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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:TBC1D5-AZI2 (FusionGDB2 ID:88765) |
Fusion Gene Summary for TBC1D5-AZI2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TBC1D5-AZI2 | Fusion gene ID: 88765 | Hgene | Tgene | Gene symbol | TBC1D5 | AZI2 | Gene ID | 9779 | 113451 |
Gene name | TBC1 domain family member 5 | antizyme inhibitor 2 | |
Synonyms | - | ADC|AZI2|AZIB1|ODC-p|ODC1L|ODCp | |
Cytomap | 3p24.3 | 1p35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | TBC1 domain family member 5 | antizyme inhibitor 2ODC antizyme inhibitor-2ODC-like proteinODC-paraloguearginine decarboxylaseornithine decarboxylase likeornithine decarboxylase-like proteinornithine decarboxylase-paralog | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | . | Q9H6S1 | |
Ensembl transtripts involved in fusion gene | ENST00000414318, ENST00000253692, ENST00000429383, ENST00000446818, ENST00000429924, | ENST00000479665, ENST00000295748, ENST00000334100, ENST00000420543, ENST00000457172, | |
Fusion gene scores | * DoF score | 20 X 16 X 9=2880 | 3 X 5 X 3=45 |
# samples | 22 | 4 | |
** MAII score | log2(22/2880*10)=-3.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TBC1D5 [Title/Abstract] AND AZI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | TBC1D5(17413567)-AZI2(28368441), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | TBC1D5-AZI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TBC1D5 | GO:0006914 | autophagy | 22354992 |
Hgene | TBC1D5 | GO:0042594 | response to starvation | 22354992 |
Tgene | AZI2 | GO:0042177 | negative regulation of protein catabolic process | 17900240 |
Fusion gene breakpoints across TBC1D5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across AZI2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | GBM | TCGA-02-2483-01A | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
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Fusion Gene ORF analysis for TBC1D5-AZI2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000414318 | ENST00000479665 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
intron-5UTR | ENST00000414318 | ENST00000295748 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
intron-intron | ENST00000414318 | ENST00000334100 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
intron-intron | ENST00000414318 | ENST00000420543 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
intron-intron | ENST00000414318 | ENST00000457172 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
Frame-shift | ENST00000253692 | ENST00000479665 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-5UTR | ENST00000253692 | ENST00000295748 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000253692 | ENST00000334100 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000253692 | ENST00000420543 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000253692 | ENST00000457172 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
In-frame | ENST00000429383 | ENST00000479665 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-5UTR | ENST00000429383 | ENST00000295748 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000429383 | ENST00000334100 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000429383 | ENST00000420543 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000429383 | ENST00000457172 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
Frame-shift | ENST00000446818 | ENST00000479665 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-5UTR | ENST00000446818 | ENST00000295748 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000446818 | ENST00000334100 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000446818 | ENST00000420543 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000446818 | ENST00000457172 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
In-frame | ENST00000429924 | ENST00000479665 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-5UTR | ENST00000429924 | ENST00000295748 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000429924 | ENST00000334100 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000429924 | ENST00000420543 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
5CDS-intron | ENST00000429924 | ENST00000457172 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000429383 | TBC1D5 | chr3 | 17413567 | - | ENST00000479665 | AZI2 | chr3 | 28368441 | - | 4699 | 1172 | 177 | 1703 | 508 |
ENST00000429924 | TBC1D5 | chr3 | 17413567 | - | ENST00000479665 | AZI2 | chr3 | 28368441 | - | 4549 | 1022 | 171 | 1553 | 460 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000429383 | ENST00000479665 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - | 0.000254924 | 0.9997451 |
ENST00000429924 | ENST00000479665 | TBC1D5 | chr3 | 17413567 | - | AZI2 | chr3 | 28368441 | - | 0.000327217 | 0.9996728 |
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Fusion Genomic Features for TBC1D5-AZI2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TBC1D5-AZI2 |
Go to FGviewer for the breakpoints of chr3:17413567-chr3:28368441 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | AZI2 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000253692 | - | 13 | 22 | 57_62 | 331.6666666666667 | 796.0 | Motif | LIR 1 |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000429383 | - | 13 | 22 | 57_62 | 331.6666666666667 | 796.0 | Motif | LIR 1 |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000446818 | - | 14 | 24 | 57_62 | 331.6666666666667 | 818.0 | Motif | LIR 1 |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000334100 | 0 | 7 | 102_196 | 0 | 233.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000334100 | 0 | 7 | 40_76 | 0 | 233.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000420543 | 0 | 7 | 102_196 | 0 | 244.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000420543 | 0 | 7 | 40_76 | 0 | 244.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000457172 | 0 | 8 | 102_196 | 0 | 244.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000457172 | 0 | 8 | 40_76 | 0 | 244.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000334100 | 0 | 7 | 1_197 | 0 | 233.0 | Region | Homodimerization | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000420543 | 0 | 7 | 1_197 | 0 | 244.0 | Region | Homodimerization | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000457172 | 0 | 8 | 1_197 | 0 | 244.0 | Region | Homodimerization |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000253692 | - | 13 | 22 | 81_359 | 331.6666666666667 | 796.0 | Domain | Rab-GAP TBC |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000429383 | - | 13 | 22 | 81_359 | 331.6666666666667 | 796.0 | Domain | Rab-GAP TBC |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000446818 | - | 14 | 24 | 81_359 | 331.6666666666667 | 818.0 | Domain | Rab-GAP TBC |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000253692 | - | 13 | 22 | 785_789 | 331.6666666666667 | 796.0 | Motif | LIR 2 |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000429383 | - | 13 | 22 | 785_789 | 331.6666666666667 | 796.0 | Motif | LIR 2 |
Hgene | TBC1D5 | chr3:17413567 | chr3:28368441 | ENST00000446818 | - | 14 | 24 | 785_789 | 331.6666666666667 | 818.0 | Motif | LIR 2 |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000479665 | 5 | 8 | 102_196 | 215.66666666666666 | 393.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000479665 | 5 | 8 | 40_76 | 215.66666666666666 | 393.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000479665 | 5 | 8 | 1_197 | 215.66666666666666 | 393.0 | Region | Homodimerization |
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Fusion Gene Sequence for TBC1D5-AZI2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000429383_ENST00000479665_TCGA-02-2483-01A_TBC1D5_chr3_17413567_-_AZI2_chr3_28368441_length(transcript)=4699nt_BP=1172nt AGCCCTTCTGCGCCACAGAGATGGGGTCTCACTCTGTCATCCAGGCTGGAATATAGTGGCACAATCATAGCCCATTGTAGCCTCCATCTC AAGGACTCAGGGGATCCTCCCTTCTAGGCCTCCCAAGTAGCTGGGATTACAGGTAGTTACTTTTGGTGACGCTGTCCAGTTCCCACAATG TATCATTCCTTATCTGAAACTAGACATCCTCTGCAGCCAGAAGAACAAGAAGTAGGCATTGACCCCTTGTCCAGTTACTCTAACAAGTCT