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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TCF3-PBX1 (FusionGDB2 ID:89153)

Fusion Gene Summary for TCF3-PBX1

Fusion gene summary

Fusion gene information	Fusion gene name: TCF3-PBX1
	Fusion gene ID: 89153
		Hgene	Tgene
	Gene symbol	TCF3	PBX1
	Gene ID	83439	5087
	Gene name	transcription factor 7 like 1	PBX homeobox 1
	Synonyms	TCF-3\|TCF3	CAKUHED
	Cytomap	2p11.2	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	transcription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)	pre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1
	Modification date	20200313	20200313
	UniProtAcc	TFPT	P40424
	Ensembl transtripts involved in fusion gene	ENST00000344749, ENST00000262965, ENST00000453954, ENST00000395423, ENST00000588136,	ENST00000420696, ENST00000401534, ENST00000559240, ENST00000367897, ENST00000540236, ENST00000560641, ENST00000474046, ENST00000485769, ENST00000540246,
Fusion gene scores	* DoF score	21 X 26 X 9=4914	13 X 13 X 8=1352
	# samples	27	17
	** MAII score	log2(27/4914*10)=-4.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1352*10)=-2.99148850014448 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TCF3 [Title/Abstract] AND PBX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TCF3(1619110)-PBX1(164761730), # samples:2
Anticipated loss of major functional domain due to fusion event.	TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TCF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PBX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	acute myeloid leukemia;acute lymphoblastic lekemia;lymphoblastic lymphoma;acute non lymphocytic leukemia;B cell acute lymphoblastic leukemia	AY311345	TCF3	chr19	1619803		PBX1	chr1	164761730
ChiTaRS5.0	N/A	AY311345	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
ChiTaRS5.0	N/A	M31522	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+

