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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SULF1-EIF4A1 (FusionGDB2 ID:87423)

Fusion Gene Summary for SULF1-EIF4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: SULF1-EIF4A1
Fusion gene ID: 87423
HgeneTgene
Gene symbol

SULF1

EIF4A1

Gene ID

23213

1973

Gene namesulfatase 1eukaryotic translation initiation factor 4A1
SynonymsSULF-1DDX2A|EIF-4A|EIF4A|eIF-4A-I|eIF4A-I
Cytomap

8q13.2-q13.3

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionextracellular sulfatase Sulf-1sulfatase FPeukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4A
Modification date2020031320200322
UniProtAcc.

P60842

Ensembl transtripts involved in fusion geneENST00000260128, ENST00000458141, 
ENST00000402687, ENST00000419716, 
ENST00000521946, 		ENST00000380512, 
ENST00000293831, ENST00000577269, 
ENST00000582746, ENST00000581808, 
Fusion gene scores* DoF score13 X 15 X 5=9758 X 5 X 5=200
# samples 168
** MAII scorelog2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SULF1 [Title/Abstract] AND EIF4A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSULF1(70488444)-EIF4A1(7478437), # samples:1
Anticipated loss of major functional domain due to fusion event.SULF1-EIF4A1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SULF1-EIF4A1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSULF1

GO:0001937

negative regulation of endothelial cell proliferation

16778174

HgeneSULF1

GO:0016525

negative regulation of angiogenesis

16778174

HgeneSULF1

GO:0030177

positive regulation of Wnt signaling pathway

19520866

HgeneSULF1

GO:0030201

heparan sulfate proteoglycan metabolic process

18687675|19666466|19822709

HgeneSULF1

GO:0048010

vascular endothelial growth factor receptor signaling pathway

16778174


check buttonFusion gene breakpoints across SULF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF4A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14Z-01ASULF1chr8

70488444

+EIF4A1chr17

7478437

+


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Fusion Gene ORF analysis for SULF1-EIF4A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260128ENST00000380512SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000260128ENST00000293831SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000260128ENST00000577269SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000260128ENST00000582746SULF1chr8

70488444

+EIF4A1chr17

7478437

+
5CDS-intronENST00000260128ENST00000581808SULF1chr8

70488444

+EIF4A1chr17

7478437

+
Frame-shiftENST00000458141ENST00000380512SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000458141ENST00000293831SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000458141ENST00000577269SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000458141ENST00000582746SULF1chr8

70488444

+EIF4A1chr17

7478437

+
5CDS-intronENST00000458141ENST00000581808SULF1chr8

70488444

+EIF4A1chr17

7478437

+
Frame-shiftENST00000402687ENST00000380512SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000402687ENST00000293831SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000402687ENST00000577269SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000402687ENST00000582746SULF1chr8

70488444

+EIF4A1chr17

7478437

+
5CDS-intronENST00000402687ENST00000581808SULF1chr8

70488444

+EIF4A1chr17

7478437

+
Frame-shiftENST00000419716ENST00000380512SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000419716ENST00000293831SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000419716ENST00000577269SULF1chr8

70488444

+EIF4A1chr17

7478437

+
In-frameENST00000419716ENST00000582746SULF1chr8

70488444

+EIF4A1chr17

7478437

+
5CDS-intronENST00000419716ENST00000581808SULF1chr8

70488444

+EIF4A1chr17

7478437

+
intron-3CDSENST00000521946ENST00000380512SULF1chr8

70488444

+EIF4A1chr17

7478437

+
intron-3CDSENST00000521946ENST00000293831SULF1chr8

70488444

+EIF4A1chr17

7478437

+
intron-3CDSENST00000521946ENST00000577269SULF1chr8

70488444

+EIF4A1chr17

7478437

+
intron-3CDSENST00000521946ENST00000582746SULF1chr8

70488444

+EIF4A1chr17

7478437

+
intron-intronENST00000521946ENST00000581808SULF1chr8

70488444

+EIF4A1chr17

7478437

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260128SULF1chr870488444+ENST00000293831EIF4A1chr177478437+266411297172144475
ENST00000260128SULF1chr870488444+ENST00000577269EIF4A1chr177478437+223811297171967416
ENST00000260128SULF1chr870488444+ENST00000582746EIF4A1chr177478437+256911297171949410
ENST00000458141SULF1chr870488444+ENST00000293831EIF4A1chr177478437+25029675551982475
ENST00000458141SULF1chr870488444+ENST00000577269EIF4A1chr177478437+20769675551805416
ENST00000458141SULF1chr870488444+ENST00000582746EIF4A1chr177478437+24079675551787410
ENST00000402687SULF1chr870488444+ENST00000293831EIF4A1chr177478437+270211677552182475
ENST00000402687SULF1chr870488444+ENST00000577269EIF4A1chr177478437+227611677552005416
ENST00000402687SULF1chr870488444+ENST00000582746EIF4A1chr177478437+260711677551987410
ENST00000419716SULF1chr870488444+ENST00000293831EIF4A1chr177478437+25089735611988475
ENST00000419716SULF1chr870488444+ENST00000577269EIF4A1chr177478437+20829735611811416
ENST00000419716SULF1chr870488444+ENST00000582746EIF4A1chr177478437+24139735611793410

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260128ENST00000293831SULF1chr870488444+EIF4A1chr177478437+0.001079120.9989209
ENST00000260128ENST00000577269SULF1chr870488444+EIF4A1chr177478437+0.0013140120.998686
ENST00000260128ENST00000582746SULF1chr870488444+EIF4A1chr177478437+0.0012704660.9987295
ENST00000458141ENST00000293831SULF1chr870488444+EIF4A1chr177478437+0.0012484650.9987515
ENST00000458141ENST00000577269SULF1chr870488444+EIF4A1chr177478437+0.0016814830.99831855
ENST00000458141ENST00000582746SULF1chr870488444+EIF4A1chr177478437+0.0015022220.9984977
ENST00000402687ENST00000293831SULF1chr870488444+EIF4A1chr177478437+0.0010662320.99893373
ENST00000402687ENST00000577269SULF1chr870488444+EIF4A1chr177478437+0.0013977630.9986022
ENST00000402687ENST00000582746SULF1chr870488444+EIF4A1chr177478437+0.0012900630.9987099
ENST00000419716ENST00000293831SULF1chr870488444+EIF4A1chr177478437+0.0012645820.99873537
ENST00000419716ENST00000577269SULF1chr870488444+EIF4A1chr177478437+0.0017089340.9982911
ENST00000419716ENST00000582746SULF1chr870488444+EIF4A1chr177478437+0.0015246540.9984754

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Fusion Genomic Features for SULF1-EIF4A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SULF1chr870488444+EIF4A1chr177478436+0.178140180.82185984
SULF1chr870488444+EIF4A1chr177478436+0.178140180.82185984

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SULF1-EIF4A1


check button Go to

FGviewer for the breakpoints of chr8:70488444-chr17:7478437

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF4A1

P60842

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF4A1chr8:70488444chr17:7478437ENST00000293831211245_40668.33333333333333407.0DomainHelicase C-terminal
TgeneEIF4A1chr8:70488444chr17:7478437ENST00000577269211245_40668.33333333333333348.0DomainHelicase C-terminal
TgeneEIF4A1chr8:70488444chr17:7478437ENST00000293831211182_18568.33333333333333407.0MotifNote=DEAD box
TgeneEIF4A1chr8:70488444chr17:7478437ENST00000577269211182_18568.33333333333333348.0MotifNote=DEAD box
TgeneEIF4A1chr8:70488444chr17:7478437ENST0000029383121176_8368.33333333333333407.0Nucleotide bindingATP
TgeneEIF4A1chr8:70488444chr17:7478437ENST0000057726921176_8368.33333333333333348.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF4A1chr8:70488444chr17:7478437ENST0000029383121163_23468.33333333333333407.0DomainHelicase ATP-binding
TgeneEIF4A1chr8:70488444chr17:7478437ENST0000057726921163_23468.33333333333333348.0DomainHelicase ATP-binding
TgeneEIF4A1chr8:70488444chr17:7478437ENST0000029383121132_6068.33333333333333407.0MotifNote=Q motif
TgeneEIF4A1chr8:70488444chr17:7478437ENST0000057726921132_6068.33333333333333348.0MotifNote=Q motif


