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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TARS2-VPS45 (FusionGDB2 ID:88501)

Fusion Gene Summary for TARS2-VPS45

Fusion gene summary

Fusion gene information	Fusion gene name: TARS2-VPS45
	Fusion gene ID: 88501
		Hgene	Tgene
	Gene symbol	TARS2	VPS45
	Gene ID	80222	11311
	Gene name	threonyl-tRNA synthetase 2, mitochondrial	vacuolar protein sorting 45 homolog
	Synonyms	COXPD21\|TARSL1\|thrRS	H1\|H1VPS45\|SCN5\|VPS45A\|VPS45B\|VPS54A\|VSP45\|VSP45A
	Cytomap	1q21.2	1q21.2
	Type of gene	protein-coding	protein-coding
	Description	threonine--tRNA ligase, mitochondrialthreonyl-tRNA synthetase 2, mitochondrial (putative)threonyl-tRNA synthetase-like 1	vacuolar protein sorting-associated protein 45leucocyte vacuolar protein sorting 45vacuolar protein sorting 45A
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000438568, ENST00000369054, ENST00000369064, ENST00000606933, ENST00000463555,	ENST00000369130, ENST00000369128, ENST00000535106, ENST00000484306,
Fusion gene scores	* DoF score	5 X 7 X 5=175	8 X 7 X 6=336
	# samples	6	10
	** MAII score	log2(6/175*10)=-1.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TARS2 [Title/Abstract] AND VPS45 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TARS2(150464965)-VPS45(150116887), # samples:3
Anticipated loss of major functional domain due to fusion event.	TARS2-VPS45 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TARS2-VPS45 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TARS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VPS45 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-6560-01A	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
ChimerDB4	LUSC	TCGA-85-6560	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
ChimerDB4	LUSC	TCGA-85-6560	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
ChimerDB4	LUSC	TCGA-85-6560	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
ChimerDB4	LUSC	TCGA-85-6560-01A	TARS2	chr1	150464965	-	VPS45	chr1	150116887	+
ChimerDB4	LUSC	TCGA-85-6560-01A	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
ChimerDB4	LUSC	TCGA-85-6560-01A	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
ChimerDB4	LUSC	TCGA-85-6560-01A	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+

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Fusion Gene ORF analysis for TARS2-VPS45

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000438568	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3CDS	ENST00000438568	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3UTR	ENST00000438568	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3UTR	ENST00000438568	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000369054	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000369054	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000369054	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000369054	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
In-frame	ENST00000369064	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
Frame-shift	ENST00000369064	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
5CDS-3UTR	ENST00000369064	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
5CDS-3UTR	ENST00000369064	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
In-frame	ENST00000606933	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
Frame-shift	ENST00000606933	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
5CDS-3UTR	ENST00000606933	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
5CDS-3UTR	ENST00000606933	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3CDS	ENST00000463555	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3CDS	ENST00000463555	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3UTR	ENST00000463555	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3UTR	ENST00000463555	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
3UTR-3CDS	ENST00000438568	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000438568	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000438568	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000438568	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000369054	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000369054	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000369054	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000369054	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
In-frame	ENST00000369064	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
Frame-shift	ENST00000369064	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000369064	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000369064	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
In-frame	ENST00000606933	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
Frame-shift	ENST00000606933	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000606933	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000606933	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000463555	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000463555	ENST00000369128	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000463555	ENST00000535106	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000463555	ENST00000484306	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000438568	ENST00000369130	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
3UTR-3CDS	ENST00000438568	ENST00000369128	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
3UTR-3UTR	ENST00000438568	ENST00000535106	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
3UTR-3UTR	ENST00000438568	ENST00000484306	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000369054	ENST00000369130	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000369054	ENST00000369128	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000369054	ENST00000535106	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000369054	ENST00000484306	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
In-frame	ENST00000369064	ENST00000369130	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
Frame-shift	ENST00000369064	ENST00000369128	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
5CDS-3UTR	ENST00000369064	ENST00000535106	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
5CDS-3UTR	ENST00000369064	ENST00000484306	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000606933	ENST00000369130	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000606933	ENST00000369128	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000606933	ENST00000535106	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000606933	ENST00000484306	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000463555	ENST00000369130	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3CDS	ENST00000463555	ENST00000369128	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000463555	ENST00000535106	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
intron-3UTR	ENST00000463555	ENST00000484306	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
3UTR-3CDS	ENST00000438568	ENST00000369130	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000438568	ENST00000369128	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000438568	ENST00000535106	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000438568	ENST00000484306	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000369054	ENST00000369130	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000369054	ENST00000369128	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000369054	ENST00000535106	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000369054	ENST00000484306	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
In-frame	ENST00000369064	ENST00000369130	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
Frame-shift	ENST00000369064	ENST00000369128	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000369064	ENST00000535106	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000369064	ENST00000484306	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
In-frame	ENST00000606933	ENST00000369130	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
Frame-shift	ENST00000606933	ENST00000369128	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000606933	ENST00000535106	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000606933	ENST00000484306	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000463555	ENST00000369130	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000463555	ENST00000369128	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000463555	ENST00000535106	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000463555	ENST00000484306	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000438568	ENST00000369130	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
3UTR-3CDS	ENST00000438568	ENST00000369128	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000438568	ENST00000535106	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
3UTR-3UTR	ENST00000438568	ENST00000484306	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000369054	ENST00000369130	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000369054	ENST00000369128	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000369054	ENST00000535106	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000369054	ENST00000484306	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
In-frame	ENST00000369064	ENST00000369130	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
Frame-shift	ENST00000369064	ENST00000369128	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000369064	ENST00000535106	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
5CDS-3UTR	ENST00000369064	ENST00000484306	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000606933	ENST00000369130	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000606933	ENST00000369128	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000606933	ENST00000535106	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000606933	ENST00000484306	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000463555	ENST00000369130	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3CDS	ENST00000463555	ENST00000369128	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000463555	ENST00000535106	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-3UTR	ENST00000463555	ENST00000484306	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
intron-intron	ENST00000438568	ENST00000369130	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000438568	ENST00000369128	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000438568	ENST00000535106	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000438568	ENST00000484306	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369054	ENST00000369130	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369054	ENST00000369128	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369054	ENST00000535106	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369054	ENST00000484306	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369064	ENST00000369130	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369064	ENST00000369128	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369064	ENST00000535106	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000369064	ENST00000484306	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000606933	ENST00000369130	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000606933	ENST00000369128	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000606933	ENST00000535106	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000606933	ENST00000484306	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000463555	ENST00000369130	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000463555	ENST00000369128	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000463555	ENST00000535106	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
intron-intron	ENST00000463555	ENST00000484306	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369064	TARS2	chr1	150464965	+	ENST00000369130	VPS45	chr1	150116887	+	1427	808	34	1020	328
ENST00000606933	TARS2	chr1	150464965	+	ENST00000369130	VPS45	chr1	150116887	+	1424	805	31	1017	328
ENST00000369064	TARS2	chr1	150464965	+	ENST00000369130	VPS45	chr1	150116886	+	1427	808	34	1020	328
ENST00000606933	TARS2	chr1	150464965	+	ENST00000369130	VPS45	chr1	150116886	+	1424	805	31	1017	328
ENST00000369064	TARS2	chr1	150469104	+	ENST00000369130	VPS45	chr1	150116887	+	1574	955	34	1167	377
ENST00000369064	TARS2	chr1	150464964	+	ENST00000369130	VPS45	chr1	150116886	+	1427	808	34	1020	328
ENST00000606933	TARS2	chr1	150464964	+	ENST00000369130	VPS45	chr1	150116886	+	1424	805	31	1017	328
ENST00000369064	TARS2	chr1	150469103	+	ENST00000369130	VPS45	chr1	150116886	+	1574	955	34	1167	377

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369064	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+	0.05013822	0.94986176
ENST00000606933	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+	0.050457105	0.94954294
ENST00000369064	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+	0.05013822	0.94986176
ENST00000606933	ENST00000369130	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+	0.050457105	0.94954294
ENST00000369064	ENST00000369130	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+	0.06682958	0.93317044
ENST00000369064	ENST00000369130	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+	0.05013822	0.94986176
ENST00000606933	ENST00000369130	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+	0.050457105	0.94954294
ENST00000369064	ENST00000369130	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+	0.06682958	0.93317044

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Fusion Genomic Features for TARS2-VPS45

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TARS2	chr1	150469104	+	VPS45	chr1	150116886	+	0.006917232	0.99308276
TARS2	chr1	150469104	+	VPS45	chr1	150116886	+	0.006917232	0.99308276
TARS2	chr1	150464965	+	VPS45	chr1	150116886	+	0.000370123	0.99962986
TARS2	chr1	150464965	+	VPS45	chr1	150116886	+	0.000370123	0.99962986
TARS2	chr1	150469104	+	VPS45	chr1	150116886	+	0.006917232	0.99308276
TARS2	chr1	150469104	+	VPS45	chr1	150116886	+	0.006917232	0.99308276
TARS2	chr1	150464965	+	VPS45	chr1	150116886	+	0.000370123	0.99962986
TARS2	chr1	150464965	+	VPS45	chr1	150116886	+	0.000370123	0.99962986

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TARS2-VPS45

Go to
FGviewer for the breakpoints of chr1:150464965-chr1:150116887
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TARS2

chr1:150464964

chr1:150116886

ENST00000369064

55_121

258.0

719.0

Domain

TGS

Hgene

TARS2

chr1:150464965

chr1:150116886

ENST00000369064

55_121

258.0

719.0

Domain

TGS

Hgene

TARS2

chr1:150464965

chr1:150116887

ENST00000369064

55_121

258.0

719.0

Domain

TGS

Hgene

TARS2

chr1:150469103

chr1:150116886

ENST00000369064

55_121

307.0

719.0

Domain

TGS

Hgene

TARS2

chr1:150469104

chr1:150116887

ENST00000369064

55_121

307.0

719.0

Domain

TGS

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TARS2-VPS45

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464965_+_VPS45_chr1_150116887_length(transcript)=1427nt_BP=808nt
CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG
GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG
ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC
CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG
GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT
GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA
GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA
GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC
AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTT
TCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACG
GTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCT
GTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTC
TGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTG
ACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCC
TTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTT

>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464965_+_VPS45_chr1_150116887_length(amino acids)=328AA_start in transcript=34_stop in transcript=1020
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ

--------------------------------------------------------------
>In-frame_ENST00000606933_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464965_+_VPS45_chr1_150116887_length(transcript)=1424nt_BP=805nt
TTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCT
ACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATT
AGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCC
CTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCC
CTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGG
GGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGA
GAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGC
TTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGT
ATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCC
TAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTG
GTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTG
CTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGA
GCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACT
TGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTA
ACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTT

>In-frame_ENST00000606933_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464965_+_VPS45_chr1_150116887_length(amino acids)=328AA_start in transcript=31_stop in transcript=1017
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ

--------------------------------------------------------------
>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560_TARS2_chr1_150464965_+_VPS45_chr1_150116886_length(transcript)=1427nt_BP=808nt
CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG
GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG
ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC
CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG
GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT
GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA
GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA
GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC
AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTT
TCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACG
GTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCT
GTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTC
TGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTG
ACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCC
TTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTT

>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560_TARS2_chr1_150464965_+_VPS45_chr1_150116886_length(amino acids)=328AA_start in transcript=34_stop in transcript=1020
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ

--------------------------------------------------------------
>In-frame_ENST00000606933_ENST00000369130_TCGA-85-6560_TARS2_chr1_150464965_+_VPS45_chr1_150116886_length(transcript)=1424nt_BP=805nt
TTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCT
ACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATT
AGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCC
CTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCC
CTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGG
GGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGA
GAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGC
TTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGT
ATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCC
TAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTG
GTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTG
CTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGA
GCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACT
TGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTA
ACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTT

>In-frame_ENST00000606933_ENST00000369130_TCGA-85-6560_TARS2_chr1_150464965_+_VPS45_chr1_150116886_length(amino acids)=328AA_start in transcript=31_stop in transcript=1017
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ

--------------------------------------------------------------
>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560_TARS2_chr1_150469104_+_VPS45_chr1_150116887_length(transcript)=1574nt_BP=955nt
CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG
GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG
ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC
CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG
GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT
GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA
GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA
GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC
AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGAA
CTCATCATCCTTATGGAGGTCTTCAGGGGCCCCAGAGACACTGCAGAGAGTGTCAGGGATTTCCTTCCCCACAACAGAATTGCTGAGGGT
CTGGGAAGCATGGAGGGAGGAAGCAGAATTGCGGGACCACCGGCGCATTGGGAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACA
GCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTG
TCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCC
CACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGT
CTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGG
CTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCC
TGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTG

>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560_TARS2_chr1_150469104_+_VPS45_chr1_150116887_length(amino acids)=377AA_start in transcript=34_stop in transcript=1167
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSNSSSLWRSSGAP
ETLQRVSGISFPTTELLRVWEAWREEAELRDHRRIGKFPRGSSGFWTAQPKQGELSSHIKVSEQKMKRWLGEGHSFLSCPHYRFSLLNKG

--------------------------------------------------------------
>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464964_+_VPS45_chr1_150116886_length(transcript)=1427nt_BP=808nt
CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG
GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG
ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC
CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG
GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT
GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA
GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA
GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC
AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTT
TCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACG
GTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCT
GTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTC
TGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTG
ACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCC
TTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTT

>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464964_+_VPS45_chr1_150116886_length(amino acids)=328AA_start in transcript=34_stop in transcript=1020
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ

--------------------------------------------------------------
>In-frame_ENST00000606933_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464964_+_VPS45_chr1_150116886_length(transcript)=1424nt_BP=805nt
TTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCT
ACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAGATT
AGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCC
CTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCGGCC
CTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCTGGG
GGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAAGGA
GAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGC
TTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAACAGT
ATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGTTTCC
TAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTG
GTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTG
CTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGA
GCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACT
TGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTA
ACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTT

>In-frame_ENST00000606933_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150464964_+_VPS45_chr1_150116886_length(amino acids)=328AA_start in transcript=31_stop in transcript=1017
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSFPRGSSGFWTAQ

--------------------------------------------------------------
>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150469103_+_VPS45_chr1_150116886_length(transcript)=1574nt_BP=955nt
CTGTTTGAGGATGTAGGCACTGGTGTGAAGGAACATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAG
GCTACACACGGCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAGGAGCTGTGGGCTGCTCAGGTAAAGAG
ATTAGCAAGCATGGCACAGAAGGAACCCCGGACTATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAAC
CCCCTACCAACTAGCCCGGCAGATCAGTTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTGAATGGAGAACCTTATGATCTGGAGCG
GCCCTTGGAGACAGATTCTGACCTCAGATTTCTGACATTCGATTCCCCAGAGGGGAAAGCAGTGTTCTGGCACTCCAGCACCCATGTCCT
GGGGGCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGCTTTTACCATGATTTCTTCCTGGGAAA
GGAGAGGACAATCCGGGGCTCAGAGCTGCCTGTTTTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGA
GGCTTCACGGGATCAGCTTCGCCAGTTGTTCAAGGATAACCCCTTTAAGCTTCACTTGATTGAGGAGAAAGTGACAGGTCCAACAGCAAC
AGTATATGGGTGTGGCACATTGGTTGACCTTTGCCAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCGAA
CTCATCATCCTTATGGAGGTCTTCAGGGGCCCCAGAGACACTGCAGAGAGTGTCAGGGATTTCCTTCCCCACAACAGAATTGCTGAGGGT
CTGGGAAGCATGGAGGGAGGAAGCAGAATTGCGGGACCACCGGCGCATTGGGAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACA
GCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTG
TCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCC
CACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGT
CTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGG
CTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCC
TGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTG

>In-frame_ENST00000369064_ENST00000369130_TCGA-85-6560-01A_TARS2_chr1_150469103_+_VPS45_chr1_150116886_length(amino acids)=377AA_start in transcript=34_stop in transcript=1167
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISST
LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSNSSSLWRSSGAP
ETLQRVSGISFPTTELLRVWEAWREEAELRDHRRIGKFPRGSSGFWTAQPKQGELSSHIKVSEQKMKRWLGEGHSFLSCPHYRFSLLNKG

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Fusion Gene PPI Analysis for TARS2-VPS45

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TARS2-VPS45

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TARS2-VPS45

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TARS2	C4014668	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 21	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	VPS45	C3809031	NEUTROPENIA, SEVERE CONGENITAL, 5, AUTOSOMAL RECESSIVE	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	VPS45	C0340970	Congenital neutropenia	1	CTD_human;GENOMICS_ENGLAND
Tgene	VPS45	C1853118	Severe congenital neutropenia	1	CTD_human
Tgene	VPS45	C2931351	Familial myelofibrosis	1	CTD_human
Tgene	VPS45	C4755251	Congenital neutropenia, myelofibrosis, nephromegaly syndrome	1	GENOMICS_ENGLAND