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Fusion Gene ORF analysis for TCF3-PBX1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000344749	ENST00000420696	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000344749	ENST00000401534	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000344749	ENST00000559240	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000344749	ENST00000367897	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000344749	ENST00000540236	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-5UTR	ENST00000344749	ENST00000560641	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000344749	ENST00000474046	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000344749	ENST00000485769	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000344749	ENST00000540246	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000262965	ENST00000420696	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000262965	ENST00000401534	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000262965	ENST00000559240	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000262965	ENST00000367897	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000262965	ENST00000540236	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-5UTR	ENST00000262965	ENST00000560641	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000262965	ENST00000474046	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000262965	ENST00000485769	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000262965	ENST00000540246	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000453954	ENST00000420696	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000453954	ENST00000401534	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000453954	ENST00000559240	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000453954	ENST00000367897	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000453954	ENST00000540236	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-5UTR	ENST00000453954	ENST00000560641	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000453954	ENST00000474046	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000453954	ENST00000485769	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000453954	ENST00000540246	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000395423	ENST00000420696	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000395423	ENST00000401534	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000395423	ENST00000559240	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000395423	ENST00000367897	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000395423	ENST00000540236	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-5UTR	ENST00000395423	ENST00000560641	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000395423	ENST00000474046	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000395423	ENST00000485769	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000395423	ENST00000540246	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000588136	ENST00000420696	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000588136	ENST00000401534	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000588136	ENST00000559240	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000588136	ENST00000367897	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-3CDS	ENST00000588136	ENST00000540236	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-5UTR	ENST00000588136	ENST00000560641	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000588136	ENST00000474046	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000588136	ENST00000485769	TCF3	chr19	1619803		PBX1	chr1	164761730
intron-intron	ENST00000588136	ENST00000540246	TCF3	chr19	1619803		PBX1	chr1	164761730
Frame-shift	ENST00000344749	ENST00000420696	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000401534	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000559240	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000367897	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000540236	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000344749	ENST00000560641	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000344749	ENST00000474046	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000344749	ENST00000485769	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000344749	ENST00000540246	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000420696	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000401534	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000559240	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000367897	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000540236	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000262965	ENST00000560641	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000262965	ENST00000474046	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000262965	ENST00000485769	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000262965	ENST00000540246	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000453954	ENST00000420696	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000453954	ENST00000401534	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000453954	ENST00000559240	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000453954	ENST00000367897	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000453954	ENST00000540236	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000453954	ENST00000560641	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000453954	ENST00000474046	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000453954	ENST00000485769	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000453954	ENST00000540246	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
In-frame	ENST00000395423	ENST00000420696	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
In-frame	ENST00000395423	ENST00000401534	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
In-frame	ENST00000395423	ENST00000559240	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
In-frame	ENST00000395423	ENST00000367897	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
In-frame	ENST00000395423	ENST00000540236	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000395423	ENST00000560641	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000395423	ENST00000474046	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000395423	ENST00000485769	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000395423	ENST00000540246	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000588136	ENST00000420696	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000588136	ENST00000401534	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000588136	ENST00000559240	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000588136	ENST00000367897	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000588136	ENST00000540236	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000588136	ENST00000560641	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000588136	ENST00000474046	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000588136	ENST00000485769	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000588136	ENST00000540246	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000262965	ENST00000560641	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000344749	ENST00000560641	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000453954	ENST00000560641	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-5UTR	ENST00000588136	ENST00000560641	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000262965	ENST00000474046	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000262965	ENST00000485769	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000262965	ENST00000540246	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000344749	ENST00000474046	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000344749	ENST00000485769	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000344749	ENST00000540246	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000453954	ENST00000474046	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000453954	ENST00000485769	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000453954	ENST00000540246	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000588136	ENST00000474046	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000588136	ENST00000485769	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
5CDS-intron	ENST00000588136	ENST00000540246	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000367897	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000401534	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000420696	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000540236	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000262965	ENST00000559240	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000367897	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000401534	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000420696	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000540236	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
Frame-shift	ENST00000344749	ENST00000559240	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000453954	ENST00000367897	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000453954	ENST00000401534	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000453954	ENST00000420696	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000453954	ENST00000540236	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000453954	ENST00000559240	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000588136	ENST00000367897	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000588136	ENST00000401534	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000588136	ENST00000420696	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000588136	ENST00000540236	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
In-frame	ENST00000588136	ENST00000559240	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-3CDS	ENST00000395423	ENST00000367897	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-3CDS	ENST00000395423	ENST00000401534	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-3CDS	ENST00000395423	ENST00000420696	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-3CDS	ENST00000395423	ENST00000540236	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-3CDS	ENST00000395423	ENST00000559240	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-5UTR	ENST00000395423	ENST00000560641	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-intron	ENST00000395423	ENST00000474046	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-intron	ENST00000395423	ENST00000485769	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
intron-intron	ENST00000395423	ENST00000540246	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395423	TCF3	chr19	1619110	-	ENST00000420696	PBX1	chr1	164761730	+	7508	1325	28	2352	774
ENST00000395423	TCF3	chr19	1619110	-	ENST00000401534	PBX1	chr1	164761730	+	2104	1325	28	2103	692
ENST00000395423	TCF3	chr19	1619110	-	ENST00000559240	PBX1	chr1	164761730	+	2080	1325	28	2079	684
ENST00000395423	TCF3	chr19	1619110	-	ENST00000367897	PBX1	chr1	164761730	+	2519	1325	28	2103	691
ENST00000395423	TCF3	chr19	1619110	-	ENST00000540236	PBX1	chr1	164761730	+	2323	1325	28	2322	765

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395423	ENST00000420696	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.000736779	0.9992632
ENST00000395423	ENST00000401534	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.02915048	0.9708495
ENST00000395423	ENST00000559240	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.03946733	0.9605326
ENST00000395423	ENST00000367897	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.023425095	0.97657496
ENST00000395423	ENST00000540236	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.02026107	0.97973895

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Fusion Genomic Features for TCF3-PBX1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TCF3	chr19	1619109	-	PBX1	chr1	164761728	+	0.000137776	0.9998622
TCF3	chr19	1619109	-	PBX1	chr1	164761728	+	0.000137776	0.9998622

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TCF3-PBX1

Go to
FGviewer for the breakpoints of chr19:1619110-chr1:164761730
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TCF3 TFPT	PBX1 P40424
253	FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:8327485, PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250\|UniProtKB:P41778, ECO:0000269\|PubMed:12609849, ECO:0000269\|PubMed:21746878, ECO:0000269\|PubMed:7791786, ECO:0000269\|PubMed:8327485, ECO:0000269\|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250\|UniProtKB:P41778}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

