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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TAOK3-DLL3 (FusionGDB2 ID:88434)

Fusion Gene Summary for TAOK3-DLL3

check button Fusion gene summary
Fusion gene informationFusion gene name: TAOK3-DLL3
Fusion gene ID: 88434
HgeneTgene
Gene symbol

TAOK3

DLL3

Gene ID

51347

10683

Gene nameTAO kinase 3delta like canonical Notch ligand 3
SynonymsDPK|JIK|MAP3K18|hKFC-ASCDO1
Cytomap

12q24.23

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase TAO3CTCL-associated antigen HD-CL-09JNK/SAPK-inhibitory kinaseSTE20-like kinasecutaneous T-cell lymphoma-associated antigen HD-CL-09dendritic cell-derived protein kinasejun kinase-inhibitory kinasekinase from chickendelta-like protein 3delta-like 3delta3drosophila Delta homolog 3
Modification date2020031320200313
UniProtAcc.

Q9NYJ7

Ensembl transtripts involved in fusion geneENST00000419821, ENST00000392533, 
ENST00000537952, ENST00000543709, 
ENST00000536979, 		ENST00000356433, 
ENST00000600579, ENST00000205143, 
Fusion gene scores* DoF score14 X 11 X 8=12323 X 4 X 2=24
# samples 164
** MAII scorelog2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TAOK3 [Title/Abstract] AND DLL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAOK3(118683880)-DLL3(39989616), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAOK3

GO:0006468

protein phosphorylation

10559204

HgeneTAOK3

GO:0006974

cellular response to DNA damage stimulus

17396146

HgeneTAOK3

GO:0046329

negative regulation of JNK cascade

10559204

HgeneTAOK3

GO:0046777

protein autophosphorylation

10559204


check buttonFusion gene breakpoints across TAOK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DLL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABC035504TAOK3chr12

118683880

-DLL3chr19

39989616

+


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Fusion Gene ORF analysis for TAOK3-DLL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000419821ENST00000356433TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000419821ENST00000600579TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000419821ENST00000205143TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3CDSENST00000392533ENST00000356433TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000392533ENST00000600579TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000392533ENST00000205143TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3CDSENST00000537952ENST00000356433TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000537952ENST00000600579TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000537952ENST00000205143TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3CDSENST00000543709ENST00000356433TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000543709ENST00000600579TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000543709ENST00000205143TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3CDSENST00000536979ENST00000356433TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000536979ENST00000600579TAOK3chr12

118683880

-DLL3chr19

39989616

+
intron-3UTRENST00000536979ENST00000205143TAOK3chr12

118683880

-DLL3chr19

39989616

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TAOK3-DLL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TAOK3-DLL3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DLL3

Q9NYJ7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TAOK3-DLL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TAOK3-DLL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TAOK3-DLL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TAOK3-DLL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDLL3C0265343Jarcho-Levin syndrome2GENOMICS_ENGLAND;UNIPROT
TgeneDLL3C0000768Congenital Abnormality1CTD_human
TgeneDLL3C0004114Astrocytoma1CTD_human
TgeneDLL3C0013366Dyschondroplasias1CTD_human
TgeneDLL3C0025237Melnick-Needles Syndrome1CTD_human
TgeneDLL3C0026760Multiple Epiphyseal Dysplasia1CTD_human
TgeneDLL3C0029422Osteochondrodysplasias1CTD_human
TgeneDLL3C0036391Schwartz-Jampel Syndrome1CTD_human
TgeneDLL3C0036439Scoliosis, unspecified1CTD_human
TgeneDLL3C0038015Spondyloepiphyseal Dysplasia1CTD_human
TgeneDLL3C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneDLL3C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneDLL3C0280785Diffuse Astrocytoma1CTD_human
TgeneDLL3C0334579Anaplastic astrocytoma1CTD_human
TgeneDLL3C0334580Protoplasmic astrocytoma1CTD_human
TgeneDLL3C0334581Gemistocytic astrocytoma1CTD_human
TgeneDLL3C0334582Fibrillary Astrocytoma1CTD_human
TgeneDLL3C0334583Pilocytic Astrocytoma1CTD_human
TgeneDLL3C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneDLL3C0376634Craniofacial Abnormalities1CTD_human
TgeneDLL3C0432272Van Buchem disease1CTD_human
TgeneDLL3C0547065Mixed oligoastrocytoma1CTD_human
TgeneDLL3C0750935Cerebral Astrocytoma1CTD_human
TgeneDLL3C0750936Intracranial Astrocytoma1CTD_human
TgeneDLL3C1704230Grade I Astrocytoma1CTD_human
TgeneDLL3C3541456Spondyloepiphyseal Dysplasia Tarda, X-Linked1CTD_human
TgeneDLL3C4551479Schwartz-Jampel Syndrome, Type 11CTD_human