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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TARS2-QARS (FusionGDB2 ID:88499)

Fusion Gene Summary for TARS2-QARS

check button Fusion gene summary
Fusion gene informationFusion gene name: TARS2-QARS
Fusion gene ID: 88499
HgeneTgene
Gene symbol

TARS2

QARS

Gene ID

80222

5859

Gene namethreonyl-tRNA synthetase 2, mitochondrialglutaminyl-tRNA synthetase 1
SynonymsCOXPD21|TARSL1|thrRSGLNRS|MSCCA|PRO2195|QARS
Cytomap

1q21.2

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionthreonine--tRNA ligase, mitochondrialthreonyl-tRNA synthetase 2, mitochondrial (putative)threonyl-tRNA synthetase-like 1glutamine--tRNA ligaseglutamine-tRNA synthetase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000438568, ENST00000369054, 
ENST00000369064, ENST00000606933, 
ENST00000463555, 		ENST00000306125, 
ENST00000414533, ENST00000470225, 
ENST00000420147, 
Fusion gene scores* DoF score5 X 7 X 5=1758 X 9 X 2=144
# samples 69
** MAII scorelog2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TARS2 [Title/Abstract] AND QARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTARS2(150464965)-QARS(49133512), # samples:1
Anticipated loss of major functional domain due to fusion event.TARS2-QARS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TARS2-QARS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneQARS

GO:0006425

glutaminyl-tRNA aminoacylation

24656866|26869582

TgeneQARS

GO:0006469

negative regulation of protein kinase activity

11096076

TgeneQARS

GO:0032873

negative regulation of stress-activated MAPK cascade

11096076

TgeneQARS

GO:0045892

negative regulation of transcription, DNA-templated

11096076

TgeneQARS

GO:2001234

negative regulation of apoptotic signaling pathway

11096076


check buttonFusion gene breakpoints across TARS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across QARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8211-01ATARS2chr1

150464965

+QARSchr3

49133512

-


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Fusion Gene ORF analysis for TARS2-QARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000438568ENST00000306125TARS2chr1

150464965

+QARSchr3

49133512

-
3UTR-3CDSENST00000438568ENST00000414533TARS2chr1

150464965

+QARSchr3

49133512

-
3UTR-intronENST00000438568ENST00000470225TARS2chr1

150464965

+QARSchr3

49133512

-
3UTR-intronENST00000438568ENST00000420147TARS2chr1

150464965

+QARSchr3

49133512

-
intron-3CDSENST00000369054ENST00000306125TARS2chr1

150464965

+QARSchr3

49133512

-
intron-3CDSENST00000369054ENST00000414533TARS2chr1

150464965

+QARSchr3

49133512

-
intron-intronENST00000369054ENST00000470225TARS2chr1

150464965

+QARSchr3

49133512

-
intron-intronENST00000369054ENST00000420147TARS2chr1

150464965

+QARSchr3

49133512

-
Frame-shiftENST00000369064ENST00000306125TARS2chr1

150464965

+QARSchr3

49133512

-
In-frameENST00000369064ENST00000414533TARS2chr1

150464965

+QARSchr3

49133512

-
5CDS-intronENST00000369064ENST00000470225TARS2chr1

150464965

+QARSchr3

49133512

-
5CDS-intronENST00000369064ENST00000420147TARS2chr1

150464965

+QARSchr3

49133512

-
Frame-shiftENST00000606933ENST00000306125TARS2chr1

150464965

+QARSchr3

49133512

-
In-frameENST00000606933ENST00000414533TARS2chr1

150464965

+QARSchr3

49133512

-
5CDS-intronENST00000606933ENST00000470225TARS2chr1

150464965

+QARSchr3

49133512

-
5CDS-intronENST00000606933ENST00000420147TARS2chr1

150464965

+QARSchr3

49133512

-
3UTR-3CDSENST00000463555ENST00000306125TARS2chr1

150464965

+QARSchr3

49133512

-
3UTR-3CDSENST00000463555ENST00000414533TARS2chr1

150464965

+QARSchr3

49133512

-
3UTR-intronENST00000463555ENST00000470225TARS2chr1

150464965

+QARSchr3

49133512

-
3UTR-intronENST00000463555ENST00000420147TARS2chr1

150464965

+QARSchr3

49133512

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369064TARS2chr1150464965+ENST00000414533QARSchr349133512-95180834858274
ENST00000606933TARS2chr1150464965+ENST00000414533QARSchr349133512-94880531855274

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369064ENST00000414533TARS2chr1150464965+QARSchr349133512-0.0380898380.9619102
ENST00000606933ENST00000414533TARS2chr1150464965+QARSchr349133512-0.038323440.9616765

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Fusion Genomic Features for TARS2-QARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TARS2-QARS


check button Go to

FGviewer for the breakpoints of chr1:150464965-chr3:49133512

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTARS2chr1:150464965chr3:49133512ENST00000369064+71855_121258.0719.0DomainTGS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneQARSchr1:150464965chr3:49133512ENST000003061252224270_280759.0776.0Motif'HIGH' region
TgeneQARSchr1:150464965chr3:49133512ENST000003061252224493_497759.0776.0Motif'KMSKS' region
TgeneQARSchr1:150464965chr3:49133512ENST000003061252224271_273759.0776.0Nucleotide bindingATP
TgeneQARSchr1:150464965chr3:49133512ENST000003061252224277_283759.0776.0Nucleotide bindingATP
TgeneQARSchr1:150464965chr3:49133512ENST000003061252224486_487759.0776.0Nucleotide bindingATP
TgeneQARSchr1:150464965chr3:49133512ENST000003061252224494_496759.0776.0Nucleotide bindingATP


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Fusion Gene Sequence for TARS2-QARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000369064_ENST00000414533_TCGA-FP-8211-01A_TARS2_chr1_150464965_+_QARS_chr3_49133512_length(transcript)=951nt_BP=808nt
CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG
GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG
ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC
CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG
GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT
GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA
GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA
GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC
AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGCT
TGTCTTTAACCGAACTGTCACACTGAAGGAAGACCCAGGAAAGGTGTGAGCTGGAAGCACTGAACCTACCTCATCCTCCTGGAGGGTGTG

>In-frame_ENST00000369064_ENST00000414533_TCGA-FP-8211-01A_TARS2_chr1_150464965_+_QARS_chr3_49133512_length(amino acids)=274AA_start in transcript=34_stop in transcript=858
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSLVFNRTVTLKED

--------------------------------------------------------------
>In-frame_ENST00000606933_ENST00000414533_TCGA-FP-8211-01A_TARS2_chr1_150464965_+_QARS_chr3_49133512_length(transcript)=948nt_BP=805nt
TTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCT
ACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATT
AGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCC
CTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCC
CTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGG
GGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGA
GAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGC
TTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGT
ATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGCTTGT
CTTTAACCGAACTGTCACACTGAAGGAAGACCCAGGAAAGGTGTGAGCTGGAAGCACTGAACCTACCTCATCCTCCTGGAGGGTGTGGCT

>In-frame_ENST00000606933_ENST00000414533_TCGA-FP-8211-01A_TARS2_chr1_150464965_+_QARS_chr3_49133512_length(amino acids)=274AA_start in transcript=31_stop in transcript=855
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSLVFNRTVTLKED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TARS2-QARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TARS2-QARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TARS2-QARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTARS2C4014668COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 212CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT