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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STRN3-PPP6R3 (FusionGDB2 ID:87125)

Fusion Gene Summary for STRN3-PPP6R3

check button Fusion gene summary
Fusion gene informationFusion gene name: STRN3-PPP6R3
Fusion gene ID: 87125
HgeneTgene
Gene symbol

STRN3

PPP6R3

Gene ID

29966

55291

Gene namestriatin 3protein phosphatase 6 regulatory subunit 3
SynonymsPPP2R6B|S/G2NA|SG2NAC11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3
Cytomap

14q12

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionstriatin-3cell cycle S/G2 nuclear autoantigencell cycle autoantigen SG2NAnuclear autoantigenprotein phosphatase 2 regulatory subunit B'''betas/G2 antigenstriatin, calmodulin binding protein 3serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355683, ENST00000357479, 
ENST00000366206, 		ENST00000393799, 
ENST00000530427, ENST00000393800, 
ENST00000534534, ENST00000524845, 
ENST00000265637, ENST00000524904, 
ENST00000393801, ENST00000265636, 
ENST00000529710, ENST00000527403, 
Fusion gene scores* DoF score18 X 12 X 9=194428 X 32 X 13=11648
# samples 1838
** MAII scorelog2(18/1944*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(38/11648*10)=-4.93793903186775
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STRN3 [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTRN3(31495110)-PPP6R3(68350511), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP6R3

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191


check buttonFusion gene breakpoints across STRN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPP6R3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A423-01ASTRN3chr14

31495110

-PPP6R3chr11

68350511

+


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Fusion Gene ORF analysis for STRN3-PPP6R3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355683ENST00000393799STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000530427STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000393800STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000534534STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000524845STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000265637STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000524904STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000393801STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000265636STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000529710STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000355683ENST00000527403STRN3chr14

31495110

-PPP6R3chr11

68350511

+
In-frameENST00000357479ENST00000393799STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000530427STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000393800STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000534534STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000524845STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000265637STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000524904STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000393801STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000265636STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000529710STRN3chr14

31495110

-PPP6R3chr11

68350511

+
5CDS-intronENST00000357479ENST00000527403STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-3CDSENST00000366206ENST00000393799STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000530427STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000393800STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000534534STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000524845STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000265637STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000524904STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000393801STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000265636STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000529710STRN3chr14

31495110

-PPP6R3chr11

68350511

+
intron-intronENST00000366206ENST00000527403STRN3chr14

31495110

-PPP6R3chr11

68350511

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355683STRN3chr1431495110-ENST00000393799PPP6R3chr1168350511+38054982161592458
ENST00000357479STRN3chr1431495110-ENST00000393799PPP6R3chr1168350511+37864791971573458

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355683ENST00000393799STRN3chr1431495110-PPP6R3chr1168350511+0.0012052460.9987947
ENST00000357479ENST00000393799STRN3chr1431495110-PPP6R3chr1168350511+0.0011996180.9988004

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Fusion Genomic Features for STRN3-PPP6R3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STRN3chr1431495109-PPP6R3chr1168350510+5.65E-070.9999994
STRN3chr1431495109-PPP6R3chr1168350510+5.65E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STRN3-PPP6R3


check button Go to

FGviewer for the breakpoints of chr14:31495110-chr11:68350511

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-1166_1394.0714.0Compositional biasNote=Poly-Gly
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-1186_1394.0798.0Compositional biasNote=Poly-Gly
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-11671_7994.0714.0RegionCaveolin-binding
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-11871_7994.0798.0RegionCaveolin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-11677_13694.0714.0Coiled coilOntology_term=ECO:0000255
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-11877_13694.0798.0Coiled coilOntology_term=ECO:0000255
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-116166_18394.0714.0RegionCalmodulin-binding
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-118166_18394.0798.0RegionCalmodulin-binding
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-116478_51794.0714.0RepeatNote=WD 1
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-116531_57094.0714.0RepeatNote=WD 2
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-116584_62394.0714.0RepeatNote=WD 3
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-116679_71894.0714.0RepeatNote=WD 4
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-116721_76094.0714.0RepeatNote=WD 5
HgeneSTRN3chr14:31495110chr11:68350511ENST00000355683-116767_79694.0714.0RepeatNote=WD 6
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-118478_51794.0798.0RepeatNote=WD 1
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-118531_57094.0798.0RepeatNote=WD 2
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-118584_62394.0798.0RepeatNote=WD 3
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-118679_71894.0798.0RepeatNote=WD 4
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-118721_76094.0798.0RepeatNote=WD 5
HgeneSTRN3chr14:31495110chr11:68350511ENST00000357479-118767_79694.0798.0RepeatNote=WD 6


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Fusion Gene Sequence for STRN3-PPP6R3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000355683_ENST00000393799_TCGA-EW-A423-01A_STRN3_chr14_31495110_-_PPP6R3_chr11_68350511_length(transcript)=3805nt_BP=498nt
AAAGTGAGTGAGTGAGACGGGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGC
AACGACCCCTTCCCCGCCCCTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGC
GTCTCGCCCTGCGCCCCGGCCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCC
CGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGA
GCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGG
TTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGGGCCGAACTGCAGGTTACAACCTGCCATATTCATTCATCCAGTGATGATGAAATT
GACTTTAAAGAAACGGGTTTCTCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTGATTATCAGATGCAACAAATGACGTCCAATTTTATT
GACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATGACATTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACT
CTCAATACAAATGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAACAGTTTGATGATGGTGGCTCTGATGAG
GAAGATATATGGGAGGAAAAGCACATCGCATTCACACCAGAATCCCAAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTACA
GACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCAACACGGAGGATAAAATGGAGGTGGACCTGAGTGAA
CCACCCAACTGGTCAGCTAACTTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATTCTGTGGGATCTGATGTCTGGAGCACA
GAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTCAGAGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAAT
TCTCCAGTGGAAATGGAAACCAGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCCTGGCAGTGCAGCCAGAAGCGGCAGGC
AGTGTGGCCATGGAAGCCAGCTCTGACGGAGAGGAGGATGCAGAAAGTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATGAAG
GAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCTTCAAAAGGTTATTGGGAGGATGCAGTGAGGAAGGGAAACTGTCT
ACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGT
CCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTGACTGA
GGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCA
GGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGACAAATACCAAGAA
TTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCCTGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACT
ATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAACTTTGACAATTATTAGTGTGA
CCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATG
AAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAACCAGTTT
TTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCTACATC
ATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAATGATTATTCCTACAAGTGAAACACTAG
ACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCATTTGGTA
GTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATCACCAATGAACATTTCAGAGCAATCTGCATATTTAACAG
ACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGTATTTT
AAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATT
TTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCTATGTCAATACAAAAATACATC
ACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACTTTTAG
ATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTTTCCTGACCAGTATTTAAAACCAAAAG
GATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAAAGAAT
CAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAG
TAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAG
AGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTT
GGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTG
GCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACC
CAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTCTTTCG
TAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCTCATTT
TGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAATACAATACCTGTATTCAAAATAACAA

>In-frame_ENST00000355683_ENST00000393799_TCGA-EW-A423-01A_STRN3_chr14_31495110_-_PPP6R3_chr11_68350511_length(amino acids)=458AA_start in transcript=216_stop in transcript=1592
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER
AELQVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALF
EACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPM
ETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEE
DAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKRLLGGCSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQRTGQPSAPG

--------------------------------------------------------------
>In-frame_ENST00000357479_ENST00000393799_TCGA-EW-A423-01A_STRN3_chr14_31495110_-_PPP6R3_chr11_68350511_length(transcript)=3786nt_BP=479nt
GGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGCAACGACCCCTTCCCCGCCC
CTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGCGTCTCGCCCTGCGCCCCGG
CCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTG
GGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCC
CCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGC
ACTGGGAGGTGGAACGGGCCGAACTGCAGGTTACAACCTGCCATATTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGTT
TCTCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTGATTATCAGATGCAACAAATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACG
ATGAGAAGTTTGCAGATCAAGATGACATTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAATGAAAGTG
GAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAACAGTTTGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAA
AGCACATCGCATTCACACCAGAATCCCAAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATG
GAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCAACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTA
ACTTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATTCTGTGGGATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTA
AAGAGACGGGCTGGGCTTCTTTTTCAGAGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAA
CCAGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCCTGGCAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCA
GCTCTGACGGAGAGGAGGATGCAGAAAGTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTG
TAGATGCCAAGACAGAGACTGCGGTCTTCAAAAGGTTATTGGGAGGATGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTT
GTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCC
AACCAAGCGCACCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCA
CTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATAT
TCTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGACAAATACCAAGAATTTTTGCGTATGTTTATAT
TGTATTGTTCTAAATAATGGGTAGCCTGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAA
GAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAACTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTT
TCATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAAATGCCCTCTAAGTGTT
ATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTC
TGTATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCTACATCATAGTTGATAAATTGATGT
TATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAATGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATG
GCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACC
CATTCACCAAAATTTACCTTGTTAACAAGCATCACCAATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATT
AGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATC
TGGCACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACTGGTTTGTG
TATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCTATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCT
CAAGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACTTTTAGATGCAAATCAGTTTTTCAT
TTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTTTCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCC
AACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAAAGAATCAAACGTCTAATGCCTTAT
TATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGG
CAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCC
TCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGG
TAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGG
TATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGC
TTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGA
CAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTC
TGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAATACAATACCTGTATTCAAAATAACAAAAATAAAGCCTGATTCTTT

>In-frame_ENST00000357479_ENST00000393799_TCGA-EW-A423-01A_STRN3_chr14_31495110_-_PPP6R3_chr11_68350511_length(amino acids)=458AA_start in transcript=197_stop in transcript=1573
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER
AELQVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALF
EACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPM
ETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEE
DAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKRLLGGCSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQRTGQPSAPG

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Fusion Gene PPI Analysis for STRN3-PPP6R3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STRN3-PPP6R3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STRN3-PPP6R3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource