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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:TBC1D22A-GCAT (FusionGDB2 ID:88677) |
Fusion Gene Summary for TBC1D22A-GCAT |
Fusion gene summary |
Fusion gene information | Fusion gene name: TBC1D22A-GCAT | Fusion gene ID: 88677 | Hgene | Tgene | Gene symbol | TBC1D22A | GCAT | Gene ID | 25771 | 23464 |
Gene name | TBC1 domain family member 22A | glycine C-acetyltransferase | |
Synonyms | C22orf4|HSC79E021 | KBL | |
Cytomap | 22q13.31 | 22q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | TBC1 domain family member 22Aputative GTPase activator | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial2-amino-3-ketobutyrate-CoA ligaseAKB ligaseaminoacetone synthaseglycine acetyltransferase | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000337137, ENST00000380995, ENST00000407381, ENST00000355704, ENST00000472791, ENST00000406733, | ENST00000323205, ENST00000248924, ENST00000415371, | |
Fusion gene scores | * DoF score | 34 X 18 X 14=8568 | 3 X 3 X 3=27 |
# samples | 37 | 3 | |
** MAII score | log2(37/8568*10)=-4.53336130423394 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TBC1D22A [Title/Abstract] AND GCAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | TBC1D22A(47393605)-GCAT(38206034), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across TBC1D22A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across GCAT (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-CV-6941-01A | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
ChimerDB4 | HNSC | TCGA-CV-6941 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
ChimerDB4 | HNSC | TCGA-CV-6941-01A | TBC1D22A | chr22 | 47393605 | - | GCAT | chr22 | 38206034 | + |
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Fusion Gene ORF analysis for TBC1D22A-GCAT |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000337137 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
In-frame | ENST00000337137 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
5CDS-intron | ENST00000337137 | ENST00000415371 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
intron-3CDS | ENST00000380995 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
intron-3CDS | ENST00000380995 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
intron-intron | ENST00000380995 | ENST00000415371 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
In-frame | ENST00000407381 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
In-frame | ENST00000407381 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
5CDS-intron | ENST00000407381 | ENST00000415371 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
In-frame | ENST00000355704 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
In-frame | ENST00000355704 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
5CDS-intron | ENST00000355704 | ENST00000415371 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
intron-3CDS | ENST00000472791 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
intron-3CDS | ENST00000472791 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
intron-intron | ENST00000472791 | ENST00000415371 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
In-frame | ENST00000406733 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
In-frame | ENST00000406733 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
5CDS-intron | ENST00000406733 | ENST00000415371 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000337137 | TBC1D22A | chr22 | 47393605 | + | ENST00000323205 | GCAT | chr22 | 38206034 | + | 2685 | 1367 | 166 | 1404 | 412 |
ENST00000337137 | TBC1D22A | chr22 | 47393605 | + | ENST00000248924 | GCAT | chr22 | 38206034 | + | 2610 | 1367 | 166 | 2430 | 754 |
ENST00000407381 | TBC1D22A | chr22 | 47393605 | + | ENST00000323205 | GCAT | chr22 | 38206034 | + | 2457 | 1139 | 115 | 1176 | 353 |
ENST00000407381 | TBC1D22A | chr22 | 47393605 | + | ENST00000248924 | GCAT | chr22 | 38206034 | + | 2382 | 1139 | 115 | 2202 | 695 |
ENST00000355704 | TBC1D22A | chr22 | 47393605 | + | ENST00000323205 | GCAT | chr22 | 38206034 | + | 2391 | 1073 | 1101 | 2135 | 344 |
