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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TAF1A-SLC12A7 (FusionGDB2 ID:88135) |
Fusion Gene Summary for TAF1A-SLC12A7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAF1A-SLC12A7 | Fusion gene ID: 88135 | Hgene | Tgene | Gene symbol | TAF1A | SLC12A7 | Gene ID | 9015 | 10723 |
| Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit A | solute carrier family 12 member 7 | |
| Synonyms | MGC:17061|RAFI48|SL1|TAFI48 | KCC4 | |
| Cytomap | 1q41 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TATA box-binding protein-associated factor RNA polymerase I subunit ARNA polymerase I-specific TBP-associated factor 48 kDaSL1, 48kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDTATA box binding protein (TBP)-assoc | solute carrier family 12 member 7K-Cl cotransporter 4SUCO/SLC12A7 fusionelectroneutral potassium-chloride cotransporter 4potassium/chloride transporter KCC4solute carrier family 12 (potassium/chloride transporter), member 7solute carrier family 12 ( | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000366890, ENST00000350027, ENST00000352967, ENST00000391882, ENST00000543857, ENST00000465263, | ENST00000264930, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 4=144 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAF1A [Title/Abstract] AND SLC12A7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TAF1A(222757470)-SLC12A7(1085588), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | TAF1A-SLC12A7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TAF1A-SLC12A7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TAF1A-SLC12A7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across TAF1A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SLC12A7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-DQ-7589-01A | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| ChimerDB4 | HNSC | TCGA-DQ-7589-01A | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
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Fusion Gene ORF analysis for TAF1A-SLC12A7 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000366890 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| Frame-shift | ENST00000350027 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| In-frame | ENST00000352967 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| intron-3CDS | ENST00000391882 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| In-frame | ENST00000543857 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| 5UTR-3CDS | ENST00000465263 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000352967 | TAF1A | chr1 | 222757470 | - | ENST00000264930 | SLC12A7 | chr5 | 1085588 | - | 5033 | 480 | 189 | 3056 | 955 |
