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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBCK-USP10 (FusionGDB2 ID:88881)

Fusion Gene Summary for TBCK-USP10

check button Fusion gene summary
Fusion gene informationFusion gene name: TBCK-USP10
Fusion gene ID: 88881
HgeneTgene
Gene symbol

TBCK

USP10

Gene ID

93627

84669

Gene nameTBC1 domain containing kinaseubiquitin specific peptidase 32
SynonymsHSPC302|IHPRF3|TBCKLNY-REN-60|USP10
Cytomap

4q24

17q23.1-q23.2

Type of geneprotein-codingprotein-coding
DescriptionTBC domain-containing protein kinase-like proteinubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000273980, ENST00000432496, 
ENST00000361687, ENST00000394706, 
ENST00000394708, ENST00000514689, 
ENST00000219473, ENST00000570191, 
ENST00000562743, 
Fusion gene scores* DoF score7 X 5 X 6=21017 X 15 X 9=2295
# samples 719
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2295*10)=-3.59442282997022
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBCK [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBCK(107016639)-USP10(84806147), # samples:1
Anticipated loss of major functional domain due to fusion event.TBCK-USP10 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TBCK-USP10 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TBCK-USP10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TBCK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across USP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0RS-01ATBCKchr4

107016639

-USP10chr16

84806147

+


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Fusion Gene ORF analysis for TBCK-USP10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000273980ENST00000219473TBCKchr4

107016639

-USP10chr16

84806147

+
In-frameENST00000273980ENST00000570191TBCKchr4

107016639

-USP10chr16

84806147

+
5CDS-intronENST00000273980ENST00000562743TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000432496ENST00000219473TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000432496ENST00000570191TBCKchr4

107016639

-USP10chr16

84806147

+
5CDS-intronENST00000432496ENST00000562743TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000361687ENST00000219473TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000361687ENST00000570191TBCKchr4

107016639

-USP10chr16

84806147

+
5CDS-intronENST00000361687ENST00000562743TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000394706ENST00000219473TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000394706ENST00000570191TBCKchr4

107016639

-USP10chr16

84806147

+
5CDS-intronENST00000394706ENST00000562743TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000394708ENST00000219473TBCKchr4

107016639

-USP10chr16

84806147

+
Frame-shiftENST00000394708ENST00000570191TBCKchr4

107016639

-USP10chr16

84806147

+
5CDS-intronENST00000394708ENST00000562743TBCKchr4

107016639

-USP10chr16

84806147

+
intron-3CDSENST00000514689ENST00000219473TBCKchr4

107016639

-USP10chr16

84806147

+
intron-3CDSENST00000514689ENST00000570191TBCKchr4

107016639

-USP10chr16

84806147

+
intron-intronENST00000514689ENST00000562743TBCKchr4

107016639

-USP10chr16

84806147

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273980TBCKchr4107016639-ENST00000219473USP10chr1684806147+391730194483417989
ENST00000273980TBCKchr4107016639-ENST00000570191USP10chr1684806147+353030194483417989

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273980ENST00000219473TBCKchr4107016639-USP10chr1684806147+0.0001718670.9998281
ENST00000273980ENST00000570191TBCKchr4107016639-USP10chr1684806147+0.0002089840.9997911

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Fusion Genomic Features for TBCK-USP10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBCKchr4107016638-USP10chr1684806146+0.0010226140.9989774
TBCKchr4107016638-USP10chr1684806146+0.0010226140.9989774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TBCK-USP10


check button Go to

FGviewer for the breakpoints of chr4:107016639-chr16:84806147

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCKchr4:107016639chr16:84806147ENST00000273980-26271_273857.0894.0DomainProtein kinase
HgeneTBCKchr4:107016639chr16:84806147ENST00000273980-2627466_651857.0894.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr16:84806147ENST00000361687-23241_273794.0831.0DomainProtein kinase
HgeneTBCKchr4:107016639chr16:84806147ENST00000361687-2324466_651794.0831.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr16:84806147ENST00000394706-25261_273818.0855.0DomainProtein kinase
HgeneTBCKchr4:107016639chr16:84806147ENST00000394706-2526466_651818.0855.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr16:84806147ENST00000394708-25261_273857.0894.0DomainProtein kinase
HgeneTBCKchr4:107016639chr16:84806147ENST00000394708-2526466_651857.0894.0DomainRab-GAP TBC
HgeneTBCKchr4:107016639chr16:84806147ENST00000432496-25261_273857.0894.0DomainProtein kinase
HgeneTBCKchr4:107016639chr16:84806147ENST00000432496-2526466_651857.0894.0DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBCKchr4:107016639chr16:84806147ENST00000273980-2627790_889857.0894.0DomainRhodanese
HgeneTBCKchr4:107016639chr16:84806147ENST00000361687-2324790_889794.0831.0DomainRhodanese
HgeneTBCKchr4:107016639chr16:84806147ENST00000394706-2526790_889818.0855.0DomainRhodanese
HgeneTBCKchr4:107016639chr16:84806147ENST00000394708-2526790_889857.0894.0DomainRhodanese
HgeneTBCKchr4:107016639chr16:84806147ENST00000432496-2526790_889857.0894.0DomainRhodanese
TgeneUSP10chr4:107016639chr16:84806147ENST000002194731014415_795666.0799.0DomainNote=USP
TgeneUSP10chr4:107016639chr16:84806147ENST000005701911115415_795670.0803.0DomainNote=USP


