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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TBC1D2B-ETFA (FusionGDB2 ID:88726)

Fusion Gene Summary for TBC1D2B-ETFA

Fusion gene summary

Fusion gene information	Fusion gene name: TBC1D2B-ETFA
	Fusion gene ID: 88726
		Hgene	Tgene
	Gene symbol	TBC1D2B	ETFA
	Gene ID	23102	2108
	Gene name	TBC1 domain family member 2B	electron transfer flavoprotein subunit alpha
	Synonyms	-	EMA\|GA2\|MADD
	Cytomap	15q24.3-q25.1	15q24.2-q24.3
	Type of gene	protein-coding	protein-coding
	Description	TBC1 domain family member 2B	electron transfer flavoprotein subunit alpha, mitochondrialalpha-ETFelectron transfer flavoprotein alpha subunitelectron transfer flavoprotein, alpha polypeptideepididymis secretory sperm binding proteinglutaric aciduria II
	Modification date	20200313	20200313
	UniProtAcc	.	P13804
	Ensembl transtripts involved in fusion gene	ENST00000300584, ENST00000409931, ENST00000492078,	ENST00000557943, ENST00000433983, ENST00000560726, ENST00000559602, ENST00000560816,
Fusion gene scores	* DoF score	10 X 10 X 8=800	8 X 7 X 6=336
	# samples	12	8
	** MAII score	log2(12/800*10)=-2.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TBC1D2B [Title/Abstract] AND ETFA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TBC1D2B(78369635)-ETFA(76588078), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ETFA	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	25416781

Fusion gene breakpoints across TBC1D2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ETFA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-76-4931-01A	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-

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Fusion Gene ORF analysis for TBC1D2B-ETFA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000300584	ENST00000557943	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000300584	ENST00000433983	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000300584	ENST00000560726	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000300584	ENST00000559602	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000300584	ENST00000560816	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
In-frame	ENST00000409931	ENST00000557943	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000409931	ENST00000433983	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000409931	ENST00000560726	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000409931	ENST00000559602	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
5CDS-intron	ENST00000409931	ENST00000560816	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
intron-3CDS	ENST00000492078	ENST00000557943	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
intron-intron	ENST00000492078	ENST00000433983	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
intron-intron	ENST00000492078	ENST00000560726	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
intron-intron	ENST00000492078	ENST00000559602	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-
intron-intron	ENST00000492078	ENST00000560816	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000300584	TBC1D2B	chr15	78369635	-	ENST00000557943	ETFA	chr15	76588078	-	2527	360	0	1322	440
ENST00000409931	TBC1D2B	chr15	78369635	-	ENST00000557943	ETFA	chr15	76588078	-	2599	432	72	1394	440

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000300584	ENST00000557943	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-	0.001466783	0.99853325
ENST00000409931	ENST00000557943	TBC1D2B	chr15	78369635	-	ETFA	chr15	76588078	-	0.001375638	0.9986243

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Fusion Genomic Features for TBC1D2B-ETFA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBC1D2B-ETFA

Go to
FGviewer for the breakpoints of chr15:78369635-chr15:76588078
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ETFA P13804
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). {ECO:0000269\|PubMed:10356313, ECO:0000269\|PubMed:12815589, ECO:0000269\|PubMed:1430199, ECO:0000269\|PubMed:15159392, ECO:0000269\|PubMed:15975918, ECO:0000269\|PubMed:27499296, ECO:0000269\|PubMed:9334218, ECO:0000303\|PubMed:17941859, ECO:0000305\|PubMed:1882842}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000433983

263_266

285.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000433983

281_286

285.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000433983

318_319

285.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000557943

263_266

13.0

334.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000557943

281_286

13.0

334.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000557943

318_319

13.0

334.0

Nucleotide binding

FAD

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000433983

205_333

285.0

Region

Domain II

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000433983

20_204

285.0

Region

Domain I

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000557943

205_333

13.0

334.0

Region

Domain II

Tgene

ETFA

chr15:78369635

chr15:76588078

ENST00000557943

20_204

13.0

334.0

Region

Domain I

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TBC1D2B

chr15:78369635

chr15:76588078

ENST00000300584

337_535

120.0

964.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2B

chr15:78369635

chr15:76588078

ENST00000409931

337_535

120.0

915.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TBC1D2B

chr15:78369635

chr15:76588078

ENST00000300584

34_139

120.0

964.0

Domain

Hgene

TBC1D2B

chr15:78369635

chr15:76588078

ENST00000300584

662_856

120.0

964.0

Domain

Rab-GAP TBC

Hgene

TBC1D2B

chr15:78369635

chr15:76588078

ENST00000409931

34_139

120.0

915.0

Domain

Hgene

TBC1D2B

chr15:78369635

chr15:76588078

ENST00000409931

662_856

120.0

915.0

Domain

Rab-GAP TBC

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Fusion Gene Sequence for TBC1D2B-ETFA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000300584_ENST00000557943_TCGA-76-4931-01A_TBC1D2B_chr15_78369635_-_ETFA_chr15_76588078_length(transcript)=2527nt_BP=360nt
ATGCCGGGGGCCGGAGCCCGGGCGGAGGAGGGCGGCGGCGGCGGCGAGGGCGCGGCGCAGGGGGCGGCCGCGGAGCCCGGGGCGGGTCCG
GCGCGGGAGCCAGCGCGGCTGTGTGGCTATCTGCAGAAGCTGTCGGGCAAGGGCCCCCTGCGTGGCTACCGCAGCCGCTGGTTCGTGTTC
GACGCGCGCCGCTGCTACCTTTACTATTTCAAGAGTCCGCAGGACGCGCTGCCCCTCGGCCACTTGGACATCGCGGACGCCTGCTTCAGC
TACCAGGGCCCCGACGAGGCGGCGGAGCCGGGCACGGAGCCGCCCGCGCACTTCCAGGTGCACAGCGCGGGAGCCGTCACGGTGCTCAAG
GCCTCATTGCTACGATTTCAGAGTACCCTGGTAATAGCTGAGCATGCAAATGATTCCCTAGCACCCATTACTTTAAATACCATTACTGCA
GCCACACGCCTTGGAGGTGAAGTGTCCTGCTTAGTAGCTGGAACCAAATGTGACAAGGTGGCACAAGATCTCTGTAAAGTAGCAGGCATA
GCAAAAGTTCTGGTGGCTCAGCATGATGTGTACAAAGGCCTACTTCCAGAGGAACTGACACCATTGATTTTGGCAACTCAGAAGCAGTTC
