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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TDRD3-GLI1 (FusionGDB2 ID:89310)

Fusion Gene Summary for TDRD3-GLI1

check button Fusion gene summary
Fusion gene informationFusion gene name: TDRD3-GLI1
Fusion gene ID: 89310
HgeneTgene
Gene symbol

TDRD3

GLI1

Gene ID

81550

2735

Gene nametudor domain containing 3GLI family zinc finger 1
Synonyms-GLI|PAPA8|PPD1
Cytomap

13q21.2

12q13.3

Type of geneprotein-codingprotein-coding
Descriptiontudor domain-containing protein 3zinc finger protein GLI1GLI-Kruppel family member GLI1glioma-associated oncogene 1glioma-associated oncogene homolog 1 (zinc finger protein)oncogene GLI
Modification date2020031320200313
UniProtAcc.

P08151

Ensembl transtripts involved in fusion geneENST00000196169, ENST00000377894, 
ENST00000535286, ENST00000377881, 
ENST00000463109, 		ENST00000543426, 
ENST00000228682, ENST00000546141, 
Fusion gene scores* DoF score10 X 9 X 5=45011 X 12 X 4=528
# samples 1110
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/528*10)=-2.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TDRD3 [Title/Abstract] AND GLI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTDRD3(60971539)-GLI1(57864100), # samples:2
Anticipated loss of major functional domain due to fusion event.TDRD3-GLI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TDRD3-GLI1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TDRD3-GLI1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
TDRD3-GLI1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TDRD3-GLI1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLI1

GO:0001649

osteoblast differentiation

12165851

TgeneGLI1

GO:0007224

smoothened signaling pathway

19878745

TgeneGLI1

GO:0009913

epidermal cell differentiation

12165851

TgeneGLI1

GO:0045740

positive regulation of DNA replication

12165851

TgeneGLI1

GO:0045880

positive regulation of smoothened signaling pathway

17035233

TgeneGLI1

GO:0045893

positive regulation of transcription, DNA-templated

11238441|12165851|17035233

TgeneGLI1

GO:0045944

positive regulation of transcription by RNA polymerase II

9118802|10693759|12165851

TgeneGLI1

GO:0060045

positive regulation of cardiac muscle cell proliferation

28583401

TgeneGLI1

GO:1902808

positive regulation of cell cycle G1/S phase transition

28583401


check buttonFusion gene breakpoints across TDRD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GLI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-41-5651-01ATDRD3chr13

60971539

+GLI1chr12

57864100

+
ChimerDB4GBMTCGA-41-5651-01ATDRD3chr13

60971539

+GLI1chr12

57864100

+


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Fusion Gene ORF analysis for TDRD3-GLI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000196169ENST00000543426TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000196169ENST00000228682TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000196169ENST00000546141TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000377894ENST00000543426TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000377894ENST00000228682TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000377894ENST00000546141TDRD3chr13

60971539

+GLI1chr12

57864100

+
In-frameENST00000535286ENST00000543426TDRD3chr13

60971539

+GLI1chr12

57864100

+
Frame-shiftENST00000535286ENST00000228682TDRD3chr13

60971539

+GLI1chr12

57864100

+
In-frameENST00000535286ENST00000546141TDRD3chr13

60971539

+GLI1chr12

57864100

+
5UTR-3CDSENST00000377881ENST00000543426TDRD3chr13

60971539

+GLI1chr12

57864100

+
5UTR-3CDSENST00000377881ENST00000228682TDRD3chr13

60971539

+GLI1chr12

57864100

+
5UTR-3CDSENST00000377881ENST00000546141TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000463109ENST00000543426TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000463109ENST00000228682TDRD3chr13

60971539

+GLI1chr12

57864100

+
intron-3CDSENST00000463109ENST00000546141TDRD3chr13

60971539

+GLI1chr12

57864100

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535286TDRD3chr1360971539+ENST00000543426GLI1chr1257864100+20571132171857546
ENST00000535286TDRD3chr1360971539+ENST00000546141GLI1chr1257864100+20571132171857546

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535286ENST00000543426TDRD3chr1360971539+GLI1chr1257864100+0.0085462670.99145377
ENST00000535286ENST00000546141TDRD3chr1360971539+GLI1chr1257864100+0.0085462670.99145377

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Fusion Genomic Features for TDRD3-GLI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TDRD3chr1360971539+GLI1chr1257864099+3.91E-050.9999609
TDRD3chr1360971539+GLI1chr1257864099+3.91E-050.9999609

