FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TAOK1-VMP1 (FusionGDB2 ID:88423)

Fusion Gene Summary for TAOK1-VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TAOK1-VMP1
Fusion gene ID: 88423
HgeneTgene
Gene symbol

TAOK1

VMP1

Gene ID

57551

81671

Gene nameTAO kinase 1vacuole membrane protein 1
SynonymsKFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1EPG3|TANGO5|TMEM49
Cytomap

17q11.2

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kinvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2020031520200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261716, ENST00000536202, 
ENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
Fusion gene scores* DoF score42 X 23 X 20=1932042 X 34 X 19=27132
# samples 52151
** MAII scorelog2(52/19320*10)=-5.21543966069468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(151/27132*10)=-4.16737494326024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TAOK1 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAOK1(27844674)-VMP1(57842332), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAOK1

GO:0006974

cellular response to DNA damage stimulus

17396146

HgeneTAOK1

GO:0016310

phosphorylation

12639963

HgeneTAOK1

GO:0046330

positive regulation of JNK cascade

16407310

HgeneTAOK1

GO:0097194

execution phase of apoptosis

16407310


check buttonFusion gene breakpoints across TAOK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VMP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AZ-4323-01ATAOK1chr17

27844674

+VMP1chr17

57842332

+
ChimerDB4COADTCGA-AZ-4323TAOK1chr17

27844674

+VMP1chr17

57842331

+
ChimerDB4COADTCGA-AZ-4323-01ATAOK1chr17

27844674

+VMP1chr17

57842332

+
ChimerDB4COADTCGA-AZ-4323-01ATAOK1chr17

27844674

-VMP1chr17

57842332

+


Top

Fusion Gene ORF analysis for TAOK1-VMP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261716ENST00000262291TAOK1chr17