170_176

483.3333333333333

655.0

Motif

Nuclear localization signal

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

19_27

483.3333333333333

655.0

Motif

Note=9aaTAD

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

170_176

483.3333333333333

652.0

Motif

Nuclear localization signal

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

19_27

483.3333333333333

652.0

Motif

Note=9aaTAD

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

170_176

483.3333333333333

527.0

Motif

Nuclear localization signal

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

19_27

483.3333333333333

527.0

Motif

Note=9aaTAD

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

389_425

483.3333333333333

655.0

Region

Note=Leucine-zipper

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

389_425

483.3333333333333

652.0

Region

Note=Leucine-zipper

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

389_425

483.3333333333333

527.0

Region

Note=Leucine-zipper

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000367897

127_135

88.33333333333333

408.3333333333333

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000401534

127_135

88.33333333333333

348.0

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000420696

127_135

88.33333333333333

431.0

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000540236

127_135

88.33333333333333

421.0

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000367897

233_295

88.33333333333333

408.3333333333333

DNA binding

Homeobox%3B TALE-type

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000401534

233_295

88.33333333333333

348.0

DNA binding

Homeobox%3B TALE-type

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000420696

233_295

88.33333333333333

431.0

DNA binding

Homeobox%3B TALE-type

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000540236

233_295

88.33333333333333

421.0

DNA binding

Homeobox%3B TALE-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

549_602

483.3333333333333

655.0

Domain

bHLH

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

549_602

483.3333333333333

652.0

Domain

bHLH

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

549_602

483.3333333333333

527.0

Domain

bHLH

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000367897

40_232

88.33333333333333

408.3333333333333

Domain

PBC

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000401534

40_232

88.33333333333333

348.0

Domain

PBC

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000420696

40_232

88.33333333333333

431.0

Domain

PBC

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000540236

40_232

88.33333333333333

421.0

Domain

PBC

