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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SYTL2-PICALM (FusionGDB2 ID:87972)

Fusion Gene Summary for SYTL2-PICALM

check button Fusion gene summary
Fusion gene informationFusion gene name: SYTL2-PICALM
Fusion gene ID: 87972
HgeneTgene
Gene symbol

SYTL2

PICALM

Gene ID

54843

8301

Gene namesynaptotagmin like 2phosphatidylinositol binding clathrin assembly protein
SynonymsCHR11SYT|EXO4|PPP1R151|SGA72M|SLP2|SLP2ACALM|CLTH|LAP
Cytomap

11q14.1

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionsynaptotagmin-like protein 2breast cancer-associated antigen SGA-72Mchromosome 11 synaptotagminexophilin-4protein phosphatase 1, regulatory subunit 151phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
Modification date2020032020200322
UniProtAcc.

Q13492

Ensembl transtripts involved in fusion geneENST00000389960, ENST00000316356, 
ENST00000528231, ENST00000527523, 
ENST00000524452, ENST00000359152, 
ENST00000354566, ENST00000525702, 
ENST00000525423, ENST00000529581, 
ENST00000389958, ENST00000533892, 
ENST00000528566, 		ENST00000532317, 
ENST00000526033, ENST00000393346, 
ENST00000528398, ENST00000356360, 
ENST00000528411, 
Fusion gene scores* DoF score7 X 8 X 5=28035 X 26 X 12=10920
# samples 944
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(44/10920*10)=-4.63332552228256
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYTL2 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPICALM(85779693)-SYTL2(85456815), # samples:1
PICALM(85779693)-SYTL2(85448699), # samples:1
PICALM(85685751)-SYTL2(85469157), # samples:1
PICALM(85718585)-SYTL2(85469157), # samples:1
SYTL2(85468668)-PICALM(85685855), # samples:1
Anticipated loss of major functional domain due to fusion event.PICALM-SYTL2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PICALM-SYTL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SYTL2-PICALM seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SYTL2-PICALM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYTL2

GO:0006887

exocytosis

18812475

HgeneSYTL2

GO:0006904

vesicle docking involved in exocytosis

18812475

HgeneSYTL2

GO:0010923

negative regulation of phosphatase activity

19389623

TgenePICALM

GO:0006897

endocytosis

22118466

TgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

TgenePICALM

GO:0032880

regulation of protein localization

10436022

TgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

TgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

TgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across SYTL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CJ-5681-11ASYTL2chr11

85468668

-PICALMchr11

85685855

-


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Fusion Gene ORF analysis for SYTL2-PICALM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000389960ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000389960ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000389960ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000389960ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000389960ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
5CDS-intronENST00000389960ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000316356ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000316356ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000316356ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000316356ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
Frame-shiftENST00000316356ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
5CDS-intronENST00000316356ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000528231ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000528231ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000528231ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000528231ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000528231ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
5CDS-intronENST00000528231ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000527523ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000527523ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000527523ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000527523ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000527523ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000527523ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000524452ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000524452ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000524452ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000524452ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
In-frameENST00000524452ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
5CDS-intronENST00000524452ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000359152ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000359152ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000359152ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000359152ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000359152ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000359152ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000354566ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000354566ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000354566ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000354566ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000354566ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000354566ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525702ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525702ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525702ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525702ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525702ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000525702ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525423ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525423ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525423ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525423ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000525423ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000525423ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000529581ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000529581ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000529581ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000529581ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000529581ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000529581ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000389958ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000389958ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000389958ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000389958ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000389958ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000389958ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000533892ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000533892ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000533892ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000533892ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000533892ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000533892ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000528566ENST00000532317SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000528566ENST00000526033SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000528566ENST00000393346SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000528566ENST00000528398SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-3CDSENST00000528566ENST00000356360SYTL2chr11