AATTACACACACATCTGTGCTGGAGCATCTGCCTTCGGAAAGAACCTTTTGCCCAGAGTAGCAGCCAAACTTGAGGTTGCCCCGATTTCT
GACATCATTGCAATCAAGTCACCTGACACATTTGTGAGAACTATTTATGCAGGAAATGCTCTATGTACAGTGAAGTGTGATGAGAAAGTG
AAAGTGTTTTCTGTCCGTGGAACATCCTTTGATGCTGCAGCAACAAGTGGCGGTAGTGCCAGTTCAGAAAAGGCATCAAGTACTTCACCA
GTGGAAATATCAGAGTGGCTTGACCAGAAATTAACAAAAAGTGATCGACCAGAGCTAACAGGTGCCAAAGTGGTGGTATCTGGTGGTCGA
GGCTTGAAGAGTGGAGAGAACTTTAAGTTGTTATATGACTTGGCAGATCAACTACATGCTGCAGTTGGTGCTTCCCGTGCTGCTGTTGAT
GCTGGCTTTGTTCCCAATGACATGCAAGTTGGACAGACGGGAAAAATAGTAGCACCAGAACTTTATATTGCTGTTGGAATATCTGGAGCC
ATCCAACATTTAGCTGGGATGAAAGACAGCAAGACAATTGTGGCAATTAATAAAGACCCAGAAGCTCCAATTTTCCAAGTGGCAGATTAT
GGAATAGTTGCAGATTTATTTAAGGTAGTTCCTGAAATGACTGAGATATTGAAGAAAAAATGAATCAGGATCATGCCTTAAAAAGAAAAC
TTTTGTTAAAGTATTCCACTGAAATCACAGATATTTGTGGGTATTATAACAATCATTGGAAAGCATGGAGAGCTACATTTCATAATTTGA
GGGAAAATTTCTAACAGATGCCAGAATGCTTGTTTATGGGATTGCTGTGTTTCCTTTTAATTATTTGTGGTTCCAAACAATTATTGTTTG
AACTTTTTAAATTCTGTACTAAAATCTATAATAAAGCTTTTCCACAGCTTTAAAACTATCAGAAATATGCCTAGCCTCTAGAGAAAATTG
AAGAAAAGGAGTAAAAATTTTGTTTATTTATTTATTTTTTTGCCTTTCTTGTTCATGGAGAGCTCTATGTTTTAGGAAGATTGTAAACAT
GATTGTCTCCACCAGCCTAATCAACCTACTAATCTCATTGTTGAAGGGCAAACTTCATAGGAGAAGGTAACTGAATTGGCAAGTGCAGAG
TTAAAAAAGCACGGCTATAAAGCATGAATATTATCTTAAACATACTCCAGTCTTCAGAAGACCATAGCTAATGTGACAAAAGCAGACCTG
ACTTAAACCTGACCCAGCTCCATGTATTTAGTTGGCTTAAGGTAAATTTCATTTTCCGTTTAATTTTAAGGTTTTGTCAGTTTATAGGAC
TTTTGTCTGTAAAGGAGGGAGAGTGGAGGAGGGGCTGCTTTGAGACAGCATGGCCTCTGATGCAAGCAGATAGTTTGATGTTATTATAAA
CATTCAAAATCCTGTGCAGAGAATGCTCTAGCCTTTCTTTTGCCTTCTGTTGGCTTCTTTTGGGCTCTCTTAGGAAGCACCCAGGCCTGT
GTAGTCACCTCTGGCACTCTCATTCTGCTGCCCAGGGCACAGCTGAGGTCCAAGAGTGTCACCAGGGCTGCAGCTGGTGTGGATGCAGGC
CCAAGAGCAGAGGCTGGTGAGGCTTTGAACAGGCCTGCAGGAAGGCGTGGGTAGGTAGGTGAGTAGAACAAAGAGGGCTGCCCTCCTGAA
TCAGATCTGCAGAAGTAGGAGTAGTGACCTGGATCAAGCAGACAGTAGGGAAGAGAAGGGAAGTGATAAGTGATGGAGGTGGCTAGAGTG
CCTTTGTGTGACCAGCCTGGGGCCCTTCCCCAGCTGACTAGTGAACCCTTTCTGATTTGTGTCACAATCAGTTGCTATAAAACACTTTTA

>In-frame_ENST00000300584_ENST00000557943_TCGA-76-4931-01A_TBC1D2B_chr15_78369635_-_ETFA_chr15_76588078_length(amino acids)=440AA_start in transcript=0_stop in transcript=1322
MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVFDARRCYLYYFKSPQDALPLGHLDIADACFS
YQGPDEAAEPGTEPPAHFQVHSAGAVTVLKASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQDLCKVAGI
AKVLVAQHDVYKGLLPEELTPLILATQKQFNYTHICAGASAFGKNLLPRVAAKLEVAPISDIIAIKSPDTFVRTIYAGNALCTVKCDEKV
KVFSVRGTSFDAAATSGGSASSEKASSTSPVEISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVD

--------------------------------------------------------------
>In-frame_ENST00000409931_ENST00000557943_TCGA-76-4931-01A_TBC1D2B_chr15_78369635_-_ETFA_chr15_76588078_length(transcript)=2599nt_BP=432nt
GGGGGTAGGGGGCGCAGCGGCCGCGGCGCGGAGGCGCAGGGCGCGGGCGCCTACGGTTGGCGCGCGGTAGCGATGCCGGGGGCCGGAGCC
CGGGCGGAGGAGGGCGGCGGCGGCGGCGAGGGCGCGGCGCAGGGGGCGGCCGCGGAGCCCGGGGCGGGTCCGGCGCGGGAGCCAGCGCGG
CTGTGTGGCTATCTGCAGAAGCTGTCGGGCAAGGGCCCCCTGCGTGGCTACCGCAGCCGCTGGTTCGTGTTCGACGCGCGCCGCTGCTAC
CTTTACTATTTCAAGAGTCCGCAGGACGCGCTGCCCCTCGGCCACTTGGACATCGCGGACGCCTGCTTCAGCTACCAGGGCCCCGACGAG
GCGGCGGAGCCGGGCACGGAGCCGCCCGCGCACTTCCAGGTGCACAGCGCGGGAGCCGTCACGGTGCTCAAGGCCTCATTGCTACGATTT
CAGAGTACCCTGGTAATAGCTGAGCATGCAAATGATTCCCTAGCACCCATTACTTTAAATACCATTACTGCAGCCACACGCCTTGGAGGT
GAAGTGTCCTGCTTAGTAGCTGGAACCAAATGTGACAAGGTGGCACAAGATCTCTGTAAAGTAGCAGGCATAGCAAAAGTTCTGGTGGCT
CAGCATGATGTGTACAAAGGCCTACTTCCAGAGGAACTGACACCATTGATTTTGGCAACTCAGAAGCAGTTCAATTACACACACATCTGT
GCTGGAGCATCTGCCTTCGGAAAGAACCTTTTGCCCAGAGTAGCAGCCAAACTTGAGGTTGCCCCGATTTCTGACATCATTGCAATCAAG
TCACCTGACACATTTGTGAGAACTATTTATGCAGGAAATGCTCTATGTACAGTGAAGTGTGATGAGAAAGTGAAAGTGTTTTCTGTCCGT
GGAACATCCTTTGATGCTGCAGCAACAAGTGGCGGTAGTGCCAGTTCAGAAAAGGCATCAAGTACTTCACCAGTGGAAATATCAGAGTGG
CTTGACCAGAAATTAACAAAAAGTGATCGACCAGAGCTAACAGGTGCCAAAGTGGTGGTATCTGGTGGTCGAGGCTTGAAGAGTGGAGAG
AACTTTAAGTTGTTATATGACTTGGCAGATCAACTACATGCTGCAGTTGGTGCTTCCCGTGCTGCTGTTGATGCTGGCTTTGTTCCCAAT
GACATGCAAGTTGGACAGACGGGAAAAATAGTAGCACCAGAACTTTATATTGCTGTTGGAATATCTGGAGCCATCCAACATTTAGCTGGG
ATGAAAGACAGCAAGACAATTGTGGCAATTAATAAAGACCCAGAAGCTCCAATTTTCCAAGTGGCAGATTATGGAATAGTTGCAGATTTA
TTTAAGGTAGTTCCTGAAATGACTGAGATATTGAAGAAAAAATGAATCAGGATCATGCCTTAAAAAGAAAACTTTTGTTAAAGTATTCCA
CTGAAATCACAGATATTTGTGGGTATTATAACAATCATTGGAAAGCATGGAGAGCTACATTTCATAATTTGAGGGAAAATTTCTAACAGA
TGCCAGAATGCTTGTTTATGGGATTGCTGTGTTTCCTTTTAATTATTTGTGGTTCCAAACAATTATTGTTTGAACTTTTTAAATTCTGTA
CTAAAATCTATAATAAAGCTTTTCCACAGCTTTAAAACTATCAGAAATATGCCTAGCCTCTAGAGAAAATTGAAGAAAAGGAGTAAAAAT
TTTGTTTATTTATTTATTTTTTTGCCTTTCTTGTTCATGGAGAGCTCTATGTTTTAGGAAGATTGTAAACATGATTGTCTCCACCAGCCT
AATCAACCTACTAATCTCATTGTTGAAGGGCAAACTTCATAGGAGAAGGTAACTGAATTGGCAAGTGCAGAGTTAAAAAAGCACGGCTAT
AAAGCATGAATATTATCTTAAACATACTCCAGTCTTCAGAAGACCATAGCTAATGTGACAAAAGCAGACCTGACTTAAACCTGACCCAGC
TCCATGTATTTAGTTGGCTTAAGGTAAATTTCATTTTCCGTTTAATTTTAAGGTTTTGTCAGTTTATAGGACTTTTGTCTGTAAAGGAGG
GAGAGTGGAGGAGGGGCTGCTTTGAGACAGCATGGCCTCTGATGCAAGCAGATAGTTTGATGTTATTATAAACATTCAAAATCCTGTGCA
GAGAATGCTCTAGCCTTTCTTTTGCCTTCTGTTGGCTTCTTTTGGGCTCTCTTAGGAAGCACCCAGGCCTGTGTAGTCACCTCTGGCACT
CTCATTCTGCTGCCCAGGGCACAGCTGAGGTCCAAGAGTGTCACCAGGGCTGCAGCTGGTGTGGATGCAGGCCCAAGAGCAGAGGCTGGT
GAGGCTTTGAACAGGCCTGCAGGAAGGCGTGGGTAGGTAGGTGAGTAGAACAAAGAGGGCTGCCCTCCTGAATCAGATCTGCAGAAGTAG
GAGTAGTGACCTGGATCAAGCAGACAGTAGGGAAGAGAAGGGAAGTGATAAGTGATGGAGGTGGCTAGAGTGCCTTTGTGTGACCAGCCT

>In-frame_ENST00000409931_ENST00000557943_TCGA-76-4931-01A_TBC1D2B_chr15_78369635_-_ETFA_chr15_76588078_length(amino acids)=440AA_start in transcript=72_stop in transcript=1394
MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVFDARRCYLYYFKSPQDALPLGHLDIADACFS
YQGPDEAAEPGTEPPAHFQVHSAGAVTVLKASLLRFQSTLVIAEHANDSLAPITLNTITAATRLGGEVSCLVAGTKCDKVAQDLCKVAGI
AKVLVAQHDVYKGLLPEELTPLILATQKQFNYTHICAGASAFGKNLLPRVAAKLEVAPISDIIAIKSPDTFVRTIYAGNALCTVKCDEKV
KVFSVRGTSFDAAATSGGSASSEKASSTSPVEISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBC1D2B-ETFA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TBC1D2B-ETFA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TBC1D2B-ETFA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	ETFA	C0268596	Multiple Acyl Coenzyme A Dehydrogenase Deficiency	11	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	ETFA	C0029408	Degenerative polyarthritis	1	CTD_human
Tgene	ETFA	C0086743	Osteoarthrosis Deformans	1	CTD_human
Tgene	ETFA	C0369183	Erythrocyte Mean Corpuscular Hemoglobin Test	1	GENOMICS_ENGLAND
Tgene	ETFA	C1261502	Finding of Mean Corpuscular Hemoglobin	1	GENOMICS_ENGLAND
Tgene	ETFA	C2239176	Liver carcinoma	1	CTD_human
Tgene	ETFA	C3278154	GLUTARIC ACIDEMIA IIA	1	GENOMICS_ENGLAND
Tgene	ETFA	C4317009	Diverticular Diseases	1	CTD_human
Tgene	ETFA	C4505353	Diverticular Bleeding	1	CTD_human