafness11CLINGEN
TgeneMYO7AC0154860Hereditary retinal dystrophy9CLINGEN
TgeneMYO7AC1848638USHER SYNDROME, TYPE IB (disorder)9CLINGEN
TgeneMYO7AC1848639USHER SYNDROME, TYPE IA, FORMERLY9CLINGEN
TgeneMYO7AC1848640USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY9CLINGEN
TgeneMYO7AC1832475Deafness, Autosomal Dominant 115CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneMYO7AC1838701DEAFNESS, AUTOSOMAL RECESSIVE 25CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneMYO7AC1568249Usher Syndrome, Type II2CTD_human;ORPHANET
TgeneMYO7AC0025202melanoma1CTD_human
TgeneMYO7AC0271097Usher Syndrome1CTD_human
TgeneMYO7AC0339534Usher syndrome type 21ORPHANET
TgeneMYO7AC1384666hearing impairment1GENOMICS_ENGLAND
TgeneMYO7AC1568248Usher Syndrome, Type III1CTD_human
TgeneMYO7AC2931205Usher syndrome, type 1A1CTD_human