ENST00000355704 | TBC1D22A | chr22 | 47393605 | + | ENST00000248924 | GCAT | chr22 | 38206034 | + | 2316 | 1073 | 106 | 2136 | 676 |
ENST00000406733 | TBC1D22A | chr22 | 47393605 | + | ENST00000323205 | GCAT | chr22 | 38206034 | + | 2766 | 1448 | 241 | 1485 | 414 |
ENST00000406733 | TBC1D22A | chr22 | 47393605 | + | ENST00000248924 | GCAT | chr22 | 38206034 | + | 2691 | 1448 | 241 | 2511 | 756 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000337137 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.006102411 | 0.9938976 |
ENST00000337137 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.013714108 | 0.98628587 |
ENST00000407381 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.00316283 | 0.99683714 |
ENST00000407381 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.011897722 | 0.9881023 |
ENST00000355704 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.004644616 | 0.99535537 |
ENST00000355704 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.013117728 | 0.98688227 |
ENST00000406733 | ENST00000323205 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.007811305 | 0.9921887 |
ENST00000406733 | ENST00000248924 | TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206034 | + | 0.016108533 | 0.9838914 |
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Fusion Genomic Features for TBC1D22A-GCAT |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206033 | + | 0.001449177 | 0.99855083 |
TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206033 | + | 0.001449177 | 0.99855083 |
TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206033 | + | 0.001449177 | 0.99855083 |
TBC1D22A | chr22 | 47393605 | + | GCAT | chr22 | 38206033 | + | 0.001449177 | 0.99855083 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TBC1D22A-GCAT |
Go to FGviewer for the breakpoints of chr22:47393605-chr22:38206034 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | GCAT | chr22:47393605 | chr22:38206034 | ENST00000248924 | 0 | 9 | 134_135 | 65.33333333333333 | 420.0 | Region | Pyridoxal phosphate binding | |
Tgene | GCAT | chr22:47393605 | chr22:38206034 | ENST00000248924 | 0 | 9 | 262_265 | 65.33333333333333 | 420.0 | Region | Pyridoxal phosphate binding | |
Tgene | GCAT | chr22:47393605 | chr22:38206034 | ENST00000248924 | 0 | 9 | 295_296 | 65.33333333333333 | 420.0 | Region | Pyridoxal phosphate binding%3B shared with dimeric partner | |
Tgene | GCAT | chr22:47393605 | chr22:38206034 | ENST00000323205 | 0 | 10 | 134_135 | 0 | 442.3333333333333 | Region | Pyridoxal phosphate binding | |
Tgene | GCAT | chr22:47393605 | chr22:38206034 | ENST00000323205 | 0 | 10 | 262_265 | 0 | 442.3333333333333 | Region | Pyridoxal phosphate binding | |
Tgene | GCAT | chr22:47393605 | chr22:38206034 | ENST00000323205 | 0 | 10 | 295_296 | 0 | 442.3333333333333 | Region | Pyridoxal phosphate binding%3B shared with dimeric partner |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TBC1D22A | chr22:47393605 | chr22:38206034 | ENST00000337137 | + | 10 | 13 | 222_446 | 400.3333333333333 | 518.0 | Domain | Rab-GAP TBC |
Hgene | TBC1D22A | chr22:47393605 | chr22:38206034 | ENST00000355704 | + | 8 | 11 | 222_446 | 322.3333333333333 | 440.0 | Domain | Rab-GAP TBC |
Hgene | TBC1D22A | chr22:47393605 | chr22:38206034 | ENST00000380995 | + | 1 | 9 | 222_446 | 0 | 325.0 | Domain | Rab-GAP TBC |
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Fusion Gene Sequence for TBC1D22A-GCAT |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000337137_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2685nt_BP=1367nt GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCG GAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGA CACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGAT CTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTG TGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTG GTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACT CGTGAGCCGGATTGATGAATCCTTAACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCAG GCTCTGGAGGAGTTTGGAGCTGGCCTCAGCTCTGTCCGCTTTATCTGTGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCC CGCTTCCACCAGCGGGAGGATGCCATCCTCTATCCCAGCTGTTATGACGCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGAC GCAGTCCTGTCGGACGAGCTGAACCATGCCTCCATCATCGACGGCATCCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGAC ATGGCCGACCTAGAAGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGAC ATCGCACCCCTGCAGGAGATCTGCTGCCTCGCCTCTAGATATGGTGCCCTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGGG CCCACAGGACGGGGCACAGATGAGCTGCTGGGTGTGATGGACCAGGTCACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGCA TCAGGGGGCTACACGACAGGGCCTGGGCCCCTGGTGTCCCTGCTGCGGCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCT GCTGTCGTTGGCTGCGCCTCCAAGGCCCTAGATCTGCTGATGGGGAGTAACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTTC CGTAGTAAGATGGAAGCTGCTGGCTTCACTATCTCGGGAGCCAGTCACCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCT CGCATGGCGGATGACATGCTGAAGAGAGGCATCTTTGTCATCGGGTTCAGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGTA CAGATCTCAGCAGTGCATAGCGAGGAAGACATTGACCGCTGCGTGGAGGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGA GCTCTGGGCCCAGTCCTGTGGCCGGTTGAAGAATCAGGCAGGAGCCAGGGCTCTGAGGGGAGGCGCCTGAGGACTGCAGATCTCCACTGA CCTCTTTCCCTAGATTAAGATGGGACCCAGTGGCCGGGCACGGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTAGGCGG >In-frame_ENST00000337137_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=412AA_start in transcript=166_stop in transcript=1404 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE -------------------------------------------------------------- >In-frame_ENST00000337137_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2610nt_BP=1367nt GCGCGTAGGCACAACTTCCGGAAGGAGGCGGAAGAGCTTCTCGGCTCTAGGCTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCA CAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGG GGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCC ACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGA GAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCAT GGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAG GCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAG TGCCAGCGATGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCT CAGCAGCTCAGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATT ACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCG GAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGA CACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGAT CTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTG TGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTG GTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACT CGTGAGCCGGATTGATGGAATCCTTAACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCA GGCTCTGGAGGAGTTTGGAGCTGGCCTCAGCTCTGTCCGCTTTATCTGTGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGC CCGCTTCCACCAGCGGGAGGATGCCATCCTCTATCCCAGCTGTTATGACGCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGA CGCAGTCCTGTCGGACGAGCTGAACCATGCCTCCATCATCGACGGCATCCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGA CATGGCCGACCTAGAAGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGA CATCGCACCCCTGCAGGAGATCTGCTGCCTCGCCTCTAGATATGGTGCCCTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGG GCCCACAGGACGGGGCACAGATGAGCTGCTGGGTGTGATGGACCAGGTCACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGC ATCAGGGGGCTACACGACAGGGCCTGGGCCCCTGGTGTCCCTGCTGCGGCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACC TGCTGTCGTTGGCTGCGCCTCCAAGGCCCTAGATCTGCTGATGGGGAGTAACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTT CCGTAGTAAGATGGAAGCTGCTGGCTTCACTATCTCGGGAGCCAGTCACCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTC TCGCATGGCGGATGACATGCTGAAGAGAGGCATCTTTGTCATCGGGTTCAGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGT ACAGATCTCAGCAGTGCATAGCGAGGAAGACATTGACCGCTGCGTGGAGGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTG AGCTCTGGGTAAGGACGAGAAGAGCCAAGGTCCGCCTACTGCCACAGGGTCAAAGGAGGTTTTCGATCAGCCCAGACCAGAGGCTCTGAG CCCTGAACCAAAGTCCCAGAGCTGGGCTGGGACGTGACCTGTGCTGAGGGCTGTGAGAATGTGAAACAACAGTGTGAAAATTGGCTGTGA >In-frame_ENST00000337137_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=754AA_start in transcript=166_stop in transcript=2430 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRND EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNL EAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAF SMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFS NSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGK -------------------------------------------------------------- >In-frame_ENST00000407381_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2457nt_BP=1139nt CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGT GCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGC CCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAATCCTTAACTTCTGTGCCAACAACTACCTG GGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCAGGCTCTGGAGGAGTTTGGAGCTGGCCTCAGCTCTGTCCGCTTTATCTGT GGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCCCGCTTCCACCAGCGGGAGGATGCCATCCTCTATCCCAGCTGTTATGAC GCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGACGCAGTCCTGTCGGACGAGCTGAACCATGCCTCCATCATCGACGGCATC CGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGACATGGCCGACCTAGAAGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCTG CGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGACATCGCACCCCTGCAGGAGATCTGCTGCCTCGCCTCTAGATATGGTGCC CTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGGGCCCACAGGACGGGGCACAGATGAGCTGCTGGGTGTGATGGACCAGGTC ACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGCATCAGGGGGCTACACGACAGGGCCTGGGCCCCTGGTGTCCCTGCTGCGG CAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCTGCTGTCGTTGGCTGCGCCTCCAAGGCCCTAGATCTGCTGATGGGGAGT AACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTTCCGTAGTAAGATGGAAGCTGCTGGCTTCACTATCTCGGGAGCCAGTCAC CCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCTCGCATGGCGGATGACATGCTGAAGAGAGGCATCTTTGTCATCGGGTTC AGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGTACAGATCTCAGCAGTGCATAGCGAGGAAGACATTGACCGCTGCGTGGAG GCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGAGCTCTGGGCCCAGTCCTGTGGCCGGTTGAAGAATCAGGCAGGAGCCAG GGCTCTGAGGGGAGGCGCCTGAGGACTGCAGATCTCCACTGACCTCTTTCCCTAGATTAAGATGGGACCCAGTGGCCGGGCACGGTGGCT CAGGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTAGGCGGATCACCTGAGGTCGGGAGTTTGAGACCAGCCTGACCAACATGGAGAAA >In-frame_ENST00000407381_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=353AA_start in transcript=115_stop in transcript=1176 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYL PANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPF -------------------------------------------------------------- >In-frame_ENST00000407381_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2382nt_BP=1139nt CTCTGGAGTCCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCG CGGGTCTGAGGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGCAT CCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACATGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACC AGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCT GGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCC CACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAA GTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGAC GTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTAT TGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGC GTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGG TATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGT GCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGC CCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGGAATCCTTAACTTCTGTGCCAACAACTACCT GGGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCAGGCTCTGGAGGAGTTTGGAGCTGGCCTCAGCTCTGTCCGCTTTATCTG TGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCCCGCTTCCACCAGCGGGAGGATGCCATCCTCTATCCCAGCTGTTATGA CGCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGACGCAGTCCTGTCGGACGAGCTGAACCATGCCTCCATCATCGACGGCAT CCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGACATGGCCGACCTAGAAGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCT GCGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGACATCGCACCCCTGCAGGAGATCTGCTGCCTCGCCTCTAGATATGGTGC CCTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGGGCCCACAGGACGGGGCACAGATGAGCTGCTGGGTGTGATGGACCAGGT CACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGCATCAGGGGGCTACACGACAGGGCCTGGGCCCCTGGTGTCCCTGCTGCG GCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCTGCTGTCGTTGGCTGCGCCTCCAAGGCCCTAGATCTGCTGATGGGGAG TAACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTTCCGTAGTAAGATGGAAGCTGCTGGCTTCACTATCTCGGGAGCCAGTCA CCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCTCGCATGGCGGATGACATGCTGAAGAGAGGCATCTTTGTCATCGGGTT CAGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGTACAGATCTCAGCAGTGCATAGCGAGGAAGACATTGACCGCTGCGTGGA GGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGAGCTCTGGGTAAGGACGAGAAGAGCCAAGGTCCGCCTACTGCCACAGG GTCAAAGGAGGTTTTCGATCAGCCCAGACCAGAGGCTCTGAGCCCTGAACCAAAGTCCCAGAGCTGGGCTGGGACGTGACCTGTGCTGAG >In-frame_ENST00000407381_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=695AA_start in transcript=115_stop in transcript=2202 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYL PANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPF FVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDGILNFCANNYLGLSSHPEV IQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKY RYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLG KALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLG -------------------------------------------------------------- >In-frame_ENST00000355704_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2391nt_BP=1073nt CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAA ACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGA CATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCA CCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGT GGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGG CATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAATCCTT AACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCAGGCTCTGGAGGAGTTTGGAGCTGGC CTCAGCTCTGTCCGCTTTATCTGTGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCCCGCTTCCACCAGCGGGAGGATGCC ATCCTCTATCCCAGCTGTTATGACGCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGACGCAGTCCTGTCGGACGAGCTGAAC CATGCCTCCATCATCGACGGCATCCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGACATGGCCGACCTAGAAGCCAAGCTG CAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGACATCGCACCCCTGCAGGAGATCTGC TGCCTCGCCTCTAGATATGGTGCCCTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGGGCCCACAGGACGGGGCACAGATGAG CTGCTGGGTGTGATGGACCAGGTCACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGCATCAGGGGGCTACACGACAGGGCCT GGGCCCCTGGTGTCCCTGCTGCGGCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCTGCTGTCGTTGGCTGCGCCTCCAAG GCCCTAGATCTGCTGATGGGGAGTAACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTTCCGTAGTAAGATGGAAGCTGCTGGC TTCACTATCTCGGGAGCCAGTCACCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCTCGCATGGCGGATGACATGCTGAAG AGAGGCATCTTTGTCATCGGGTTCAGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGTACAGATCTCAGCAGTGCATAGCGAG GAAGACATTGACCGCTGCGTGGAGGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGAGCTCTGGGCCCAGTCCTGTGGCCG GTTGAAGAATCAGGCAGGAGCCAGGGCTCTGAGGGGAGGCGCCTGAGGACTGCAGATCTCCACTGACCTCTTTCCCTAGATTAAGATGGG ACCCAGTGGCCGGGCACGGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTAGGCGGATCACCTGAGGTCGGGAGTTTGAG >In-frame_ENST00000355704_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=344AA_start in transcript=1101_stop in transcript=2135 MGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDG IRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQ VTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGAS -------------------------------------------------------------- >In-frame_ENST00000355704_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2316nt_BP=1073nt CCCGGGAGCAGTGAGGGGCCACCCGGGGCACAGGAAAGGGCCGCTAGGGGAGGGCCGGGTGCACTCGGGGTGTCTGGGCCGCGGGTCTGA GGGATGAGGAGGGGCCATGGCCAGCGACGGGGCCAGGAAGCAATTCTGGAAGCGCAGCAACAGCAAGCTCCCGGGCAGTTTGCTCAGGTC CACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATACCAGCGATGCCTGGGACGC TGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGCCAACCGTGTGCTGCGTAA CCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGCAGAGCCGCCCTCACCCCC CAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAGGAATTACGGAGGTTGAGCTGGTCCGGAAT CCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAA ACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGA CATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCA CCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGT GGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGG CATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGGAATCCT TAACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCAGGCTCTGGAGGAGTTTGGAGCTGG CCTCAGCTCTGTCCGCTTTATCTGTGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCCCGCTTCCACCAGCGGGAGGATGC CATCCTCTATCCCAGCTGTTATGACGCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGACGCAGTCCTGTCGGACGAGCTGAA CCATGCCTCCATCATCGACGGCATCCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGACATGGCCGACCTAGAAGCCAAGCT GCAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGACATCGCACCCCTGCAGGAGATCTG CTGCCTCGCCTCTAGATATGGTGCCCTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGGGCCCACAGGACGGGGCACAGATGA GCTGCTGGGTGTGATGGACCAGGTCACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGCATCAGGGGGCTACACGACAGGGCC TGGGCCCCTGGTGTCCCTGCTGCGGCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCTGCTGTCGTTGGCTGCGCCTCCAA GGCCCTAGATCTGCTGATGGGGAGTAACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTTCCGTAGTAAGATGGAAGCTGCTGG CTTCACTATCTCGGGAGCCAGTCACCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCTCGCATGGCGGATGACATGCTGAA GAGAGGCATCTTTGTCATCGGGTTCAGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGTACAGATCTCAGCAGTGCATAGCGA GGAAGACATTGACCGCTGCGTGGAGGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGAGCTCTGGGTAAGGACGAGAAGAG CCAAGGTCCGCCTACTGCCACAGGGTCAAAGGAGGTTTTCGATCAGCCCAGACCAGAGGCTCTGAGCCCTGAACCAAAGTCCCAGAGCTG >In-frame_ENST00000355704_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=676AA_start in transcript=106_stop in transcript=2136 MASDGARKQFWKRSNSKLPGSLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQ GRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYF AFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDV SGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVR FICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQK HRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVS LLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFV -------------------------------------------------------------- >In-frame_ENST00000406733_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2766nt_BP=1448nt AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGC CACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAG GCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCAT ATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACAT AGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAG CAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCG GATTGATGAATCCTTAACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCAGGCTCTGGAG GAGTTTGGAGCTGGCCTCAGCTCTGTCCGCTTTATCTGTGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCCCGCTTCCAC CAGCGGGAGGATGCCATCCTCTATCCCAGCTGTTATGACGCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGACGCAGTCCTG TCGGACGAGCTGAACCATGCCTCCATCATCGACGGCATCCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGACATGGCCGAC CTAGAAGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGACATCGCACCC CTGCAGGAGATCTGCTGCCTCGCCTCTAGATATGGTGCCCTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGGGCCCACAGGA CGGGGCACAGATGAGCTGCTGGGTGTGATGGACCAGGTCACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGCATCAGGGGGC TACACGACAGGGCCTGGGCCCCTGGTGTCCCTGCTGCGGCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCTGCTGTCGTT GGCTGCGCCTCCAAGGCCCTAGATCTGCTGATGGGGAGTAACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTTCCGTAGTAAG ATGGAAGCTGCTGGCTTCACTATCTCGGGAGCCAGTCACCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCTCGCATGGCG GATGACATGCTGAAGAGAGGCATCTTTGTCATCGGGTTCAGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGTACAGATCTCA GCAGTGCATAGCGAGGAAGACATTGACCGCTGCGTGGAGGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGAGCTCTGGGC CCAGTCCTGTGGCCGGTTGAAGAATCAGGCAGGAGCCAGGGCTCTGAGGGGAGGCGCCTGAGGACTGCAGATCTCCACTGACCTCTTTCC CTAGATTAAGATGGGACCCAGTGGCCGGGCACGGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTAGGCGGATCACCTGA >In-frame_ENST00000406733_ENST00000323205_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=414AA_start in transcript=241_stop in transcript=1485 MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSR NDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCN -------------------------------------------------------------- >In-frame_ENST00000406733_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(transcript)=2691nt_BP=1448nt AGAAGTCTGTGCCCTTACCCATCACAGCCTCATCCTTATCTCCTCCATTCCCTAGGGGACTTAACAGGTGTTGAAATTATTACAGAGAAA GCTGACTCACTCACCAGGAATCTGATCCTGCTGTGGGCTGGCTTGGGTGGAGGTGTTCCTCCCGCCCCCGCACCCATCCTCCTGTTTGAA CTCAGGCTGCTGCCTGCTGGGCCTGCCTGCCCTTGGAGCCCTGCTGAGCTCAGCCTGAGGCCTGGCTCCTCCAGGCTGGGGGAAAACCAG GCTTGCTGTGCTCGGCAGCAGAGATTCTTCTGGAGTGAGCATCCAGCACGTGTATGGTGCCCAGCACCCCCCCTTTGATCCACTGTTACA TGGCACTTTGCTCAGGTCCACGGCCAAGATGCCGACCACACCAGTGAAGGCCAAGAGGGTCAGCACCTTCCAGGAGTTTGAGAGCAATAC CAGCGATGCCTGGGACGCTGGGGAGGACGACGATGAGCTCCTGGCCATGGCGGCGGAGAGCCTGAACTCCGAGGTGGTCATGGAGACGGC CAACCGTGTGCTGCGTAACCACAGCCAGCGGCAGGGGCGGCCCACGCTGCAGGAGGGGCCAGGGCTTCAGCAGAAGCCCAGGCCCGAGGC AGAGCCGCCCTCACCCCCCAGCGGCGACCTCCGGCTGGTGAAGTCGGTCAGTGAGAGCCACACGTCCTGTCCTGCAGAAAGTGCCAGCGA TGCCGCCCCTCTGCAGAGGTCCCAGTCTCTCCCACACTCGGCCACCGTCACGCTGGGTGGCACATCTGACCCCAGCACTCTCAGCAGCTC AGCGCTGAGCGAAAGAGAGGCCTCCCGGCTCGACAAGTTCAAGCAGCTGCTTGCCGGCCCCAACACGGACCTTGAGGAATTACGGAGGTT GAGCTGGTCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGC CACTCTCCAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAG GCAGATCCACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCAT ATGGGCGATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACAT AGAGGCAGAGGAGGTGGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAG CAAGCTGCTGGATGGCATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCG GATTGATGGAATCCTTAACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGCCACCCTGAGGTGATCCAGGCAGGTCTGCAGGCTCTGGA GGAGTTTGGAGCTGGCCTCAGCTCTGTCCGCTTTATCTGTGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCCCGCTTCCA CCAGCGGGAGGATGCCATCCTCTATCCCAGCTGTTATGACGCCAACGCCGGCCTCTTTGAGGCCCTGCTGACCCCAGAGGACGCAGTCCT GTCGGACGAGCTGAACCATGCCTCCATCATCGACGGCATCCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGACATGGCCGA CCTAGAAGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCCACTGATGGGGCCTTTTCCATGGATGGCGACATCGCACC CCTGCAGGAGATCTGCTGCCTCGCCTCTAGATATGGTGCCCTGGTCTTCATGGATGAATGCCATGCCACTGGCTTCCTGGGGCCCACAGG ACGGGGCACAGATGAGCTGCTGGGTGTGATGGACCAGGTCACCATCATCAACTCCACCCTGGGGAAGGCCCTGGGTGGAGCATCAGGGGG CTACACGACAGGGCCTGGGCCCCTGGTGTCCCTGCTGCGGCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCTGCTGTCGT TGGCTGCGCCTCCAAGGCCCTAGATCTGCTGATGGGGAGTAACACCATTGTCCAGTCTATGGCTGCCAAGACCCAGAGGTTCCGTAGTAA GATGGAAGCTGCTGGCTTCACTATCTCGGGAGCCAGTCACCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCTCGCATGGC GGATGACATGCTGAAGAGAGGCATCTTTGTCATCGGGTTCAGCTACCCCGTGGTCCCCAAGGGCAAGGCCCGGATCCGGGTACAGATCTC AGCAGTGCATAGCGAGGAAGACATTGACCGCTGCGTGGAGGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGAGCTCTGGG TAAGGACGAGAAGAGCCAAGGTCCGCCTACTGCCACAGGGTCAAAGGAGGTTTTCGATCAGCCCAGACCAGAGGCTCTGAGCCCTGAACC >In-frame_ENST00000406733_ENST00000248924_TCGA-CV-6941-01A_TBC1D22A_chr22_47393605_+_GCAT_chr22_38206034_length(amino acids)=756AA_start in transcript=241_stop in transcript=2511 MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSR NDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCN IEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHK NLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDG AFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYL FSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TBC1D22A-GCAT |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TBC1D22A-GCAT |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TBC1D22A-GCAT |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GCAT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |