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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SYNE2-GEMIN2 (FusionGDB2 ID:87814)

Fusion Gene Summary for SYNE2-GEMIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: SYNE2-GEMIN2
Fusion gene ID: 87814
HgeneTgene
Gene symbol

SYNE2

GEMIN2

Gene ID

23224

8487

Gene namespectrin repeat containing nuclear envelope protein 2gem nuclear organelle associated protein 2
SynonymsEDMD5|KASH2|NUA|NUANCE|Nesp2|Nesprin-2|SYNE-2|TROPHSIP1|SIP1-delta
Cytomap

14q23.2

14q21.1

Type of geneprotein-codingprotein-coding
Descriptionnesprin-2KASH domain-containing protein 2nesprin 2nuclear envelope spectrin repeat protein 2nucleus and actin connecting element proteinpolytrophinspectrin repeat containing, nuclear envelope 2synaptic nuclear envelope protein 2synaptic nuclei expgem-associated protein 2SMN interacting protein 1-deltacomponent of gems 2gemin-2survival of motor neuron protein interacting protein 1
Modification date2020032020200322
UniProtAcc.

O14893

Ensembl transtripts involved in fusion geneENST00000357395, ENST00000358025, 
ENST00000344113, ENST00000341472, 
ENST00000356081, ENST00000554584, 
ENST00000555002, ENST00000394768, 
ENST00000556725, ENST00000553455, 
ENST00000555022, ENST00000554805, 
ENST00000458046, ENST00000441438, 
ENST00000308317, ENST00000396249, 
ENST00000250379, 
Fusion gene scores* DoF score20 X 22 X 9=39606 X 7 X 4=168
# samples 247
** MAII scorelog2(24/3960*10)=-4.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYNE2 [Title/Abstract] AND GEMIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSYNE2(64319861)-GEMIN2(39584033), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYNE2

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

TgeneGEMIN2

GO:0000387

spliceosomal snRNP assembly

18984161


check buttonFusion gene breakpoints across SYNE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GEMIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A5U6-01ASYNE2chr14

64319861

+GEMIN2chr14

39584033

+
ChimerDB4ESCATCGA-LN-A5U6SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
ChimerDB4ESCATCGA-LN-A5U6SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
ChimerDB4ESCATCGA-LN-A5U6SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
ChimerDB4ESCATCGA-LN-A5U6-01ASYNE2chr14

64319861

-GEMIN2chr14

39584033

+


Top

Fusion Gene ORF analysis for SYNE2-GEMIN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000357395ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000357395ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000357395ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000358025ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000358025ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000358025ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000344113ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000344113ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000344113ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000341472ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000341472ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000341472ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000356081ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000356081ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000356081ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554584ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554584ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554584ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555002ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555002ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555002ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000394768ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000394768ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000394768ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000556725ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000556725ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000556725ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000553455ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000553455ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000553455ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555022ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555022ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555022ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554805ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554805ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554805ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000458046ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000458046ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000458046ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000441438ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000441438ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
intron-3CDSENST00000441438ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000357395ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000357395ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000357395ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000358025ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000358025ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000358025ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000344113ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000344113ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000344113ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000341472ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000341472ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000341472ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000356081ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000356081ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000356081ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000554584ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000554584ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000554584ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000555002ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000555002ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000555002ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000394768ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000394768ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000394768ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000556725ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000556725ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000556725ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000553455ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000553455ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000553455ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000555022ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000555022ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000555022ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000554805ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000554805ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000554805ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000458046ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000458046ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000458046ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000441438ENST00000308317SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000441438ENST00000396249SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
intron-3CDSENST00000441438ENST00000250379SYNE2chr14

64319861

+GEMIN2chr14

39587203

+
5UTR-3CDSENST00000357395ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000357395ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000357395ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000358025ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000358025ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000358025ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000344113ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000344113ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000344113ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000341472ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000341472ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000341472ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000356081ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000356081ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
5UTR-3CDSENST00000356081ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554584ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554584ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554584ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555002ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555002ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555002ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000394768ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000394768ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000394768ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000556725ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000556725ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000556725ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000553455ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000553455ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000553455ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555022ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555022ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000555022ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554805ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554805ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000554805ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000458046ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000458046ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000458046ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000441438ENST00000308317SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000441438ENST00000396249SYNE2chr14

64319865

+GEMIN2chr14

39584033

+
intron-3CDSENST00000441438ENST00000250379SYNE2chr14

64319865

+GEMIN2chr14

39584033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SYNE2-GEMIN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SYNE2chr1464319861+GEMIN2chr1439584032+6.35E-070.9999994
SYNE2chr1464319861+GEMIN2chr1439584032+6.35E-070.9999994
SYNE2chr1464319861+GEMIN2chr1439587202+5.33E-101
SYNE2chr1464319861+GEMIN2chr1439584032+6.35E-070.9999994
SYNE2chr1464319861+GEMIN2chr1439584032+6.35E-070.9999994
SYNE2chr1464319861+GEMIN2chr1439587202+5.33E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SYNE2-GEMIN2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GEMIN2

O14893

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:9323129}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SYNE2-GEMIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SYNE2-GEMIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SYNE2-GEMIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SYNE2-GEMIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSYNE2C0004238Atrial Fibrillation2CTD_human
HgeneSYNE2C0235480Paroxysmal atrial fibrillation2CTD_human
HgeneSYNE2C2585653Persistent atrial fibrillation2CTD_human
HgeneSYNE2C2751805EMERY-DREIFUSS MUSCULAR DYSTROPHY 5, AUTOSOMAL DOMINANT2GENOMICS_ENGLAND;UNIPROT
HgeneSYNE2C3468561familial atrial fibrillation2CTD_human
HgeneSYNE2C0007134Renal Cell Carcinoma1CTD_human
HgeneSYNE2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneSYNE2C0699743Congenital muscular dystrophy (disorder)1GENOMICS_ENGLAND
HgeneSYNE2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneSYNE2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneSYNE2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneSYNE2C1306837Papillary Renal Cell Carcinoma1CTD_human