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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBCB-B3GALNT1 (FusionGDB2 ID:88833)

Fusion Gene Summary for TBCB-B3GALNT1

check button Fusion gene summary
Fusion gene informationFusion gene name: TBCB-B3GALNT1
Fusion gene ID: 88833
HgeneTgene
Gene symbol

TBCB

B3GALNT1

Gene ID

1155

8706

Gene nametubulin folding cofactor Bbeta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
SynonymsCG22|CKAP1|CKAPIB3GALT3|GLCT3|GLOB|Gb4Cer|P|P1|beta3Gal-T3|galT3
Cytomap

19q13.12

3q26.1

Type of geneprotein-codingprotein-coding
Descriptiontubulin-folding cofactor Bcytoskeleton associated protein 1cytoskeleton-associated protein CKAPItubulin-specific chaperone BUDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1P antigen synthaseP blood group globosideUDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 (Globoside blood group)UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypepti
Modification date2020031320200313
UniProtAcc.

O75752

Ensembl transtripts involved in fusion geneENST00000221855, ENST00000392178, 
ENST00000589996, ENST00000585746, 
ENST00000586868, 		ENST00000320474, 
ENST00000392779, ENST00000392780, 
ENST00000392781, ENST00000473285, 
ENST00000417187, ENST00000488170, 
ENST00000494818, 
Fusion gene scores* DoF score7 X 6 X 4=1681 X 1 X 1=1
# samples 71
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: TBCB [Title/Abstract] AND B3GALNT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBCB(36611637)-B3GALNT1(160804539), # samples:1
Anticipated loss of major functional domain due to fusion event.TBCB-B3GALNT1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TBCB-B3GALNT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TBCB-B3GALNT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TBCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across B3GALNT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA235308TBCBchr19

36611637

+B3GALNT1chr3

160804539

-


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Fusion Gene ORF analysis for TBCB-B3GALNT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000221855ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000221855ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000221855ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000221855ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
5CDS-intronENST00000221855ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-3CDSENST00000392178ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
3UTR-intronENST00000392178ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000589996ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000589996ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000589996ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
5CDS-intronENST00000589996ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000585746ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
Frame-shiftENST00000585746ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
In-frameENST00000585746ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
5CDS-intronENST00000585746ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000320474TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000392779TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000392780TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000392781TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000473285TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000417187TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-3CDSENST00000586868ENST00000488170TBCBchr19

36611637

+B3GALNT1chr3

160804539

-
intron-intronENST00000586868ENST00000494818TBCBchr19

36611637

+B3GALNT1chr3

160804539

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000221855TBCBchr1936611637+ENST00000473285B3GALNT1chr3160804539-26739048201896358
ENST00000221855TBCBchr1936611637+ENST00000488170B3GALNT1chr3160804539-18979048201896359
ENST00000589996TBCBchr1936611637+ENST00000473285B3GALNT1chr3160804539-21403712871363358
ENST00000589996TBCBchr1936611637+ENST00000488170B3GALNT1chr3160804539-13643712871363359
ENST00000585746TBCBchr1936611637+ENST00000473285B3GALNT1chr3160804539-20753062221298358
ENST00000585746TBCBchr1936611637+ENST00000488170B3GALNT1chr3160804539-12993062221298358

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000221855ENST00000473285TBCBchr1936611637+B3GALNT1chr3160804539-0.0020800710.99792
ENST00000221855ENST00000488170TBCBchr1936611637+B3GALNT1chr3160804539-0.0103217010.98967826
ENST00000589996ENST00000473285TBCBchr1936611637+B3GALNT1chr3160804539-0.0012001790.9987998
ENST00000589996ENST00000488170TBCBchr1936611637+B3GALNT1chr3160804539-0.0043352880.9956648
ENST00000585746ENST00000473285TBCBchr1936611637+B3GALNT1chr3160804539-0.0011338930.9988661
ENST00000585746ENST00000488170TBCBchr1936611637+B3GALNT1chr3160804539-0.0031136240.9968863

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Fusion Genomic Features for TBCB-B3GALNT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBCB-B3GALNT1


check button Go to

FGviewer for the breakpoints of chr19:36611637-chr3:160804539

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.B3GALNT1

O75752

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transfers N-acetylgalactosamine onto globotriaosylceramide (PubMed:10993897). Plays a critical role in preimplantation stage embryonic development (By similarity). {ECO:0000250|UniProtKB:Q920V1, ECO:0000269|PubMed:10993897}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneB3GALNT1chr19:36611637chr3:160804539ENST00000320474051_200332.0Topological domainCytoplasmic
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003204740544_3310332.0Topological domainLumenal
TgeneB3GALNT1chr19:36611637chr3:160804539ENST00000392779041_200332.0Topological domainCytoplasmic
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003927790444_3310332.0Topological domainLumenal
TgeneB3GALNT1chr19:36611637chr3:160804539ENST00000392780061_200332.0Topological domainCytoplasmic
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003927800644_3310332.0Topological domainLumenal
TgeneB3GALNT1chr19:36611637chr3:160804539ENST00000392781081_200332.0Topological domainCytoplasmic
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003927810844_3310332.0Topological domainLumenal
TgeneB3GALNT1chr19:36611637chr3:160804539ENST00000473285051_200332.0Topological domainCytoplasmic
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000004732850544_3310332.0Topological domainLumenal
TgeneB3GALNT1chr19:36611637chr3:160804539ENST00000488170051_200332.0Topological domainCytoplasmic
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000004881700544_3310332.0Topological domainLumenal
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003204740521_430332.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003927790421_430332.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003927800621_430332.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000003927810821_430332.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000004732850521_430332.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneB3GALNT1chr19:36611637chr3:160804539ENST000004881700521_430332.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCBchr19:36611637chr3:160804539ENST00000221855+16183_2250245.0DomainCAP-Gly


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Fusion Gene Sequence for TBCB-B3GALNT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000221855_ENST00000473285_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(transcript)=2673nt_BP=904nt
GCCGCCTCGGGCTCGGCTCTCTCCGCGCAGAGGTTTCATGGCTTGCTTCAATCTTTTGATATCTTAGAGTAATTGCTTCCAATTTTTGGG
CATCGCCGCCTCAGTTTACAGAATAGTATGGATCTGGTGCCAGAGCCGGGAAAACGATGCGCATCGTAAACCGCAAAACACTGAGCATCC
AGGACAGAAGCCAAGGCGCTTGGCTTGGTTGAAGGCCAGTGCGCATGCGCGAGTTTACCCTTCGCGGACTGGGCGAGCTCTTGCCACTCC
TACCTCCGGGCTTCAGTCTTCGCCGCCTGTTCTGGTCCTTTCCCGGGCCGCTATTGGAAGAACCGTGAACTATGGAAGGCCCCTCTGGAT
TGGCTGGGCTGGCCCAAGAGTAAGGAGAGCCCTCTTCCTGGCGGTGGGGAAGGGACGGCGGCGATTGGCGGACGCTCCTGGCAGGAGAGC
GCGGATTGGTCAGGCACGGAGCAGGAGGCGGGGCTGATAGCCCAGCAGCAGCAGCGGCGGCGGCGGCTGCGGAGCGGGTGTGAGGCGGCT
GGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGCAGCTCCC
TCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGTGTAAACTGGAGTTGCTGGTGGGCAGCCCTG
CTTCCTGCATGGAACTGGAGCTGTATGGAGTTGACGACAAGTTCTACAGCAAGCTGGATCAAGAGGATGCGCTCCTGGGCTCCTACCCTG
TAGATGACGGCTGCCGCATCCACTGGTGAGTATGAGGACGTGTCCCGGGTGGAGAAGTACACGATCTCACAAGAAGCCTACGACCAGAGG
CAAGGCCTCGGCTCTCTGGACTGTCCTTCCGAGTAGGATGTCACTGAGATCCCTCAAATGGAGCCTCCTGCTGCTGTCACTCCTGAGTTT
CTTTGTGATGTGGTACCTCAGCCTTCCCCACTACAATGTGATAGAACGCGTGAACTGGATGTACTTCTATGAGTATGAGCCGATTTACAG
ACAAGACTTTCACTTCACACTTCGAGAGCATTCAAACTGCTCTCATCAAAATCCATTTCTGGTCATTCTGGTGACCTCCCACCCTTCAGA
TGTGAAAGCCAGGCAGGCCATTAGAGTTACTTGGGGTGAAAAAAAGTCTTGGTGGGGATATGAGGTTCTTACATTTTTCTTATTAGGCCA
AGAGGCTGAAAAGGAAGACAAAATGTTGGCATTGTCCTTAGAGGATGAACACCTTCTTTATGGTGACATAATCCGACAAGATTTTTTAGA
CACATATAATAACCTGACCTTGAAAACCATTATGGCATTCAGGTGGGTAACTGAGTTTTGCCCCAATGCCAAGTACGTAATGAAGACAGA
CACTGATGTTTTCATCAATACTGGCAATTTAGTGAAGTATCTTTTAAACCTAAACCACTCAGAGAAGTTTTTCACAGGTTATCCTCTAAT
TGATAATTATTCCTATAGAGGATTTTACCAAAAAACCCATATTTCTTACCAGGAGTATCCTTTCAAGGTGTTCCCTCCATACTGCAGTGG
GTTGGGTTATATAATGTCCAGAGATTTGGTGCCAAGGATCTATGAAATGATGGGTCACGTAAAACCCATCAAGTTTGAAGATGTTTATGT
CGGGATCTGTTTGAATTTATTAAAAGTGAACATTCATATTCCAGAAGACACAAATCTTTTCTTTCTATATAGAATCCATTTGGATGTCTG
TCAACTGAGACGTGTGATTGCAGCCCATGGCTTTTCTTCCAAGGAGATCATCACTTTTTGGCAGGTCATGCTAAGGAACACCACATGCCA
TTATTAACTTCACATTCTACAAAAAGCCTAGAAGGACAGGATACTTTGTGGAAAGTGTTAAATAAAGTAGGTACTGTGGAAAATTCATGG
GGAGGTCAGTGTGCTGGCTTACACTGAACTGAAACTCATGAAAAACCCAGACTGGAGACTGGAGGGTTACACTTGTGATTTATTAGTCAG
GCCCTTCAAAGATGATATGTGGAGGAATTAAATATAAAGGAATTGGAGGTTTTTGCTAAAGAAATTAATAGGACCAAACAATTTGGACAT
GTCATTCTGTAGACTAGAATTTCTTAAAAGGGTGTTACTGAGTTATAAGCTCACTAGGCTGTAAAAACAAAACAATGTAGAGTTTTATTT
ATTGAACAATGTAGTCACTTGAAGGTTTTGTGTATATCTTATGTGGATTACCAATTTAAAAATATATGTAGTTCTGTGTCAAAAAACTTC
TTCACTGAAGTTATACTGAACAAAATTTTACCTGTTTTTGGTCATTTATAAAGTACTTCAAGATGTTGCAGTATTTCACAGTTATTATTA
TTTAAAATTACTTCAACTTTGTGTTTTTAAATGTTTTGACGATTTCAATACAAGATAAAAAGGATAGTGAATCATTCTTTACATGCAAAC
ATTTTCCAGTTACTTAACTGATCAGTTTATTATTGATACATCACTCCATTAATGTAAAGTCATAGGTCATTATTGCATATCAGTAATCTC

>In-frame_ENST00000221855_ENST00000473285_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(amino acids)=358AA_start in transcript=820_stop in transcript=1896
MPHPLVSMRTCPGWRSTRSHKKPTTRGKASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDF
HFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYN
NLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGY

--------------------------------------------------------------
>In-frame_ENST00000221855_ENST00000488170_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(transcript)=1897nt_BP=904nt
GCCGCCTCGGGCTCGGCTCTCTCCGCGCAGAGGTTTCATGGCTTGCTTCAATCTTTTGATATCTTAGAGTAATTGCTTCCAATTTTTGGG
CATCGCCGCCTCAGTTTACAGAATAGTATGGATCTGGTGCCAGAGCCGGGAAAACGATGCGCATCGTAAACCGCAAAACACTGAGCATCC
AGGACAGAAGCCAAGGCGCTTGGCTTGGTTGAAGGCCAGTGCGCATGCGCGAGTTTACCCTTCGCGGACTGGGCGAGCTCTTGCCACTCC
TACCTCCGGGCTTCAGTCTTCGCCGCCTGTTCTGGTCCTTTCCCGGGCCGCTATTGGAAGAACCGTGAACTATGGAAGGCCCCTCTGGAT
TGGCTGGGCTGGCCCAAGAGTAAGGAGAGCCCTCTTCCTGGCGGTGGGGAAGGGACGGCGGCGATTGGCGGACGCTCCTGGCAGGAGAGC
GCGGATTGGTCAGGCACGGAGCAGGAGGCGGGGCTGATAGCCCAGCAGCAGCAGCGGCGGCGGCGGCTGCGGAGCGGGTGTGAGGCGGCT
GGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGCAGCTCCC
TCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGTGTAAACTGGAGTTGCTGGTGGGCAGCCCTG
CTTCCTGCATGGAACTGGAGCTGTATGGAGTTGACGACAAGTTCTACAGCAAGCTGGATCAAGAGGATGCGCTCCTGGGCTCCTACCCTG
TAGATGACGGCTGCCGCATCCACTGGTGAGTATGAGGACGTGTCCCGGGTGGAGAAGTACACGATCTCACAAGAAGCCTACGACCAGAGG
CAAGGCCTCGGCTCTCTGGACTGTCCTTCCGAGTAGGATGTCACTGAGATCCCTCAAATGGAGCCTCCTGCTGCTGTCACTCCTGAGTTT
CTTTGTGATGTGGTACCTCAGCCTTCCCCACTACAATGTGATAGAACGCGTGAACTGGATGTACTTCTATGAGTATGAGCCGATTTACAG
ACAAGACTTTCACTTCACACTTCGAGAGCATTCAAACTGCTCTCATCAAAATCCATTTCTGGTCATTCTGGTGACCTCCCACCCTTCAGA
TGTGAAAGCCAGGCAGGCCATTAGAGTTACTTGGGGTGAAAAAAAGTCTTGGTGGGGATATGAGGTTCTTACATTTTTCTTATTAGGCCA
AGAGGCTGAAAAGGAAGACAAAATGTTGGCATTGTCCTTAGAGGATGAACACCTTCTTTATGGTGACATAATCCGACAAGATTTTTTAGA
CACATATAATAACCTGACCTTGAAAACCATTATGGCATTCAGGTGGGTAACTGAGTTTTGCCCCAATGCCAAGTACGTAATGAAGACAGA
CACTGATGTTTTCATCAATACTGGCAATTTAGTGAAGTATCTTTTAAACCTAAACCACTCAGAGAAGTTTTTCACAGGTTATCCTCTAAT
TGATAATTATTCCTATAGAGGATTTTACCAAAAAACCCATATTTCTTACCAGGAGTATCCTTTCAAGGTGTTCCCTCCATACTGCAGTGG
GTTGGGTTATATAATGTCCAGAGATTTGGTGCCAAGGATCTATGAAATGATGGGTCACGTAAAACCCATCAAGTTTGAAGATGTTTATGT
CGGGATCTGTTTGAATTTATTAAAAGTGAACATTCATATTCCAGAAGACACAAATCTTTTCTTTCTATATAGAATCCATTTGGATGTCTG
TCAACTGAGACGTGTGATTGCAGCCCATGGCTTTTCTTCCAAGGAGATCATCACTTTTTGGCAGGTCATGCTAAGGAACACCACATGCCA

>In-frame_ENST00000221855_ENST00000488170_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(amino acids)=359AA_start in transcript=820_stop in transcript=1896
MPHPLVSMRTCPGWRSTRSHKKPTTRGKASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDF
HFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYN
NLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGY

--------------------------------------------------------------
>In-frame_ENST00000589996_ENST00000473285_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(transcript)=2140nt_BP=371nt
GGCGGCTGGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGC
AGCTCCCTCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGTGTAAACTGGAGTTGCTGGTGGGC
AGCCCTGCTTCCTGCATGGAACTGGAGCTGTATGGAGTTGACGACAAGTTCTACAGCAAGCTGGATCAAGAGGATGCGCTCCTGGGCTCC
TACCCTGTAGATGACGGCTGCCGCATCCACTGGTGAGTATGAGGACGTGTCCCGGGTGGAGAAGTACACGATCTCACAAGAAGCCTACGA
CCAGAGGCAAGGCCTCGGCTCTCTGGACTGTCCTTCCGAGTAGGATGTCACTGAGATCCCTCAAATGGAGCCTCCTGCTGCTGTCACTCC
TGAGTTTCTTTGTGATGTGGTACCTCAGCCTTCCCCACTACAATGTGATAGAACGCGTGAACTGGATGTACTTCTATGAGTATGAGCCGA
TTTACAGACAAGACTTTCACTTCACACTTCGAGAGCATTCAAACTGCTCTCATCAAAATCCATTTCTGGTCATTCTGGTGACCTCCCACC
CTTCAGATGTGAAAGCCAGGCAGGCCATTAGAGTTACTTGGGGTGAAAAAAAGTCTTGGTGGGGATATGAGGTTCTTACATTTTTCTTAT
TAGGCCAAGAGGCTGAAAAGGAAGACAAAATGTTGGCATTGTCCTTAGAGGATGAACACCTTCTTTATGGTGACATAATCCGACAAGATT
TTTTAGACACATATAATAACCTGACCTTGAAAACCATTATGGCATTCAGGTGGGTAACTGAGTTTTGCCCCAATGCCAAGTACGTAATGA
AGACAGACACTGATGTTTTCATCAATACTGGCAATTTAGTGAAGTATCTTTTAAACCTAAACCACTCAGAGAAGTTTTTCACAGGTTATC
CTCTAATTGATAATTATTCCTATAGAGGATTTTACCAAAAAACCCATATTTCTTACCAGGAGTATCCTTTCAAGGTGTTCCCTCCATACT
GCAGTGGGTTGGGTTATATAATGTCCAGAGATTTGGTGCCAAGGATCTATGAAATGATGGGTCACGTAAAACCCATCAAGTTTGAAGATG
TTTATGTCGGGATCTGTTTGAATTTATTAAAAGTGAACATTCATATTCCAGAAGACACAAATCTTTTCTTTCTATATAGAATCCATTTGG
ATGTCTGTCAACTGAGACGTGTGATTGCAGCCCATGGCTTTTCTTCCAAGGAGATCATCACTTTTTGGCAGGTCATGCTAAGGAACACCA
CATGCCATTATTAACTTCACATTCTACAAAAAGCCTAGAAGGACAGGATACTTTGTGGAAAGTGTTAAATAAAGTAGGTACTGTGGAAAA
TTCATGGGGAGGTCAGTGTGCTGGCTTACACTGAACTGAAACTCATGAAAAACCCAGACTGGAGACTGGAGGGTTACACTTGTGATTTAT
TAGTCAGGCCCTTCAAAGATGATATGTGGAGGAATTAAATATAAAGGAATTGGAGGTTTTTGCTAAAGAAATTAATAGGACCAAACAATT
TGGACATGTCATTCTGTAGACTAGAATTTCTTAAAAGGGTGTTACTGAGTTATAAGCTCACTAGGCTGTAAAAACAAAACAATGTAGAGT
TTTATTTATTGAACAATGTAGTCACTTGAAGGTTTTGTGTATATCTTATGTGGATTACCAATTTAAAAATATATGTAGTTCTGTGTCAAA
AAACTTCTTCACTGAAGTTATACTGAACAAAATTTTACCTGTTTTTGGTCATTTATAAAGTACTTCAAGATGTTGCAGTATTTCACAGTT
ATTATTATTTAAAATTACTTCAACTTTGTGTTTTTAAATGTTTTGACGATTTCAATACAAGATAAAAAGGATAGTGAATCATTCTTTACA
TGCAAACATTTTCCAGTTACTTAACTGATCAGTTTATTATTGATACATCACTCCATTAATGTAAAGTCATAGGTCATTATTGCATATCAG

>In-frame_ENST00000589996_ENST00000473285_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(amino acids)=358AA_start in transcript=287_stop in transcript=1363
MPHPLVSMRTCPGWRSTRSHKKPTTRGKASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDF
HFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYN
NLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGY

--------------------------------------------------------------
>In-frame_ENST00000589996_ENST00000488170_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(transcript)=1364nt_BP=371nt
GGCGGCTGGACCGCGCTGCAGGCATCCGCAGGGCGCGGCAAGATGGAGGTGACGGGGGTGTCGGCACCCACGGTGACCGTTTTCATCAGC
AGCTCCCTCAACACCTTCCGCTCCGAGAAGCGATACAGCCGCAGCCTCACCATCGCTGAGTTCAAGTGTAAACTGGAGTTGCTGGTGGGC
AGCCCTGCTTCCTGCATGGAACTGGAGCTGTATGGAGTTGACGACAAGTTCTACAGCAAGCTGGATCAAGAGGATGCGCTCCTGGGCTCC
TACCCTGTAGATGACGGCTGCCGCATCCACTGGTGAGTATGAGGACGTGTCCCGGGTGGAGAAGTACACGATCTCACAAGAAGCCTACGA
CCAGAGGCAAGGCCTCGGCTCTCTGGACTGTCCTTCCGAGTAGGATGTCACTGAGATCCCTCAAATGGAGCCTCCTGCTGCTGTCACTCC
TGAGTTTCTTTGTGATGTGGTACCTCAGCCTTCCCCACTACAATGTGATAGAACGCGTGAACTGGATGTACTTCTATGAGTATGAGCCGA
TTTACAGACAAGACTTTCACTTCACACTTCGAGAGCATTCAAACTGCTCTCATCAAAATCCATTTCTGGTCATTCTGGTGACCTCCCACC
CTTCAGATGTGAAAGCCAGGCAGGCCATTAGAGTTACTTGGGGTGAAAAAAAGTCTTGGTGGGGATATGAGGTTCTTACATTTTTCTTAT
TAGGCCAAGAGGCTGAAAAGGAAGACAAAATGTTGGCATTGTCCTTAGAGGATGAACACCTTCTTTATGGTGACATAATCCGACAAGATT
TTTTAGACACATATAATAACCTGACCTTGAAAACCATTATGGCATTCAGGTGGGTAACTGAGTTTTGCCCCAATGCCAAGTACGTAATGA
AGACAGACACTGATGTTTTCATCAATACTGGCAATTTAGTGAAGTATCTTTTAAACCTAAACCACTCAGAGAAGTTTTTCACAGGTTATC
CTCTAATTGATAATTATTCCTATAGAGGATTTTACCAAAAAACCCATATTTCTTACCAGGAGTATCCTTTCAAGGTGTTCCCTCCATACT
GCAGTGGGTTGGGTTATATAATGTCCAGAGATTTGGTGCCAAGGATCTATGAAATGATGGGTCACGTAAAACCCATCAAGTTTGAAGATG
TTTATGTCGGGATCTGTTTGAATTTATTAAAAGTGAACATTCATATTCCAGAAGACACAAATCTTTTCTTTCTATATAGAATCCATTTGG
ATGTCTGTCAACTGAGACGTGTGATTGCAGCCCATGGCTTTTCTTCCAAGGAGATCATCACTTTTTGGCAGGTCATGCTAAGGAACACCA

>In-frame_ENST00000589996_ENST00000488170_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(amino acids)=359AA_start in transcript=287_stop in transcript=1363
MPHPLVSMRTCPGWRSTRSHKKPTTRGKASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDF
HFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYN
NLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGY

--------------------------------------------------------------
>In-frame_ENST00000585746_ENST00000473285_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(transcript)=2075nt_BP=306nt
CTCGAGAGTGCAGAGATGAGGGCCGGGTCCAGCGAAAAATCCGACGGTCCAGAGGGCGGGGGCAAGAGGCGAGGGGCTGGATTGCGGCCC
CTGTAAACTGGAGTTGCTGGTGGGCAGCCCTGCTTCCTGCATGGAACTGGAGCTGTATGGAGTTGACGACAAGTTCTACAGCAAGCTGGA
TCAAGAGGATGCGCTCCTGGGCTCCTACCCTGTAGATGACGGCTGCCGCATCCACTGGTGAGTATGAGGACGTGTCCCGGGTGGAGAAGT
ACACGATCTCACAAGAAGCCTACGACCAGAGGCAAGGCCTCGGCTCTCTGGACTGTCCTTCCGAGTAGGATGTCACTGAGATCCCTCAAA
TGGAGCCTCCTGCTGCTGTCACTCCTGAGTTTCTTTGTGATGTGGTACCTCAGCCTTCCCCACTACAATGTGATAGAACGCGTGAACTGG
ATGTACTTCTATGAGTATGAGCCGATTTACAGACAAGACTTTCACTTCACACTTCGAGAGCATTCAAACTGCTCTCATCAAAATCCATTT
CTGGTCATTCTGGTGACCTCCCACCCTTCAGATGTGAAAGCCAGGCAGGCCATTAGAGTTACTTGGGGTGAAAAAAAGTCTTGGTGGGGA
TATGAGGTTCTTACATTTTTCTTATTAGGCCAAGAGGCTGAAAAGGAAGACAAAATGTTGGCATTGTCCTTAGAGGATGAACACCTTCTT
TATGGTGACATAATCCGACAAGATTTTTTAGACACATATAATAACCTGACCTTGAAAACCATTATGGCATTCAGGTGGGTAACTGAGTTT
TGCCCCAATGCCAAGTACGTAATGAAGACAGACACTGATGTTTTCATCAATACTGGCAATTTAGTGAAGTATCTTTTAAACCTAAACCAC
TCAGAGAAGTTTTTCACAGGTTATCCTCTAATTGATAATTATTCCTATAGAGGATTTTACCAAAAAACCCATATTTCTTACCAGGAGTAT
CCTTTCAAGGTGTTCCCTCCATACTGCAGTGGGTTGGGTTATATAATGTCCAGAGATTTGGTGCCAAGGATCTATGAAATGATGGGTCAC
GTAAAACCCATCAAGTTTGAAGATGTTTATGTCGGGATCTGTTTGAATTTATTAAAAGTGAACATTCATATTCCAGAAGACACAAATCTT
TTCTTTCTATATAGAATCCATTTGGATGTCTGTCAACTGAGACGTGTGATTGCAGCCCATGGCTTTTCTTCCAAGGAGATCATCACTTTT
TGGCAGGTCATGCTAAGGAACACCACATGCCATTATTAACTTCACATTCTACAAAAAGCCTAGAAGGACAGGATACTTTGTGGAAAGTGT
TAAATAAAGTAGGTACTGTGGAAAATTCATGGGGAGGTCAGTGTGCTGGCTTACACTGAACTGAAACTCATGAAAAACCCAGACTGGAGA
CTGGAGGGTTACACTTGTGATTTATTAGTCAGGCCCTTCAAAGATGATATGTGGAGGAATTAAATATAAAGGAATTGGAGGTTTTTGCTA
AAGAAATTAATAGGACCAAACAATTTGGACATGTCATTCTGTAGACTAGAATTTCTTAAAAGGGTGTTACTGAGTTATAAGCTCACTAGG
CTGTAAAAACAAAACAATGTAGAGTTTTATTTATTGAACAATGTAGTCACTTGAAGGTTTTGTGTATATCTTATGTGGATTACCAATTTA
AAAATATATGTAGTTCTGTGTCAAAAAACTTCTTCACTGAAGTTATACTGAACAAAATTTTACCTGTTTTTGGTCATTTATAAAGTACTT
CAAGATGTTGCAGTATTTCACAGTTATTATTATTTAAAATTACTTCAACTTTGTGTTTTTAAATGTTTTGACGATTTCAATACAAGATAA
AAAGGATAGTGAATCATTCTTTACATGCAAACATTTTCCAGTTACTTAACTGATCAGTTTATTATTGATACATCACTCCATTAATGTAAA
GTCATAGGTCATTATTGCATATCAGTAATCTCTTGGACTTTGTTAAATATTTTACTGTGGTAATATAGAGAAGAATTAAAGCAAGAAAAT

>In-frame_ENST00000585746_ENST00000473285_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(amino acids)=358AA_start in transcript=222_stop in transcript=1298
MPHPLVSMRTCPGWRSTRSHKKPTTRGKASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDF
HFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYN
NLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGY

--------------------------------------------------------------
>In-frame_ENST00000585746_ENST00000488170_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(transcript)=1299nt_BP=306nt
CTCGAGAGTGCAGAGATGAGGGCCGGGTCCAGCGAAAAATCCGACGGTCCAGAGGGCGGGGGCAAGAGGCGAGGGGCTGGATTGCGGCCC
CTGTAAACTGGAGTTGCTGGTGGGCAGCCCTGCTTCCTGCATGGAACTGGAGCTGTATGGAGTTGACGACAAGTTCTACAGCAAGCTGGA
TCAAGAGGATGCGCTCCTGGGCTCCTACCCTGTAGATGACGGCTGCCGCATCCACTGGTGAGTATGAGGACGTGTCCCGGGTGGAGAAGT
ACACGATCTCACAAGAAGCCTACGACCAGAGGCAAGGCCTCGGCTCTCTGGACTGTCCTTCCGAGTAGGATGTCACTGAGATCCCTCAAA
TGGAGCCTCCTGCTGCTGTCACTCCTGAGTTTCTTTGTGATGTGGTACCTCAGCCTTCCCCACTACAATGTGATAGAACGCGTGAACTGG
ATGTACTTCTATGAGTATGAGCCGATTTACAGACAAGACTTTCACTTCACACTTCGAGAGCATTCAAACTGCTCTCATCAAAATCCATTT
CTGGTCATTCTGGTGACCTCCCACCCTTCAGATGTGAAAGCCAGGCAGGCCATTAGAGTTACTTGGGGTGAAAAAAAGTCTTGGTGGGGA
TATGAGGTTCTTACATTTTTCTTATTAGGCCAAGAGGCTGAAAAGGAAGACAAAATGTTGGCATTGTCCTTAGAGGATGAACACCTTCTT
TATGGTGACATAATCCGACAAGATTTTTTAGACACATATAATAACCTGACCTTGAAAACCATTATGGCATTCAGGTGGGTAACTGAGTTT
TGCCCCAATGCCAAGTACGTAATGAAGACAGACACTGATGTTTTCATCAATACTGGCAATTTAGTGAAGTATCTTTTAAACCTAAACCAC
TCAGAGAAGTTTTTCACAGGTTATCCTCTAATTGATAATTATTCCTATAGAGGATTTTACCAAAAAACCCATATTTCTTACCAGGAGTAT
CCTTTCAAGGTGTTCCCTCCATACTGCAGTGGGTTGGGTTATATAATGTCCAGAGATTTGGTGCCAAGGATCTATGAAATGATGGGTCAC
GTAAAACCCATCAAGTTTGAAGATGTTTATGTCGGGATCTGTTTGAATTTATTAAAAGTGAACATTCATATTCCAGAAGACACAAATCTT
TTCTTTCTATATAGAATCCATTTGGATGTCTGTCAACTGAGACGTGTGATTGCAGCCCATGGCTTTTCTTCCAAGGAGATCATCACTTTT

>In-frame_ENST00000585746_ENST00000488170_DA235308_TBCB_chr19_36611637_+_B3GALNT1_chr3_160804539_length(amino acids)=358AA_start in transcript=222_stop in transcript=1298
MPHPLVSMRTCPGWRSTRSHKKPTTRGKASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDF
HFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYN
NLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBCB-B3GALNT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBCB-B3GALNT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBCB-B3GALNT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBCBC0027627Neoplasm Metastasis1CTD_human