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Fusion Gene Sequence for TBCK-USP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000273980_ENST00000219473_TCGA-B6-A0RS-01A_TBCK_chr4_107016639_-_USP10_chr16_84806147_length(transcript)=3917nt_BP=3019nt
TCCTCACTTCTCAGACCGGGCAGCCGGTCAGAGACGCTCCTCACCTCCCAGACGGGGTGGCGGCGGGGCAGAGACACTCCTCAGTTCCCA
GACAGGGTCGCGGCCGGGCAGAGGCGCTCTTCACATCTCAGACGGGGCGACGGGGCAGAGATGCTCCCCACATCCCAGATGATGGGCGGC
TGGGCAGAGACGCTCCTCACTTCCTAGACAGGATGACGGCCGGGAAGAGGCCAGGGCTGGTCCTGCTGCGAACGGACTACCCATTAGCAG
CGCAGGCCAGGTCCTCTCTCCTGGAGGCAAGTTAGAGAAGGAAGACCCCTACGATCGCAATCGGCGATCCCCGAGTGAGTGACCCGCCAC
GACGTCACTCACATGAAGCGGAGGACCACGGGTTCCGAGACAGCCACAGCAGGAAGCATATTATCTTAGAAGACCTAGGACTCCAAAAAT
GTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCT
CACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAG
GGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTC
AACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTCCTCATAA
TATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATTTCCCAAT
AGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTC
TGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGA
AAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGA
GCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAA
AGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCT
GCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTT
GGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGA
GGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAG
ATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTC
TGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGC
TTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGG
AGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCG
CTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGA
TCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTC
TGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGAT
TGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTT
TACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGC
AATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGA
ACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTC
TGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAATCCATCCC
ATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCCACTTCAA
AACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTCACATTTC
AGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGAACTTCAA
AGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCC
TGTCCTCGTGCTGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTT
GGAAATTAGTAAAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCA
TCACGGCAACAGTGCGACGGGCGGCCATTACACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGT
CAAGGTGATCAACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAAC
CCTGTGTGCGCTGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCACCTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGA
GAAACTCTTTCTCCCTTTGCAAAAATGGGCTAGAATGAAAAGGAGATGCCTTGGGGTTCGTGCACAACACAGCTTCTGTTGACTCTAACT
TCCAAATCAAAATCATTTGGTTGAAACAGACTGTTGCTTGATTTTAGAAAATACACAAAAACCCATATTTCTGAAATAATGCTGATTCCT
GAGATAAGAAAGTGGATTTGATCCCCAGTCTCATTGCTTAGTAGAATAAATCCTGCACCAGCAACAACACTTGTAAATTTGTGAAAATGA
ATTTTATCTTTCCTTAAAAAAGAAATTTTTTAATCCATCACACTTTTCTTCCCTACCCTTTAGTTTTTGATAAATGATAAAAATGAGCCA

>In-frame_ENST00000273980_ENST00000219473_TCGA-B6-A0RS-01A_TBCK_chr4_107016639_-_USP10_chr16_84806147_length(amino acids)=989AA_start in transcript=448_stop in transcript=3417
MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERKPVSC
STVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLP
SGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKD
KVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLF
EDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLK
AYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHP
DLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTM
FTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPS
SDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHI
SGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVD

--------------------------------------------------------------
>In-frame_ENST00000273980_ENST00000570191_TCGA-B6-A0RS-01A_TBCK_chr4_107016639_-_USP10_chr16_84806147_length(transcript)=3530nt_BP=3019nt
TCCTCACTTCTCAGACCGGGCAGCCGGTCAGAGACGCTCCTCACCTCCCAGACGGGGTGGCGGCGGGGCAGAGACACTCCTCAGTTCCCA
GACAGGGTCGCGGCCGGGCAGAGGCGCTCTTCACATCTCAGACGGGGCGACGGGGCAGAGATGCTCCCCACATCCCAGATGATGGGCGGC
TGGGCAGAGACGCTCCTCACTTCCTAGACAGGATGACGGCCGGGAAGAGGCCAGGGCTGGTCCTGCTGCGAACGGACTACCCATTAGCAG
CGCAGGCCAGGTCCTCTCTCCTGGAGGCAAGTTAGAGAAGGAAGACCCCTACGATCGCAATCGGCGATCCCCGAGTGAGTGACCCGCCAC
GACGTCACTCACATGAAGCGGAGGACCACGGGTTCCGAGACAGCCACAGCAGGAAGCATATTATCTTAGAAGACCTAGGACTCCAAAAAT
GTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCACATGATGTTTGTGGAAGCAATGGACTTCCTCT
CACACCAAATTCCATCAAAATTTTAGGGCGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCTAG
GGGAAAGCATGAACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGACTTGCTTCGAGAAAGGAAACCTGTGAGCTGTTC
AACGGTTTTGTGTATAGCATTTGAGGTTCTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTCCTCATAA
TATCCTGTTGGACCGAAAGGGACATATTAAATTGGCTAAATTTGGACTTTATCACATGACAGCTCATGGTGATGATGTTGATTTCCCAAT
AGGGTATCCCTCGTACTTGGCCCCTGAGGTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCTTC
TGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTGGGAAGAAAATTATTTCAGAGCTTGGATATTTCTGA
AAGACTAAAATTTTTGCTTACTTTGGATTGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAGGA
GCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAGAGGCCAACCCCAGATCAATTAATGAAGGACAA
AGTATTCAGTGAGGTATCACCTTTATATACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACTCT
GCCTGAGGATATCAGTCAGTTGTGTAAAGATATAAATAATGATTACCTGGCAGAAAGATCTATTGAAGAAGTGTATTACCTTTGGTGTTT
GGCTGGAGGTGACTTGGAGAAAGAGCTTGTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAATTTTCTCTTTGA
GGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACTGTGACATTGTCGTTATGCCAGCTAAGAAATAG
ATTGAAAGATGTTGGTGGAGAAGCATTTTACCCATTACTTGAAGATGACCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTGTC
TGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAATAGAATTATTCTCTTCGACAGGCTGCTAAAGGC
TTATCCATATAAAAAAAACCAAATCTGGAAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTGGG
AGTTGAGGGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCTACAGATAGACAAATTGAAGTGGATATTCCTCG
CTGTCATCAGTACGATGAACTGTTATCATCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCTGA
TCTTGTGTATTGGCAAGGTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTCAATAATGAAGCCTTGGCTTATGCATGTATGTC
TGCTTTTATTCCCAAATACCTGTATAACTTCTTCTTAAAAGACAACTCACATGTAATACAAGAGTATCTGACTGTCTTCTCTCAGATGAT
TGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGATCTCTATGCCATCCCTTGGTTTCTTACCATGTT
TACTCATGTATTTCCACTACACAAAATTTTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTAGC
AATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTTCTCTTCTCCGATTTACCAGAAATTGACATTGA
ACGCTGTGTGAGAGAATCTATCAACCTGTTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCTTC
TGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCTCCAAAGACAGATCTGTCAAGAGAATCCATCCC
ATTAAATGACCTGAAGTCAGAAGTATCACCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCCACTTCAA
AACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGGAATAGTGAAGACTTTATTCGTGGTCACATTTC
AGGAAGCATCAACATTCCATTCAGTGCTGCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGAACTTCAA
AGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCC
TGTCCTCGTGCTGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTT
GGAAATTAGTAAAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCA
TCACGGCAACAGTGCGACGGGCGGCCATTACACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGT
CAAGGTGATCAACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAAC
CCTGTGTGCGCTGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCACCTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGA

>In-frame_ENST00000273980_ENST00000570191_TCGA-B6-A0RS-01A_TBCK_chr4_107016639_-_USP10_chr16_84806147_length(amino acids)=989AA_start in transcript=448_stop in transcript=3417
MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERKPVSC
STVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLP
SGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDQLMKD
KVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLF
EDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLK
AYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHP
DLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTM
FTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPS
SDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHI
SGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVD

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Fusion Gene PPI Analysis for TBCK-USP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneUSP10chr4:107016639chr16:84806147ENST0000021947310142_100666.0799.0p53/TP53
TgeneUSP10chr4:107016639chr16:84806147ENST0000057019111152_100670.0803.0p53/TP53


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBCK-USP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBCK-USP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBCKC4225161HYPOTONIA, INFANTILE, WITH PSYCHOMOTOR RETARDATION AND CHARACTERISTIC FACIES 37CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTBCKC0036572Seizures1GENOMICS_ENGLAND