FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TBC1D4-COMMD6 (FusionGDB2 ID:88756)

Fusion Gene Summary for TBC1D4-COMMD6

check button Fusion gene summary
Fusion gene informationFusion gene name: TBC1D4-COMMD6
Fusion gene ID: 88756
HgeneTgene
Gene symbol

TBC1D4

COMMD6

Gene ID

9882

170622

Gene nameTBC1 domain family member 4COMM domain containing 6
SynonymsAS160|NIDDM5Acrg
Cytomap

13q22.2

13q22.2

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 4TBC (Tre-2, BUB2, CDC16) domain-containing proteinakt substrate of 160 kDaCOMM domain-containing protein 6Acrg embryonic lethality minimal region ortholog
Modification date2020031320200313
UniProtAcc.

Q7Z4G1

Ensembl transtripts involved in fusion geneENST00000377636, ENST00000431480, 
ENST00000425511, ENST00000377625, 
ENST00000478591, 		ENST00000406936, 
ENST00000377615, ENST00000377619, 
ENST00000355801, ENST00000460675, 
Fusion gene scores* DoF score5 X 6 X 5=1505 X 7 X 4=140
# samples 66
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBC1D4 [Title/Abstract] AND COMMD6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBC1D4(76055406)-COMMD6(76104402), # samples:3
Anticipated loss of major functional domain due to fusion event.TBC1D4-COMMD6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOMMD6

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16573520


check buttonFusion gene breakpoints across TBC1D4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across COMMD6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14N-01ATBC1D4chr13

76055406

-COMMD6chr13

76100775

-
ChimerDB4BRCATCGA-OL-A5S0-01ATBC1D4chr13

76055406

-COMMD6chr13

76104402

-
ChimerDB4BRCATCGA-OL-A5S0-01ATBC1D4chr13

76055406

-COMMD6chr13

76104402

-
ChimerDB4BRCATCGA-OL-A5S0-01ATBC1D4chr13

76055410

-COMMD6chr13

76100779

-
ChimerDB4BRCATCGA-OL-A5S0-01ATBC1D4chr13

76055408

-COMMD6chr13

76104404

-
ChimerDB4BRCATCGA-OL-A5S0-01ATBC1D4chr13

76055406

-COMMD6chr13

76100775

-
ChimerDB4BRCATCGA-E2-A14N-01ATBC1D4chr13

76055406

-COMMD6chr13

76111811

-
ChimerDB4BRCATCGA-OL-A5S0-01ATBC1D4chr13

76055406

-COMMD6chr13

76104402

-


Top

Fusion Gene ORF analysis for TBC1D4-COMMD6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000377636ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000377636ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000377636ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
In-frameENST00000377636ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5CDS-5UTRENST00000377636ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000431480ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000431480ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000431480ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
In-frameENST00000431480ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5CDS-5UTRENST00000431480ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-3CDSENST00000425511ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5UTR-5UTRENST00000425511ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000377625ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000377625ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
Frame-shiftENST00000377625ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
In-frameENST00000377625ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
5CDS-5UTRENST00000377625ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-3CDSENST00000478591ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
intron-5UTRENST00000478591ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76100775

-
In-frameENST00000377636ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377636ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377636ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377636ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5CDS-5UTRENST00000377636ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000431480ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5CDS-5UTRENST00000431480ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-3CDSENST00000425511ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5UTR-5UTRENST00000425511ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
In-frameENST00000377625ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
5CDS-5UTRENST00000377625ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-3CDSENST00000478591ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
intron-5UTRENST00000478591ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76104402

-
Frame-shiftENST00000377636ENST00000406936TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000377636ENST00000377615TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000377636ENST00000377619TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
In-frameENST00000377636ENST00000355801TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5CDS-5UTRENST00000377636ENST00000460675TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000431480ENST00000406936TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000431480ENST00000377615TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000431480ENST00000377619TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
In-frameENST00000431480ENST00000355801TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5CDS-5UTRENST00000431480ENST00000460675TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5UTR-3CDSENST00000425511ENST00000377619TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5UTR-3CDSENST00000425511ENST00000355801TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5UTR-5UTRENST00000425511ENST00000460675TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000377625ENST00000406936TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000377625ENST00000377615TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
Frame-shiftENST00000377625ENST00000377619TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
In-frameENST00000377625ENST00000355801TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
5CDS-5UTRENST00000377625ENST00000460675TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
intron-3CDSENST00000478591ENST00000377619TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
intron-3CDSENST00000478591ENST00000355801TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
intron-5UTRENST00000478591ENST00000460675TBC1D4chr13

76055410

-COMMD6chr13

76100779

-
In-frameENST00000377636ENST00000406936TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377636ENST00000377615TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377636ENST00000377619TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377636ENST00000355801TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5CDS-5UTRENST00000377636ENST00000460675TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000431480ENST00000406936TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000431480ENST00000377615TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000431480ENST00000377619TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000431480ENST00000355801TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5CDS-5UTRENST00000431480ENST00000460675TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5UTR-3CDSENST00000425511ENST00000377619TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5UTR-3CDSENST00000425511ENST00000355801TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5UTR-5UTRENST00000425511ENST00000460675TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377625ENST00000406936TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377625ENST00000377615TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377625ENST00000377619TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377625ENST00000355801TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
5CDS-5UTRENST00000377625ENST00000460675TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
intron-3CDSENST00000478591ENST00000377619TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
intron-3CDSENST00000478591ENST00000355801TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
intron-5UTRENST00000478591ENST00000460675TBC1D4chr13