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TDRD3-GLI1


check button Go to

FGviewer for the breakpoints of chr13:60971539-chr12:57864100

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GLI1

P08151

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGLI1chr13:60971539chr12:57864100ENST0000022868210121038_1055525.33333333333341107.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneGLI1chr13:60971539chr12:57864100ENST000005461419111038_1055484.33333333333331066.0Compositional biasNote=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTDRD3chr13:60971539chr12:57864100ENST00000196169+114193_2330556.0DomainUBA
HgeneTDRD3chr13:60971539chr12:57864100ENST00000196169+114555_6150556.0DomainTudor
HgeneTDRD3chr13:60971539chr12:57864100ENST00000377881+114193_2330713.6666666666666DomainUBA
HgeneTDRD3chr13:60971539chr12:57864100ENST00000377881+114555_6150713.6666666666666DomainTudor
HgeneTDRD3chr13:60971539chr12:57864100ENST00000377894+114193_2330731.6666666666666DomainUBA
HgeneTDRD3chr13:60971539chr12:57864100ENST00000377894+114555_6150731.6666666666666DomainTudor
HgeneTDRD3chr13:60971539chr12:57864100ENST00000535286+114193_23313.666666666666666795.0DomainUBA
HgeneTDRD3chr13:60971539chr12:57864100ENST00000535286+114555_61513.666666666666666795.0DomainTudor
TgeneGLI1chr13:60971539chr12:57864100ENST0000022868210121_20525.33333333333341107.0RegionSNAG domain
TgeneGLI1chr13:60971539chr12:57864100ENST000005461419111_20484.33333333333331066.0RegionSNAG domain
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012235_260525.33333333333341107.0Zinc fingerC2H2-type 1
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012268_295525.33333333333341107.0Zinc fingerC2H2-type 2
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012301_325525.33333333333341107.0Zinc fingerC2H2-type 3
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012331_356525.33333333333341107.0Zinc fingerC2H2-type 4
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012362_387525.33333333333341107.0Zinc fingerC2H2-type 5
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911235_260484.33333333333331066.0Zinc fingerC2H2-type 1
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911268_295484.33333333333331066.0Zinc fingerC2H2-type 2
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911301_325484.33333333333331066.0Zinc fingerC2H2-type 3
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911331_356484.33333333333331066.0Zinc fingerC2H2-type 4
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911362_387484.33333333333331066.0Zinc fingerC2H2-type 5


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Fusion Gene Sequence for TDRD3-GLI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000535286_ENST00000543426_TCGA-41-5651-01A_TDRD3_chr13_60971539_+_GLI1_chr12_57864100_length(transcript)=2057nt_BP=113nt
GGGGTCTCAAGTAGGAGGCCTCCCCATCACCCCCACCCCAGCCCCCCACCACCCCCGGCCTAAGCAGCTACCATGGCCCAGGTGGCCGGC
GCGGCGTTGTCCCAGGCGGGTTGGTACCACTGTGTCCCGCCGCGTGGGCCCCCCAGTCTCTCTTGAACGCCGCAGCAGCAGCTCCAGCAG
CATCAGCTCTGCCTATACTGTCAGCCGCCGCTCCTCCCTGGCCTCTCCTTTCCCCCCTGGCTCCCCACCAGAGAATGGAGCATCCTCCCT
GCCTGGCCTTATGCCTGCCCAGCACTACCTGCTTCGGGCAAGATATGCTTCAGCCAGAGGGGGTGGTACTTCGCCCACTGCAGCATCCAG
CCTGGATCGGATAGGTGGTCTTCCCATGCCTCCTTGGAGAAGCCGAGCCGAGTATCCAGGATACAACCCCAATGCAGGGGTCACCCGGAG
GGCCAGTGACCCAGCCCAGGCTGCTGACCGTCCTGCTCCAGCTAGAGTCCAGAGGTTCAAGAGCCTGGGCTGTGTCCATACCCCACCCAC
TGTGGCAGGGGGAGGACAGAACTTTGATCCTTACCTCCCAACCTCTGTCTACTCACCACAGCCCCCCAGCATCACTGAGAATGCTGCCAT
GGATGCTAGAGGGCTACAGGAAGAGCCAGAAGTTGGGACCTCCATGGTGGGCAGTGGTCTGAACCCCTATATGGACTTCCCACCTACTGA
TACTCTGGGATATGGGGGACCTGAAGGGGCAGCAGCTGAGCCTTATGGAGCGAGGGGTCCAGGCTCTCTGCCTCTTGGGCCTGGTCCACC
CACCAACTATGGCCCCAACCCCTGTCCCCAGCAGGCCTCATATCCTGACCCCACCCAAGAAACATGGGGTGAGTTCCCTTCCCACTCTGG
GCTGTACCCAGGCCCCAAGGCTCTAGGTGGAACCTACAGCCAGTGTCCTCGACTTGAACATTATGGACAAGTGCAAGTCAAGCCAGAACA
GGGGTGCCCAGTGGGGTCTGACTCCACAGGACTGGCACCCTGCCTCAATGCCCACCCCAGTGAGGGGCCCCCACATCCACAGCCTCTCTT
TTCCCATTACCCCCAGCCCTCTCCTCCCCAATATCTCCAGTCAGGCCCCTATACCCAGCCACCCCCTGATTATCTTCCTTCAGAACCCAG
GCCTTGCCTGGACTTTGATTCCCCCACCCATTCCACAGGGCAGCTCAAGGCTCAGCTTGTGTGTAATTATGTTCAATCTCAACAGGAGCT
ACTGTGGGAGGGTGGGGGCAGGGAAGATGCCCCCGCCCAGGAACCTTCCTACCAGAGTCCCAAGTTTCTGGGGGGTTCCCAGGTTAGCCC
AAGCCGTGCTAAAGCTCCAGTGAACACATATGGACCTGGCTTTGGACCCAACTTGCCCAATCACAAGTCAGGTTCCTATCCCACCCCTTC
ACCATGCCATGAAAATTTTGTAGTGGGGGCAAATAGGGCTTCACATAGGGCAGCAGCACCACCTCGACTTCTGCCCCCATTGCCCACTTG
CTATGGGCCTCTCAAAGTGGGAGGCACAAACCCCAGCTGTGGTCATCCTGAGGTGGGCAGGCTAGGAGGGGGTCCTGCCTTGTACCCTCC
TCCCGAAGGACAGGTATGTAACCCCCTGGACTCTCTTGATCTTGACAACACTCAGCTGGACTTTGTGGCTATTCTGGATGAGCCCCAGGG
GCTGAGTCCTCCTCCTTCCCATGATCAGCGGGGCAGCTCTGGACATACCCCACCTCCCTCTGGGCCCCCCAACATGGCTGTGGGCAACAT
GAGTGTCTTACTGAGATCCCTACCTGGGGAAACAGAATTCCTCAACTCTAGTGCCTAAAGAGTAGGGAATCTCATCCATCACAGATCGCA
TTTCCTAAGGGGTTTCTATCCTTCCAGAAAAATTGGGGGAGCTGCAGTCCCATGCACAAGATGCCCCAGGGATGGGAGGTATGGGCTGGG