GGAGGAGATTCAAATAAAAATGGAAGAAGAACAAGTTCTACTTTAGACTCTGAAGGGACTTTTAATTCCTATAGGAAAGAATGGGAAGAA CTATTTGTAAACAACAATTACTTGGCAACAATAAGGCAGAAGGGGATTAATGGGCAGCTGAGAAGCAGCAGGTTCCGCAGCATTTGCTGG AAGCTATTTCTTTGTGTTCTTCCTCAAGACAAAAGTCAATGGATAAGTAGAATTGAAGAATTAAGAGCATGGTATAGCAACATTAAAGAA ATACATATTACCAACCCGAGGAAGGTTGTTGGCCAACAAGATTTGATGATCAATAATCCTCTTTCACAGGATGAAGGGAGTCTTTGGAAC AAATTCTTCCAAGATAAAGAACTTCGATCAATGATTGAACAAGATGTCAAAAGAACGTTTCCTGAAATGCAGTTTTTCCAGCAAGAAAAT GTGAGAAAAATTCTTACAGATGTTCTTTTCTGTTATGCCAGAGAAAACGAGCAGTTGCTTTATAAACAGGGCATGCACGAACTGTTAGCA CCTATAGTCTTTGTCCTTCACTGTGACCACCAAGCTTTTCTACATGCCAGTGAGTCTGCACAGCCCAGTGAGGAAATGAAAACTGTCTTG AACCCTGAGTATCTGGAACATGATGCCTATGCAGTGTTCTCACAACTTATGGAAACTGCTGAACCTTGGTTTTCAACTTTTGAGCATGAT GGTCAGAAGGGGAAAGAAACACTGATGACTCCCATTCCCTTTGCTAGACCACAAGATTTAGGGCCAACAATTGCTATTGTTACTAAAGTC AACCAGATCCAGGATCATCTACTGAAGAAGCATGATATTGAGCTTTACATGCACTTGAACAGACTAGAAATTGCACCACAGATATATGGG TTTGATAATATGCAGCATGCATACTGGGAACTGAAGAGAGAAATGTCTAATTTACATCTGGTGACTCAAGTACAAGCTGAACTACTAAGA AAACTGAAAACCTCAACTGCAATCAAGAAAGCCTGTGCCCCTGTAGGATGCAGTGAAGACCTTGGAAGAGACAGCACAAAACTGCACTTG ATGAATTTTACTGCAACATACACAAGACATCCCCCTCTCTTACCAAATGGCAAAGCTCTTTGTCATACCACATCTTCCCCTTTACCAGGA GATGTAAAGGTTTTATCAGAGAAAGCAATCCTCCAATCATGGACAGACAATGAGAGATCCATTCCTAATGATGGTACATGCTTTCAGGAA CACAGTTCTTATGGCAGAAATTCTCTGGAAGACAATTCCTGGGTATTTCCAAGTCCTCCTAAATCAAGTGAGACAGCATTTGGGGAAACT AAAACTAAAACTTTGCCTTTACCCAACCTTCCACCACTGCATTACTTGGATCAACATAATCAGAACTGCCTTTATAAGAATTAATTTGGA AGAGATTCACGATTTCACCATGAGGACACTTATCTCTTTCAGTGGTCCTCCCAAGAAATTATTTAACAAACTGAAAGGAGATTTTGATTA AAATTTTGCAGAGGTCTTCAGTATCTATATTTGAACACACTGTACAATAGTACAAAAACCAACATAGTTGGTTTTCTAGTATGAAAGAGC ACCCTCTAGCTCCATATTCTAAGAATCTGAAATATGCTACTATACTAATTAATAAGTAAACTTAAGGTGTTTAAAAAACTCTGCCTTCTA TATTAATTGTAAAATTTTGCCTCTCAGAAGAATGGAATTGGAGATTGTAGACGTGGTTTTACAAAATGTGAAATGTCTAAATATCTGTTC ATAAAAATAAAAGGAAAACATGTTTCTTCAAATTGCATAATGGAACAAATGGCAATGTGAGTAGGTTACATTTCTGTTGTTATAATGCGT AAAGATATTGAAAATATAATGAAATAAAAGCATCTTAGGTTATACCATCTTTATATGCTATTGCGTTTCAATATTTAAGATTTAAAGTGA TTTTTTGGTCACAGTGTTTTGTTGATAAAATTTTTTTAGAATTGAAGTTTGAATTCTAAGACTTGAAACAACCTGATCACTGAAGCCAAC TTTGTCCCAGCACATTCCTTAAGTCCTAATTGGGAAAAAAAAAAAAAAAAATGAAATAGTTGAAAAACTCTGGGGTGTAAACAAATGATT GTAACCCTACACACTATTCAATAAGTAGTAGAAGGAGCATCACACAGATTTCAGTCTAATCTGCCCTTCTGTGGGCCATAATATAAACAT AAATGTGTGTAATGATAAAAAGTCATTTTCTTCAAAGAGACTACAGCTAGCTGCACATTGTGTAGAGCAGCTTCTAAATTGTTAGACTTT GTGTTGAAATGTAATATTCTATTTATTGAGAAAGTGATTTAAAATTATTATTTTTAATCATAGAAATCAGGGTTTGGGCTGTATTGATAT TGTCGATCATGAAATGTCCACACTTATTCTAAGTGGCCAATTATTTGGAAATAAAGAAGGAAATAAAGATGGCTTCACATGGAAATTTAA GTTCTTTCAGGGTGGAGATTTACTTGGTTCATACACCTTTTGCCTGAATTAAAGTATTTCATGTAGGAGGACTTTTATCCTTTTTGATAG ACAGTTTCATATATCTTGAACTCAATATCTCAGATCTCTTCTACTGTATTACTGAATAGCATACATACATAGACAATGTTCGCCATTCAC