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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBCK-DENND5B (FusionGDB2 ID:88876)

Fusion Gene Summary for TBCK-DENND5B

check button Fusion gene summary
Fusion gene informationFusion gene name: TBCK-DENND5B
Fusion gene ID: 88876
HgeneTgene
Gene symbol

TBCK

DENND5B

Gene ID

93627

160518

Gene nameTBC1 domain containing kinaseDENN domain containing 5B
SynonymsHSPC302|IHPRF3|TBCKL-
Cytomap

4q24

12p11.21

Type of geneprotein-codingprotein-coding
DescriptionTBC domain-containing protein kinase-like proteinDENN domain-containing protein 5BDENN/MADD domain containing 5Brab6IP1-like protein
Modification date2020031320200313
UniProtAcc.

Q6ZUT9

Ensembl transtripts involved in fusion geneENST00000273980, ENST00000432496, 
ENST00000361687, ENST00000394706, 
ENST00000394708, ENST00000514689, 
ENST00000306833, ENST00000389082, 
ENST00000536562, ENST00000354285, 
ENST00000545147, 
Fusion gene scores* DoF score7 X 5 X 6=2106 X 6 X 4=144
# samples 76
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBCK [Title/Abstract] AND DENND5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBCK(107016639)-DENND5B(31595859), # samples:1
Anticipated loss of major functional domain due to fusion event.TBCK-DENND5B seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TBCK-DENND5B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TBCK-DENND5B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TBCK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DENND5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-2624-01ATBCKchr4

107016639

-DENND5Bchr12

31595859

-


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Fusion Gene ORF analysis for TBCK-DENND5B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000273980ENST00000306833TBCKchr4

107016639

-DENND5Bchr12

31595859

-
Frame-shiftENST00000273980ENST00000389082TBCKchr4

107016639

-DENND5Bchr12

31595859

-
Frame-shiftENST00000273980ENST00000536562TBCKchr4

107016639

-DENND5Bchr12

31595859

-
Frame-shiftENST00000273980ENST00000354285TBCKchr4

107016639

-DENND5Bchr12

31595859

-
5CDS-intronENST00000273980ENST00000545147TBCKchr4

107016639

-DENND5Bchr12

31595859

-
Frame-shiftENST00000432496ENST00000306833TBCKchr4

107016639

-DENND5Bchr12

31595859

-
Frame-shiftENST00000432496ENST00000389082TBCKchr4

107016639

-DENND5Bchr12

31595859

-
Frame-shiftENST00000432496ENST00000536562TBCKchr4

107016639

-DENND5Bchr12

31595859

-
Frame-shiftENST00000432496ENST00000354285TBCKchr4

107016639

-DENND5Bchr12

31595859

-
5CDS-intronENST00000432496ENST00000545147TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000361687ENST00000306833TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000361687ENST00000389082TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000361687ENST00000536562TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000361687ENST00000354285TBCKchr4

107016639

-DENND5Bchr12

31595859

-
5CDS-intronENST00000361687ENST00000545147TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394706ENST00000306833TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394706ENST00000389082TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394706ENST00000536562TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394706ENST00000354285TBCKchr4

107016639

-DENND5Bchr12

31595859

-
5CDS-intronENST00000394706ENST00000545147TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394708ENST00000306833TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394708ENST00000389082TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394708ENST00000536562TBCKchr4

107016639

-DENND5Bchr12

31595859

-
In-frameENST00000394708ENST00000354285TBCKchr4

107016639

-DENND5Bchr12

31595859

-
5CDS-intronENST00000394708ENST00000545147TBCKchr4

107016639

-DENND5Bchr12

31595859

-
intron-3CDSENST00000514689ENST00000306833TBCKchr4

107016639

-DENND5Bchr12

31595859

-
intron-3CDSENST00000514689ENST00000389082TBCKchr4

107016639

-DENND5Bchr12

31595859

-
intron-3CDSENST00000514689ENST00000536562TBCKchr4

107016639

-DENND5Bchr12

31595859

-
intron-3CDSENST00000514689ENST00000354285TBCKchr4

107016639

-DENND5Bchr12

31595859

-
intron-intronENST00000514689ENST00000545147TBCKchr4

107016639

-DENND5Bchr12

31595859

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361687TBCKchr4107016639-ENST00000306833DENND5Bchr1231595859-1005527112422734830
ENST00000361687TBCKchr4107016639-ENST00000389082DENND5Bchr1231595859-1005527112422734830
ENST00000361687TBCKchr4107016639-ENST00000536562DENND5Bchr1231595859-488527112422734830
ENST00000361687TBCKchr4107016639-ENST00000354285DENND5Bchr1231595859-373627112422734830
ENST00000394706TBCKchr4107016639-ENST00000306833DENND5Bchr1231595859-1010327592182782854
ENST00000394706TBCKchr4107016639-ENST00000389082DENND5Bchr1231595859-1010327592182782854
ENST00000394706TBCKchr4107016639-ENST00000536562DENND5Bchr1231595859-493327592182782854
ENST00000394706TBCKchr4107016639-ENST00000354285DENND5Bchr1231595859-378427592182782854
ENST00000394708TBCKchr4107016639-ENST00000306833DENND5Bchr1231595859-1028029362782959893
ENST00000394708TBCKchr4107016639-ENST00000389082DENND5Bchr1231595859-1028029362782959893
ENST00000394708TBCKchr4107016639-ENST00000536562DENND5Bchr1231595859-511029362782959893
ENST00000394708TBCKchr4107016639-ENST00000354285DENND5Bchr1231595859-396129362782959893

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361687ENST00000306833TBCKchr4107016639-DENND5Bchr1231595859-0.0006224670.99937755
ENST00000361687ENST00000389082TBCKchr4107016639-DENND5Bchr1231595859-0.0006224670.99937755
ENST00000361687ENST00000536562TBCKchr4107016639-DENND5Bchr1231595859-0.0019445840.99805546
ENST00000361687ENST00000354285TBCKchr4107016639-DENND5Bchr1231595859-0.0007858290.9992142
ENST00000394706ENST00000306833TBCKchr4107016639-DENND5Bchr1231595859-0.0003471250.99965286
ENST00000394706ENST00000389082TBCKchr4107016639-DENND5Bchr1231595859-0.0003471250.99965286
ENST00000394706ENST00000536562TBCKchr4107016639-DENND5Bchr1231595859-0.0011275530.99887246
ENST00000394706ENST00000354285TBCKchr4107016639-DENND5Bchr1231595859-0.0004380470.99956197
ENST00000394708ENST00000306833TBCKchr4107016639-DENND5Bchr1231595859-0.0001814790.9998185
ENST00000394708ENST00000389082TBCKchr4107016639-DENND5Bchr1231595859-0.0001814790.9998185
ENST00000394708ENST00000536562TBCKchr4107016639-DENND5Bchr1231595859-0.0006202030.99937975
ENST00000394708ENST00000354285TBCKchr4107016639-DENND5Bchr1231595859-0.0002379740.999762

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Fusion Genomic Features for TBCK-DENND5B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBCK-DENND5B


check button Go to

FGviewer for the breakpoints of chr4:107016639-chr12:31595859

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DENND5B

Q6ZUT9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCKchr4:107016639chr12:31595859ENST00000273980-26271_273857.0894.0DomainProtein kinase
HgeneTBCKchr4:107016639chr12:31595859ENST00000273980-2627466_651857.0894.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr12:31595859ENST00000361687-23241_273794.0831.0DomainProtein kinase
HgeneTBCKchr4:107016639chr12:31595859ENST00000361687-2324466_651794.0831.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr12:31595859ENST00000394706-25261_273818.0855.0DomainProtein kinase
HgeneTBCKchr4:107016639chr12:31595859ENST00000394706-2526466_651818.0855.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr12:31595859ENST00000394708-25261_273857.0894.0DomainProtein kinase
HgeneTBCKchr4:107016639chr12:31595859ENST00000394708-2526466_651857.0894.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr12:31595859ENST00000432496-25261_273857.0894.0DomainProtein kinase
HgeneTBCKchr4:107016639chr12:31595859ENST00000432496-2526466_651857.0894.0DomainRab-GAP TBC
TgeneDENND5Bchr4:107016639chr12:31595859ENST00000354285691118_1267642.3333333333334739.0DomainRUN 2
TgeneDENND5Bchr4:107016639chr12:31595859ENST0000035428569772_932642.3333333333334739.0DomainRUN 1
TgeneDENND5Bchr4:107016639chr12:31595859ENST0000035428569936_1044642.3333333333334739.0DomainPLAT
TgeneDENND5Bchr4:107016639chr12:31595859ENST000003890825211118_1267620.33333333333341275.0DomainRUN 2
TgeneDENND5Bchr4:107016639chr12:31595859ENST00000389082521772_932620.33333333333341275.0DomainRUN 1
TgeneDENND5Bchr4:107016639chr12:31595859ENST00000389082521936_1044620.33333333333341275.0DomainPLAT
TgeneDENND5Bchr4:107016639chr12:31595859ENST0000035428569916_936642.3333333333334739.0TransmembraneHelical
TgeneDENND5Bchr4:107016639chr12:31595859ENST00000389082521916_936620.33333333333341275.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCKchr4:107016639chr12:31595859ENST00000273980-2627790_889857.0894.0DomainRhodanese
HgeneTBCKchr4:107016639chr12:31595859ENST00000361687-2324790_889794.0831.0DomainRhodanese
HgeneTBCKchr4:107016639chr12:31595859ENST00000394706-2526790_889818.0855.0DomainRhodanese
HgeneTBCKchr4:107016639chr12:31595859ENST00000394708-2526790_889857.0894.0DomainRhodanese
HgeneTBCKchr4:107016639chr12:31595859ENST00000432496-2526790_889857.0894.0DomainRhodanese
TgeneDENND5Bchr4:107016639chr12:31595859ENST0000035428569263_399642.3333333333334739.0DomaincDENN
TgeneDENND5Bchr4:107016639chr12:31595859ENST000003542856939_244642.3333333333334739.0DomainuDENN
TgeneDENND5Bchr4:107016639chr12:31595859ENST0000035428569401_581642.3333333333334739.0DomaindDENN
TgeneDENND5Bchr4:107016639chr12:31595859ENST00000389082521263_399620.33333333333341275.0DomaincDENN
TgeneDENND5Bchr4:107016639chr12:31595859ENST0000038908252139_244620.33333333333341275.0DomainuDENN
TgeneDENND5Bchr4:107016639chr12:31595859ENST00000389082521401_581620.33333333333341275.0DomaindDENN