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Fusion Gene Sequence for TCF3-PBX1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000395423_ENST00000420696_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(transcript)=7508nt_BP=1325nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTTCTTCCAGTTC
TTTTAACATGTCAAACTCTGGAGATTTGTTCATGAGCGTGCAGTCACTCAATGGGGATTCTTACCAAGGGGCCCAGGTTGGAGCCAACGT
GCAATCACAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCA
GGGCATCAGTGCTAATGGAGGTTGGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGA
TACCTCCAACTGATCTCCCAGCAATCGCATCCCGGCTGACCCTGTGCCCCAGTTGGGGCAGGGGCAGGAGGGAGGGTTTCTCTCCCAACG
CTGAAGCGGTCAGACTGGAGGTCGAAGCAATCAGCAAACACAATAAGAGTCTCCTTCTCTTCTCTTCTTTGGGATGCTATTTCAGCCAAT
CTGGACACTTCTTTATACTCTCTTCCCTTTTTTTTCTGGGTAGAAGCCACCCTTCCCTGCCTCCAGCTGTCAGCCTGGTTTTCGTCATCT
TCCCTGCCCCTGTGCCTCTGTCCTAGACTCCCGGGGTCCCCGCCCTCTCTCATATCACTGAAGGATATTTTCAACAATTAGAGGAATTTA
AAGAGGAAAAAAATTACAAAGAAAATAATAAAAGTGTTTGTACGTTTTCATGCTGGTGGTTTGAGGAGCCAAATTTACCTCACTCGAATC
CCTCACTCCCTATGTTAACAGGCAATCCTTCTCTGTTTCTCTTATTACTCTCACTACCTCTTAGCAGGAATACTCCACATTGCCCTATTC
ATTCCAGGCCTCCCTGCTTCCTCTTGCTCTTCCTCCCTGGGGACAGTACTGATTGGAACACTTTCCTCCTCTTCCTTCCTAGCCCCAGCT
ATTCACTGGGGACTGTCATAGCTGGGATTCTAAAGGTGCCACATTTTTCAGTTTCATCTCCACTAGGTTGGTTCCCGGGCAGGAAGTCAG
GCAGCAGGGAAGGACACGGGAACAGCAGGTGGAGAATTCCTACAGTCTTTCTTACCCTGCTAGCAATAGCTCTCAGTTTCAGAGGCACAG
TCTTTGGAGACCATTCAGCACTGAGAAAGCAATATTTAGAACCTATTGCAAAACTGGGCCTGAGTTAGGCATGGTGATGAATGCATCAGC
AAGGAATAGAAAGTTCTTATCGTGAAACCCTTCAACCTCAACTATGCCTTCATAGACACACACGTTCATGCACATGTAGGCACATGTACC
ATCTCACATCTTCACTTTCCCGAGATGCCATATACAATTACCTACATTAATAACTGTAGCACTATGCCTTTTGAGCCCGAGAGAGGGAAT
TAGTGACTCTAAGTGAAGGTCACTGACACAGAGAAGCAGTATGTGTCTGGGGCTTCCAGGACCTGCAGGCCCACTAGCGTGCACTTACCA
GAATGGCATACACAGGACCTGATCATGAGGAAGACCAGGTTTCCAGTGTAAACTACTCTTGTTCCCACCACCTCTGGAGCACTCAGGGAG
CCCCATACAGTACTTACAATGTCTTTAATGGACTTGATTCTGTTTAATTTTTTGTTTTATATTAGGCACACTGTATTAATTTTCCAAAAT
GTTATACCACACTATGTTCTTGGTCCTGACCTATTGCTCTGGAGGAAAGAGTTGTATAAGAACGTGGCTCATGTGAACTTTTGCTAGCTT
CATTTGAGGACCTGAGAATCATGGGGAAAGGGAAGGTAATGTTTTCATTGAAATCATCACAGTGATTTTTATTCCCTGGGAACACAGCGT
GTACTAAAAATACATGAGAAAATAGCATGTATATGAAAGCTATTCTCAAAAGTCACCTGAGCTCACCATCTTCATAGCCAACCCTACCAG
TTATAAAGATGGCAGCTCTATCACTTGATTAAGTGGGAGGTGGTCAAATATTTTGGTGCCTCATTTTCTTCATCTGTGAGATGGGAACTG
TTATGCCTGGCTTACTAAGAGTCTTGTGAGAGACTGAGAAGTTGATTTTGTTCATATCCAATCTGTAAATGCGAAGTCAGGGGAAGTAAT
GTCCCTGAAATAAACGGGTTCATGCCATCTAGGGACAATAAATGGTTTTCTTGTTGTAACTTCTGGTTAATATCAGTACCTTGATGTCAT
CACCGTGATGACAAAGAGAAGAGTTATTGTTGATCTTCTTGGTTTTGGTCTGTCTCTTTTCTTAGGATAAAGAAAAACTTCCAAACTAGA
AAAACAGGCCCTGGTTCCCTTAGTTTGCACTTGAACCCAATATGTTGCCTTGTACATACTTGGTCCCTGTCACATTGACTGCTTGGGAGG
CTTCCAGGGAGAAGTATGAGACCCTGAGGGGTGAGAATGGGCAGCTAGCAAGAACATGGAAATTCTGCTTGGCACTACAGTCATAAATAG
AAAACACTGTGTGTGCTCAGGGGAGCAGGGGATGCCACTGAAGAAACTCAAGGGAATGTGTATTTGAAGGAAATGCAAAAACTAAGTATT
TAGCAAAATGAAATTATGCCTTGATGACTAAAAGGCACTAGAAAGGTTGTGTCTACTAACTTCAGCCCTAATCAGAACAGATGCCTAGAA
GGAGCATTTTTGTGACAACTTCATAGTGATTAGAATCAGTGGAGAACTCCATCTTAGTGGCAGGAATATAATGAAACTACCCACGCAAGA
ACATGGTTGAATCACATTTGCTTGACTTAGGGCAAAGTACGAAAGAGAGACAAAAGGGTTCTCTTGGAAACAAGAAGAGTGACTCCAGAT
GTGGCCTGAATAATTGCCATGTTAAGTTAATGCAAAAGATCAGAACAGGGCTACATTTGCACAGGCAGTTTCTCTCCGGGCCGTAGTTTT
CACTGATGATCACCTTTCACAGCATTTTCCCCAACCAGCATTTCACTTAGTCTTCTCTATACCCAGCACCTCCCCCGGCACCCCCGGCAA
GCCCACTATCACTTCCGACTTCCAACGTGGCATCCGTGAGATCTGTCCACATTAGGCGAAGCAGGAGAACACTGAGAGCAGCAGGATGGG
TTTGGAAAGAGCATGCCTCTGGAAACACAGCTTCCTGGGAATTCACATGAGGCCAGTCCTACAGAGAGCAAGATGCACCCCAGGATTTCT
TCATTTTCTAATAGATGTGGGAGTGCTCCATTTTCCCCGACAGCGAATTTCCCCTGAGAAACGATACTAGACCCTGGGTTTGCCCACCTT
GTAACTCTTCCTTATCTCCTCCTTTTCATCCCTAATCCATCCTCCCTCTGGCATGGAATTGACGCCCGTGCAGTACATTTGCCAAGTGGC
ACCTTCTTTCAATTTATGTTTTATTTTGCTATGGTGGTGATTCTTTATTTGCTGGTTGTCTTTTCTCACACATCTTTCTCTCTGTCTCTC
TCTTTCCTGCTCTTTGTTTTTCTGCCCAGAAAAACCTGACTTCGATACCAAAAAAGATGAAACTACAGAAACTCAAATTTAAAAAAAACT
TTAAAAGAAACAAAAAAATACTCAACGATTCTTTCAGCTTTATTAACATTTTCCATTGTTTCTTGCGACTTGTGTCTCGTTCTTTGTAGT
ATTGATGATGAACATTTGATAATGAATGTTCTTGTATATTCAGATAAAGAAAAAAAAAACCAAAAAAGCGGTCTGAATTTAATAGTGTTT
ATAATAAAAATTTTAAAAATGACCCTCATAGCACGCAAAACAGGATGGGGAATTTCCCCTCTTCTTTCTGTGACAATGCGCATCATTCCT
GCATTAGTTTTTAACACCAGACTACCTACATTCATCATTTCCCTCATTTTTCTTTTATTTTCTTGCATTTGTGAATTAGTTCAAGAATGC
TAGAAAAGTGTCGAGTTGTGCACATCCATTTCTTGTTTCACAATGTTTAAAAGTGACAGTAATTCATTTTGTAAACTAAAAAAAAAAAAA
AAAAGGTTGGAATAGTGAGCATAATAGGTACAACCTAACACATTATTATGTTTATTAACTTTGAGACCCAGAAATAAATTCTTTTCTTTT
CTTGATTCTTGCTCTTAAAAATACAAAAAAAAAAATGTTTTGTTTTGTGTTATTTTTGGTTTGTTTATTGGGGGGCTTTTTTTAATTGTC
AGGATTATGATCTTGCTGTTTTTCTTCAATATGTATACAAGGTGATGTGAAAAGATGACTTGGGCAGAGGAGTAAGAACAAGTAGGCTTG
TTCTTCTACTTTGCTTCAGAATTCAGTTAATGCCAAAAGCGAAGATCAAGCCCATGTTGATGTCTCGTTGCTCACCTGCATTTCCAGAGA
GTGTGACACTCATGCAGTCCCTGAGAAAAATAAAATCAGGGACATACTTCTCCTTTTAGCCTTTTAAAAATTCAAAAACGTTTAGTCCAA
GGGAACTTTTTATGCTATCAGGAAAGGTTTTTGCTGTTTTTGATTCTGATTATCACAGCCAAGTACTTTGTTTTATTTCTCCCTAATTAA
TAACTACATTCCATGAGGCCTCTTCCAACCAAAGAGGCCTTTTCTTCCAGGAGAGTCCCGCAGGAGATGCTGGTATGATGGGCACCATTG
GTTAAGTAAACTACATGCAGGAAGAAGTCCTTGGGGCCAGTCTGCCAGCTGAGTCCTGGTTTTGGATGAAGAGTTAATGAGATATTGGGC
CAGGCTCAATGCTGTAGTTTTAATGCTAAGAGGTTACGTTTACTTCACAGAGTACACCTCTTAGTAACCTCTGACTTAGGCAGCTGCTTA
AAGCAAATTGCAAAACTGGCTTGATTTGGAATGTTTTTATTAGAGGAAAAAAGAAAGCCATATTATCTGGAAAAAAATTCATTTTAAATA
CCATCATTCAACAAATTATGTTCAGAAAGTGGTCAGAACTTAAGCAAGAAAAGTAAAGAAAGAATGCAGAATTGTGGAGCAATGCTTTAG
GAAATATTTCTACCTGAACACTTGTACTCTTGAAGTCACAACAAAATAATGATGAGCTTTTCACATCACCTTTATGGTTTCAATCCCTAG
CTCAAAGCTTCCTGGAATCTTTTATTTTTTGTAAACTTTTTTTTCTTTTGTTAAAATAAATAAAACATTCAATGTTTTTCTCCTTTTCTC
TCTTATTACTTCTTTCCTTTGGCATTTTCAATTTGAAATGCTTTCCTTTGGTTGTTGGTTTTATTCTCCCCCTACCCCTCCCCTTTTCTT
ATTATTCAGAATATAAACCTGCAAAGCTCTGCTCTGTTTTGGTTTTGAAAGTTTAAGCTTTTCTGCTTCTGTGAGAGCACAGGCTTCTGT
CCCTTTTGATTCCAACTGAACTTTTGTGTTCTCTAATGATACTAACACGGTGTAGGTTTTACAGTCTCCTAATTTGTACTGGTAATGCAT

