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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBL1XR1-CACNA1C (FusionGDB2 ID:88915)

Fusion Gene Summary for TBL1XR1-CACNA1C

check button Fusion gene summary
Fusion gene informationFusion gene name: TBL1XR1-CACNA1C
Fusion gene ID: 88915
HgeneTgene
Gene symbol

TBL1XR1

CACNA1C

Gene ID

79718

775

Gene nameTBL1X receptor 1calcium voltage-gated channel subunit alpha1 C
SynonymsC21|DC42|IRA1|MRD41|TBLR1CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS|TS. LQT8
Cytomap

3q26.32

12p13.33

Type of geneprotein-codingprotein-coding
DescriptionF-box-like/WD repeat-containing protein TBL1XR1TBL1-related protein 1nuclear receptor co-repressor/HDAC3 complex subunitnuclear receptor corepressor/HDAC3 complex subunit TBLR1transducin beta like 1 X-linked receptor 1voltage-dependent L-type calcium channel subunit alpha-1CDHPR, alpha-1 subunitcalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac musclecalcium channel, cardic dihydropyridine-sensitive, alpha-1 subunitcalcium channel, voltage-dependent,
Modification date2020031320200315
UniProtAcc.

Q13936

Ensembl transtripts involved in fusion geneENST00000430069, ENST00000457928, 
ENST00000335762, ENST00000399655, 
ENST00000480911, ENST00000399644, 
ENST00000344100, ENST00000399638, 
ENST00000399629, ENST00000399597, 
ENST00000327702, ENST00000399621, 
ENST00000399649, ENST00000399637, 
ENST00000402845, ENST00000399591, 
ENST00000399641, ENST00000347598, 
ENST00000399606, ENST00000399595, 
ENST00000399601, ENST00000399603, 
ENST00000399634, ENST00000399617, 
ENST00000406454, ENST00000491104, 
Fusion gene scores* DoF score51 X 31 X 15=2371521 X 20 X 10=4200
# samples 6624
** MAII scorelog2(66/23715*10)=-5.16719003372107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/4200*10)=-4.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBL1XR1 [Title/Abstract] AND CACNA1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBL1XR1(176816254)-CACNA1C(2721069), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBL1XR1

GO:0000122

negative regulation of transcription by RNA polymerase II

12628926

HgeneTBL1XR1

GO:0045893

positive regulation of transcription, DNA-templated

18193033

HgeneTBL1XR1

GO:0045944

positive regulation of transcription by RNA polymerase II

18193033

TgeneCACNA1C

GO:0007204

positive regulation of cytosolic calcium ion concentration

12130699

TgeneCACNA1C

GO:0061577

calcium ion transmembrane transport via high voltage-gated calcium channel

15454078

TgeneCACNA1C

GO:0070588

calcium ion transmembrane transport

15454078


check buttonFusion gene breakpoints across TBL1XR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CACNA1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27V-01ATBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
ChimerDB4BRCATCGA-D8-A27VTBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
ChimerDB4BRCATCGA-D8-A27VTBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
ChimerDB4BRCATCGA-D8-A27V-01ATBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
ChimerDB4BRCATCGA-D8-A27V-01ATBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
ChimerDB4BRCATCGA-D8-A27V-01ATBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
ChimerDB4BRCATCGA-D8-A27V-01ATBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+


Top

Fusion Gene ORF analysis for TBL1XR1-CACNA1C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000430069ENST00000335762TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399655TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000480911TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399644TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000344100TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399638TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399629TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399597TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000327702TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399621TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399649TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399637TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000402845TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399591TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399641TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000347598TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399606TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399595TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399601TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399603TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399634TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000399617TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000406454TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-intronENST00000430069ENST00000491104TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000335762TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399655TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000480911TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399644TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000344100TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399638TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399629TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399597TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000327702TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399621TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399649TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399637TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000402845TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399591TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399641TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000347598TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399606TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399595TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399601TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399603TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399634TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399617TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000406454TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-intronENST00000457928ENST00000491104TBL1XR1chr3