76055408

-COMMD6chr13

76104404

-
In-frameENST00000377636ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000377636ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377636ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377636ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377636ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000431480ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000431480ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000431480ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000431480ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000431480ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-3CDSENST00000425511ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-3CDSENST00000425511ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-intronENST00000425511ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-intronENST00000425511ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5UTR-intronENST00000425511ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000377625ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
In-frameENST00000377625ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377625ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377625ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
5CDS-intronENST00000377625ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-3CDSENST00000478591ENST00000406936TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-3CDSENST00000478591ENST00000377615TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-intronENST00000478591ENST00000377619TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-intronENST00000478591ENST00000355801TBC1D4chr13

76055406

-COMMD6chr13

76111811

-
intron-intronENST00000478591ENST00000460675TBC1D4chr13

76055406

-COMMD6chr13

76111811

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for TBC1D4-COMMD6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TBC1D4-COMMD6


check button Go to

FGviewer for the breakpoints of chr13:76055406-chr13:76100775

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COMMD6

Q7Z4G1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOMMD6chr13:76055406chr13:76104402ENST000003558011518_8518.099.0DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76104402ENST000003776152518_8518.086.0DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76104402ENST000004069361418_8518.086.0DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76111811ENST000003558010518_8514.099.0DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76111811ENST000003776151518_8514.086.0DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76111811ENST000004069360418_8514.086.0DomainCOMM
TgeneCOMMD6chr13:76055408chr13:76104404ENST000003558011518_8518.099.0DomainCOMM
TgeneCOMMD6chr13:76055408chr13:76104404ENST000003776152518_8518.086.0DomainCOMM
TgeneCOMMD6chr13:76055408chr13:76104404ENST000004069361418_8518.086.0DomainCOMM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377625-119672_759166.01236.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377636-121672_759166.01299.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000425511-120672_7590463.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000431480-120672_759166.01291.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-119672_759166.01236.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-121672_759166.01299.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-120672_7590463.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-120672_759166.01291.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-119672_759166.01236.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-121672_759166.01299.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-120672_7590463.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-120672_759166.01291.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377625-119672_759166.01236.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377636-121672_759166.01299.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000425511-120672_7590463.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000431480-120672_759166.01291.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377625-119672_759166.01236.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377636-121672_759166.01299.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000425511-120672_7590463.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000431480-120672_759166.01291.0Compositional biasNote=Ser-rich
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377625-119312_468166.01236.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377625-11953_209166.01236.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377625-119918_1112166.01236.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377636-121312_468166.01299.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377636-12153_209166.01299.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000377636-121918_1112166.01299.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000425511-120312_4680463.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000425511-12053_2090463.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000425511-120918_11120463.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000431480-120312_468166.01291.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000431480-12053_209166.01291.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76100775ENST00000431480-120918_1112166.01291.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-119312_468166.01236.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-11953_209166.01236.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377625-119918_1112166.01236.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-121312_468166.01299.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-12153_209166.01299.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000377636-121918_1112166.01299.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-120312_4680463.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-12053_2090463.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000425511-120918_11120463.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-120312_468166.01291.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-12053_209166.01291.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76104402ENST00000431480-120918_1112166.01291.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-119312_468166.01236.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-11953_209166.01236.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377625-119918_1112166.01236.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-121312_468166.01299.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-12153_209166.01299.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000377636-121918_1112166.01299.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-120312_4680463.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-12053_2090463.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000425511-120918_11120463.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-120312_468166.01291.0DomainPID 2
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-12053_209166.01291.0DomainPID 1
HgeneTBC1D4chr13:76055406chr13:76111811ENST00000431480-120918_1112166.01291.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377625-119312_468166.01236.0DomainPID 2
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377625-11953_209166.01236.0DomainPID 1
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377625-119918_1112166.01236.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377636-121312_468166.01299.0DomainPID 2
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377636-12153_209166.01299.0DomainPID 1
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000377636-121918_1112166.01299.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000425511-120312_4680463.0DomainPID 2
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000425511-12053_2090463.0DomainPID 1
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000425511-120918_11120463.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000431480-120312_468166.01291.0DomainPID 2
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000431480-12053_209166.01291.0DomainPID 1
HgeneTBC1D4chr13:76055408chr13:76104404ENST00000431480-120918_1112166.01291.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377625-119312_468166.01236.0DomainPID 2
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377625-11953_209166.01236.0DomainPID 1
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377625-119918_1112166.01236.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377636-121312_468166.01299.0DomainPID 2
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377636-12153_209166.01299.0DomainPID 1
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000377636-121918_1112166.01299.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000425511-120312_4680463.0DomainPID 2
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000425511-12053_2090463.0DomainPID 1
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000425511-120918_11120463.0DomainRab-GAP TBC
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000431480-120312_468166.01291.0DomainPID 2
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000431480-12053_209166.01291.0DomainPID 1
HgeneTBC1D4chr13:76055410chr13:76100779ENST00000431480-120918_1112166.01291.0DomainRab-GAP TBC
TgeneCOMMD6chr13:76055406chr13:76100775ENST000003558013518_8582.099.0DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76100775ENST000003776153518_8569.086.0DomainCOMM
TgeneCOMMD6chr13:76055406chr13:76100775ENST000004069362418_8569.086.0DomainCOMM
TgeneCOMMD6chr13:76055410chr13:76100779ENST000003558013518_8582.099.0DomainCOMM
TgeneCOMMD6chr13:76055410chr13:76100779ENST000003776153518_8569.086.0DomainCOMM
TgeneCOMMD6chr13:76055410chr13:76100779ENST000004069362418_8569.086.0DomainCOMM


Top

Fusion Gene Sequence for TBC1D4-COMMD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TBC1D4-COMMD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TBC1D4-COMMD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TBC1D4-COMMD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBC1D4C3495676Anorectal Malformations1GENOMICS_ENGLAND