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Fusion Gene Sequence for SULF1-EIF4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000260128_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2664nt_BP=1129nt
AGGTTACTTGACTGGGAGTTCTCAGACCTCCAGTTTCAGCCCTGCCCTCAGCCTCCAATCCGTAAGAGACACCCAGCCCCAGCAATTGGA
TTGGGCAGCCCGTCTTGACACACCACTGTGCTGAGTGCTTGAGGACGTGTTTCAACAGATGGTTGGGGTTAGTGTGTGTCATCACATTCG
AGTGGGGATTAAGAGAAGGAAGGCTGCCTTGCTGGAGCTGTGTGGTCTTCTCCAAGTGAGAGTCGCAGGCAATAGAACTACTTTGCTTTT
GGAGGAAAAGGAGGAATTCATTTTCAGCAGACACAAGAAAAGCAGTTTTTTTTTCAGGGATTCTTCACTTCTCTTGAACAAGGAACTCAC
TCAGAGACTAACACAAAGGAAGTAATTTCTTACCTGGTCATTATTTAGTCTACAATAAGTTCATCCTTCTTCAGTGTGACCAGTAAATTC
TTCCCATACTCTTGAAGAGAGCATAATTGGAATGGAGAGGTGCTGACGGCCACCCACCATCATCTAAAGAAGATAAACTTGGCAAATGAC
ATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGA
TTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAACATTGGACCAAATACAATG
AAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGA
GGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAA
GTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGG
TCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCAT
GAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAA
ACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTG
GCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCT
GAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCC
CCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAG
CTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATT
CGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACA
CTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATG
CATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCT
AGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAGTCATCAACTATGACCTTCCCACCAAC
AGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGG
ACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCA
CCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTT
TTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCC
AGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCACC
TCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAGGGAGAACCCCTAAAACCC
CTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTACATTGTTTTGTATAGTAT

>In-frame_ENST00000260128_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=475AA_start in transcript=717_stop in transcript=2144
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK
MHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDK

--------------------------------------------------------------
>In-frame_ENST00000260128_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2238nt_BP=1129nt
AGGTTACTTGACTGGGAGTTCTCAGACCTCCAGTTTCAGCCCTGCCCTCAGCCTCCAATCCGTAAGAGACACCCAGCCCCAGCAATTGGA
TTGGGCAGCCCGTCTTGACACACCACTGTGCTGAGTGCTTGAGGACGTGTTTCAACAGATGGTTGGGGTTAGTGTGTGTCATCACATTCG
AGTGGGGATTAAGAGAAGGAAGGCTGCCTTGCTGGAGCTGTGTGGTCTTCTCCAAGTGAGAGTCGCAGGCAATAGAACTACTTTGCTTTT
GGAGGAAAAGGAGGAATTCATTTTCAGCAGACACAAGAAAAGCAGTTTTTTTTTCAGGGATTCTTCACTTCTCTTGAACAAGGAACTCAC
TCAGAGACTAACACAAAGGAAGTAATTTCTTACCTGGTCATTATTTAGTCTACAATAAGTTCATCCTTCTTCAGTGTGACCAGTAAATTC
TTCCCATACTCTTGAAGAGAGCATAATTGGAATGGAGAGGTGCTGACGGCCACCCACCATCATCTAAAGAAGATAAACTTGGCAAATGAC
ATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGA
TTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAACATTGGACCAAATACAATG
AAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGA
GGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAA
GTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGG
TCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCAT
GAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAA
ACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTG
GCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCT
GAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCC
CCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAG
CTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATT
CGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACA
CTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATG
CATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCT
AGCAGAGTTTTGATTACCACTGACCTGCTGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTAT
TAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGC
TGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGG

>In-frame_ENST00000260128_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=416AA_start in transcript=717_stop in transcript=1967
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------
>In-frame_ENST00000260128_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2569nt_BP=1129nt
AGGTTACTTGACTGGGAGTTCTCAGACCTCCAGTTTCAGCCCTGCCCTCAGCCTCCAATCCGTAAGAGACACCCAGCCCCAGCAATTGGA
TTGGGCAGCCCGTCTTGACACACCACTGTGCTGAGTGCTTGAGGACGTGTTTCAACAGATGGTTGGGGTTAGTGTGTGTCATCACATTCG
AGTGGGGATTAAGAGAAGGAAGGCTGCCTTGCTGGAGCTGTGTGGTCTTCTCCAAGTGAGAGTCGCAGGCAATAGAACTACTTTGCTTTT
GGAGGAAAAGGAGGAATTCATTTTCAGCAGACACAAGAAAAGCAGTTTTTTTTTCAGGGATTCTTCACTTCTCTTGAACAAGGAACTCAC
TCAGAGACTAACACAAAGGAAGTAATTTCTTACCTGGTCATTATTTAGTCTACAATAAGTTCATCCTTCTTCAGTGTGACCAGTAAATTC
TTCCCATACTCTTGAAGAGAGCATAATTGGAATGGAGAGGTGCTGACGGCCACCCACCATCATCTAAAGAAGATAAACTTGGCAAATGAC
ATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGA
TTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAACATTGGACCAAATACAATG
AAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGA
GGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAA
GTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGG
TCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCAT
GAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAA
ACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTG
GCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCT
GAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCC
CCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATCTATGACATATTCCAAAAG
CTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATT
CGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACA
CTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATG
CATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCT
AGCAGAGTTTTGATTACCACTGACCTGCTGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGA
AGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGC
TGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACAT
CTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTTGGGGTAGG
CTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATCCCAGAGGC
TCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAGGGAGAACC
CCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTACATTGTTT

>In-frame_ENST00000260128_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=410AA_start in transcript=717_stop in transcript=1949
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------
>In-frame_ENST00000458141_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2502nt_BP=967nt
AGGTTACTTGACTGGGAGTTCTCAGACCTCCAGTTTCAGCCCTGCCCTCAGCCTCCAATCCGTAAGAGACACCCAGCCCCAGCAATTGGA
TTGGGCAGCCCGTCTTGACACACCACTGTGCTGAGTGCTTGAGGACGTGTTTCAACAGATGGTTGGGGTTAGTGTGTGTCATCACATTCG
AGTGGGGATTAAGAGAAGGAAGGCTGCCTTGCTGGAGCTGTGTGGTCTTCTCCAAGTGAGAGTCGCAGGCAATAGAACTACTTTGCTTTT
GGAGGAAAAGGAGGAATTCATTTTCAGCAGACACAAGAAAAGCAGTTTTTTTTTCAGGTGCTGACGGCCACCCACCATCATCTAAAGAAG
ATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTGAATACC
TCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAAC
ATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTC
AGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTG
GAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCC
ATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCC
TCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCTCAAGCC
CAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTA
GCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGG
GGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTT
AACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATC
TATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAG
TTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAG
GAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGAC
TGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGG
GAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAGTCATCAAC
TATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTG
ACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATC
TGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGG
ATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCCTTTTCTTT
GGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTCCAGATC
CCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAAATCTGGAG
GGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCATTTTTA

>In-frame_ENST00000458141_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=475AA_start in transcript=555_stop in transcript=1982
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK
MHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDK

--------------------------------------------------------------
>In-frame_ENST00000458141_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2076nt_BP=967nt
AGGTTACTTGACTGGGAGTTCTCAGACCTCCAGTTTCAGCCCTGCCCTCAGCCTCCAATCCGTAAGAGACACCCAGCCCCAGCAATTGGA
TTGGGCAGCCCGTCTTGACACACCACTGTGCTGAGTGCTTGAGGACGTGTTTCAACAGATGGTTGGGGTTAGTGTGTGTCATCACATTCG
AGTGGGGATTAAGAGAAGGAAGGCTGCCTTGCTGGAGCTGTGTGGTCTTCTCCAAGTGAGAGTCGCAGGCAATAGAACTACTTTGCTTTT
GGAGGAAAAGGAGGAATTCATTTTCAGCAGACACAAGAAAAGCAGTTTTTTTTTCAGGTGCTGACGGCCACCCACCATCATCTAAAGAAG
ATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTGAATACC
TCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAAC
ATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTC
AGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTG
GAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCC
ATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCC
TCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCTCAAGCC
CAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTA
GCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGG
GGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTT
AACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATC
TATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAG
TTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAG
GAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGAC
TGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGG
GAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGG
CCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGA
AATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGC
AGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAAC

>In-frame_ENST00000458141_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=416AA_start in transcript=555_stop in transcript=1805
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------
>In-frame_ENST00000458141_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2407nt_BP=967nt
AGGTTACTTGACTGGGAGTTCTCAGACCTCCAGTTTCAGCCCTGCCCTCAGCCTCCAATCCGTAAGAGACACCCAGCCCCAGCAATTGGA
TTGGGCAGCCCGTCTTGACACACCACTGTGCTGAGTGCTTGAGGACGTGTTTCAACAGATGGTTGGGGTTAGTGTGTGTCATCACATTCG
AGTGGGGATTAAGAGAAGGAAGGCTGCCTTGCTGGAGCTGTGTGGTCTTCTCCAAGTGAGAGTCGCAGGCAATAGAACTACTTTGCTTTT
GGAGGAAAAGGAGGAATTCATTTTCAGCAGACACAAGAAAAGCAGTTTTTTTTTCAGGTGCTGACGGCCACCCACCATCATCTAAAGAAG
ATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTGAATACC
TCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAAC
ATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTC
AGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTG
GAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCC
ATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCC
TCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCTCAAGCC
CAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTGGTCCTA
GCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGTATCGGG
GGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGATATGCTT
AACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGACCAGATC
TATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACCAAGAAG
TTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAACGAGAG
GAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAGGTGGAC
TGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATTATGAGG
GAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTAT
TAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGC
TGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGG
GAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACAC
CCTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAA
CCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACC
AAATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTA

>In-frame_ENST00000458141_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=410AA_start in transcript=555_stop in transcript=1787
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------
>In-frame_ENST00000402687_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2702nt_BP=1167nt
TTTGTCTGGCAGCGTTGGTTCTATGGGGGTGTGTGATGATAATAATACGCGGGCTTATATAACCGTCTTCATCTTGCGAGCACTTCGCAG
ACCGTCGCTAATGAATCTTGGGGCCGGTGTCGGGCCGGGGCGGCTTGATCGGCAACTAGGAAACCCCAGGCGCAGAGGCCAGGAGCGAGG
GCAGCGAGGATCAGAGGCCAGGCCTTCCCGGCTGCCGGCGCTCCTCGGAGGTCAGGGCAGATGAGGAACATGACTCTCCCCCTTCGGAGG
AGGAAGGAAGTCCCGCTGCCACCTTATCTCTGCTCCTCTGCCTCCTCCCTGTTCCCAGAGCTTTTTCTCTAGAGAAGATTTTGAAGGCGG
CTTTTGGATTCTTCACTTCTCTTGAACAAGGAACTCACTCAGAGACTAACACAAAGGAAGTAATTTCTTACCTGGTCATTATTTAGTCTA
CAATAAGTTCATCCTTCTTCAGTGTGACCAGTAAATTCTTCCCATACTCTTGAAGAGAGCATAATTGGAATGGAGAGGTGCTGACGGCCA
CCCACCATCATCTAAAGAAGATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTAT
CTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGA
CATTTTGTCAGTTTTGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGG
GAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGC
TTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCA
ATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACA
ACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTT
ATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAG
CCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCT
CCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTG
GCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCC
GTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATG
TGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCT
ACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCA
ACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGG
AACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGC
AGGTTTCTTTAGTCATCAACTATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAG
GTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCC
TCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGG
GGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACA
TTTTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCT
AACCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCAT
TTGCTGGACCAAATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGA
GAAAATGGTAGCCATTTTTACATTGTTTTGTATAGTATTTATTGATTCAGGAAACAAACACAAAATTCTGAATAAAATGACTTGGAAACT

>In-frame_ENST00000402687_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=475AA_start in transcript=755_stop in transcript=2182
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK
MHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDK

--------------------------------------------------------------
>In-frame_ENST00000402687_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2276nt_BP=1167nt
TTTGTCTGGCAGCGTTGGTTCTATGGGGGTGTGTGATGATAATAATACGCGGGCTTATATAACCGTCTTCATCTTGCGAGCACTTCGCAG
ACCGTCGCTAATGAATCTTGGGGCCGGTGTCGGGCCGGGGCGGCTTGATCGGCAACTAGGAAACCCCAGGCGCAGAGGCCAGGAGCGAGG
GCAGCGAGGATCAGAGGCCAGGCCTTCCCGGCTGCCGGCGCTCCTCGGAGGTCAGGGCAGATGAGGAACATGACTCTCCCCCTTCGGAGG
AGGAAGGAAGTCCCGCTGCCACCTTATCTCTGCTCCTCTGCCTCCTCCCTGTTCCCAGAGCTTTTTCTCTAGAGAAGATTTTGAAGGCGG
CTTTTGGATTCTTCACTTCTCTTGAACAAGGAACTCACTCAGAGACTAACACAAAGGAAGTAATTTCTTACCTGGTCATTATTTAGTCTA
CAATAAGTTCATCCTTCTTCAGTGTGACCAGTAAATTCTTCCCATACTCTTGAAGAGAGCATAATTGGAATGGAGAGGTGCTGACGGCCA
CCCACCATCATCTAAAGAAGATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTAT
CTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGA
CATTTTGTCAGTTTTGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGG
GAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGC
TTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCA
ATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACA
ACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTT
ATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAG
CCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCT
CCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTG
GCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCC
GTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATG
TGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCT
ACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCA
ACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGG
AACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGGAAAACTATATCCACAGAATC
GGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTC
TACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATC
TCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTT

>In-frame_ENST00000402687_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=416AA_start in transcript=755_stop in transcript=2005
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------
>In-frame_ENST00000402687_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2607nt_BP=1167nt
TTTGTCTGGCAGCGTTGGTTCTATGGGGGTGTGTGATGATAATAATACGCGGGCTTATATAACCGTCTTCATCTTGCGAGCACTTCGCAG
ACCGTCGCTAATGAATCTTGGGGCCGGTGTCGGGCCGGGGCGGCTTGATCGGCAACTAGGAAACCCCAGGCGCAGAGGCCAGGAGCGAGG
GCAGCGAGGATCAGAGGCCAGGCCTTCCCGGCTGCCGGCGCTCCTCGGAGGTCAGGGCAGATGAGGAACATGACTCTCCCCCTTCGGAGG
AGGAAGGAAGTCCCGCTGCCACCTTATCTCTGCTCCTCTGCCTCCTCCCTGTTCCCAGAGCTTTTTCTCTAGAGAAGATTTTGAAGGCGG
CTTTTGGATTCTTCACTTCTCTTGAACAAGGAACTCACTCAGAGACTAACACAAAGGAAGTAATTTCTTACCTGGTCATTATTTAGTCTA
CAATAAGTTCATCCTTCTTCAGTGTGACCAGTAAATTCTTCCCATACTCTTGAAGAGAGCATAATTGGAATGGAGAGGTGCTGACGGCCA
CCCACCATCATCTAAAGAAGATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTAT
CTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGA
CATTTTGTCAGTTTTGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGG
GAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGC
TTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCA
ATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACA
ACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTT
ATGATGTGATTGCTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAG
CCACCCAGGCCTTGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCT
CCTGTCACGCCTGTATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTG
GCCGTGTGTTTGATATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCC
GTGGATTCAAGGACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATG
TGCTTGAGGTGACCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCT
ACATCAACGTGGAACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCA
ACACCCGGAGGAAGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGG
AACGAGACGTGATTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGAATCGGTCGAGGTGGACGGTTT
GGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAG
GAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCA
GCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGA
ACCGTGAACATTTTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAAT
CCATTTCCCTAACCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCAC
TCAGCCTCATTTGCTGGACCAAATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAA

>In-frame_ENST00000402687_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=410AA_start in transcript=755_stop in transcript=1987
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------
>In-frame_ENST00000419716_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2508nt_BP=973nt
GTGATGATAATAATACGCGGGCTTATATAACCGTCTTCATCTTGCGAGCACTTCGCAGACCGTCGCTAATGAATCTTGGGGCCGGTGTCG
GGCCGGGGCGGCTTGATCGGCAACTAGGAAACCCCAGGCGCAGAGGCCAGGAGCGAGGGCAGCGAGGATCAGAGGCCAGGCCTTCCCGGC
TGCCGGCGCTCCTCGGAGGTCAGGGCAGATGAGGAACATGACTCTCCCCCTTCGGAGGAGGAAGGAAGTCCCGCTGCCACCTTATCTCTG
CTCCTCTGCCTCCTCCCTGTTCCCAGAGCTTTTTCTCTAGAGAAGATTTTGAAGGCGGCTTTTGTGCTGACGGCCACCCACCATCATCTA
AAGAAGATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTG
AATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTT
TGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCG
ACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAA
GATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACT
ACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCT
TCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCT
CAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTG
GTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGT
ATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGAT
ATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGAC
CAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACC
AAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAA
CGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAG
GTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATT
ATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAGTC
ATCAACTATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTAAC
ATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTGAC
CTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGAGC
CAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCCTT
TTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACCTC
CAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAAAT
CTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGCCA

>In-frame_ENST00000419716_ENST00000293831_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=475AA_start in transcript=561_stop in transcript=1988
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK
MHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDK

--------------------------------------------------------------
>In-frame_ENST00000419716_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2082nt_BP=973nt
GTGATGATAATAATACGCGGGCTTATATAACCGTCTTCATCTTGCGAGCACTTCGCAGACCGTCGCTAATGAATCTTGGGGCCGGTGTCG
GGCCGGGGCGGCTTGATCGGCAACTAGGAAACCCCAGGCGCAGAGGCCAGGAGCGAGGGCAGCGAGGATCAGAGGCCAGGCCTTCCCGGC
TGCCGGCGCTCCTCGGAGGTCAGGGCAGATGAGGAACATGACTCTCCCCCTTCGGAGGAGGAAGGAAGTCCCGCTGCCACCTTATCTCTG
CTCCTCTGCCTCCTCCCTGTTCCCAGAGCTTTTTCTCTAGAGAAGATTTTGAAGGCGGCTTTTGTGCTGACGGCCACCCACCATCATCTA
AAGAAGATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTG
AATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTT
TGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCG
ACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAA
GATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACT
ACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCT
TCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCT
CAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTG
GTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGT
ATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGAT
ATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGAC
CAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACC
AAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAA
CGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAG
GTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATT
ATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACG
GTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCAT
TGAGGAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGG
AGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGA

>In-frame_ENST00000419716_ENST00000577269_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=416AA_start in transcript=561_stop in transcript=1811
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------
>In-frame_ENST00000419716_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(transcript)=2413nt_BP=973nt
GTGATGATAATAATACGCGGGCTTATATAACCGTCTTCATCTTGCGAGCACTTCGCAGACCGTCGCTAATGAATCTTGGGGCCGGTGTCG
GGCCGGGGCGGCTTGATCGGCAACTAGGAAACCCCAGGCGCAGAGGCCAGGAGCGAGGGCAGCGAGGATCAGAGGCCAGGCCTTCCCGGC
TGCCGGCGCTCCTCGGAGGTCAGGGCAGATGAGGAACATGACTCTCCCCCTTCGGAGGAGGAAGGAAGTCCCGCTGCCACCTTATCTCTG
CTCCTCTGCCTCCTCCCTGTTCCCAGAGCTTTTTCTCTAGAGAAGATTTTGAAGGCGGCTTTTGTGCTGACGGCCACCCACCATCATCTA
AAGAAGATAAACTTGGCAAATGACATGCAGGTTCTTCAAGGCAGAATAATTGCAGAAAATCTTCAAAGGACCCTATCTGCAGATGTTCTG
AATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTT
TGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCG
ACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAA
GATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACT
ACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCT
TCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGGTTATGATGTGATTGCT
CAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCTTG
GTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCTGT
ATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTGAT
ATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGGAC
CAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGACC
AAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGGAA
CGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGAAG
GTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGATT
ATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGT
GGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAA
TGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAG
GGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTT
AGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACC
TAGTAACCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGC
TGGACCAAATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAA

>In-frame_ENST00000419716_ENST00000582746_TCGA-E2-A14Z-01A_SULF1_chr8_70488444_+_EIF4A1_chr17_7478437_length(amino acids)=410AA_start in transcript=561_stop in transcript=1793
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPS
RSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRE
LAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQ
KLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SULF1-EIF4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SULF1-EIF4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneEIF4A1P60842DB09130CopperSmall moleculeApproved|Investigational
TgeneEIF4A1P60842DB09130CopperSmall moleculeApproved|Investigational
TgeneEIF4A1P60842DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for SULF1-EIF4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSULF1C0032927Precancerous Conditions1CTD_human
HgeneSULF1C0282313Condition, Preneoplastic1CTD_human
HgeneSULF1C0919267ovarian neoplasm1CTD_human
HgeneSULF1C1140680Malignant neoplasm of ovary1CTD_human
HgeneSULF1C1838162Mesomelia-synostoses syndrome1GENOMICS_ENGLAND
TgeneEIF4A1C0019693HIV Infections1CTD_human
TgeneEIF4A1C4505456HIV Coinfection1CTD_human