TAGATATTTTTTTCTATTATCTTACACTTATTCAAGCTTGTCTGTGATTAATGGAATTGGTGTCAGATGCTGGAATTTATTCTGACCAAT GAACACAGCTGACTCAGGGGAGTACAATCTCCTGCCAAGTAATAGAACCAAACCCAATATGCATAAAAGAAATACAATACTCCAGGCTTT AGCTGAAGGAAGCAACTACCTGTGTAATAACAAAGCAGCAAAAACTATTTCTCATGTGGCTGCATAGGCTGTATATTATATCTGATCTCT AATGTAGCTTACTGGTTTGCCTTTTTTAAAACCAAAATTGGAAATTTTCCTTTGTAAAGAAAAAAAGTCTTATGAGATAATTGCTTGATT AATGTTTTGAACAATACCAAGAAATTGTTTAATTAAAATAAATATTTTTGTTTGAAATTGAAGTGGATGTGAAATATTGTCCTTGCCTAT AGATCTCAAAATCTAGTACTAATTGTTGGTTGTTAATATGATTCATACAATAGACATTTGTTAAACCAGCTTTTGAGTGGAGAAAATTAT TTTCCATTTAAACAGTACAGTGATGATAGCTATCAAACAGGTATACTAAAAAGTCAGTGACTGTGACAGTTTAAAGTGTTAGACAAATGA TGTATAAGGTTCTTTAGTAAGGAAAGATTAGCCAAAAATTTTTTACCCAGCTAGAAGCTTTTAAATCTACACTTGATATCTCTGTTCTAG GTAAAATTCAAACAACCAAAAAACAGTGGCCCATCTGTAGCTTATGAATCTATTTAAAATTGAATATTTTATGTTGACTTCTTTCATACT AGCTGAAACTTGCTCTAAAGAGCTTCCTTTGGAATCTTTAGATTTCTTTTTATAAGGTTCAATTCAGTACATCCATAAATCGACAGAATG AAGAAAACATAACAAAAAGCCACCTATTCCTTCCTCTTGCTCCCTTATTAGCTAAAGTAAAATTTACATCTGTAAGACTTACTGAGTTGC TGCCAAAATGGAACTGAATTCTTAAAAGCAGGAACATGCCTATGTGAAACATTAGAAAACCAAAATAAATGGGAAAATTCAGACTTGAAG AGCTGAATCATGTGACAACAAAGTACTGATCTTAATTCAGAAAGGCTACTTGGAGAAGGTGTATCTTAAGGGGTAAAAAACCTGTGGGTT ACCACATATTAACAGGGAATAATATCAACAGAGGCACCCATAAGCAAGCAAGACACAACTGAGACAGATGTACCAGGTGAAAAAAATCTT CAGTATGGATACACATGGGTATTCTGAAGGCTACAATGAATGGTTTAGTCTTTGACATAAGGAGGATGAACATATTATTTATACTGTGTA ATCTAATCTGGCTTCTATGGGGAAAGCAACATGTACATAAGTGAATTTTCTACATGAAGTGGGCTACTTCTGATTTTAATCAAAGCTATA AAATAGATTGTATATTTCACTAGCTTCTTAAAGTAACTCTTCCATTTTCATTTATCTCTAAAAACAGTTAACTTCCTGTGCTCTAGGAAA TGCACCAATACCAAAGGTCAATGTGGAAATATGGGCATGTTTGCCCCTATGCTGTGTGGTCTCTAGATTTCTATATTTGCTTTGCTTTTG TCTGCTCTAGTAATCTCCCTCCTTTTGATCTGTGGCCTGGGAAAATGTGGTTTCTTTGTATTTCAAATAAAAGTAAAATAGTTTTTTGAG >In-frame_ENST00000429383_ENST00000479665_TCGA-02-2483-01A_TBC1D5_chr3_17413567_-_AZI2_chr3_28368441_length(amino acids)=508AA_start in transcript=177_stop in transcript=1703 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSIC WKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEH DGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGFDNMQHAYWELKREMSNLHLVTQVQAELL RKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQ -------------------------------------------------------------- >In-frame_ENST00000429924_ENST00000479665_TCGA-02-2483-01A_TBC1D5_chr3_17413567_-_AZI2_chr3_28368441_length(transcript)=4549nt_BP=1022nt ACATATTCATTAAATCTACGGAAGAACTGTGTCCAAAAAGACAGCCATGCGTTCAGAAACAGTACACAACTAAATATATATGTTTTAAAA GTTGCATTTTTTAGACTTACTTAAAATTAATTTCCCGTAGAACTTCTCTCCAAGCAGAGGAATTTTAACAAAAGGATTCTCATGCTTTGG TTTCTTTCATATAGGAAAGAATGGGAAGAACTATTTGTAAACAACAATTACTTGGCAACAATAAGGCAGAAGGGGATTAATGGGCAGCTG AGAAGCAGCAGGTTCCGCAGCATTTGCTGGAAGCTATTTCTTTGTGTTCTTCCTCAAGACAAAAGTCAATGGATAAGTAGAATTGAAGAA