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Fusion Gene Sequence for TBCK-DENND5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000361687_ENST00000306833_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=10055nt_BP=2711nt
AGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAG
GTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAA
ATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCT
TTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAG
CCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGC
GCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGG
CTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCAC
AGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTT
TATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATG
ACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCC
TTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTA
CCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATA
ATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGG
AAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCT
CGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTAC
TTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGG
ATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAA
GAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTG
ATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAG
GTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTC
CATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAA
AAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATG
AGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCT
GGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATG
GCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGA
CTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCT
CTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTT
CAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGC
TCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTG
CAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAAC
ACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCA
AGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAG
TGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGA
GGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTCAGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGA
AGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTTGGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGC
AAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCTTTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCA
GGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGACAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGG
ACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAACGCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAG
TGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAGACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCT
TTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGCTTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCT
TTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTTCACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAA
GCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGTATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCT
CCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGACCACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCT
AGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATACATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGG
GAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGCATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAA
GTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGACAGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGG
AGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGAAAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCT
GGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATCTGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAA
AGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAATGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCA
CTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAAGGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCT
GCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCATCACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGT
CAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCACCATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAA
CTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAACTAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGG
CAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACAGACAAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGT
ATAAAATAGAGTATTTTCATGTGTTAGATGTGTGTAAATATGCTATCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAG
ATTGAATATTCCTGTGACTTAAAATAAGTAGCTTAAAAATGTTGGGGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAAC
ATGTAAATATAGTGCAACCCAGTCGGGCTTTTTTTTTTCTCCAGGTATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCA
TCTTGGAGTCTGATCCTTTGTATTGTGGATGCACACAGCTTTACCTACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTG
TTTTATATATTTGAATCGCTAGTCACTTTTCCAGTCTTTTGGAAAAAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAAC
ACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGAGAACATACAAAGCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACAC
TTCGGAAAGATTAGCCTAGACTAACTTCATTCTTGGCATTTTTATTCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTA
GATTCATAGTGATAAGAACTGCAAACAGCAATTTGATTCTGTACTTTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGA
TAACCATGAGCCCTGTCTTTGTTAGGGTCTAATCACCCACCTCTCCAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGG
AGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTGAAAGCATTTGTTGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCC
TTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCTTTGTAGGAAGGGGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCAC
TGGCAGCACAGGCTGACAAAATGGAAGCAAAGCAAGAGGTGGCAACAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATA
GTTTATAAAGAAGTTAAGTAAATGTAGTATTGGCTAGTTACTGTAAGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTG
TACATTTTTAGCAGCAAAATTGCCTCAGCAGAGCTCCCAGTTTTATTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTT
GTGCAATCGGAGGTTGCTGGGCTTTCACCACCTGTGTTGTTAACCTTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCC
TTTATCAAACACAGCCAAGGACAGCCTCTTTTAACATGTGACTTCATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCAT
GGAGCCGGGTGCGGTGGCTCACGCCTATGATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCC
TGGCTAACACCGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGG
AGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAGTAAGCTGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCT
CAAAAAATAAATAGATAAAAATAAAAACCCATGGAAATGGTTTAAGAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAA
AGTGTGTCTACAATGGTACAGCTCTTCCAGGGACATGGGAAGTTTATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTG
TGTTTGGTGATCAGAAACTATAGAGGGGTCCAACCCAGGATTTCATGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAAC
CTGGGGGATGACTTAGGTTAATGTGCTAGGATTGACACACCTCATCCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAG
ATTAAATCTTACACTTACCCCACAGCTGGTTACTGACAACACAAGCTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGC
ATGAGACTGACCTTCCGGCATTCTTACTAATAGTCTTTCTATTATACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGG
ATGAATATTCATTTAGAAGAATTAATATTCATATTAACACATTGCTCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGG
CCAGGTACGGTGGCTAACGCCTGTAATCCTGACACTTTGGGAGTCTGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAG
ACTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAAAAAAAATAGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAG
CTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAAACACAGGAGGTGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGG
GTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAAACTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACT
TTAAAAAGTAATACCCCCAAAAAAGTTACACCTGAAGTTTCATCTTCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTA
AAAAAAACACATCAGAACTGACACATCCTCTTGGATGATGGGTCCTTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCC
TGTGCTATAAACATGTGGGGCCCTCCTTGTGTGAGCTGCTTGAATGGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATC
TTGGCCTTTAAGAATAAATTTAAATATTTGGAAATAGTCCTTAGGATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGG
TCACATAAGAAGTGCAGTTATAAAGAAATAAGACATGTTGGGCATGGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAG
GAGGATCACTTCAACCCAGGAGTTTGAGTCCAGCCTGGGTAACATAGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTT
ATGTGGCTCATAAGTGTCTCTAAGTTATACCAAAAGTTTGAGCACAACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGC
TGACTTTTGGAAGGACCATACCCACATAGAGGCATCTTTTCTGCTGTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCA
AAGTAAATAAAAAAATCAATATTTAATTTGTTTTTTTCCTGCAAATAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATA
GCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCCAAAAGTATTACCTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAA
CCCCTAATCTTGACCTTTATGACACAGTGGCATTACACTGATGTTGGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCT
TAAAAATGACTGCGAGTCAGTGTGAAGTAGTATAAAGTGGAGTCCTACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCC
TCCCCACCTTGTTTTCCACTGGGAATGAGAATTTGATATGAGAAACTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGT
TTCACACATTTTTGTACCTTTTGTAACCTTGTGGTATTTACTTTCACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTA
TATGAATGATATGGGGGAAATACTGAACTGCTCATATTTCCTTTTTTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGG
TTCAAGACTATACAACAGCTTATGTGTAGTATATGTTGACATCCCTAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTT
CCAGGGAAATATTTATTTCACAACATTAGGAGTGTAGCTCTTCATAATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAG
GGAACTGTGAATATTTTCTGTGAGGTTTACAGAAACTAGTGTATCCTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATA
TTTCAGTATTAACACACCTTCACTGATTGAGAGTCTTGAGCCCTTCTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCT
TTTGAAGTCTGTTTCTTATATAAGTATTTATTACTTTACTGTTTAGCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTT
ATTCCTATTAAAATAAATTTATAAATCCCTTGAATCAACTGAATTCTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAAT
CTAAGGAGAACCTCCTCTCCAAAATCTGATTGGAGCTGTTCACCCTCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCA
AGCTAGAGGAAAAAAAAAAAACCTCAAATAAAATTTTTCCTCATTCGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATA
TTTGTTCTAATTTACCTGAATGTACTTGTGTGTGAATCCAATCTTGATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAG
GAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAACATTTAGAATGCTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCT
TTTTTTTAATTAGCTTTTCTGAATTTAAATTATATTGTTTTTCTTTGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATC
TGAACATAATATAAAATTTGAAAGAGTATTGTGATATTAAGCACTTTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGG

>In-frame_ENST00000361687_ENST00000306833_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=830AA_start in transcript=242_stop in transcript=2734
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLK
FLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPED
ISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKD
VGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEG
AIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFI
PKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ
QLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLND
LKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKV

--------------------------------------------------------------
>In-frame_ENST00000361687_ENST00000389082_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=10055nt_BP=2711nt
AGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAG
GTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAA
ATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCT
TTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAG
CCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGC
GCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGG
CTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCAC
AGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTT
TATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATG
ACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCC
TTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTA
CCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATA
ATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGG
AAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCT
CGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTAC
TTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGG
ATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAA
GAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTG
ATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAG
GTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTC
CATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAA
AAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATG
AGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCT
GGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATG
GCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGA
CTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCT
CTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTT
CAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGC
TCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTG
CAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAAC
ACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCA
AGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAG
TGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGA
GGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTCAGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGA
AGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTTGGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGC
AAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCTTTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCA
GGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGACAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGG
ACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAACGCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAG
TGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAGACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCT
TTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGCTTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCT
TTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTTCACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAA
GCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGTATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCT
CCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGACCACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCT
AGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATACATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGG
GAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGCATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAA
GTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGACAGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGG
AGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGAAAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCT
GGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATCTGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAA
AGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAATGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCA
CTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAAGGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCT
GCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCATCACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGT
CAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCACCATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAA
CTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAACTAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGG
CAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACAGACAAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGT
ATAAAATAGAGTATTTTCATGTGTTAGATGTGTGTAAATATGCTATCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAG
ATTGAATATTCCTGTGACTTAAAATAAGTAGCTTAAAAATGTTGGGGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAAC
ATGTAAATATAGTGCAACCCAGTCGGGCTTTTTTTTTTCTCCAGGTATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCA
TCTTGGAGTCTGATCCTTTGTATTGTGGATGCACACAGCTTTACCTACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTG
TTTTATATATTTGAATCGCTAGTCACTTTTCCAGTCTTTTGGAAAAAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAAC
ACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGAGAACATACAAAGCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACAC
TTCGGAAAGATTAGCCTAGACTAACTTCATTCTTGGCATTTTTATTCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTA
GATTCATAGTGATAAGAACTGCAAACAGCAATTTGATTCTGTACTTTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGA
TAACCATGAGCCCTGTCTTTGTTAGGGTCTAATCACCCACCTCTCCAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGG
AGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTGAAAGCATTTGTTGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCC
TTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCTTTGTAGGAAGGGGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCAC
TGGCAGCACAGGCTGACAAAATGGAAGCAAAGCAAGAGGTGGCAACAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATA
GTTTATAAAGAAGTTAAGTAAATGTAGTATTGGCTAGTTACTGTAAGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTG
TACATTTTTAGCAGCAAAATTGCCTCAGCAGAGCTCCCAGTTTTATTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTT
GTGCAATCGGAGGTTGCTGGGCTTTCACCACCTGTGTTGTTAACCTTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCC
TTTATCAAACACAGCCAAGGACAGCCTCTTTTAACATGTGACTTCATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCAT
GGAGCCGGGTGCGGTGGCTCACGCCTATGATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCC
TGGCTAACACCGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGG
AGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAGTAAGCTGAGATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCT
CAAAAAATAAATAGATAAAAATAAAAACCCATGGAAATGGTTTAAGAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAA
AGTGTGTCTACAATGGTACAGCTCTTCCAGGGACATGGGAAGTTTATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTG
TGTTTGGTGATCAGAAACTATAGAGGGGTCCAACCCAGGATTTCATGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAAC
CTGGGGGATGACTTAGGTTAATGTGCTAGGATTGACACACCTCATCCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAG
ATTAAATCTTACACTTACCCCACAGCTGGTTACTGACAACACAAGCTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGC
ATGAGACTGACCTTCCGGCATTCTTACTAATAGTCTTTCTATTATACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGG
ATGAATATTCATTTAGAAGAATTAATATTCATATTAACACATTGCTCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGG
CCAGGTACGGTGGCTAACGCCTGTAATCCTGACACTTTGGGAGTCTGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAG
ACTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAAAAAAAATAGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAG
CTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAAACACAGGAGGTGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGG
GTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAAACTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACT
TTAAAAAGTAATACCCCCAAAAAAGTTACACCTGAAGTTTCATCTTCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTA
AAAAAAACACATCAGAACTGACACATCCTCTTGGATGATGGGTCCTTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCC
TGTGCTATAAACATGTGGGGCCCTCCTTGTGTGAGCTGCTTGAATGGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATC
TTGGCCTTTAAGAATAAATTTAAATATTTGGAAATAGTCCTTAGGATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGG
TCACATAAGAAGTGCAGTTATAAAGAAATAAGACATGTTGGGCATGGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAG
GAGGATCACTTCAACCCAGGAGTTTGAGTCCAGCCTGGGTAACATAGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTT
ATGTGGCTCATAAGTGTCTCTAAGTTATACCAAAAGTTTGAGCACAACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGC
TGACTTTTGGAAGGACCATACCCACATAGAGGCATCTTTTCTGCTGTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCA
AAGTAAATAAAAAAATCAATATTTAATTTGTTTTTTTCCTGCAAATAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATA
GCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCCAAAAGTATTACCTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAA
CCCCTAATCTTGACCTTTATGACACAGTGGCATTACACTGATGTTGGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCT
TAAAAATGACTGCGAGTCAGTGTGAAGTAGTATAAAGTGGAGTCCTACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCC
TCCCCACCTTGTTTTCCACTGGGAATGAGAATTTGATATGAGAAACTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGT
TTCACACATTTTTGTACCTTTTGTAACCTTGTGGTATTTACTTTCACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTA
TATGAATGATATGGGGGAAATACTGAACTGCTCATATTTCCTTTTTTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGG
TTCAAGACTATACAACAGCTTATGTGTAGTATATGTTGACATCCCTAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTT
CCAGGGAAATATTTATTTCACAACATTAGGAGTGTAGCTCTTCATAATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAG
GGAACTGTGAATATTTTCTGTGAGGTTTACAGAAACTAGTGTATCCTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATA
TTTCAGTATTAACACACCTTCACTGATTGAGAGTCTTGAGCCCTTCTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCT
TTTGAAGTCTGTTTCTTATATAAGTATTTATTACTTTACTGTTTAGCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTT
ATTCCTATTAAAATAAATTTATAAATCCCTTGAATCAACTGAATTCTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAAT
CTAAGGAGAACCTCCTCTCCAAAATCTGATTGGAGCTGTTCACCCTCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCA
AGCTAGAGGAAAAAAAAAAAACCTCAAATAAAATTTTTCCTCATTCGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATA
TTTGTTCTAATTTACCTGAATGTACTTGTGTGTGAATCCAATCTTGATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAG
GAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAACATTTAGAATGCTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCT
TTTTTTTAATTAGCTTTTCTGAATTTAAATTATATTGTTTTTCTTTGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATC
TGAACATAATATAAAATTTGAAAGAGTATTGTGATATTAAGCACTTTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGG

>In-frame_ENST00000361687_ENST00000389082_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=830AA_start in transcript=242_stop in transcript=2734
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLK
FLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPED
ISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKD
VGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEG
AIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFI
PKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ
QLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLND
LKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKV

--------------------------------------------------------------
>In-frame_ENST00000361687_ENST00000536562_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=4885nt_BP=2711nt
AGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAG
GTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAA
ATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCT
TTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAG
CCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGC
GCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGG
CTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCAC
AGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTT
TATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATG
ACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCC
TTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTA
CCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATA
ATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGG
AAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCT
CGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTAC
TTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGG
ATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAA
GAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTG
ATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAG
GTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTC
CATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAA
AAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATG
AGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCT
GGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATG
GCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGA
CTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCT
CTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTT
CAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGC
TCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTG
CAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAAC
ACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCA
AGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAG
TGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGA
GGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTCAGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGA
AGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTTGGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGC
AAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCTTTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCA
GGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGACAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGG
ACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAACGCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAG
TGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAGACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCT
TTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGCTTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCT
TTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTTCACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAA
GCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGTATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCT
CCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGACCACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCT
AGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATACATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGG
GAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGCATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAA
GTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGACAGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGG
AGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGAAAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCT
GGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATCTGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAA
AGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAATGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCA
CTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAAGGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCT
GCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCATCACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGT
CAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCACCATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAA
CTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAACTAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGG
CAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACAGACAAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGT

>In-frame_ENST00000361687_ENST00000536562_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=830AA_start in transcript=242_stop in transcript=2734
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLK
FLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPED
ISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKD
VGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEG
AIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFI
PKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ
QLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLND
LKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKV

--------------------------------------------------------------
>In-frame_ENST00000361687_ENST00000354285_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=3736nt_BP=2711nt
AGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAG
GTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAA
ATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCT
TTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAG
CCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGC
GCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGG
CTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCAC
AGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTT
TATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATG
ACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCC
TTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTA
CCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATA
ATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGG
AAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCT
CGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTAC
TTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGG
ATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAA
GAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTG
ATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAG
GTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTC
CATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAA
AAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATG
AGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCT
GGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATG
GCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGA
CTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCT
CTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTT
CAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGC
TCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTG
CAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAAC
ACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCA
AGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAG
TGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGAGCATGTTGGGCTGGACAACGACTTGAGGGAGGTATGTGGTCTACC
TTCCTGGGGTGCCTCACAGCAAGCGCCATGAACTAGGCTTATTCCTTCCAGCAGATGTCATTGTGTAGATTCTTAATGTTCTTTAAAAAA
AAAACTGTTTAGTTATAGTTTAAAATATTAATCCTTTTGTACGGACATATAGCAGAAAACACCCTTTTTTCCATTTTTGTAATTTCAAGA
CATCTATAATAAGGCTCTAAAACAAGTCTTTCTGTGTATTACATCAAGTAAAGATCAAGTTGAGGATAAATTTTTAGTTACTATGTCTCC
TATAGGAGAAAAATTGTCTGCATGAGAAGCCTAGACATTTCTAAGTTTCAAGCATAATTATAAGGAGTAGTGTGATGTACTTGCCTATGC
TTTGTTCTTGGCTTGCTGGCACCAGTTTTTTTTCTTGAATCTCTAAATCTACTTTATATTTTTGAAAGTGTTTTAAAACTATTTTTAAAT
TAAGATCCTTACACTTTTATTTGTACTCTTTGAAAATAAGACCATAATTATACAACAAGTAAGTTTTGATTTTTTTCTGTGTGAAATCTG
CATATATATATAGTGTCTTGCTATGTTGCCCAGGTCTTGAACTCCTGGGCTCAAGCAGTGCTCCTGCCTCAGCCTCCCAAAGTATTGGGA
TTACAGGTGTGAGCTGCCATGCCCAGCCTGATTGTTTCGTTTCTTATGATCAAAAGAGAAATGCAATCAGAAGACTTGTTAACTGTTTTC

>In-frame_ENST00000361687_ENST00000354285_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=830AA_start in transcript=242_stop in transcript=2734
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLK
FLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPED
ISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKD
VGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEG
AIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFI
PKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQ
QLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLND
LKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKV

--------------------------------------------------------------
>In-frame_ENST00000394706_ENST00000306833_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=10103nt_BP=2759nt
GGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCG
CGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCC
GTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGAC
TCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTC
TGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCA
CCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGG
AAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACA
AACATGGTATAGTACACAGGGCATTGTCTCCTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATC
ACATGACAGCTCATGGTGATGATGTTGATTTCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGGAAGAAAATTATTTCAGAGCTTGG
ATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACA
TTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAA
TGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTG
ATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACC
TTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATT
TTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGC
TAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATA
ATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGC
TGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTG
CTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGG
ATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGT
CTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATG
CATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCT
CTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTC
TTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTA
TTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAA
TTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAA
AGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAG
AATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAG
GCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTG
GTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCC
AGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAAT
GGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGA
TGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTC
TGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTC
AGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTT
GGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCT
TTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGA
CAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAAC
GCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAG
ACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGC
TTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTT
CACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGT
ATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGAC
CACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATAC
ATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGC
ATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGAC
AGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGA
AAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATC
TGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAA
TGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAA
GGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCAT
CACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCAC
CATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAAC
TAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACA
GACAAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGTATAAAATAGAGTATTTTCATGTGTTAGATGTGTGTAAATATG
CTATCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAGATTGAATATTCCTGTGACTTAAAATAAGTAGCTTAAAAATGT
TGGGGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAACATGTAAATATAGTGCAACCCAGTCGGGCTTTTTTTTTTCTCC
AGGTATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCATCTTGGAGTCTGATCCTTTGTATTGTGGATGCACACAGCTTT
ACCTACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTGTTTTATATATTTGAATCGCTAGTCACTTTTCCAGTCTTTTGG
AAAAAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAACACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGAGAACATAC
AAAGCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACACTTCGGAAAGATTAGCCTAGACTAACTTCATTCTTGGCATTTT
TATTCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTAGATTCATAGTGATAAGAACTGCAAACAGCAATTTGATTCTGT
ACTTTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGATAACCATGAGCCCTGTCTTTGTTAGGGTCTAATCACCCACCT
CTCCAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGGAGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTGAAAGCATT
TGTTGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCCTTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCTTTGTAGGA
AGGGGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCACTGGCAGCACAGGCTGACAAAATGGAAGCAAAGCAAGAGGTGG
CAACAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATAGTTTATAAAGAAGTTAAGTAAATGTAGTATTGGCTAGTTACT
GTAAGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTGTACATTTTTAGCAGCAAAATTGCCTCAGCAGAGCTCCCAGTT
TTATTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTTGTGCAATCGGAGGTTGCTGGGCTTTCACCACCTGTGTTGTTA
ACCTTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCCTTTATCAAACACAGCCAAGGACAGCCTCTTTTAACATGTGAC
TTCATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCATGGAGCCGGGTGCGGTGGCTCACGCCTATGATCCCAGCACTTT
GGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCCTGGCTAACACCGTGAAACCCCGTCTCTACTAAAAATACAAAA
AATTAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAGTAAGCTGA
GATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAATAAATAGATAAAAATAAAAACCCATGGAAATGGTT
TAAGAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAAAGTGTGTCTACAATGGTACAGCTCTTCCAGGGACATGGGAAG
TTTATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTGTGTTTGGTGATCAGAAACTATAGAGGGGTCCAACCCAGGATT
TCATGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAACCTGGGGGATGACTTAGGTTAATGTGCTAGGATTGACACACCT
CATCCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAGATTAAATCTTACACTTACCCCACAGCTGGTTACTGACAACAC
AAGCTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGCATGAGACTGACCTTCCGGCATTCTTACTAATAGTCTTTCTAT
TATACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGGATGAATATTCATTTAGAAGAATTAATATTCATATTAACACAT
TGCTCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGGCCAGGTACGGTGGCTAACGCCTGTAATCCTGACACTTTGGGA
GTCTGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAGACTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAAAAAA
AATAGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAAACACAGGA
GGTGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGGGTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAA
AAACTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACTTTAAAAAGTAATACCCCCAAAAAAGTTACACCTGAAGTTTCA
TCTTCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTAAAAAAAACACATCAGAACTGACACATCCTCTTGGATGATGGG
TCCTTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCCTGTGCTATAAACATGTGGGGCCCTCCTTGTGTGAGCTGCTTG
AATGGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATCTTGGCCTTTAAGAATAAATTTAAATATTTGGAAATAGTCCTT
AGGATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGGTCACATAAGAAGTGCAGTTATAAAGAAATAAGACATGTTGGG
CATGGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAGGAGGATCACTTCAACCCAGGAGTTTGAGTCCAGCCTGGGTAA
CATAGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTTATGTGGCTCATAAGTGTCTCTAAGTTATACCAAAAGTTTGAG
CACAACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGCTGACTTTTGGAAGGACCATACCCACATAGAGGCATCTTTTCT
GCTGTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCAAAGTAAATAAAAAAATCAATATTTAATTTGTTTTTTTCCTGC
AAATAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATAGCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCCAAAAGTAT
TACCTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAACCCCTAATCTTGACCTTTATGACACAGTGGCATTACACTGAT
GTTGGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCTTAAAAATGACTGCGAGTCAGTGTGAAGTAGTATAAAGTGGAG
TCCTACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCCTCCCCACCTTGTTTTCCACTGGGAATGAGAATTTGATATGAG
AAACTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGTTTCACACATTTTTGTACCTTTTGTAACCTTGTGGTATTTACT
TTCACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTATATGAATGATATGGGGGAAATACTGAACTGCTCATATTTCCT
TTTTTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGGTTCAAGACTATACAACAGCTTATGTGTAGTATATGTTGACAT
CCCTAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTTCCAGGGAAATATTTATTTCACAACATTAGGAGTGTAGCTCTT
CATAATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAGGGAACTGTGAATATTTTCTGTGAGGTTTACAGAAACTAGTGT
ATCCTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATATTTCAGTATTAACACACCTTCACTGATTGAGAGTCTTGAGCC
CTTCTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCTTTTGAAGTCTGTTTCTTATATAAGTATTTATTACTTTACTGT
TTAGCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTTATTCCTATTAAAATAAATTTATAAATCCCTTGAATCAACTGA
ATTCTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAATCTAAGGAGAACCTCCTCTCCAAAATCTGATTGGAGCTGTTCA
CCCTCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCAAGCTAGAGGAAAAAAAAAAAACCTCAAATAAAATTTTTCCTC
ATTCGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATATTTGTTCTAATTTACCTGAATGTACTTGTGTGTGAATCCAAT
CTTGATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAGGAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAACATTTAGA
ATGCTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCTTTTTTTTAATTAGCTTTTCTGAATTTAAATTATATTGTTTTT
CTTTGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATCTGAACATAATATAAAATTTGAAAGAGTATTGTGATATTAAGC
ACTTTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGGGAGTACATTTAAATATGACTTTTCATGCTTTGTTCTTTACAA

>In-frame_ENST00000394706_ENST00000306833_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=854AA_start in transcript=218_stop in transcript=2782
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLY
TPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGR
DRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIW
KEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDS
LCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKI
FHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSA
PYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSA

--------------------------------------------------------------
>In-frame_ENST00000394706_ENST00000389082_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=10103nt_BP=2759nt
GGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCG
CGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCC
GTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGAC
TCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTC
TGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCA
CCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGG
AAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACA
AACATGGTATAGTACACAGGGCATTGTCTCCTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATC
ACATGACAGCTCATGGTGATGATGTTGATTTCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGGAAGAAAATTATTTCAGAGCTTGG
ATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACA
TTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAA
TGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTG
ATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACC
TTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATT
TTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGC
TAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATA
ATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGC
TGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTG
CTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGG
ATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGT
CTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATG
CATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCT
CTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTC
TTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTA
TTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAA
TTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAA
AGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAG
AATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAG
GCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTG
GTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCC
AGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAAT
GGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGA
TGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTC
TGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTC
AGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTT
GGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCT
TTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGA
CAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAAC
GCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAG
ACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGC
TTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTT
CACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGT
ATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGAC
CACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATAC
ATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGC
ATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGAC
AGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGA
AAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATC
TGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAA
TGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAA
GGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCAT
CACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCAC
CATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAAC
TAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACA
GACAAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGTATAAAATAGAGTATTTTCATGTGTTAGATGTGTGTAAATATG
CTATCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAGATTGAATATTCCTGTGACTTAAAATAAGTAGCTTAAAAATGT
TGGGGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAACATGTAAATATAGTGCAACCCAGTCGGGCTTTTTTTTTTCTCC
AGGTATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCATCTTGGAGTCTGATCCTTTGTATTGTGGATGCACACAGCTTT
ACCTACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTGTTTTATATATTTGAATCGCTAGTCACTTTTCCAGTCTTTTGG
AAAAAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAACACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGAGAACATAC
AAAGCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACACTTCGGAAAGATTAGCCTAGACTAACTTCATTCTTGGCATTTT
TATTCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTAGATTCATAGTGATAAGAACTGCAAACAGCAATTTGATTCTGT
ACTTTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGATAACCATGAGCCCTGTCTTTGTTAGGGTCTAATCACCCACCT
CTCCAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGGAGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTGAAAGCATT
TGTTGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCCTTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCTTTGTAGGA
AGGGGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCACTGGCAGCACAGGCTGACAAAATGGAAGCAAAGCAAGAGGTGG
CAACAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATAGTTTATAAAGAAGTTAAGTAAATGTAGTATTGGCTAGTTACT
GTAAGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTGTACATTTTTAGCAGCAAAATTGCCTCAGCAGAGCTCCCAGTT
TTATTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTTGTGCAATCGGAGGTTGCTGGGCTTTCACCACCTGTGTTGTTA
ACCTTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCCTTTATCAAACACAGCCAAGGACAGCCTCTTTTAACATGTGAC
TTCATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCATGGAGCCGGGTGCGGTGGCTCACGCCTATGATCCCAGCACTTT
GGGAGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCCTGGCTAACACCGTGAAACCCCGTCTCTACTAAAAATACAAAA
AATTAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAGTAAGCTGA
GATCGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAATAAATAGATAAAAATAAAAACCCATGGAAATGGTT
TAAGAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAAAGTGTGTCTACAATGGTACAGCTCTTCCAGGGACATGGGAAG
TTTATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTGTGTTTGGTGATCAGAAACTATAGAGGGGTCCAACCCAGGATT
TCATGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAACCTGGGGGATGACTTAGGTTAATGTGCTAGGATTGACACACCT
CATCCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAGATTAAATCTTACACTTACCCCACAGCTGGTTACTGACAACAC
AAGCTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGCATGAGACTGACCTTCCGGCATTCTTACTAATAGTCTTTCTAT
TATACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGGATGAATATTCATTTAGAAGAATTAATATTCATATTAACACAT
TGCTCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGGCCAGGTACGGTGGCTAACGCCTGTAATCCTGACACTTTGGGA
GTCTGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAGACTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAAAAAA
AATAGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAAACACAGGA
GGTGGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGGGTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAA
AAACTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACTTTAAAAAGTAATACCCCCAAAAAAGTTACACCTGAAGTTTCA
TCTTCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTAAAAAAAACACATCAGAACTGACACATCCTCTTGGATGATGGG
TCCTTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCCTGTGCTATAAACATGTGGGGCCCTCCTTGTGTGAGCTGCTTG
AATGGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATCTTGGCCTTTAAGAATAAATTTAAATATTTGGAAATAGTCCTT
AGGATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGGTCACATAAGAAGTGCAGTTATAAAGAAATAAGACATGTTGGG
CATGGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAGGAGGATCACTTCAACCCAGGAGTTTGAGTCCAGCCTGGGTAA
CATAGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTTATGTGGCTCATAAGTGTCTCTAAGTTATACCAAAAGTTTGAG
CACAACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGCTGACTTTTGGAAGGACCATACCCACATAGAGGCATCTTTTCT
GCTGTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCAAAGTAAATAAAAAAATCAATATTTAATTTGTTTTTTTCCTGC
AAATAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATAGCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCCAAAAGTAT
TACCTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAACCCCTAATCTTGACCTTTATGACACAGTGGCATTACACTGAT
GTTGGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCTTAAAAATGACTGCGAGTCAGTGTGAAGTAGTATAAAGTGGAG
TCCTACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCCTCCCCACCTTGTTTTCCACTGGGAATGAGAATTTGATATGAG
AAACTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGTTTCACACATTTTTGTACCTTTTGTAACCTTGTGGTATTTACT
TTCACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTATATGAATGATATGGGGGAAATACTGAACTGCTCATATTTCCT
TTTTTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGGTTCAAGACTATACAACAGCTTATGTGTAGTATATGTTGACAT
CCCTAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTTCCAGGGAAATATTTATTTCACAACATTAGGAGTGTAGCTCTT
CATAATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAGGGAACTGTGAATATTTTCTGTGAGGTTTACAGAAACTAGTGT
ATCCTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATATTTCAGTATTAACACACCTTCACTGATTGAGAGTCTTGAGCC
CTTCTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCTTTTGAAGTCTGTTTCTTATATAAGTATTTATTACTTTACTGT
TTAGCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTTATTCCTATTAAAATAAATTTATAAATCCCTTGAATCAACTGA
ATTCTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAATCTAAGGAGAACCTCCTCTCCAAAATCTGATTGGAGCTGTTCA
CCCTCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCAAGCTAGAGGAAAAAAAAAAAACCTCAAATAAAATTTTTCCTC
ATTCGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATATTTGTTCTAATTTACCTGAATGTACTTGTGTGTGAATCCAAT
CTTGATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAGGAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAACATTTAGA
ATGCTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCTTTTTTTTAATTAGCTTTTCTGAATTTAAATTATATTGTTTTT
CTTTGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATCTGAACATAATATAAAATTTGAAAGAGTATTGTGATATTAAGC
ACTTTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGGGAGTACATTTAAATATGACTTTTCATGCTTTGTTCTTTACAA

>In-frame_ENST00000394706_ENST00000389082_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=854AA_start in transcript=218_stop in transcript=2782
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLY
TPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGR
DRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIW
KEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDS
LCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKI
FHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSA
PYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSA

--------------------------------------------------------------
>In-frame_ENST00000394706_ENST00000536562_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=4933nt_BP=2759nt
GGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCG
CGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCC
GTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGAC
TCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTC
TGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCA
CCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGG
AAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACA
AACATGGTATAGTACACAGGGCATTGTCTCCTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATC
ACATGACAGCTCATGGTGATGATGTTGATTTCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGGAAGAAAATTATTTCAGAGCTTGG
ATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACA
TTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAA
TGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTG
ATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACC
TTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATT
TTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGC
TAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATA
ATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGC
TGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTG
CTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGG
ATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGT
CTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATG
CATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCT
CTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTC
TTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTA
TTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAA
TTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAA
AGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAG
AATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAG
GCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTG
GTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCC
AGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAAT
GGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGA
TGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTC
TGAGCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTC
AGACCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTT
GGTGGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCT
TTGTGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGA
CAGAGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAAC
GCTCAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAG
ACTGTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGC
TTTTCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTT
CACCACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGT
ATCAGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGAC
CACTGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATAC
ATACAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGC
ATCAGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGAC
AGGAAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGA
AAAAGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATC
TGCCCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAA
TGAAGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAA
GGATGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCAT
CACTCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCAC
CATAGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAAC
TAGGGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACA

>In-frame_ENST00000394706_ENST00000536562_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=854AA_start in transcript=218_stop in transcript=2782
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLY
TPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGR
DRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIW
KEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDS
LCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKI
FHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSA
PYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSA

--------------------------------------------------------------
>In-frame_ENST00000394706_ENST00000354285_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=3784nt_BP=2759nt
GGGTGAAAAGCTCGGATCTGTGTTTGGGGAAGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCG
CGAGCAAAGGGCAGCGTCTGAGCTCCCGGCGTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCC
GTAGCGGCAGCAGCAGCCACAGCGACAGCGCTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGAC
TCAGAGATTATCTTAGAAGACCTAGGACTCCAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTC
TGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCA
CCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGG
AAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACA
AACATGGTATAGTACACAGGGCATTGTCTCCTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATC
ACATGACAGCTCATGGTGATGATGTTGATTTCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGGAAGAAAATTATTTCAGAGCTTGG
ATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACA
TTATAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAA
TGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTG
ATTTAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACC
TTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATT
TTCTCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGC
TAAGAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATA
ATGAGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGC
TGCTAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTG
CTCTTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGG
ATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGT
CTCATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATG
CATGTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCT
CTCAGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTC
TTACCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTA
TTGGAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAA
TTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAA
AGCCATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAG
AATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAG
GCCACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTG
GTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCC
AGAACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAAT
GGATCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGA
TGTCTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTC
TGAGCATGTTGGGCTGGACAACGACTTGAGGGAGGTATGTGGTCTACCTTCCTGGGGTGCCTCACAGCAAGCGCCATGAACTAGGCTTAT
TCCTTCCAGCAGATGTCATTGTGTAGATTCTTAATGTTCTTTAAAAAAAAAACTGTTTAGTTATAGTTTAAAATATTAATCCTTTTGTAC
GGACATATAGCAGAAAACACCCTTTTTTCCATTTTTGTAATTTCAAGACATCTATAATAAGGCTCTAAAACAAGTCTTTCTGTGTATTAC
ATCAAGTAAAGATCAAGTTGAGGATAAATTTTTAGTTACTATGTCTCCTATAGGAGAAAAATTGTCTGCATGAGAAGCCTAGACATTTCT
AAGTTTCAAGCATAATTATAAGGAGTAGTGTGATGTACTTGCCTATGCTTTGTTCTTGGCTTGCTGGCACCAGTTTTTTTTCTTGAATCT
CTAAATCTACTTTATATTTTTGAAAGTGTTTTAAAACTATTTTTAAATTAAGATCCTTACACTTTTATTTGTACTCTTTGAAAATAAGAC
CATAATTATACAACAAGTAAGTTTTGATTTTTTTCTGTGTGAAATCTGCATATATATATAGTGTCTTGCTATGTTGCCCAGGTCTTGAAC
TCCTGGGCTCAAGCAGTGCTCCTGCCTCAGCCTCCCAAAGTATTGGGATTACAGGTGTGAGCTGCCATGCCCAGCCTGATTGTTTCGTTT
CTTATGATCAAAAGAGAAATGCAATCAGAAGACTTGTTAACTGTTTTCTAGTATCAAATTTGTAAAAATAAAGCAGAAAACATCATCCCA

>In-frame_ENST00000394706_ENST00000354285_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=854AA_start in transcript=218_stop in transcript=2782
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLY
TPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGR
DRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIW
KEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDS
LCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKI
FHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSA
PYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSA

--------------------------------------------------------------
>In-frame_ENST00000394708_ENST00000306833_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=10280nt_BP=2936nt
AGCGTTGGGTCGCGGTGGCTGTGAGGGCGGAAGAAAAGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGA
AGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGC
GTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCG
CTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTC
CAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGAC
TTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATA
TTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGA
GCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTC
CTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATT
TCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCAT
TGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATA
TTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTA
TAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGA
AGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATT
TAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTT
GGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTC
TCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAA
GAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATG
AGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGC
TAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTC
TTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATA
TTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTC
ATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCAT
GTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTC
AGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTA
CCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTG
GAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTG
ACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGC
CATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAAT
CCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCC
ACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTC
ACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGA
ACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGA
TCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGT
CTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGA
GCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTCAGA
CCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTTGGT
GGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCTTTG
TGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGACAG
AGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAACGCT
CAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAGACT
GTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGCTTT
TCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTTCAC
CACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGTATC
AGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGACCAC
TGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATACATA
CAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGCATC
AGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGACAGG
AAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGAAAA
AGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATCTGC
CCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAATGA
AGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAAGGA
TGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCATCAC
TCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCACCAT
AGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAACTAG
GGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACAGAC
AAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGTATAAAATAGAGTATTTTCATGTGTTAGATGTGTGTAAATATGCTA
TCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAGATTGAATATTCCTGTGACTTAAAATAAGTAGCTTAAAAATGTTGG
GGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAACATGTAAATATAGTGCAACCCAGTCGGGCTTTTTTTTTTCTCCAGG
TATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCATCTTGGAGTCTGATCCTTTGTATTGTGGATGCACACAGCTTTACC
TACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTGTTTTATATATTTGAATCGCTAGTCACTTTTCCAGTCTTTTGGAAA
AAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAACACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGAGAACATACAAA
GCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACACTTCGGAAAGATTAGCCTAGACTAACTTCATTCTTGGCATTTTTAT
TCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTAGATTCATAGTGATAAGAACTGCAAACAGCAATTTGATTCTGTACT
TTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGATAACCATGAGCCCTGTCTTTGTTAGGGTCTAATCACCCACCTCTC
CAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGGAGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTGAAAGCATTTGT
TGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCCTTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCTTTGTAGGAAGG
GGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCACTGGCAGCACAGGCTGACAAAATGGAAGCAAAGCAAGAGGTGGCAA
CAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATAGTTTATAAAGAAGTTAAGTAAATGTAGTATTGGCTAGTTACTGTA
AGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTGTACATTTTTAGCAGCAAAATTGCCTCAGCAGAGCTCCCAGTTTTA
TTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTTGTGCAATCGGAGGTTGCTGGGCTTTCACCACCTGTGTTGTTAACC
TTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCCTTTATCAAACACAGCCAAGGACAGCCTCTTTTAACATGTGACTTC
ATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCATGGAGCCGGGTGCGGTGGCTCACGCCTATGATCCCAGCACTTTGGG
AGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCCTGGCTAACACCGTGAAACCCCGTCTCTACTAAAAATACAAAAAAT
TAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAGTAAGCTGAGAT
CGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAATAAATAGATAAAAATAAAAACCCATGGAAATGGTTTAA
GAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAAAGTGTGTCTACAATGGTACAGCTCTTCCAGGGACATGGGAAGTTT
ATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTGTGTTTGGTGATCAGAAACTATAGAGGGGTCCAACCCAGGATTTCA
TGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAACCTGGGGGATGACTTAGGTTAATGTGCTAGGATTGACACACCTCAT
CCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAGATTAAATCTTACACTTACCCCACAGCTGGTTACTGACAACACAAG
CTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGCATGAGACTGACCTTCCGGCATTCTTACTAATAGTCTTTCTATTAT
ACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGGATGAATATTCATTTAGAAGAATTAATATTCATATTAACACATTGC
TCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGGCCAGGTACGGTGGCTAACGCCTGTAATCCTGACACTTTGGGAGTC
TGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAGACTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAAAAAAAAT
AGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAAACACAGGAGGT
GGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGGGTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAAA
CTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACTTTAAAAAGTAATACCCCCAAAAAAGTTACACCTGAAGTTTCATCT
TCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTAAAAAAAACACATCAGAACTGACACATCCTCTTGGATGATGGGTCC
TTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCCTGTGCTATAAACATGTGGGGCCCTCCTTGTGTGAGCTGCTTGAAT
GGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATCTTGGCCTTTAAGAATAAATTTAAATATTTGGAAATAGTCCTTAGG
ATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGGTCACATAAGAAGTGCAGTTATAAAGAAATAAGACATGTTGGGCAT
GGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAGGAGGATCACTTCAACCCAGGAGTTTGAGTCCAGCCTGGGTAACAT
AGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTTATGTGGCTCATAAGTGTCTCTAAGTTATACCAAAAGTTTGAGCAC
AACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGCTGACTTTTGGAAGGACCATACCCACATAGAGGCATCTTTTCTGCT
GTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCAAAGTAAATAAAAAAATCAATATTTAATTTGTTTTTTTCCTGCAAA
TAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATAGCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCCAAAAGTATTAC
CTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAACCCCTAATCTTGACCTTTATGACACAGTGGCATTACACTGATGTT
GGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCTTAAAAATGACTGCGAGTCAGTGTGAAGTAGTATAAAGTGGAGTCC
TACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCCTCCCCACCTTGTTTTCCACTGGGAATGAGAATTTGATATGAGAAA
CTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGTTTCACACATTTTTGTACCTTTTGTAACCTTGTGGTATTTACTTTC
ACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTATATGAATGATATGGGGGAAATACTGAACTGCTCATATTTCCTTTT
TTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGGTTCAAGACTATACAACAGCTTATGTGTAGTATATGTTGACATCCC
TAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTTCCAGGGAAATATTTATTTCACAACATTAGGAGTGTAGCTCTTCAT
AATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAGGGAACTGTGAATATTTTCTGTGAGGTTTACAGAAACTAGTGTATC
CTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATATTTCAGTATTAACACACCTTCACTGATTGAGAGTCTTGAGCCCTT
CTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCTTTTGAAGTCTGTTTCTTATATAAGTATTTATTACTTTACTGTTTA
GCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTTATTCCTATTAAAATAAATTTATAAATCCCTTGAATCAACTGAATT
CTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAATCTAAGGAGAACCTCCTCTCCAAAATCTGATTGGAGCTGTTCACCC
TCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCAAGCTAGAGGAAAAAAAAAAAACCTCAAATAAAATTTTTCCTCATT
CGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATATTTGTTCTAATTTACCTGAATGTACTTGTGTGTGAATCCAATCTT
GATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAGGAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAACATTTAGAATG
CTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCTTTTTTTTAATTAGCTTTTCTGAATTTAAATTATATTGTTTTTCTT
TGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATCTGAACATAATATAAAATTTGAAAGAGTATTGTGATATTAAGCACT
TTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGGGAGTACATTTAAATATGACTTTTCATGCTTTGTTCTTTACAAATA

>In-frame_ENST00000394708_ENST00000306833_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=893AA_start in transcript=278_stop in transcript=2959
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKE
LPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCL
AGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELS
AAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPR
CHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMI
AFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIE
RCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFK

--------------------------------------------------------------
>In-frame_ENST00000394708_ENST00000389082_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=10280nt_BP=2936nt
AGCGTTGGGTCGCGGTGGCTGTGAGGGCGGAAGAAAAGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGA
AGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGC
GTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCG
CTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTC
CAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGAC
TTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATA
TTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGA
GCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTC
CTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATT
TCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCAT
TGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATA
TTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTA
TAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGA
AGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATT
TAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTT
GGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTC
TCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAA
GAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATG
AGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGC
TAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTC
TTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATA
TTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTC
ATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCAT
GTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTC
AGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTA
CCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTG
GAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTG
ACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGC
CATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAAT
CCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCC
ACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTC
ACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGA
ACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGA
TCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGT
CTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGA
GCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTCAGA
CCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTTGGT
GGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCTTTG
TGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGACAG
AGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAACGCT
CAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAGACT
GTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGCTTT
TCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTTCAC
CACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGTATC
AGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGACCAC
TGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATACATA
CAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGCATC
AGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGACAGG
AAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGAAAA
AGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATCTGC
CCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAATGA
AGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAAGGA
TGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCATCAC
TCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCACCAT
AGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAACTAG
GGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACAGAC
AAGGCAAAATGTTGTATTGTAGTTCATTTGAACCTGGAATTTAGTATAAAATAGAGTATTTTCATGTGTTAGATGTGTGTAAATATGCTA
TCTTCTTTAAGAAATTATATTACTCTAATAAGATGCTTTTCTTAGATTGAATATTCCTGTGACTTAAAATAAGTAGCTTAAAAATGTTGG
GGGTTGGGGGGAAGAGTGGTGCTAGCCAGGAAGAAGCCAGTAAACATGTAAATATAGTGCAACCCAGTCGGGCTTTTTTTTTTCTCCAGG
TATCACAAAGAAACCCAGAATGCATTGTTATGTAGTAGCCATCCATCTTGGAGTCTGATCCTTTGTATTGTGGATGCACACAGCTTTACC
TACTGTACTGGTAGTCTTCACTTCTATCTTTTAAGTTACAAACTGTTTTATATATTTGAATCGCTAGTCACTTTTCCAGTCTTTTGGAAA
AAAATTTCAGTCCGCACAAGATGATATAATTGGAGTATTTTAAACACTAGACCCCAGGAGCTTGGCTGAACTGGAAAGAGAACATACAAA
GCTCTGAGAAATGTGTTCAATTGTGGGATTATAACTTCTTTACACTTCGGAAAGATTAGCCTAGACTAACTTCATTCTTGGCATTTTTAT
TCTTGTTATTTGAGGTACTTTGGGAAGATGTGAATTTCAGTGTTAGATTCATAGTGATAAGAACTGCAAACAGCAATTTGATTCTGTACT
TTTAATTTGGCCATCTAAACTGTGCAGTGGTCTACCTCTTAAGGATAACCATGAGCCCTGTCTTTGTTAGGGTCTAATCACCCACCTCTC
CAGGGCCCATCCCCCCTCGGGAAATGGAAGGAATGTCTAAGGAGGAGGAGGGCTGTGTGTGGCTTGGAATGTTTTTGTGAAAGCATTTGT
TGACCATGATAATGCAAATAACAGAAGGAGAGAGAGAATGAACCCTTTCTGGGTGTTTCAGGGCAAGCTTTACGTTCCTTTGTAGGAAGG
GGAGTAATAATGTAAAACAACTGACCCAGAGAAGCTAAAAGCCACTGGCAGCACAGGCTGACAAAATGGAAGCAAAGCAAGAGGTGGCAA
CAATTTTGAAAGACCAAAAGTTGTGAGTAACTTTCCAGTTTGATAGTTTATAAAGAAGTTAAGTAAATGTAGTATTGGCTAGTTACTGTA
AGTCCTCATCTTCTGGTAGGTCCTGTAACTCTAATTAGGCATTTGTACATTTTTAGCAGCAAAATTGCCTCAGCAGAGCTCCCAGTTTTA
TTCCCAGTTGTGGCTGAAAAGCAAAGCCATGGCATCAGTATCCTTGTGCAATCGGAGGTTGCTGGGCTTTCACCACCTGTGTTGTTAACC
TTATTTCCTGGAGGAAGAAACAGATGAAACAAGTGCCTAACTCCCTTTATCAAACACAGCCAAGGACAGCCTCTTTTAACATGTGACTTC
ATACTTGAGGAAAAGGAGAGTTGACAGCTGTATTTAAAAACCCATGGAGCCGGGTGCGGTGGCTCACGCCTATGATCCCAGCACTTTGGG
AGGCCGAGGCAGGCGGATCACAAGGTCAGGAGATTGAGACCCTCCTGGCTAACACCGTGAAACCCCGTCTCTACTAAAAATACAAAAAAT
TAGCCGGGCGTGGTGGCGGGTGCCTGTACAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGCGAGGCGGAGCTTGCAGTAAGCTGAGAT
CGCGCCACTGCCCTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAATAAATAGATAAAAATAAAAACCCATGGAAATGGTTTAA
GAAAATGGTTCTGGGTACACCAGAAATTTGTTTGCCTGAAGCTAAAGTGTGTCTACAATGGTACAGCTCTTCCAGGGACATGGGAAGTTT
ATCGTGGGAGATATCCAGAACCTGTTTTACACTGGGCTCCTACTGTGTTTGGTGATCAGAAACTATAGAGGGGTCCAACCCAGGATTTCA
TGTTTGTATCTTCATAAGGCCATGCTCCTGACAGGTCTAGGCAACCTGGGGGATGACTTAGGTTAATGTGCTAGGATTGACACACCTCAT
CCAGCCTTCTTACTTTGTGGATGGGAACACTTAAGGAATAGAGAGATTAAATCTTACACTTACCCCACAGCTGGTTACTGACAACACAAG
CTCTAGAATTCATGTTTGTTTGTTTGTTTTATTTCACCAGGCTGCATGAGACTGACCTTCCGGCATTCTTACTAATAGTCTTTCTATTAT
ACTATTGGATCTTTATTCATCCACCTATACAAGTAGGAAATAAGGATGAATATTCATTTAGAAGAATTAATATTCATATTAACACATTGC
TCTCAGATTATTGGGAATTAACATCTTGTAAAAACTGGGAGCAGGCCAGGTACGGTGGCTAACGCCTGTAATCCTGACACTTTGGGAGTC
TGAGGCGGGTGGTTCATCTGAGGTCAGTCGGGAGTTCAAGACCAGACTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAAAAAAAAT
AGACAAAAATTAGCGGGGGGGTGGTGGCAGGGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGTTTAAACACAGGAGGT
GGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAACCTGGGTGACAAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAAA
CTGCAGCCAAAGTTGGATTTGCGGCCTATGAATAAAACCATTACTTTAAAAAGTAATACCCCCAAAAAAGTTACACCTGAAGTTTCATCT
TCATGCCTTTGTGTAATATTACTATAATGGTGAAATGATGATTTAAAAAAAACACATCAGAACTGACACATCCTCTTGGATGATGGGTCC
TTCAGTCACCTTGTGAGCCCATGTACTTATTCCGTTGATACAGCCTGTGCTATAAACATGTGGGGCCCTCCTTGTGTGAGCTGCTTGAAT
GGCCAGTACCCCCATTCTTTTGAATATTCCCAATGGCAGTCAATCTTGGCCTTTAAGAATAAATTTAAATATTTGGAAATAGTCCTTAGG
ATCCAAGTTTGATCAATGAAAAGGATGCTTAAGCTGAGTTTGGGGTCACATAAGAAGTGCAGTTATAAAGAAATAAGACATGTTGGGCAT
GGCAGTACACACCTGTAGTCCCAGCTGCTTGGGAAGCCAAGGCAGGAGGATCACTTCAACCCAGGAGTTTGAGTCCAGCCTGGGTAACAT
AGGGAAACCCCATCTCAAAAAAACAAAACAAAGGACTTAGTTTTTATGTGGCTCATAAGTGTCTCTAAGTTATACCAAAAGTTTGAGCAC
AACAGTAGTAGCAGAATGCTTAGAATAAATGCTTGACTTTTAAGCTGACTTTTGGAAGGACCATACCCACATAGAGGCATCTTTTCTGCT
GTGGTAATTTTTTAAATTAATACATTGCTTTAGGATTACATCTCAAAGTAAATAAAAAAATCAATATTTAATTTGTTTTTTTCCTGCAAA
TAAATTAAATGCTGGGACCATAATGATTATTTTTGCATAGTAATAGCTGGTGAAGAAGTTGTTTTAAAATTAAATTGCCAAAAGTATTAC
CTCTTGAAAAATTTATTTTCCCAAAGTTTTTCATATGTCATGAAACCCCTAATCTTGACCTTTATGACACAGTGGCATTACACTGATGTT
GGAAGCATGTGTGAGATCTGTGCCCTGGTCGGGAGTCATATGCCTTAAAAATGACTGCGAGTCAGTGTGAAGTAGTATAAAGTGGAGTCC
TACGTGGGAAAAAGCAGGCTACTGAGGACAAAAACCTCCCAACCCTCCCCACCTTGTTTTCCACTGGGAATGAGAATTTGATATGAGAAA
CTTCAACCTTGCAGAAGTGTGGATTTCCCTCTGAAATTTAAATGTTTCACACATTTTTGTACCTTTTGTAACCTTGTGGTATTTACTTTC
ACATGGCTTTTTAAAAAATTATTTTAATGAACTTCTATCACACTATATGAATGATATGGGGGAAATACTGAACTGCTCATATTTCCTTTT
TTGGCAATAAAGCACTGTTATATGTAAATGTAAGTGAAAAAGAGGTTCAAGACTATACAACAGCTTATGTGTAGTATATGTTGACATCCC
TAAGGTATTTTGAAACATGAGGTGACAGACAAGGACCTCAAATTTCCAGGGAAATATTTATTTCACAACATTAGGAGTGTAGCTCTTCAT
AATGAAATATCTTCTTTCTGCTAAAGATTACAATTTTTCATTTAGGGAACTGTGAATATTTTCTGTGAGGTTTACAGAAACTAGTGTATC
CTTTTCACTATGTTGAAAAGACAATCTGAACTTTAGCTATTTATATTTCAGTATTAACACACCTTCACTGATTGAGAGTCTTGAGCCCTT
CTCTACTTTTATAAAGTGAATCCTATTTCCAAGTCATCCATGTCTTTTGAAGTCTGTTTCTTATATAAGTATTTATTACTTTACTGTTTA
GCATAAATAGGAGACAGAAAAGGATAATAAACTACTAGGTCCTTTATTCCTATTAAAATAAATTTATAAATCCCTTGAATCAACTGAATT
CTAAGCTTTTTGAAGAGGTTGCTGATGTAGTGTGATCAAAAGAATCTAAGGAGAACCTCCTCTCCAAAATCTGATTGGAGCTGTTCACCC
TCTCAAGGACAAGATAAAGATTGACTTCAGAGATATATCACATCAAGCTAGAGGAAAAAAAAAAAACCTCAAATAAAATTTTTCCTCATT
CGAAGGGATCCAGGGTATCCTTGGGTTATGTAGGAGGGAATCATATTTGTTCTAATTTACCTGAATGTACTTGTGTGTGAATCCAATCTT
GATTCTAAACACCAAATCTTGTCAACAGTAGAGAAGTATAGTAAGGAGTTCCTGTTGTCAATCAAATGAGGGTGTGAAACATTTAGAATG
CTCTGTGTTACACTTGAACCATGTATAAATGTAACCTGTGTATCTTTTTTTTAATTAGCTTTTCTGAATTTAAATTATATTGTTTTTCTT
TGTATTGTTAGCAAAATGCATCAGAACTGGATTTTTTTTCTCATCTGAACATAATATAAAATTTGAAAGAGTATTGTGATATTAAGCACT
TTAACATACATATCAGACAAACTGACGTGGGTTTTTCAGGTTTGGGAGTACATTTAAATATGACTTTTCATGCTTTGTTCTTTACAAATA

>In-frame_ENST00000394708_ENST00000389082_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=893AA_start in transcript=278_stop in transcript=2959
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKE
LPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCL
AGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELS
AAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPR
CHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMI
AFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIE
RCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFK

--------------------------------------------------------------
>In-frame_ENST00000394708_ENST00000536562_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=5110nt_BP=2936nt
AGCGTTGGGTCGCGGTGGCTGTGAGGGCGGAAGAAAAGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGA
AGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGC
GTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCG
CTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTC
CAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGAC
TTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATA
TTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGA
GCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTC
CTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATT
TCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCAT
TGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATA
TTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTA
TAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGA
AGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATT
TAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTT
GGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTC
TCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAA
GAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATG
AGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGC
TAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTC
TTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATA
TTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTC
ATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCAT
GTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTC
AGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTA
CCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTG
GAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTG
ACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGC
CATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAAT
CCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCC
ACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTC
ACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGA
ACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGA
TCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGT
CTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGA
GCATGTTGGGCTGGACAACGACTTGAGGGAGAAATATATGCAAGAGGCACGAAGTTTAGGAAAAAACCTGAGGCAACCCAAACTGTCAGA
CCTCTCTCCTGCAGTTATTGCACAGACCAACTGTAAATTCGTAGAAGGCTTATTAAAAGAATGTAGAATGAAGACAAAGCGCATGTTGGT
GGAGAAGATGGGACATGAAGCGGTGGAACTTGGCCATGGAGAAGCAAACATCACCGGCCTGGAGGAGAACACCTTGATCGCCAGCCTTTG
TGACCTGCTGGAGAGGATATGGAGCCATGGCTTGCAGGTCAAGCAGGGGAAGTCGGCTTTGTGGTCACATTTAATTCAATTTCAGGACAG
AGAAGAGAAACAAGAGCACCTTGCAGAATCACCAGTTGCCCTCGGACCAGAAAGAAGAAAATCTGACTCAGGAGTTATGTTGCCAACGCT
CAGGGTCTCTCTTATTCAGGACATGAGGCATATTCAAAACATGAGTGAGATCAAGACTGATGTTGGACGAGCTCGGGCGTGGATAAGACT
GTCTCTAGAAAAGAAGCTCTTGTCCCAGCATCTTAAGCAGTTGCTTTCTAACCAACCACTCACCAAGAAGCTTTATAAGCGATATGCTTT
TCTACGTTGCGAAGAAGAAAGAGAGCAGTTTCTTTACCACCTTCTTTCTCTCAATGCTGTGGACTATTTCTGCTTCACCAGTGTGTTCAC
CACTATCATGATTCCGTATAGGTCAGTGATCATCCCAATCAAAAAGCTGAGCAATGCAATAATCACATCAAACCCTTGGATCTGTGTATC
AGGAGAGCTGGGAGACACAGGAGTAATGCAGATTCCCAAAAACCTCCTCGAAATGACCTTTGAGTGCCAGAACTTGGGGAAGCTGACCAC
TGTTCAGATTGGTCACGATAACTCAGGACTGTTAGCCAAATGGCTAGTGGATTGTGTCATGGTCAGAAATGAAATCACAGGACATACATA
CAGATTCCCATGTGGGCGGTGGCTGGGGAAAGGCATTGATGATGGGAGCCTGGAGAGAATTCTTATTGGAGAGTTGATGACATCAGCATC
AGATGAAGATCTAGTAAAGCAGTGTCGGACTCCACCCCAGCAGAAGTCACCCACCACGGCTAGGAGATTGAGCATCACTTCACTGACAGG
AAAAAACAACAAACCCAATGCTGGGCAGATACAAGAAGGAATTGGAGAAGCTGTGAACAATATTGTGAAACATTTTCATAAACCTGAAAA
AGAGAGAGGAAGCCTCACCGTGTTGCTGTGTGGAGAAAATGGCCTGGTTGCAGCCCTTGAGCAAGTTTTCCACCATGGGTTCAAATCTGC
CCGCATCTTTCACAAGAATGTCTTCATCTGGGACTTCATAGAGAAAGTGGTTGCTTATTTTGAAACAACTGACCAGATTCTAGATAATGA
AGATGATGTCCTTATTCAGAAATCATCCTGCAAAACCTTCTGCCACTACGTAAATGCTATTAATACTGCACCCAGGAACATTGGGAAGGA
TGGCAAATTCCAGATTTTAGTTTGCCTTGGAACAAGGGATCGCCTGCTCCCACAGTGGATTCCATTGTTAGCTGAGTGTCCTGCCATCAC
TCGAATGTATGAAGAGAGCGCTCTCCTGCGAGACCGCATGACTGTCAACTCCCTTATCCGAATTCTGCAGACCATTCAGGACTTCACCAT
AGTCCTAGAAGGATCACTCATCAAAGGAGTGGATGTGTAACCCAACTGGCTAGAAACTCTCAGTCCAAACCTTGCTCCTTCCCCAACTAG
GGGACCGATTTGGACTTGTCTGACAGTAGTGAGTCACTGCAGGGGCAGCCAAACATATGCCCCATTTGGAACAATCCTCACTCTACAGAC

>In-frame_ENST00000394708_ENST00000536562_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=893AA_start in transcript=278_stop in transcript=2959
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKE
LPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCL
AGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELS
AAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPR
CHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMI
AFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIE
RCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFK

--------------------------------------------------------------
>In-frame_ENST00000394708_ENST00000354285_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(transcript)=3961nt_BP=2936nt
AGCGTTGGGTCGCGGTGGCTGTGAGGGCGGAAGAAAAGGCCAGGCTGAGGGGAGGGTAGAGGGTGAAAAGCTCGGATCTGTGTTTGGGGA
AGGCCAGGCTTGCGCTCCTCGCCGGGTTCCGCGAAGGTTAACCTTGGCTGACTTGGCTCGCGAGCAAAGGGCAGCGTCTGAGCTCCCGGC
GTTCCAGGAGTGGCCTCTTTTGTAGGAGCACCTGAAATGCAGCGTCTGGTGCACTAAGCCGTAGCGGCAGCAGCAGCCACAGCGACAGCG
CTGGGGCCCTGTGTAGAAGCTCCATCCCCCTTGTCTTTGTGCTTGCCTGCGTCCCCAGACTCAGAGATTATCTTAGAAGACCTAGGACTC
CAAAAATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGAC
TTCCTCTCACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATA
TTTCTAGGGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGA
GCTGTTCAACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTC
CTCATAATATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATT
TCCCAATAGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCAT
TGCCTTCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATA
TTTCTGAAAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTA
TAAAGGAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGA
AGGACAAAGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATT
TAACTCTGCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTT
GGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTC
TCTTTGAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAA
GAAATAGATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATG
AGTTGTCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGC
TAAAGGCTTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTC
TTCTGGGAGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATA
TTCCTCGCTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTC
ATCCTGATCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCAT
GTATGTCTGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTC
AGATGATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTA
CCATGTTTACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTG
GAGTAGCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTG
ACATTGAACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGC
CATCTTCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAAT
CCATCCCATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCC
ACTTCAAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTC
ACATTTCAGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGA
ACTTCAAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGCCCAATCAATTGAGCAGAGACTGATGAAAATGGA
TCACACTGCAATCCACCCACATCTACTTGATATGAAAATTGGTCAAGGCAAATATGAGCAGGGGTTCTTTCCAAAGTTACAGTCCGATGT
CTTGGCAACAGGACCAACCAGTAACAATCGCTGGGTAAGTCGGAGTGCCACTGCACAGCGCAGGAAAGAACGCCTTCGCCAGCATTCTGA
GCATGTTGGGCTGGACAACGACTTGAGGGAGGTATGTGGTCTACCTTCCTGGGGTGCCTCACAGCAAGCGCCATGAACTAGGCTTATTCC
TTCCAGCAGATGTCATTGTGTAGATTCTTAATGTTCTTTAAAAAAAAAACTGTTTAGTTATAGTTTAAAATATTAATCCTTTTGTACGGA
CATATAGCAGAAAACACCCTTTTTTCCATTTTTGTAATTTCAAGACATCTATAATAAGGCTCTAAAACAAGTCTTTCTGTGTATTACATC
AAGTAAAGATCAAGTTGAGGATAAATTTTTAGTTACTATGTCTCCTATAGGAGAAAAATTGTCTGCATGAGAAGCCTAGACATTTCTAAG
TTTCAAGCATAATTATAAGGAGTAGTGTGATGTACTTGCCTATGCTTTGTTCTTGGCTTGCTGGCACCAGTTTTTTTTCTTGAATCTCTA
AATCTACTTTATATTTTTGAAAGTGTTTTAAAACTATTTTTAAATTAAGATCCTTACACTTTTATTTGTACTCTTTGAAAATAAGACCAT
AATTATACAACAAGTAAGTTTTGATTTTTTTCTGTGTGAAATCTGCATATATATATAGTGTCTTGCTATGTTGCCCAGGTCTTGAACTCC
TGGGCTCAAGCAGTGCTCCTGCCTCAGCCTCCCAAAGTATTGGGATTACAGGTGTGAGCTGCCATGCCCAGCCTGATTGTTTCGTTTCTT
ATGATCAAAAGAGAAATGCAATCAGAAGACTTGTTAACTGTTTTCTAGTATCAAATTTGTAAAAATAAAGCAGAAAACATCATCCCAAAC

>In-frame_ENST00000394708_ENST00000354285_TCGA-19-2624-01A_TBCK_chr4_107016639_-_DENND5B_chr12_31595859_length(amino acids)=893AA_start in transcript=278_stop in transcript=2959
MCRSSIPLVFVLACVPRLRDYLRRPRTPKMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISR
GKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPI
GYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKE
LPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCL
AGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELS
AAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPR
CHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMI
AFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIE
RCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBCK-DENND5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBCK-DENND5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBCK-DENND5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBCKC4225161HYPOTONIA, INFANTILE, WITH PSYCHOMOTOR RETARDATION AND CHARACTERISTIC FACIES 37CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTBCKC0036572Seizures1GENOMICS_ENGLAND