27844674

+VMP1chr17

57842332

+
In-frameENST00000261716ENST00000537567TAOK1chr17

27844674

+VMP1chr17

57842332

+
5CDS-5UTRENST00000261716ENST00000539763TAOK1chr17

27844674

+VMP1chr17

57842332

+
5CDS-5UTRENST00000261716ENST00000536180TAOK1chr17

27844674

+VMP1chr17

57842332

+
5CDS-intronENST00000261716ENST00000545362TAOK1chr17

27844674

+VMP1chr17

57842332

+
5CDS-intronENST00000261716ENST00000588617TAOK1chr17

27844674

+VMP1chr17

57842332

+
intron-3CDSENST00000536202ENST00000262291TAOK1chr17

27844674

+VMP1chr17

57842332

+
intron-3CDSENST00000536202ENST00000537567TAOK1chr17

27844674

+VMP1chr17

57842332

+
intron-5UTRENST00000536202ENST00000539763TAOK1chr17

27844674

+VMP1chr17

57842332

+
intron-5UTRENST00000536202ENST00000536180TAOK1chr17

27844674

+VMP1chr17

57842332

+
intron-intronENST00000536202ENST00000545362TAOK1chr17

27844674

+VMP1chr17

57842332

+
intron-intronENST00000536202ENST00000588617TAOK1chr17

27844674

+VMP1chr17

57842332

+
In-frameENST00000261716ENST00000262291TAOK1chr17

27844674

+VMP1chr17

57842331

+
In-frameENST00000261716ENST00000537567TAOK1chr17

27844674

+VMP1chr17

57842331

+
5CDS-5UTRENST00000261716ENST00000539763TAOK1chr17

27844674

+VMP1chr17

57842331

+
5CDS-5UTRENST00000261716ENST00000536180TAOK1chr17

27844674

+VMP1chr17

57842331

+
5CDS-intronENST00000261716ENST00000545362TAOK1chr17

27844674

+VMP1chr17

57842331

+
5CDS-intronENST00000261716ENST00000588617TAOK1chr17

27844674

+VMP1chr17

57842331

+
intron-3CDSENST00000536202ENST00000262291TAOK1chr17

27844674

+VMP1chr17

57842331

+
intron-3CDSENST00000536202ENST00000537567TAOK1chr17

27844674

+VMP1chr17

57842331

+
intron-5UTRENST00000536202ENST00000539763TAOK1chr17

27844674

+VMP1chr17

57842331

+
intron-5UTRENST00000536202ENST00000536180TAOK1chr17

27844674

+VMP1chr17

57842331

+
intron-intronENST00000536202ENST00000545362TAOK1chr17

27844674

+VMP1chr17

57842331

+
intron-intronENST00000536202ENST00000588617TAOK1chr17

27844674

+VMP1chr17

57842331

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261716TAOK1chr1727844674+ENST00000262291VMP1chr1757842332+441524275073233908
ENST00000261716TAOK1chr1727844674+ENST00000537567VMP1chr1757842332+349424275073233908
ENST00000261716TAOK1chr1727844674+ENST00000262291VMP1chr1757842331+441524275073233908
ENST00000261716TAOK1chr1727844674+ENST00000537567VMP1chr1757842331+349424275073233908

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261716ENST00000262291TAOK1chr1727844674+VMP1chr1757842332+0.0003840720.9996159
ENST00000261716ENST00000537567TAOK1chr1727844674+VMP1chr1757842332+0.001612010.99838805
ENST00000261716ENST00000262291TAOK1chr1727844674+VMP1chr1757842331+0.0003840720.9996159
ENST00000261716ENST00000537567TAOK1chr1727844674+VMP1chr1757842331+0.001612010.99838805

Top

Fusion Genomic Features for TAOK1-VMP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TAOK1chr1727844674+VMP1chr1757842331+2.16E-081
TAOK1chr1727844674+VMP1chr1757842331+2.16E-081
TAOK1chr1727844674+VMP1chr1757842331+2.16E-081
TAOK1chr1727844674+VMP1chr1757842331+2.16E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TAOK1-VMP1


check button Go to

FGviewer for the breakpoints of chr17:27844674-chr17:57842332

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAOK1chr17:27844674chr17:57842331ENST00000261716+1620330_334636.01002.0Compositional biasNote=Poly-Glu
HgeneTAOK1chr17:27844674chr17:57842331ENST00000261716+1620347_379636.01002.0Compositional biasNote=Ser-rich
HgeneTAOK1chr17:27844674chr17:57842332ENST00000261716+1620330_334636.01002.0Compositional biasNote=Poly-Glu
HgeneTAOK1chr17:27844674chr17:57842332ENST00000261716+1620347_379636.01002.0Compositional biasNote=Ser-rich
HgeneTAOK1chr17:27844674chr17:57842331ENST00000261716+162028_281636.01002.0DomainProtein kinase
HgeneTAOK1chr17:27844674chr17:57842332ENST00000261716+162028_281636.01002.0DomainProtein kinase
HgeneTAOK1chr17:27844674chr17:57842331ENST00000261716+162034_42636.01002.0Nucleotide bindingATP
HgeneTAOK1chr17:27844674chr17:57842332ENST00000261716+162034_42636.01002.0Nucleotide bindingATP
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412173_316138.0407.0RegionVTT domain
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412173_316138.0407.0RegionVTT domain
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412272_273138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412295_305138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412327_363138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412385_406138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412272_273138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412295_305138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412327_363138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412385_406138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412251_271138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412274_294138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412306_326138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412364_384138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412251_271138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412274_294138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412306_326138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412364_384138.0407.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAOK1chr17:27844674chr17:57842331ENST00000261716+1620458_651636.01002.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842331ENST00000261716+1620754_877636.01002.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842331ENST00000536202+118458_6510854.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842331ENST00000536202+118754_8770854.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842332ENST00000261716+1620458_651636.01002.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842332ENST00000261716+1620754_877636.01002.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842332ENST00000536202+118458_6510854.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842332ENST00000536202+118754_8770854.0Coiled coilOntology_term=ECO:0000255
HgeneTAOK1chr17:27844674chr17:57842331ENST00000536202+118330_3340854.0Compositional biasNote=Poly-Glu
HgeneTAOK1chr17:27844674chr17:57842331ENST00000536202+118347_3790854.0Compositional biasNote=Ser-rich
HgeneTAOK1chr17:27844674chr17:57842332ENST00000536202+118330_3340854.0Compositional biasNote=Poly-Glu
HgeneTAOK1chr17:27844674chr17:57842332ENST00000536202+118347_3790854.0Compositional biasNote=Ser-rich
HgeneTAOK1chr17:27844674chr17:57842331ENST00000536202+11828_2810854.0DomainProtein kinase
HgeneTAOK1chr17:27844674chr17:57842332ENST00000536202+11828_2810854.0DomainProtein kinase
HgeneTAOK1chr17:27844674chr17:57842331ENST00000536202+11834_420854.0Nucleotide bindingATP
HgeneTAOK1chr17:27844674chr17:57842332ENST00000536202+11834_420854.0Nucleotide bindingATP
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412131_250138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842331ENST000002622914122_43138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842331ENST0000026229141265_77138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842331ENST0000026229141299_109138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412131_250138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842332ENST000002622914122_43138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842332ENST0000026229141265_77138.0407.0Topological domainExtracellular
TgeneVMP1chr17:27844674chr17:57842332ENST0000026229141299_109138.0407.0Topological domainCytoplasmic
TgeneVMP1chr17:27844674chr17:57842331ENST00000262291412110_130138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842331ENST0000026229141244_64138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842331ENST0000026229141278_98138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842332ENST00000262291412110_130138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842332ENST0000026229141244_64138.0407.0TransmembraneHelical
TgeneVMP1chr17:27844674chr17:57842332ENST0000026229141278_98138.0407.0TransmembraneHelical


Top

Fusion Gene Sequence for TAOK1-VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000261716_ENST00000262291_TCGA-AZ-4323-01A_TAOK1_chr17_27844674_+_VMP1_chr17_57842332_length(transcript)=4415nt_BP=2427nt
CTTACCAGGGGTGGTGTTGGTGGCGGAGGGCTGCGCGTGGGCCCGCCCGCCGAGGGGCCGCGGCGGGGGACCGAGAGGGCCTCGGCTGTG
TGAGGACTAGAGGCGGCCGAGGCCCGGGCCGGTTCCCCCGAGGCGGCGACGGAGACGGCTCCCGGCACTTCCCCGCGCCATCTTAACTGA
GCCCAAGCGCTGAGGGCGCCTCCTCGACCCCGGTCGTCCCCTCGCCCCCCCCCCCACCCCCCGCCGCCGCCGCCCCTTGTTGCAGAGCTT
GGGCTGGGCGGCTTGCTGGGGCTCGGGGGTGGGGGGCGGCGATCTGTCGCCGGGCCCCCTCCTCCTCCTCACTCCTCACCCTCCAGGGTA
GCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGAAAGGTAGTTTATGCCAACGTGACTTCATT
CATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGCTCAGCAGGATGCCATCAACTAACAGAGCA
GGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGA
AGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACT
GAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGT
GAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAAAAGCCATTACAAGAAGTGGAA
ATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATC
CTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAATTCCTTTGTGGGAACGCCGTAT
TGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAA
CTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAATGAATCCCCTACACTACAGTCT
AATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAG
CACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCAGTAAGAGAGCTGGACAATCTG
CAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCAT
GGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGTGCCAGCAGCCAAAGCAGTAGT
GTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATC
CATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAATCTCCACCCCAAGTATCTCGT
CACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGAC
TCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACTCTGGAAAACAAGCTAAAGGCT
GAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAA
CACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATTCAGGCCCAACAGAAGAAAGAA
CTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCC
AAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAAGCTAACCTTCTTCGACGTCAA
AGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGGT
CCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCA
GATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCA
ATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAG
ATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTACAGAAAGTTGGATTTTTTGGA
ATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTGGTACCTTTTTGGACCTTCTTT
GGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTCAGCAAGCACATAGTGGAGCAA
ATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTT
CACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTC
ATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAG
AAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACC
TGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTAT
CCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGCAACAGACTGGCCTTCTGTTTGTTA
CTTTCAAAAGGCCCACATGATACAATTAGAGAATTCCCACCGCACAAAAAAAGTTCCTAAGTATGTTAAATATGTCAAGCTTTTTAGGCT
TGTCACAAATGATTGCTTTGTTTTCCTAAGTCATCAAAATGTATATAAATTATCTAGATTGGATAACAGTCTTGCATGTTTATCATGTTA
CAATTTAATATTCCATCCTGCCCAACCCTTCCTCTCCCATCCTCAAAAAAGGGCCATTTTATGATGCATTGCACACCCTCTGGGGAAATT
GATCTTTAAATTTTGAGACAGTATAAGGAAAATCTGGTTGGTGTCTTACAAGTGAGCTGACACCATTTTTTATTCTGTGTATTTAGAATG
AAGTCTTGAAAAAAACTTTATAAAGACATCTTTAATCATTCCAAAATTGTGTCCGTTTTCTTGAGCGTTTTGATTTTTTACTTTTAGCTT
ATACCAGCTGAATGGCAGCCTTGCCTAATCCACCTACAACAAGAATTTCTTAAGCTTTCTTTTATTTGCATGAGAGAGCCACTACCAAGG
CATGTTTTGTTATGCTGAAACTGGGCTGCTGCATACTGCTAAATGGCACCTCTGGGATTGGCCTACCTGGGGATTTCTTGGTTTGTGAAA
ACAGGAGAGGAGAAATATCTCATACAAGTGAAAGGATACTGGAGAGAGAAATTACCCATTTCTAAAAAAAAACCACACTCTGTCGTATCT
GTGTTAATGTTTTCTAGCATGTACTCTGGTTTCAACAGACACAAATTTATATGTTAACCCAGTTTTCTTGCCGTTCTGTAAGTGTTTTAT
TCTTAGTGTGATTTTTTTCCATTGGGATGTTTTTGATTGAACTTGTTCATTTTGTTTTGCTTGGGAGGAAAATAAACAATTTTACTTTTT

>In-frame_ENST00000261716_ENST00000262291_TCGA-AZ-4323-01A_TAOK1_chr17_27844674_+_VMP1_chr17_57842332_length(amino acids)=908AA_start in transcript=507_stop in transcript=3233
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR
HNLEQDLVREGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAE
PDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFV
IITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQR

--------------------------------------------------------------
>In-frame_ENST00000261716_ENST00000537567_TCGA-AZ-4323-01A_TAOK1_chr17_27844674_+_VMP1_chr17_57842332_length(transcript)=3494nt_BP=2427nt
CTTACCAGGGGTGGTGTTGGTGGCGGAGGGCTGCGCGTGGGCCCGCCCGCCGAGGGGCCGCGGCGGGGGACCGAGAGGGCCTCGGCTGTG
TGAGGACTAGAGGCGGCCGAGGCCCGGGCCGGTTCCCCCGAGGCGGCGACGGAGACGGCTCCCGGCACTTCCCCGCGCCATCTTAACTGA
GCCCAAGCGCTGAGGGCGCCTCCTCGACCCCGGTCGTCCCCTCGCCCCCCCCCCCACCCCCCGCCGCCGCCGCCCCTTGTTGCAGAGCTT
GGGCTGGGCGGCTTGCTGGGGCTCGGGGGTGGGGGGCGGCGATCTGTCGCCGGGCCCCCTCCTCCTCCTCACTCCTCACCCTCCAGGGTA
GCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGAAAGGTAGTTTATGCCAACGTGACTTCATT
CATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGCTCAGCAGGATGCCATCAACTAACAGAGCA
GGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGA
AGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACT
GAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGT
GAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAAAAGCCATTACAAGAAGTGGAA
ATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATC
CTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAATTCCTTTGTGGGAACGCCGTAT
TGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAA
CTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAATGAATCCCCTACACTACAGTCT
AATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAG
CACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCAGTAAGAGAGCTGGACAATCTG
CAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCAT
GGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGTGCCAGCAGCCAAAGCAGTAGT
GTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATC
CATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAATCTCCACCCCAAGTATCTCGT
CACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGAC
TCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACTCTGGAAAACAAGCTAAAGGCT
GAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAA
CACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATTCAGGCCCAACAGAAGAAAGAA
CTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCC
AAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAAGCTAACCTTCTTCGACGTCAA
AGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGGT
CCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCA
GATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCA
ATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAG
ATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTACAGAAAGTTGGATTTTTTGGA
ATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTGGTACCTTTTTGGACCTTCTTT
GGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTCAGCAAGCACATAGTGGAGCAA
ATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTT
CACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTC
ATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAG
AAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACC
TGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTAT

>In-frame_ENST00000261716_ENST00000537567_TCGA-AZ-4323-01A_TAOK1_chr17_27844674_+_VMP1_chr17_57842332_length(amino acids)=908AA_start in transcript=507_stop in transcript=3233
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR
HNLEQDLVREGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAE
PDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFV
IITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQR

--------------------------------------------------------------
>In-frame_ENST00000261716_ENST00000262291_TCGA-AZ-4323_TAOK1_chr17_27844674_+_VMP1_chr17_57842331_length(transcript)=4415nt_BP=2427nt
CTTACCAGGGGTGGTGTTGGTGGCGGAGGGCTGCGCGTGGGCCCGCCCGCCGAGGGGCCGCGGCGGGGGACCGAGAGGGCCTCGGCTGTG
TGAGGACTAGAGGCGGCCGAGGCCCGGGCCGGTTCCCCCGAGGCGGCGACGGAGACGGCTCCCGGCACTTCCCCGCGCCATCTTAACTGA
GCCCAAGCGCTGAGGGCGCCTCCTCGACCCCGGTCGTCCCCTCGCCCCCCCCCCCACCCCCCGCCGCCGCCGCCCCTTGTTGCAGAGCTT
GGGCTGGGCGGCTTGCTGGGGCTCGGGGGTGGGGGGCGGCGATCTGTCGCCGGGCCCCCTCCTCCTCCTCACTCCTCACCCTCCAGGGTA
GCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGAAAGGTAGTTTATGCCAACGTGACTTCATT
CATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGCTCAGCAGGATGCCATCAACTAACAGAGCA
GGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGA
AGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACT
GAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGT
GAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAAAAGCCATTACAAGAAGTGGAA
ATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATC
CTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAATTCCTTTGTGGGAACGCCGTAT
TGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAA
CTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAATGAATCCCCTACACTACAGTCT
AATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAG
CACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCAGTAAGAGAGCTGGACAATCTG
CAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCAT
GGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGTGCCAGCAGCCAAAGCAGTAGT
GTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATC
CATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAATCTCCACCCCAAGTATCTCGT
CACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGAC
TCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACTCTGGAAAACAAGCTAAAGGCT
GAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAA
CACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATTCAGGCCCAACAGAAGAAAGAA
CTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCC
AAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAAGCTAACCTTCTTCGACGTCAA
AGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGGT
CCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCA
GATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCA
ATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAG
ATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTACAGAAAGTTGGATTTTTTGGA
ATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTGGTACCTTTTTGGACCTTCTTT
GGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTCAGCAAGCACATAGTGGAGCAA
ATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTT
CACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTC
ATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAG
AAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACC
TGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTAT
CCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGCAACAGACTGGCCTTCTGTTTGTTA
CTTTCAAAAGGCCCACATGATACAATTAGAGAATTCCCACCGCACAAAAAAAGTTCCTAAGTATGTTAAATATGTCAAGCTTTTTAGGCT
TGTCACAAATGATTGCTTTGTTTTCCTAAGTCATCAAAATGTATATAAATTATCTAGATTGGATAACAGTCTTGCATGTTTATCATGTTA
CAATTTAATATTCCATCCTGCCCAACCCTTCCTCTCCCATCCTCAAAAAAGGGCCATTTTATGATGCATTGCACACCCTCTGGGGAAATT
GATCTTTAAATTTTGAGACAGTATAAGGAAAATCTGGTTGGTGTCTTACAAGTGAGCTGACACCATTTTTTATTCTGTGTATTTAGAATG
AAGTCTTGAAAAAAACTTTATAAAGACATCTTTAATCATTCCAAAATTGTGTCCGTTTTCTTGAGCGTTTTGATTTTTTACTTTTAGCTT
ATACCAGCTGAATGGCAGCCTTGCCTAATCCACCTACAACAAGAATTTCTTAAGCTTTCTTTTATTTGCATGAGAGAGCCACTACCAAGG
CATGTTTTGTTATGCTGAAACTGGGCTGCTGCATACTGCTAAATGGCACCTCTGGGATTGGCCTACCTGGGGATTTCTTGGTTTGTGAAA
ACAGGAGAGGAGAAATATCTCATACAAGTGAAAGGATACTGGAGAGAGAAATTACCCATTTCTAAAAAAAAACCACACTCTGTCGTATCT
GTGTTAATGTTTTCTAGCATGTACTCTGGTTTCAACAGACACAAATTTATATGTTAACCCAGTTTTCTTGCCGTTCTGTAAGTGTTTTAT
TCTTAGTGTGATTTTTTTCCATTGGGATGTTTTTGATTGAACTTGTTCATTTTGTTTTGCTTGGGAGGAAAATAAACAATTTTACTTTTT