TTAAGAGCATGGTATAGCAACATTAAAGAAATACATATTACCAACCCGAGGAAGGTTGTTGGCCAACAAGATTTGATGATCAATAATCCT CTTTCACAGGATGAAGGGAGTCTTTGGAACAAATTCTTCCAAGATAAAGAACTTCGATCAATGATTGAACAAGATGTCAAAAGAACGTTT CCTGAAATGCAGTTTTTCCAGCAAGAAAATGTGAGAAAAATTCTTACAGATGTTCTTTTCTGTTATGCCAGAGAAAACGAGCAGTTGCTT TATAAACAGGGCATGCACGAACTGTTAGCACCTATAGTCTTTGTCCTTCACTGTGACCACCAAGCTTTTCTACATGCCAGTGAGTCTGCA CAGCCCAGTGAGGAAATGAAAACTGTCTTGAACCCTGAGTATCTGGAACATGATGCCTATGCAGTGTTCTCACAACTTATGGAAACTGCT GAACCTTGGTTTTCAACTTTTGAGCATGATGGTCAGAAGGGGAAAGAAACACTGATGACTCCCATTCCCTTTGCTAGACCACAAGATTTA GGGCCAACAATTGCTATTGTTACTAAAGTCAACCAGATCCAGGATCATCTACTGAAGAAGCATGATATTGAGCTTTACATGCACTTGAAC AGACTAGAAATTGCACCACAGATATATGGGTTTGATAATATGCAGCATGCATACTGGGAACTGAAGAGAGAAATGTCTAATTTACATCTG GTGACTCAAGTACAAGCTGAACTACTAAGAAAACTGAAAACCTCAACTGCAATCAAGAAAGCCTGTGCCCCTGTAGGATGCAGTGAAGAC CTTGGAAGAGACAGCACAAAACTGCACTTGATGAATTTTACTGCAACATACACAAGACATCCCCCTCTCTTACCAAATGGCAAAGCTCTT TGTCATACCACATCTTCCCCTTTACCAGGAGATGTAAAGGTTTTATCAGAGAAAGCAATCCTCCAATCATGGACAGACAATGAGAGATCC ATTCCTAATGATGGTACATGCTTTCAGGAACACAGTTCTTATGGCAGAAATTCTCTGGAAGACAATTCCTGGGTATTTCCAAGTCCTCCT AAATCAAGTGAGACAGCATTTGGGGAAACTAAAACTAAAACTTTGCCTTTACCCAACCTTCCACCACTGCATTACTTGGATCAACATAAT CAGAACTGCCTTTATAAGAATTAATTTGGAAGAGATTCACGATTTCACCATGAGGACACTTATCTCTTTCAGTGGTCCTCCCAAGAAATT ATTTAACAAACTGAAAGGAGATTTTGATTAAAATTTTGCAGAGGTCTTCAGTATCTATATTTGAACACACTGTACAATAGTACAAAAACC AACATAGTTGGTTTTCTAGTATGAAAGAGCACCCTCTAGCTCCATATTCTAAGAATCTGAAATATGCTACTATACTAATTAATAAGTAAA CTTAAGGTGTTTAAAAAACTCTGCCTTCTATATTAATTGTAAAATTTTGCCTCTCAGAAGAATGGAATTGGAGATTGTAGACGTGGTTTT ACAAAATGTGAAATGTCTAAATATCTGTTCATAAAAATAAAAGGAAAACATGTTTCTTCAAATTGCATAATGGAACAAATGGCAATGTGA GTAGGTTACATTTCTGTTGTTATAATGCGTAAAGATATTGAAAATATAATGAAATAAAAGCATCTTAGGTTATACCATCTTTATATGCTA TTGCGTTTCAATATTTAAGATTTAAAGTGATTTTTTGGTCACAGTGTTTTGTTGATAAAATTTTTTTAGAATTGAAGTTTGAATTCTAAG ACTTGAAACAACCTGATCACTGAAGCCAACTTTGTCCCAGCACATTCCTTAAGTCCTAATTGGGAAAAAAAAAAAAAAAAATGAAATAGT TGAAAAACTCTGGGGTGTAAACAAATGATTGTAACCCTACACACTATTCAATAAGTAGTAGAAGGAGCATCACACAGATTTCAGTCTAAT CTGCCCTTCTGTGGGCCATAATATAAACATAAATGTGTGTAATGATAAAAAGTCATTTTCTTCAAAGAGACTACAGCTAGCTGCACATTG TGTAGAGCAGCTTCTAAATTGTTAGACTTTGTGTTGAAATGTAATATTCTATTTATTGAGAAAGTGATTTAAAATTATTATTTTTAATCA TAGAAATCAGGGTTTGGGCTGTATTGATATTGTCGATCATGAAATGTCCACACTTATTCTAAGTGGCCAATTATTTGGAAATAAAGAAGG AAATAAAGATGGCTTCACATGGAAATTTAAGTTCTTTCAGGGTGGAGATTTACTTGGTTCATACACCTTTTGCCTGAATTAAAGTATTTC ATGTAGGAGGACTTTTATCCTTTTTGATAGACAGTTTCATATATCTTGAACTCAATATCTCAGATCTCTTCTACTGTATTACTGAATAGC ATACATACATAGACAATGTTCGCCATTCACTAGATATTTTTTTCTATTATCTTACACTTATTCAAGCTTGTCTGTGATTAATGGAATTGG TGTCAGATGCTGGAATTTATTCTGACCAATGAACACAGCTGACTCAGGGGAGTACAATCTCCTGCCAAGTAATAGAACCAAACCCAATAT GCATAAAAGAAATACAATACTCCAGGCTTTAGCTGAAGGAAGCAACTACCTGTGTAATAACAAAGCAGCAAAAACTATTTCTCATGTGGC TGCATAGGCTGTATATTATATCTGATCTCTAATGTAGCTTACTGGTTTGCCTTTTTTAAAACCAAAATTGGAAATTTTCCTTTGTAAAGA AAAAAAGTCTTATGAGATAATTGCTTGATTAATGTTTTGAACAATACCAAGAAATTGTTTAATTAAAATAAATATTTTTGTTTGAAATTG AAGTGGATGTGAAATATTGTCCTTGCCTATAGATCTCAAAATCTAGTACTAATTGTTGGTTGTTAATATGATTCATACAATAGACATTTG TTAAACCAGCTTTTGAGTGGAGAAAATTATTTTCCATTTAAACAGTACAGTGATGATAGCTATCAAACAGGTATACTAAAAAGTCAGTGA CTGTGACAGTTTAAAGTGTTAGACAAATGATGTATAAGGTTCTTTAGTAAGGAAAGATTAGCCAAAAATTTTTTACCCAGCTAGAAGCTT TTAAATCTACACTTGATATCTCTGTTCTAGGTAAAATTCAAACAACCAAAAAACAGTGGCCCATCTGTAGCTTATGAATCTATTTAAAAT TGAATATTTTATGTTGACTTCTTTCATACTAGCTGAAACTTGCTCTAAAGAGCTTCCTTTGGAATCTTTAGATTTCTTTTTATAAGGTTC AATTCAGTACATCCATAAATCGACAGAATGAAGAAAACATAACAAAAAGCCACCTATTCCTTCCTCTTGCTCCCTTATTAGCTAAAGTAA AATTTACATCTGTAAGACTTACTGAGTTGCTGCCAAAATGGAACTGAATTCTTAAAAGCAGGAACATGCCTATGTGAAACATTAGAAAAC CAAAATAAATGGGAAAATTCAGACTTGAAGAGCTGAATCATGTGACAACAAAGTACTGATCTTAATTCAGAAAGGCTACTTGGAGAAGGT GTATCTTAAGGGGTAAAAAACCTGTGGGTTACCACATATTAACAGGGAATAATATCAACAGAGGCACCCATAAGCAAGCAAGACACAACT GAGACAGATGTACCAGGTGAAAAAAATCTTCAGTATGGATACACATGGGTATTCTGAAGGCTACAATGAATGGTTTAGTCTTTGACATAA GGAGGATGAACATATTATTTATACTGTGTAATCTAATCTGGCTTCTATGGGGAAAGCAACATGTACATAAGTGAATTTTCTACATGAAGT GGGCTACTTCTGATTTTAATCAAAGCTATAAAATAGATTGTATATTTCACTAGCTTCTTAAAGTAACTCTTCCATTTTCATTTATCTCTA AAAACAGTTAACTTCCTGTGCTCTAGGAAATGCACCAATACCAAAGGTCAATGTGGAAATATGGGCATGTTTGCCCCTATGCTGTGTGGT CTCTAGATTTCTATATTTGCTTTGCTTTTGTCTGCTCTAGTAATCTCCCTCCTTTTGATCTGTGGCCTGGGAAAATGTGGTTTCTTTGTA >In-frame_ENST00000429924_ENST00000479665_TCGA-02-2483-01A_TBC1D5_chr3_17413567_-_AZI2_chr3_28368441_length(amino acids)=460AA_start in transcript=171_stop in transcript=1553 MLWFLSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMI NNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHAS ESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYM HLNRLEIAPQIYGFDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNG KALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSETAFGETKTKTLPLPNLPPLHYLD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TBC1D5-AZI2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000334100 | 0 | 7 | 216_257 | 0 | 233.0 | TBK1 and IKBKE | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000420543 | 0 | 7 | 216_257 | 0 | 244.0 | TBK1 and IKBKE | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000457172 | 0 | 8 | 216_257 | 0 | 244.0 | TBK1 and IKBKE | |
Tgene | AZI2 | chr3:17413567 | chr3:28368441 | ENST00000479665 | 5 | 8 | 216_257 | 215.66666666666666 | 393.0 | TBK1 and IKBKE |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TBC1D5-AZI2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TBC1D5-AZI2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |