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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TCF12-TPM1 (FusionGDB2 ID:89104)

Fusion Gene Summary for TCF12-TPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: TCF12-TPM1
Fusion gene ID: 89104
HgeneTgene
Gene symbol

TCF12

TPM1

Gene ID

6938

7168

Gene nametranscription factor 12tropomyosin 1
SynonymsCRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
Cytomap

15q21.3

15q22.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4tropomyosin alpha-1 chaincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappa
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000438423, ENST00000267811, 
ENST00000452095, ENST00000333725, 
ENST00000557843, ENST00000560764, 
ENST00000543579, ENST00000537840, 
ENST00000343827, ENST00000559710, 
ENST00000559703, 		ENST00000288398, 
ENST00000358278, ENST00000560445, 
ENST00000403994, ENST00000357980, 
ENST00000559556, ENST00000559397, 
ENST00000267996, ENST00000334895, 
ENST00000404484, ENST00000560959, 
ENST00000559281, ENST00000317516, 
Fusion gene scores* DoF score29 X 19 X 12=661214 X 8 X 8=896
# samples 3216
** MAII scorelog2(32/6612*10)=-4.36894291440495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/896*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TCF12 [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTCF12(57213296)-TPM1(63336226), # samples:1
Anticipated loss of major functional domain due to fusion event.TCF12-TPM1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TCF12-TPM1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTCF12

GO:0045944

positive regulation of transcription by RNA polymerase II

11802795


check buttonFusion gene breakpoints across TCF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TPM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D9-A4Z5-01ATCF12chr15

57213296

+TPM1chr15

63336226

+


Top

Fusion Gene ORF analysis for TCF12-TPM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000438423ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000438423ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000438423ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000438423ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000438423ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000438423ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000438423ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000438423ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000438423ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000438423ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000438423ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000438423ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000438423ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000267811ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000267811ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000267811ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000267811ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000267811ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000267811ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000267811ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000267811ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000267811ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000267811ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000267811ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000267811ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000267811ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000452095ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000452095ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000452095ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000452095ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000452095ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000452095ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000452095ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000452095ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000452095ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000452095ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000452095ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000452095ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000452095ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000333725ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000333725ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000333725ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000333725ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000333725ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000333725ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000333725ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000333725ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000333725ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000333725ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000333725ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000333725ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000333725ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000557843ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000557843ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000557843ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000557843ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000557843ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
Frame-shiftENST00000557843ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000557843ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000557843ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000557843ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000557843ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000557843ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000557843ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
5CDS-intronENST00000557843ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000560764ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000560764ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000560764ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000560764ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000560764ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000560764ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000560764ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000560764ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000560764ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000560764ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000560764ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000560764ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000560764ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000543579ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000543579ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000543579ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000543579ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000543579ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000543579ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000543579ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000543579ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000543579ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000543579ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000543579ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000543579ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000543579ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000537840ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000537840ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000537840ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000537840ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000537840ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000537840ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000537840ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000537840ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000537840ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000537840ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000537840ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000537840ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000537840ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000343827ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000343827ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000343827ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000343827ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000343827ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000343827ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000343827ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000343827ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000343827ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000343827ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000343827ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000343827ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000343827ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559710ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559710ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559710ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559710ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559710ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559710ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559710ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559710ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559710ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559710ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559710ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559710ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559710ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559703ENST00000288398TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559703ENST00000358278TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559703ENST00000560445TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559703ENST00000403994TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559703ENST00000357980TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-3CDSENST00000559703ENST00000559556TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559703ENST00000559397TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559703ENST00000267996TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559703ENST00000334895TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559703ENST00000404484TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559703ENST00000560959TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559703ENST00000559281TCF12chr15

57213296

+TPM1chr15

63336226

+
intron-intronENST00000559703ENST00000317516TCF12chr15

57213296

+TPM1chr15

63336226

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for TCF12-TPM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TCF12chr1557213296+TPM1chr1563336225+6.76E-050.9999324
TCF12chr1557213296+TPM1chr1563336225+6.76E-050.9999324

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TCF12-TPM1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TCF12-TPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TCF12-TPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TCF12-TPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TCF12-TPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTCF12C3715051CRANIOSYNOSTOSIS 33GENOMICS_ENGLAND;UNIPROT
HgeneTCF12C0010278Craniosynostosis1CTD_human
HgeneTCF12C0030044Acrocephaly1CTD_human
HgeneTCF12C0221356Brachycephaly1CTD_human;ORPHANET
HgeneTCF12C0265529Plagiocephaly1ORPHANET
HgeneTCF12C0265534Scaphycephaly1CTD_human
HgeneTCF12C0265535Trigonocephaly1CTD_human
HgeneTCF12C1275278Extraskeletal Myxoid Chondrosarcoma1ORPHANET
HgeneTCF12C1833340Synostotic Posterior Plagiocephaly1CTD_human
HgeneTCF12C1856266Coronal craniosynostosis1GENOMICS_ENGLAND
HgeneTCF12C1860819Metopic synostosis1CTD_human
HgeneTCF12C2931150Synostotic Anterior Plagiocephaly1CTD_human
HgeneTCF12C4551902Craniosynostosis, Type 11CTD_human
TgeneTPM1C0007194Hypertrophic Cardiomyopathy18CLINGEN
TgeneTPM1C1861863CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)9CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM1C2678476Cardiomyopathy, Dilated, 1y5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM1C0014859Esophageal Neoplasms1CTD_human
TgeneTPM1C0020538Hypertensive disease1CTD_human
TgeneTPM1C0022548Keloid1CTD_human
TgeneTPM1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM1C0340427Familial dilated cardiomyopathy1ORPHANET
TgeneTPM1C0546837Malignant neoplasm of esophagus1CTD_human
TgeneTPM1C0597124Obstructive asymmetric septal hypertrophy1CTD_human
TgeneTPM1C0700053Idiopathic hypertrophic subaortic stenosis1CTD_human
TgeneTPM1C0949658Cardiomyopathy, Hypertrophic, Familial1CTD_human
TgeneTPM1C1960469Left ventricular noncompaction1ORPHANET