| ENST00000543857 | TAF1A | chr1 | 222757470 | - | ENST00000264930 | SLC12A7 | chr5 | 1085588 | - | 5053 | 500 | 209 | 3076 | 955 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000352967 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - | 0.00193163 | 0.9980684 |
| ENST00000543857 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - | 0.001928317 | 0.99807173 |
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Fusion Genomic Features for TAF1A-SLC12A7 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TAF1A-SLC12A7 |
| Go to FGviewer for the breakpoints of chr1:222757470-chr5:1085588 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 274_275 | 225.0 | 1084.0 | Topological domain | Cytoplasmic | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 437_456 | 225.0 | 1084.0 | Topological domain | Cytoplasmic | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 515_553 | 225.0 | 1084.0 | Topological domain | Cytoplasmic | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 599_624 | 225.0 | 1084.0 | Topological domain | Cytoplasmic | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 866_1083 | 225.0 | 1084.0 | Topological domain | Cytoplasmic | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 253_273 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 276_296 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 416_436 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 457_477 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 494_514 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 554_574 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 578_598 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 625_645 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 845_865 | 225.0 | 1084.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 162_214 | 225.0 | 1084.0 | Topological domain | Cytoplasmic | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 1_118 | 225.0 | 1084.0 | Topological domain | Cytoplasmic | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 119_139 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 141_161 | 225.0 | 1084.0 | Transmembrane | Helical | |
| Tgene | SLC12A7 | chr1:222757470 | chr5:1085588 | ENST00000264930 | 5 | 24 | 215_235 | 225.0 | 1084.0 | Transmembrane | Helical |
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Fusion Gene Sequence for TAF1A-SLC12A7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000352967_ENST00000264930_TCGA-DQ-7589-01A_TAF1A_chr1_222757470_-_SLC12A7_chr5_1085588_length(transcript)=5033nt_BP=480nt GCCAACGATACGCCTGCTGCAGCAGGAGGAGTTACGAGCCGGGCCGCGCGCTGCCTAAATACCTAAACCAGGTTTAGCGCCTGCTCATAT AAAGCTCTCCTAACTCGTCTTCCGGTGGGAATTTCTTCACGTGGGCCGGAGTCGGAGACTGAGTTTAGCTTTACTGAGGAGCTCTAAATT TAGGCGGGTATGAGTGATTTCAGTGAAGAATTAAAAGGGCCTGTGACAGATGATGAAGAAGTGGAAACATCTGTGCTCAGTGGTGCAGGA ATGCATTTTCCTTGGCTTCAAACATACGTAGAAACTGTGGCCATTGGAGGGAAAAGGAGGAAGGATTTTGCTCAGACAACAAGTGCTTGT TTAAGTTTTATCCAAGAAGCTCTGCTGAAGCACCAATGGCAGCAAGCTGCAGAATACATGTACAGTTATTTTCAGACCTTGGAAGATTCA GATAGCTACAAAAGGCAGGCTGCACCTGAGACGTACATCTCCCCGGGTGCGGCCATCTTCCAGGCGGAGGCTGCAGGTGGCGAGGCGGCC GCCATGCTGCACAACATGCGTGTGTACGGCACGTGCACGCTCGTGCTCATGGCCCTGGTGGTCTTCGTGGGCGTCAAGTATGTCAACAAG CTGGCGCTGGTCTTCCTGGCCTGCGTCGTGCTGTCCATCCTGGCCATCTATGCCGGCGTCATCAAGTCTGCCTTCGACCCCCCGGACATC CCGGTCTGCCTCCTGGGGAACCGCACGCTGTCACGGCGCAGCTTCGATGCCTGCGTCAAGGCCTACGGCATCCACAACAACTCAGCCACC TCCGCGCTCTGGGGCCTCTTCTGCAACGGCTCCCAGCCCAGCGCCGCCTGTGACGAGTACTTCATCCAGAACAACGTCACCGAAATCCAG GGCATCCCGGGCGCGGCCAGTGGTGTCTTCCTGGAGAACCTGTGGAGTACGTACGCGCACGCGGGGGCGTTTGTGGAGAAGAAAGGTGTG CCCTCGGTGCCCGTGGCAGAGGAGAGCCGTGCCAGCGCACTGCCCTACGTGCTCACCGACATCGCGGCCTCCTTCACCCTGCTGGTTGGC ATCTACTTCCCTTCCGTGACCGGTATCATGGCGGGTTCAAACCGGTCCGGGGACCTCAAGGATGCACAGAAGTCCATCCCCACGGGGACC ATCCTGGCCATAGTGACGACGTCTTTCATCTATCTCTCCTGCATTGTGCTGTTTGGGGCCTGCATTGAAGGCGTGGTCTTACGAGATAAG TTCGGGGAGGCCCTGCAGGGGAACCTGGTCATCGGCATGCTGGCCTGGCCCTCCCCCTGGGTCATCGTCATCGGCTCCTTCTTCTCCACC TGCGGTGCCGGCCTGCAGAGCCTCACGGGGGCACCGCGCCTACTGCAGGCCATTGCCCGTGACGGCATCGTCCCCTTCCTGCAGGTGTTT GGCCACGGGAAGGCCAACGGGGAGCCCACGTGGGCGCTGCTGCTGACAGTCCTCATCTGCGAGACTGGCATCCTCATCGCCTCTCTGGAC AGCGTGGCCCCGATCCTCTCCATGTTCTTCCTCATGTGCTACCTGTTCGTGAACCTGGCCTGCGCCGTGCAGACCCTGCTACGTACCCCC AACTGGCGTCCACGCTTCAAGTTCTACCACTGGACCCTGTCCTTTCTGGGTATGAGCCTGTGCCTGGCGCTGATGTTCATCTGCTCCTGG TACTACGCGCTGTCCGCCATGCTCATCGCTGGCTGCATCTACAAGTACATCGAGTACCGCGGGGCCGAGAAGGAGTGGGGCGATGGCATC CGTGGCCTATCCCTGAACGCCGCCCGCTACGCCCTGCTGCGCGTGGAGCACGGTCCCCCCCACACCAAGAACTGGAGGCCCCAGGTGCTG GTGATGCTGAACCTGGACGCGGAGCAGGCCGTGAAGCACCCCCGCCTGCTGTCCTTCACGTCGCAGCTGAAGGCCGGCAAGGGCCTGACC ATCGTGGGCTCGGTGCTGGAGGGGACGTACCTGGACAAGCACATGGAGGCTCAGCGGGCCGAGGAGAACATACGGTCCCTAATGAGCACA