85468668

-PICALMchr11

85685855

-
intron-intronENST00000528566ENST00000528411SYTL2chr11

85468668

-PICALMchr11

85685855

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000528231SYTL2chr1185468668-ENST00000532317PICALMchr1185685855-1861379829103267
ENST00000528231SYTL2chr1185468668-ENST00000526033PICALMchr1185685855-1857379829103267
ENST00000528231SYTL2chr1185468668-ENST00000393346PICALMchr1185685855-73137941421167
ENST00000528231SYTL2chr1185468668-ENST00000528398PICALMchr1185685855-70637941421167
ENST00000528231SYTL2chr1185468668-ENST00000356360PICALMchr1185685855-55837921540663
ENST00000524452SYTL2chr1185468668-ENST00000532317PICALMchr1185685855-158310155175467
ENST00000524452SYTL2chr1185468668-ENST00000526033PICALMchr1185685855-157910155175467
ENST00000524452SYTL2chr1185468668-ENST00000393346PICALMchr1185685855-45310118335356
ENST00000524452SYTL2chr1185468668-ENST00000528398PICALMchr1185685855-42810118335356
ENST00000524452SYTL2chr1185468668-ENST00000356360PICALMchr1185685855-280101140943

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000528231ENST00000532317SYTL2chr1185468668-PICALMchr1185685855-0.719943760.28005624
ENST00000528231ENST00000526033SYTL2chr1185468668-PICALMchr1185685855-0.73262890.26737115
ENST00000528231ENST00000393346SYTL2chr1185468668-PICALMchr1185685855-0.210273580.7897264
ENST00000528231ENST00000528398SYTL2chr1185468668-PICALMchr1185685855-0.208417890.7915821
ENST00000528231ENST00000356360SYTL2chr1185468668-PICALMchr1185685855-0.1159099860.88409007
ENST00000524452ENST00000532317SYTL2chr1185468668-PICALMchr1185685855-0.67936280.32063723
ENST00000524452ENST00000526033SYTL2chr1185468668-PICALMchr1185685855-0.67614410.32385588
ENST00000524452ENST00000393346SYTL2chr1185468668-PICALMchr1185685855-0.295089840.7049101
ENST00000524452ENST00000528398SYTL2chr1185468668-PICALMchr1185685855-0.33554090.66445917
ENST00000524452ENST00000356360SYTL2chr1185468668-PICALMchr1185685855-0.2682960.731704

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Fusion Genomic Features for SYTL2-PICALM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SYTL2-PICALM


check button Go to

FGviewer for the breakpoints of chr11:85468668-chr11:85685855

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PICALM

Q13492

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYTL2chr11:85468668chr11:85685855ENST00000316356-219579_61933.666666666666664936.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000354566-113579_61901273.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389958-19579_6190366.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389960-219579_61933.666666666666664911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000524452-118579_61933.666666666666664911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525423-112579_61901257.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525702-19579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000527523-119579_6190903.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000528231-118579_61933.666666666666664935.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000529581-112579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000533892-111579_6190337.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85468668chr11:85685855ENST00000316356-2191_5733.666666666666664936.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000316356-219628_75333.666666666666664936.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000316356-219768_89733.666666666666664936.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000354566-1131_5701273.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000354566-113628_75301273.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000354566-113768_89701273.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389958-191_570366.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389958-19628_7530366.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389958-19768_8970366.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389960-2191_5733.666666666666664911.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389960-219628_75333.666666666666664911.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000389960-219768_89733.666666666666664911.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000524452-1181_5733.666666666666664911.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000524452-118628_75333.666666666666664911.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000524452-118768_89733.666666666666664911.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525423-1121_5701257.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525423-112628_75301257.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525423-112768_89701257.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525702-191_570377.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525702-19628_7530377.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000525702-19768_8970377.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000527523-1191_570903.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000527523-119628_7530903.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000527523-119768_8970903.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000528231-1181_5733.666666666666664935.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000528231-118628_75333.666666666666664935.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000528231-118768_89733.666666666666664935.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000529581-1121_570377.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000529581-112628_7530377.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000529581-112768_8970377.0DomainC2 2
HgeneSYTL2chr11:85468668chr11:85685855ENST00000533892-1111_570337.0DomainRabBD
HgeneSYTL2chr11:85468668chr11:85685855ENST00000533892-111628_7530337.0DomainC2 1
HgeneSYTL2chr11:85468668chr11:85685855ENST00000533892-111768_8970337.0DomainC2 2
TgenePICALMchr11:85468668chr11:85685855ENST00000356360161914_145593.0633.0DomainENTH
TgenePICALMchr11:85468668chr11:85685855ENST00000393346172014_145613.0653.0DomainENTH
TgenePICALMchr11:85468668chr11:85685855ENST00000526033172014_145606.0646.0DomainENTH
TgenePICALMchr11:85468668chr11:85685855ENST00000528398161914_145512.0552.0DomainENTH
TgenePICALMchr11:85468668chr11:85685855ENST00000532317172014_145571.0611.0DomainENTH


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Fusion Gene Sequence for SYTL2-PICALM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000528231_ENST00000532317_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=1861nt_BP=379nt
GGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACCAGGACTTCCTCATGGGA
AAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACTGAACAAGATATTTCATT
TTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCTATTATTTTTGCATGCAC
TTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGG
CCGAAGAAGAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACC
TCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGC
TCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGT
AACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTA
AGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCT
TATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGG
GATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTT
TTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATT
GTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTC
TCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAA
GCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTT
AAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAA
TGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAA
GTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGC
CAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTA
AGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACA

>In-frame_ENST00000528231_ENST00000532317_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=67AA_start in transcript=829_stop in transcript=1032

--------------------------------------------------------------
>In-frame_ENST00000528231_ENST00000526033_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=1857nt_BP=379nt
GGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACCAGGACTTCCTCATGGGA
AAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACTGAACAAGATATTTCATT
TTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCTATTATTTTTGCATGCAC
TTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGG
CCGAAGAAGAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACC
TCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGC
TCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGT
AACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTA
AGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCT
TATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGG
GATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTT
TTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATT
GTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTC
TCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAA
GCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTT
AAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAA
TGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAA
GTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGC
CAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTA
AGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACA

>In-frame_ENST00000528231_ENST00000526033_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=67AA_start in transcript=829_stop in transcript=1032

--------------------------------------------------------------
>In-frame_ENST00000528231_ENST00000393346_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=731nt_BP=379nt
GGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACCAGGACTTCCTCATGGGA
AAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACTGAACAAGATATTTCATT
TTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCTATTATTTTTGCATGCAC
TTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGG
CCGAAGAAGAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACC
TCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGC
TCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGT
AACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTA

>In-frame_ENST00000528231_ENST00000393346_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=67AA_start in transcript=414_stop in transcript=211

--------------------------------------------------------------
>In-frame_ENST00000528231_ENST00000528398_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=706nt_BP=379nt
GGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACCAGGACTTCCTCATGGGA
AAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACTGAACAAGATATTTCATT
TTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCTATTATTTTTGCATGCAC
TTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGG
CCGAAGAAGAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACC
TCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGC
TCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGT

>In-frame_ENST00000528231_ENST00000528398_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=67AA_start in transcript=414_stop in transcript=211

--------------------------------------------------------------
>In-frame_ENST00000528231_ENST00000356360_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=558nt_BP=379nt
GGAACAAGCGACCTGTTTGGCAAGGAATACAGCATCCTTCTGAGAGCCTCTTCTCGACACTATCCCACAGACCAGGACTTCCTCATGGGA
AAGAGCACTTAGGATCTTGCTATCAGCTGCCCTAAACTTTTGCTGAGCCAAAATAAGACTTTGATGCAGAACTGAACAAGATATTTCATT
TTTGTGTGTTTTAATCTTCCTGGTTGCAGTCTTAGTTGTTCAGCCCTGAGAATTTTGAGCCACATTTGTTGCTATTATTTTTGCATGCAC
TTTTCAAAATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGG
CCGAAGAAGAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACC
TCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGC

>In-frame_ENST00000528231_ENST00000356360_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=63AA_start in transcript=215_stop in transcript=406

--------------------------------------------------------------
>In-frame_ENST00000524452_ENST00000532317_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=1583nt_BP=101nt
ATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGGCCGAAGAA
GAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACC
CCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAG
CAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGT
GAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAG
ATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGA
AAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAA
TTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAA
AAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGA
CCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGA
CATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATA
AATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAG
CATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTG
AGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGA
ACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTT
TAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGAC
AGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAA

>In-frame_ENST00000524452_ENST00000532317_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=67AA_start in transcript=551_stop in transcript=754

--------------------------------------------------------------
>In-frame_ENST00000524452_ENST00000526033_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=1579nt_BP=101nt
ATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGGCCGAAGAA
GAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACC
CCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAG
CAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGT
GAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAG
ATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGA
AAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAA
TTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAA
AAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATCAGA
CCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGA
CATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATA
AATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAG
CATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTG
AGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGA
ACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTT
TAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGAC
AGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAA

>In-frame_ENST00000524452_ENST00000526033_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=67AA_start in transcript=551_stop in transcript=754

--------------------------------------------------------------
>In-frame_ENST00000524452_ENST00000393346_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=453nt_BP=101nt
ATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGGCCGAAGAA
GAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACC
CCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAG
CAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGT
GAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAG

>In-frame_ENST00000524452_ENST00000393346_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=56AA_start in transcript=183_stop in transcript=353

--------------------------------------------------------------
>In-frame_ENST00000524452_ENST00000528398_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=428nt_BP=101nt
ATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGGCCGAAGAA
GAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACC
CCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAG
CAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGT

>In-frame_ENST00000524452_ENST00000528398_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=56AA_start in transcript=183_stop in transcript=353

--------------------------------------------------------------
>In-frame_ENST00000524452_ENST00000356360_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(transcript)=280nt_BP=101nt
ATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAGCGGGATGCTGCTCTGAAGAGGGCCGAAGAA
GAGAGAGTCAGCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACC
CCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAG

>In-frame_ENST00000524452_ENST00000356360_TCGA-CJ-5681-11A_SYTL2_chr11_85468668_-_PICALM_chr11_85685855_length(amino acids)=43AA_start in transcript=140_stop in transcript=9

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SYTL2-PICALM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePICALMchr11:85468668chr11:85685855ENST000003563601619221_294593.0633.0PIMREG
TgenePICALMchr11:85468668chr11:85685855ENST000003933461720221_294613.0653.0PIMREG
TgenePICALMchr11:85468668chr11:85685855ENST000005260331720221_294606.0646.0PIMREG
TgenePICALMchr11:85468668chr11:85685855ENST000005283981619221_294512.0552.0PIMREG
TgenePICALMchr11:85468668chr11:85685855ENST000005323171720221_294571.0611.0PIMREG


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SYTL2-PICALM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SYTL2-PICALM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePICALMC0002395Alzheimer's Disease2CTD_human
TgenePICALMC0011265Presenile dementia2CTD_human
TgenePICALMC0276496Familial Alzheimer Disease (FAD)2CTD_human
TgenePICALMC0494463Alzheimer Disease, Late Onset2CTD_human
TgenePICALMC0546126Acute Confusional Senile Dementia2CTD_human
TgenePICALMC0750900Alzheimer's Disease, Focal Onset2CTD_human
TgenePICALMC0750901Alzheimer Disease, Early Onset2CTD_human
TgenePICALMC0234985Mental deterioration1CTD_human
TgenePICALMC0338656Impaired cognition1CTD_human
TgenePICALMC1270972Mild cognitive disorder1CTD_human