>In-frame_ENST00000261716_ENST00000262291_TCGA-AZ-4323_TAOK1_chr17_27844674_+_VMP1_chr17_57842331_length(amino acids)=908AA_start in transcript=507_stop in transcript=3233
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR
HNLEQDLVREGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAE
PDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFV
IITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQR

--------------------------------------------------------------
>In-frame_ENST00000261716_ENST00000537567_TCGA-AZ-4323_TAOK1_chr17_27844674_+_VMP1_chr17_57842331_length(transcript)=3494nt_BP=2427nt
CTTACCAGGGGTGGTGTTGGTGGCGGAGGGCTGCGCGTGGGCCCGCCCGCCGAGGGGCCGCGGCGGGGGACCGAGAGGGCCTCGGCTGTG
TGAGGACTAGAGGCGGCCGAGGCCCGGGCCGGTTCCCCCGAGGCGGCGACGGAGACGGCTCCCGGCACTTCCCCGCGCCATCTTAACTGA
GCCCAAGCGCTGAGGGCGCCTCCTCGACCCCGGTCGTCCCCTCGCCCCCCCCCCCACCCCCCGCCGCCGCCGCCCCTTGTTGCAGAGCTT
GGGCTGGGCGGCTTGCTGGGGCTCGGGGGTGGGGGGCGGCGATCTGTCGCCGGGCCCCCTCCTCCTCCTCACTCCTCACCCTCCAGGGTA
GCGGCTACCGGAGCGCTGCAGGGGGCTGCGCCTGCCTGCTCCGCCCCAGACCTGTCGGCGAAAGGTAGTTTATGCCAACGTGACTTCATT
CATACAGATGAACCAAGGATCGGGATAGCAGTATAAAATTAGAATCAAGACAGCTGACTGCTCAGCAGGATGCCATCAACTAACAGAGCA
GGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGA
AGCTTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACT
GAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGT
GAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAAAAGCCATTACAAGAAGTGGAA
ATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATC
CTTCTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAATTCCTTTGTGGGAACGCCGTAT
TGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAA
CTAGCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAATGAATCCCCTACACTACAGTCT
AATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAG
CACATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCAGTAAGAGAGCTGGACAATCTG
CAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCAT
GGTGTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGTGCCAGCAGCCAAAGCAGTAGT
GTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATC
CATTTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAATCTCCACCCCAAGTATCTCGT
CACAAATCACACTATCGTAATCGAGAACACTTTGCTACTATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGAC
TCTGAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACTCTGGAAAACAAGCTAAAGGCT
GAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAA
CACCAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATTCAGGCCCAACAGAAGAAAGAA
CTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCC
AAAAAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAAGCTAACCTTCTTCGACGTCAA
AGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGGT
CCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCA
GATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCA
ATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAG
ATGCTGGAACATGCAGAGTCTGCACAAGACTTTGCCTCCCGGGCCAAACTGGCAGTTCAAAAACTAGTACAGAAAGTTGGATTTTTTGGA
ATTTTGGCCTGTGCTTCAATTCCAAATCCTTTATTTGATCTGGCTGGAATAACGTGTGGACACTTTCTGGTACCTTTTTGGACCTTCTTT
GGTGCAACCCTAATTGGAAAAGCAATAATAAAAATGCATATCCAGAAAATTTTTGTTATAATAACATTCAGCAAGCACATAGTGGAGCAA
ATGGTGGCTTTCATTGGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTT
CACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTC
ATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAG
AAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACC
TGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTAT

>In-frame_ENST00000261716_ENST00000537567_TCGA-AZ-4323_TAOK1_chr17_27844674_+_VMP1_chr17_57842331_length(amino acids)=908AA_start in transcript=507_stop in transcript=3233
MLSRMPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP
NSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA
SPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIP
QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPS
MSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASL
VTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKF
QQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR
HNLEQDLVREGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAE
PDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFV
IITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TAOK1-VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TAOK1-VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TAOK1-VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTAOK1C0018781Noise-induced hearing loss1CTD_human
HgeneTAOK1C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
HgeneTAOK1C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneTAOK1C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneTAOK1C4225275MENTAL RETARDATION, AUTOSOMAL DOMINANT 401GENOMICS_ENGLAND