GAGAAGACCAAGGGCTTCTGCCAGCTGGTGGTCTCGTCCAGCCTGCGGGATGGCATGTCCCACCTGATCCAGTCGGCCGGCCTGGGCGGC CTGAAGCACAACACGGTGCTCATGGCCTGGCCCGCATCCTGGAAGCAGGAGGACAACCCCTTCTCCTGGAAGAACTTTGTGGACACCGTC CGCGACACCACCGCCGCGCACCAGGCTCTGCTGGTGGCCAAGAACGTCGACTCGTTTCCGCAAAACCAGGAGCGCTTCGGCGGGGGCCAC ATCGACGTGTGGTGGATCGTGCACGACGGCGGCATGCTCATGCTGCTGCCCTTCCTGCTGCGCCAGCACAAGGTGTGGAGGAAGTGCCGG ATGCGTATCTTCACCGTGGCCCAGGTGGACGACAACAGCATCCAGATGAAGAAGGACCTGCAGATGTTCTTGTACCACTTGCGCATCAGC GCCGAGGTGGAGGTGGTGGAGATGGTTGAAAACGACATATCTGCTTTCACCTACGAGAGGACACTAATGATGGAGCAGAGGTCGCAGATG CTGAAGCAGATGCAGCTGTCCAAGAACGAGCAGGAGCGAGAGGCCCAGCTGATCCACGACAGGAACACCGCGTCCCACACCGCGGCGGCA GCCAGGACCCAAGCGCCGCCTACGCCAGACAAGGTGCAGATGACCTGGACCAGGGAGAAGCTGATCGCTGAGAAGTACAGGAGCAGAGAC ACCAGCCTATCTGGTTTCAAAGACCTCTTCAGCATGAAGCCGGACCAGTCCAACGTCAGGCGGATGCACACGGCTGTGAAGCTCAATGGC GTCGTCCTCAACAAGTCCCAGGATGCGCAGCTGGTCCTGCTCAACATGCCAGGTCCTCCCAAAAACCGGCAGGGAGACGAGAACTACATG GAGTTTCTTGAAGTCCTGACCGAGGGGCTGAACAGAGTCCTCCTGGTCAGGGGTGGCGGCCGGGAGGTGATCACCATCTACTCCTAATGC CCAACAGCATCACGGCACTCTGGGACAGGCACGGAGGACGGCGTGGGCAGCCTGGGCCTGGGCTTGGCCCAGGGAAACAGACGGCAGACA CACCTGTCCCCCAGTGATGCCGCCCAAGCTGCCCATGGGGCTTCCTACGGAAGTTTCTAGGCCCGTCACCTAGGGCTCTCCTGTTCAGCC TTAACAGGCTCAGCAAATCAGGGCGTGGCTGGACGATTTCCTTGCATCTGAGGGCAGACGCTGCTACCGGAGTGACCTGGACGTGGCCAG ATCTTCTCGCAGGTCACAAGAAGCCAGTGAGCCCTTGCCTTGGTTTCTGGAAGTTCTTTTCCTTGGCTGGATTTACCCAGTGGTTAGGTT GCATTTCTACCCCATCCAGAACATTCTTGGAAGAGCACCCGGAGCTGAAGCTGTCCCTGATGATGAAGGTGAAACGTCAGCCCTGGCCAT GGCTCCGCTCAGGGCCCCGGTCACCTCCGAGTCACTCTGTTCCTTGACTGTCTTTGTGTTTCTGTACCTCAAGGCACTGAAGCTGGAGGA CTCTGTCCATGCCCGTGTCACCCTCGTGTGGGAGCCTCTGGGCTCGGCAGGTCCACATTTCATGAGCTGAGGCGTGGGCCAGGGCCATCT GGAAAGGGAACTCGGCTTTTCCAGAACGTGGTGGATCATCTGTCGGGTGTGTGGTGAACACGTTCAGTTCATCAGGGCCTACGCTCCGGG AAGGGGCCCCCAGCTGTGGCTCTGCCATGCCGGGCTGTGTTTGCAGCTGTCCGAGTCTCCATCCACCTTTAGAAAACCAGCCACTTCTTT TCATAAGCACTGACAGGGCCCAGCCCACAGCCACAGGTGCGATCAGTGCCTCACGCAGGCAAATGCACTGAAACCCAGGGGCACACGCGC GCAGAGTGAACAGTGAGTTCCCCCGACAGCCCACGACAGCCAGGACTGCCCTCCCCACCCCACCCCACCCCAGGAGCACGGCACACAGTT CAGCCTCTGAGCTGGCTCACACGTGCCATCCCCACCCCGGTGCTCCAGGGAAGGAGGACACGGACCCGACGTGGGAGGTCCTCAGGCAGC AGTGGCGCCTGGTGTCAGGTCTGTCTGGCTGAGTCCCGGGCGTCCCCTGCCATGGCCTGTGCCTTGCATGGAGGCGGCGGTGGCACTGAA GAGATAGCTTTCAAGGGCCCAACACTTTGCACTTCGGCTGGCTGTGAGTTTCTGCTTTGTAGGTTGTGGTCACATTTGCAGGCTGCGGGC AGTGGCACCGACTTGGGCCTCCCTTTCTATGTGGCATATTTATTTATTTAAACACCCCAGGGAGTTACGTGGTAACAAGGTTGTCCATAA AGAGGTTGCTTCTATATACTAGAGGCCCCAGATGGCCAGGCCTTGGGCTACGTCTGGCTTGCATGGTCTCCCAAGGGAATCAGCCCCATC AACAAAGTTCAAATCGGGGCAGAGGCTGCACTTGTGCCCCCAGATGTTTCTGAGGAGCCAGACTAGGGCTGGCATTGCTGTAGAGTGACG GCTGCTGCCCAGAGCGTGTCCCAGACATCACAGCGGGGCTCAGCAGTTCCCACAGCCTCTGCCTGCCTTGGCTAAGCATGAGTTAAGCAG CAAAACGCTCCTCCATGTCTGGATGGGGCCGGCAGGTCCTGTGTCCCCTGCACCTGGAGGAGAGCAGGCTAGAGGCACAGCGGCCACATG GTGCTGGCTCTGAACGTTGGTTGGTGGCTGGAAAACAGCCCTGCTTCTGAGGGCCGCTCAGTTCTGCACACGAAACCACCTCCTGAGGGC TCAGCTCTGCCCCCGCCCTGGGCTGCAGCCTCTGCACGCAAGCACCAGGCATCCTTTGTGTTGTCAACTCCGTGTAACCAGTAACTACAG >In-frame_ENST00000352967_ENST00000264930_TCGA-DQ-7589-01A_TAF1A_chr1_222757470_-_SLC12A7_chr5_1085588_length(amino acids)=955AA_start in transcript=189_stop in transcript=3056 MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGGKRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSY KRQAAPETYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVC LLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGL SLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDV WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVL -------------------------------------------------------------- >In-frame_ENST00000543857_ENST00000264930_TCGA-DQ-7589-01A_TAF1A_chr1_222757470_-_SLC12A7_chr5_1085588_length(transcript)=5053nt_BP=500nt ACTTCCGGGGTCGAGGCGAGGCCAACGATACGCCTGCTGCAGCAGGAGGAGTTACGAGCCGGGCCGCGCGCTGCCTAAATACCTAAACCA GGTTTAGCGCCTGCTCATATAAAGCTCTCCTAACTCGTCTTCCGGTGGGAATTTCTTCACGTGGGCCGGAGTCGGAGACTGAGTTTAGCT TTACTGAGGAGCTCTAAATTTAGGCGGGTATGAGTGATTTCAGTGAAGAATTAAAAGGGCCTGTGACAGATGATGAAGAAGTGGAAACAT CTGTGCTCAGTGGTGCAGGAATGCATTTTCCTTGGCTTCAAACATACGTAGAAACTGTGGCCATTGGAGGGAAAAGGAGGAAGGATTTTG CTCAGACAACAAGTGCTTGTTTAAGTTTTATCCAAGAAGCTCTGCTGAAGCACCAATGGCAGCAAGCTGCAGAATACATGTACAGTTATT TTCAGACCTTGGAAGATTCAGATAGCTACAAAAGGCAGGCTGCACCTGAGACGTACATCTCCCCGGGTGCGGCCATCTTCCAGGCGGAGG CTGCAGGTGGCGAGGCGGCCGCCATGCTGCACAACATGCGTGTGTACGGCACGTGCACGCTCGTGCTCATGGCCCTGGTGGTCTTCGTGG GCGTCAAGTATGTCAACAAGCTGGCGCTGGTCTTCCTGGCCTGCGTCGTGCTGTCCATCCTGGCCATCTATGCCGGCGTCATCAAGTCTG CCTTCGACCCCCCGGACATCCCGGTCTGCCTCCTGGGGAACCGCACGCTGTCACGGCGCAGCTTCGATGCCTGCGTCAAGGCCTACGGCA TCCACAACAACTCAGCCACCTCCGCGCTCTGGGGCCTCTTCTGCAACGGCTCCCAGCCCAGCGCCGCCTGTGACGAGTACTTCATCCAGA ACAACGTCACCGAAATCCAGGGCATCCCGGGCGCGGCCAGTGGTGTCTTCCTGGAGAACCTGTGGAGTACGTACGCGCACGCGGGGGCGT TTGTGGAGAAGAAAGGTGTGCCCTCGGTGCCCGTGGCAGAGGAGAGCCGTGCCAGCGCACTGCCCTACGTGCTCACCGACATCGCGGCCT CCTTCACCCTGCTGGTTGGCATCTACTTCCCTTCCGTGACCGGTATCATGGCGGGTTCAAACCGGTCCGGGGACCTCAAGGATGCACAGA AGTCCATCCCCACGGGGACCATCCTGGCCATAGTGACGACGTCTTTCATCTATCTCTCCTGCATTGTGCTGTTTGGGGCCTGCATTGAAG GCGTGGTCTTACGAGATAAGTTCGGGGAGGCCCTGCAGGGGAACCTGGTCATCGGCATGCTGGCCTGGCCCTCCCCCTGGGTCATCGTCA TCGGCTCCTTCTTCTCCACCTGCGGTGCCGGCCTGCAGAGCCTCACGGGGGCACCGCGCCTACTGCAGGCCATTGCCCGTGACGGCATCG TCCCCTTCCTGCAGGTGTTTGGCCACGGGAAGGCCAACGGGGAGCCCACGTGGGCGCTGCTGCTGACAGTCCTCATCTGCGAGACTGGCA TCCTCATCGCCTCTCTGGACAGCGTGGCCCCGATCCTCTCCATGTTCTTCCTCATGTGCTACCTGTTCGTGAACCTGGCCTGCGCCGTGC AGACCCTGCTACGTACCCCCAACTGGCGTCCACGCTTCAAGTTCTACCACTGGACCCTGTCCTTTCTGGGTATGAGCCTGTGCCTGGCGC TGATGTTCATCTGCTCCTGGTACTACGCGCTGTCCGCCATGCTCATCGCTGGCTGCATCTACAAGTACATCGAGTACCGCGGGGCCGAGA AGGAGTGGGGCGATGGCATCCGTGGCCTATCCCTGAACGCCGCCCGCTACGCCCTGCTGCGCGTGGAGCACGGTCCCCCCCACACCAAGA ACTGGAGGCCCCAGGTGCTGGTGATGCTGAACCTGGACGCGGAGCAGGCCGTGAAGCACCCCCGCCTGCTGTCCTTCACGTCGCAGCTGA AGGCCGGCAAGGGCCTGACCATCGTGGGCTCGGTGCTGGAGGGGACGTACCTGGACAAGCACATGGAGGCTCAGCGGGCCGAGGAGAACA TACGGTCCCTAATGAGCACAGAGAAGACCAAGGGCTTCTGCCAGCTGGTGGTCTCGTCCAGCCTGCGGGATGGCATGTCCCACCTGATCC AGTCGGCCGGCCTGGGCGGCCTGAAGCACAACACGGTGCTCATGGCCTGGCCCGCATCCTGGAAGCAGGAGGACAACCCCTTCTCCTGGA AGAACTTTGTGGACACCGTCCGCGACACCACCGCCGCGCACCAGGCTCTGCTGGTGGCCAAGAACGTCGACTCGTTTCCGCAAAACCAGG AGCGCTTCGGCGGGGGCCACATCGACGTGTGGTGGATCGTGCACGACGGCGGCATGCTCATGCTGCTGCCCTTCCTGCTGCGCCAGCACA AGGTGTGGAGGAAGTGCCGGATGCGTATCTTCACCGTGGCCCAGGTGGACGACAACAGCATCCAGATGAAGAAGGACCTGCAGATGTTCT TGTACCACTTGCGCATCAGCGCCGAGGTGGAGGTGGTGGAGATGGTTGAAAACGACATATCTGCTTTCACCTACGAGAGGACACTAATGA TGGAGCAGAGGTCGCAGATGCTGAAGCAGATGCAGCTGTCCAAGAACGAGCAGGAGCGAGAGGCCCAGCTGATCCACGACAGGAACACCG CGTCCCACACCGCGGCGGCAGCCAGGACCCAAGCGCCGCCTACGCCAGACAAGGTGCAGATGACCTGGACCAGGGAGAAGCTGATCGCTG AGAAGTACAGGAGCAGAGACACCAGCCTATCTGGTTTCAAAGACCTCTTCAGCATGAAGCCGGACCAGTCCAACGTCAGGCGGATGCACA CGGCTGTGAAGCTCAATGGCGTCGTCCTCAACAAGTCCCAGGATGCGCAGCTGGTCCTGCTCAACATGCCAGGTCCTCCCAAAAACCGGC AGGGAGACGAGAACTACATGGAGTTTCTTGAAGTCCTGACCGAGGGGCTGAACAGAGTCCTCCTGGTCAGGGGTGGCGGCCGGGAGGTGA TCACCATCTACTCCTAATGCCCAACAGCATCACGGCACTCTGGGACAGGCACGGAGGACGGCGTGGGCAGCCTGGGCCTGGGCTTGGCCC AGGGAAACAGACGGCAGACACACCTGTCCCCCAGTGATGCCGCCCAAGCTGCCCATGGGGCTTCCTACGGAAGTTTCTAGGCCCGTCACC TAGGGCTCTCCTGTTCAGCCTTAACAGGCTCAGCAAATCAGGGCGTGGCTGGACGATTTCCTTGCATCTGAGGGCAGACGCTGCTACCGG AGTGACCTGGACGTGGCCAGATCTTCTCGCAGGTCACAAGAAGCCAGTGAGCCCTTGCCTTGGTTTCTGGAAGTTCTTTTCCTTGGCTGG ATTTACCCAGTGGTTAGGTTGCATTTCTACCCCATCCAGAACATTCTTGGAAGAGCACCCGGAGCTGAAGCTGTCCCTGATGATGAAGGT GAAACGTCAGCCCTGGCCATGGCTCCGCTCAGGGCCCCGGTCACCTCCGAGTCACTCTGTTCCTTGACTGTCTTTGTGTTTCTGTACCTC AAGGCACTGAAGCTGGAGGACTCTGTCCATGCCCGTGTCACCCTCGTGTGGGAGCCTCTGGGCTCGGCAGGTCCACATTTCATGAGCTGA