176816254

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000430069ENST00000335762TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399655TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000480911TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399644TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000344100TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399638TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399629TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399597TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000327702TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399621TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399649TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399637TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000402845TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399591TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399641TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000347598TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399606TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399595TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399601TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399603TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399634TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000399617TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000430069ENST00000406454TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-intronENST00000430069ENST00000491104TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000335762TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399655TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000480911TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399644TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000344100TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399638TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399629TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399597TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000327702TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399621TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399649TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399637TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000402845TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399591TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399641TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000347598TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399606TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399595TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399601TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399603TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399634TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399617TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000406454TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
5UTR-intronENST00000457928ENST00000491104TBL1XR1chr3

176816253

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000335762TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399655TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000480911TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399644TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000344100TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399638TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399629TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399597TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000327702TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399621TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399649TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399637TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000402845TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399591TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399641TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000347598TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399606TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399595TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399601TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399603TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399634TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000399617TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000406454TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-intronENST00000430069ENST00000491104TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000335762TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399655TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000480911TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399644TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000344100TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399638TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399629TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399597TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000327702TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399621TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399649TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399637TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000402845TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399591TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399641TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000347598TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399606TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399595TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399601TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399603TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399634TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000399617TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-3CDSENST00000457928ENST00000406454TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
5UTR-intronENST00000457928ENST00000491104TBL1XR1chr3

176914908

-CACNA1Cchr12

2721068

+
intron-3CDSENST00000430069ENST00000335762TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399655TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000480911TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399644TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000344100TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399638TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399629TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399597TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000327702TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399621TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399649TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399637TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000402845TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399591TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399641TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000347598TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399606TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399595TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399601TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399603TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399634TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399617TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000406454TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-intronENST00000430069ENST00000491104TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000335762TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399655TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000480911TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399644TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000344100TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399638TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399629TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399597TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000327702TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399621TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399649TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399637TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000402845TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399591TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399641TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000347598TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399606TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399595TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399601TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399603TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399634TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000399617TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000457928ENST00000406454TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-intronENST00000457928ENST00000491104TBL1XR1chr3

176804753

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000335762TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399655TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000480911TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399644TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000344100TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399638TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399629TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399597TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000327702TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399621TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399649TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399637TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000402845TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399591TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399641TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000347598TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399606TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399595TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399601TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399603TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399634TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000399617TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-3CDSENST00000430069ENST00000406454TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
intron-intronENST00000430069ENST00000491104TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000335762TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399655TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000480911TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399644TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000344100TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399638TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399629TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399597TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000327702TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399621TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399649TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399637TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000402845TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399591TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399641TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000347598TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399606TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399595TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399601TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399603TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399634TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000399617TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-3CDSENST00000457928ENST00000406454TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+
5UTR-intronENST00000457928ENST00000491104TBL1XR1chr3

176914909

-CACNA1Cchr12

2721069

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TBL1XR1-CACNA1C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBL1XR1chr3176816253-CACNA1Cchr122721068+2.44E-081
TBL1XR1chr3176816253-CACNA1Cchr122721068+2.44E-081
TBL1XR1chr3176914908-CACNA1Cchr122721068+4.15E-101
TBL1XR1chr3176914908-CACNA1Cchr122721068+4.15E-101
TBL1XR1chr3176816253-CACNA1Cchr122721068+2.44E-081
TBL1XR1chr3176816253-CACNA1Cchr122721068+2.44E-081
TBL1XR1chr3176914908-CACNA1Cchr122721068+4.15E-101
TBL1XR1chr3176914908-CACNA1Cchr122721068+4.15E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TBL1XR1-CACNA1C


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CACNA1C

Q13936

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:11741969, ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:7737988, ECO:0000269|PubMed:8099908, ECO:0000269|PubMed:8392192, ECO:0000269|PubMed:9013606, ECO:0000269|PubMed:9087614, ECO:0000269|PubMed:9607315, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TBL1XR1-CACNA1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TBL1XR1-CACNA1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TBL1XR1-CACNA1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00308IbutilideActivatorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00381AmlodipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00401NisoldipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00661VerapamilInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB00898EthanolSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB01115NifedipineInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB04855DronedaroneInhibitorSmall moleculeApproved
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00270IsradipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00343DiltiazemBlockerSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00393NimodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00568CinnarizineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB00622NicardipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01023FelodipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB01054NitrendipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB04920ClevidipineSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06712NilvadipineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB06751DrotaverineInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB09237LevamlodipineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB11633IsavuconazoleInhibitorSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational
TgeneCACNA1CQ13936DB12278PropiverineAntagonistSmall moleculeApproved|Investigational

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Related Diseases for TBL1XR1-CACNA1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTBL1XR1C1865644Plantar Lipomatosis, Unusual Facies, and Developmental Delay5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTBL1XR1C4310784MENTAL RETARDATION, AUTOSOMAL DOMINANT 415CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTBL1XR1C0004352Autistic Disorder1GENOMICS_ENGLAND
HgeneTBL1XR1C0023487Acute Promyelocytic Leukemia1ORPHANET
HgeneTBL1XR1C0033578Prostatic Neoplasms1CTD_human
HgeneTBL1XR1C0345967Malignant mesothelioma1CTD_human
HgeneTBL1XR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneTBL1XR1C1535926Neurodevelopmental Disorders1CTD_human
TgeneCACNA1CC0005586Bipolar Disorder9CTD_human;PSYGENET
TgeneCACNA1CC1832916Timothy syndrome8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCACNA1CC1142166Brugada Syndrome (disorder)7CLINGEN;GENOMICS_ENGLAND
TgeneCACNA1CC1269683Major Depressive Disorder6CTD_human;PSYGENET
TgeneCACNA1CC0011570Mental Depression5PSYGENET
TgeneCACNA1CC0011581Depressive disorder5PSYGENET
TgeneCACNA1CC0041696Unipolar Depression5PSYGENET
TgeneCACNA1CC0525045Mood Disorders5PSYGENET
TgeneCACNA1CC2678478Brugada Syndrome 35CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneCACNA1CC0005587Depression, Bipolar4CTD_human
TgeneCACNA1CC0024713Manic Disorder4CTD_human
TgeneCACNA1CC0036341Schizophrenia4PSYGENET
TgeneCACNA1CC0338831Manic4CTD_human
TgeneCACNA1CC0033975Psychotic Disorders3PSYGENET
TgeneCACNA1CC0178417Anhedonia2PSYGENET
TgeneCACNA1CC0002895Anemia, Sickle Cell1GENOMICS_ENGLAND
TgeneCACNA1CC0003257Antibody Deficiency Syndrome1CTD_human
TgeneCACNA1CC0003469Anxiety Disorders1CTD_human
TgeneCACNA1CC0003811Cardiac Arrhythmia1CTD_human
TgeneCACNA1CC0004352Autistic Disorder1CTD_human
TgeneCACNA1CC0007194Hypertrophic Cardiomyopathy1GENOMICS_ENGLAND
TgeneCACNA1CC0011574Involutional Depression1CTD_human
TgeneCACNA1CC0020538Hypertensive disease1CTD_human
TgeneCACNA1CC0020615Hypoglycemia1CTD_human
TgeneCACNA1CC0021051Immunologic Deficiency Syndromes1CTD_human
TgeneCACNA1CC0038441Stress Disorders, Traumatic1CTD_human
TgeneCACNA1CC0039070Syncope1GENOMICS_ENGLAND
TgeneCACNA1CC0085298Sudden Cardiac Death1GENOMICS_ENGLAND
TgeneCACNA1CC0151879Shortened QT interval1GENOMICS_ENGLAND
TgeneCACNA1CC0206762Limb Deformities, Congenital1CTD_human
TgeneCACNA1CC0234985Mental deterioration1CTD_human
TgeneCACNA1CC0271708Fasting Hypoglycemia1CTD_human
TgeneCACNA1CC0271710Reactive hypoglycemia1CTD_human
TgeneCACNA1CC0338656Impaired cognition1CTD_human
TgeneCACNA1CC0342788Renal carnitine transport defect1GENOMICS_ENGLAND
TgeneCACNA1CC0349204Nonorganic psychosis1PSYGENET
TgeneCACNA1CC0376280Anxiety States, Neurotic1CTD_human
TgeneCACNA1CC0392156Akathisia1CTD_human
TgeneCACNA1CC1270972Mild cognitive disorder1CTD_human
TgeneCACNA1CC1279420Anxiety neurosis (finding)1CTD_human
TgeneCACNA1CC1571983Involutional paraphrenia1CTD_human
TgeneCACNA1CC1571984Psychosis, Involutional1CTD_human
TgeneCACNA1CC3887612Psychomotor Agitation1CTD_human