>In-frame_ENST00000395423_ENST00000420696_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(amino acids)=774AA_start in transcript=28_stop in transcript=2352
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN
KRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRH

--------------------------------------------------------------
>In-frame_ENST00000395423_ENST00000401534_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(transcript)=2104nt_BP=1325nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTGGATACCCTTC

>In-frame_ENST00000395423_ENST00000401534_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(amino acids)=692AA_start in transcript=28_stop in transcript=2103
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN

--------------------------------------------------------------
>In-frame_ENST00000395423_ENST00000559240_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(transcript)=2080nt_BP=1325nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCAGGG
CATCAGTGCTAATGGAGGTTGGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGATAC

>In-frame_ENST00000395423_ENST00000559240_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(amino acids)=684AA_start in transcript=28_stop in transcript=2079
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHV

--------------------------------------------------------------
>In-frame_ENST00000395423_ENST00000367897_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(transcript)=2519nt_BP=1325nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTGGATACCCTTC
GCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCAGGGCATCAGTGCTAATGGAGGTT
GGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGCCCTGGCAGTGTTCACTCTGATACCTCCAACTGATCTCCCAGCA
ATCGCATCCCGGCTGACCCTGTGCCCCAGTTGGGGCAGGGGCAGGAGGGAGGGTTTCTCTCCCAACGCTGAAGCGGTCAGACTGGAGGTC
GAAGCAATCAGCAAACACAATAAGAGTCTCCTTCTCTTCTCTTCTTTGGGATGCTATTTCAGCCAATCTGGACACTTCTTTATACTCTCT

>In-frame_ENST00000395423_ENST00000367897_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(amino acids)=691AA_start in transcript=28_stop in transcript=2103
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN

--------------------------------------------------------------
>In-frame_ENST00000395423_ENST00000540236_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(transcript)=2323nt_BP=1325nt
CTGAGGTGCCCGCCCTGGCCCCAGGAGAATGAACCAGCCGCAGAGGATGGCGCCTGTGGGCACAGACAAGGAGCTCAGTGACCTCCTGGA
CTTCAGCATGATGTTCCCGCTGCCTGTCACCAACGGGAAGGGCCGGCCCGCCTCCCTGGCCGGGGCGCAGTTCGGAGGTTCAGGCAAGAG
CGGTGAGCGGGGCGCCTATGCCTCCTTCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCT
CAACAGCCCCGGGCCCCTGTCCCCTTCGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGC
AGACGGCAGCCTAGACACGCAGCCCAAGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGA
CTACGGCAGGGATGCCACCGCCTACCCGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCA
CCCCTCAGCCGAGCTCTGGAGTCCCCCGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGG
TAGCGGCCCGGTGGGCAGCAGTGGAAGCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGA
GGTGAACGGTGGGCTCCCATCTGCATCCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAG
CGGGGCCGACAGCCTCCTGGGCTCCCGAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCC
GGATCACTCAAGCAATAACTTCTCGTCCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGC
AGGAGCCCCCGGTGCCTTATCGCCCAGCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCA
CGTGCTCCGCAGCCACGCCGTGGGCACAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCC
CATGTCACTGGGCGGGCGGCACGCAGGCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCA
CGCGGCCCTCCCCAGCCAGCCAGGCACCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGTTTTGAGTATCCGAGGAGCCCAGGA
GGAGGAACCCACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCTGAGAAGGGCGGAGGGTCGGC
GGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGTTCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGAT
CAGACAAATCTACCATACGGAGCTGGAGAAATACGAGCAGGCCTGCAACGAGTTCACCACCCACGTGATGAATCTCCTGCGAGAGCAAAG
CCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATGGTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCA
GAGCACGTGCGAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCGGCGGAAGAGACGGAATTTCAACAAGCAAGCGACAGAAAT
CCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTACCCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGT
CTCCCAGGTATCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAGGAAGCCAATATTTATGCTGC
CAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGAAGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTGGTTCTTCCAGTTC
TTTTAACATGTCAAACTCTGGAGATTTGTTCATGAGCGTGCAGTCACTCAATGGGGATTCTTACCAAGGGGCCCAGGTTGGAGCCAACGT
GCAATCACAGGTGGATACCCTTCGCCATGTTATCAGCCAGACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCA

>In-frame_ENST00000395423_ENST00000540236_AY311345_TCF3_chr19_1619110_-_PBX1_chr1_164761730_length(amino acids)=765AA_start in transcript=28_stop in transcript=2322
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN
KRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TCF3-PBX1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TCF3-PBX1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TCF3-PBX1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TCF3	C0006413	Burkitt Lymphoma	2	CTD_human;ORPHANET
Hgene	TCF3	C0343640	African Burkitt's lymphoma	2	CTD_human
Hgene	TCF3	C4721444	Burkitt Leukemia	2	CTD_human
Hgene	TCF3	C0001768	Agammaglobulinemia	1	CTD_human;GENOMICS_ENGLAND
Hgene	TCF3	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	TCF3	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	TCF3	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1	CTD_human
Hgene	TCF3	C0398686	Primary immune deficiency disorder	1	GENOMICS_ENGLAND
Hgene	TCF3	C1832241	Agammaglobulinemia, non-Bruton type	1	ORPHANET
Hgene	TCF3	C1844383	Recurrent bacterial infection	1	GENOMICS_ENGLAND
Hgene	TCF3	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Hgene	TCF3	C4310786	AGAMMAGLOBULINEMIA 8, AUTOSOMAL DOMINANT	1	GENOMICS_ENGLAND
Tgene	PBX1	C0006413	Burkitt Lymphoma	2	CTD_human;ORPHANET
Tgene	PBX1	C0343640	African Burkitt's lymphoma	2	CTD_human
Tgene	PBX1	C1968949	Cakut	2	GENOMICS_ENGLAND
Tgene	PBX1	C4721444	Burkitt Leukemia	2	CTD_human
Tgene	PBX1	C0013146	Drug abuse	1	CTD_human
Tgene	PBX1	C0013170	Drug habituation	1	CTD_human
Tgene	PBX1	C0013222	Drug Use Disorders	1	CTD_human
Tgene	PBX1	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	PBX1	C0038580	Substance Dependence	1	CTD_human
Tgene	PBX1	C0038586	Substance Use Disorders	1	CTD_human
Tgene	PBX1	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	PBX1	C0431692	Bilateral renal hypoplasia	1	ORPHANET
Tgene	PBX1	C0740858	Substance abuse problem	1	CTD_human
Tgene	PBX1	C1510472	Drug Dependence	1	CTD_human
Tgene	PBX1	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	PBX1	C4539968	CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY	1	GENOMICS_ENGLAND