GGCGTGGGCCAGGGCCATCTGGAAAGGGAACTCGGCTTTTCCAGAACGTGGTGGATCATCTGTCGGGTGTGTGGTGAACACGTTCAGTTC ATCAGGGCCTACGCTCCGGGAAGGGGCCCCCAGCTGTGGCTCTGCCATGCCGGGCTGTGTTTGCAGCTGTCCGAGTCTCCATCCACCTTT AGAAAACCAGCCACTTCTTTTCATAAGCACTGACAGGGCCCAGCCCACAGCCACAGGTGCGATCAGTGCCTCACGCAGGCAAATGCACTG AAACCCAGGGGCACACGCGCGCAGAGTGAACAGTGAGTTCCCCCGACAGCCCACGACAGCCAGGACTGCCCTCCCCACCCCACCCCACCC CAGGAGCACGGCACACAGTTCAGCCTCTGAGCTGGCTCACACGTGCCATCCCCACCCCGGTGCTCCAGGGAAGGAGGACACGGACCCGAC GTGGGAGGTCCTCAGGCAGCAGTGGCGCCTGGTGTCAGGTCTGTCTGGCTGAGTCCCGGGCGTCCCCTGCCATGGCCTGTGCCTTGCATG GAGGCGGCGGTGGCACTGAAGAGATAGCTTTCAAGGGCCCAACACTTTGCACTTCGGCTGGCTGTGAGTTTCTGCTTTGTAGGTTGTGGT CACATTTGCAGGCTGCGGGCAGTGGCACCGACTTGGGCCTCCCTTTCTATGTGGCATATTTATTTATTTAAACACCCCAGGGAGTTACGT GGTAACAAGGTTGTCCATAAAGAGGTTGCTTCTATATACTAGAGGCCCCAGATGGCCAGGCCTTGGGCTACGTCTGGCTTGCATGGTCTC CCAAGGGAATCAGCCCCATCAACAAAGTTCAAATCGGGGCAGAGGCTGCACTTGTGCCCCCAGATGTTTCTGAGGAGCCAGACTAGGGCT GGCATTGCTGTAGAGTGACGGCTGCTGCCCAGAGCGTGTCCCAGACATCACAGCGGGGCTCAGCAGTTCCCACAGCCTCTGCCTGCCTTG GCTAAGCATGAGTTAAGCAGCAAAACGCTCCTCCATGTCTGGATGGGGCCGGCAGGTCCTGTGTCCCCTGCACCTGGAGGAGAGCAGGCT AGAGGCACAGCGGCCACATGGTGCTGGCTCTGAACGTTGGTTGGTGGCTGGAAAACAGCCCTGCTTCTGAGGGCCGCTCAGTTCTGCACA CGAAACCACCTCCTGAGGGCTCAGCTCTGCCCCCGCCCTGGGCTGCAGCCTCTGCACGCAAGCACCAGGCATCCTTTGTGTTGTCAACTC CGTGTAACCAGTAACTACAGCCATTTACAATTGACTCCGTTTCCTTTTGTAGGTTTCCCTGTCTGTCTGTGTTAGTAGAAAAATAAAATC >In-frame_ENST00000543857_ENST00000264930_TCGA-DQ-7589-01A_TAF1A_chr1_222757470_-_SLC12A7_chr5_1085588_length(amino acids)=955AA_start in transcript=209_stop in transcript=3076 MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGGKRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSY KRQAAPETYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVC LLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGE ALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGL SLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDV WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TAF1A-SLC12A7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TAF1A-SLC12A7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TAF1A-SLC12A7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TAF1A | C0340427 | Familial dilated cardiomyopathy | 1 | ORPHANET |
| Tgene | SLC12A7 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Tgene | SLC12A7 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
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