>In-frame_ENST00000535286_ENST00000543426_TCGA-41-5651-01A_TDRD3_chr13_60971539_+_GLI1_chr12_57864100_length(amino acids)=546AA_start in transcript=217_stop in transcript=1857
MASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPA
PARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAA
EPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLA
PCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPA
QEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPS
CGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETE

--------------------------------------------------------------
>In-frame_ENST00000535286_ENST00000546141_TCGA-41-5651-01A_TDRD3_chr13_60971539_+_GLI1_chr12_57864100_length(transcript)=2057nt_BP=113nt
GGGGTCTCAAGTAGGAGGCCTCCCCATCACCCCCACCCCAGCCCCCCACCACCCCCGGCCTAAGCAGCTACCATGGCCCAGGTGGCCGGC
GCGGCGTTGTCCCAGGCGGGTTGGTACCACTGTGTCCCGCCGCGTGGGCCCCCCAGTCTCTCTTGAACGCCGCAGCAGCAGCTCCAGCAG
CATCAGCTCTGCCTATACTGTCAGCCGCCGCTCCTCCCTGGCCTCTCCTTTCCCCCCTGGCTCCCCACCAGAGAATGGAGCATCCTCCCT
GCCTGGCCTTATGCCTGCCCAGCACTACCTGCTTCGGGCAAGATATGCTTCAGCCAGAGGGGGTGGTACTTCGCCCACTGCAGCATCCAG
CCTGGATCGGATAGGTGGTCTTCCCATGCCTCCTTGGAGAAGCCGAGCCGAGTATCCAGGATACAACCCCAATGCAGGGGTCACCCGGAG
GGCCAGTGACCCAGCCCAGGCTGCTGACCGTCCTGCTCCAGCTAGAGTCCAGAGGTTCAAGAGCCTGGGCTGTGTCCATACCCCACCCAC
TGTGGCAGGGGGAGGACAGAACTTTGATCCTTACCTCCCAACCTCTGTCTACTCACCACAGCCCCCCAGCATCACTGAGAATGCTGCCAT
GGATGCTAGAGGGCTACAGGAAGAGCCAGAAGTTGGGACCTCCATGGTGGGCAGTGGTCTGAACCCCTATATGGACTTCCCACCTACTGA
TACTCTGGGATATGGGGGACCTGAAGGGGCAGCAGCTGAGCCTTATGGAGCGAGGGGTCCAGGCTCTCTGCCTCTTGGGCCTGGTCCACC
CACCAACTATGGCCCCAACCCCTGTCCCCAGCAGGCCTCATATCCTGACCCCACCCAAGAAACATGGGGTGAGTTCCCTTCCCACTCTGG
GCTGTACCCAGGCCCCAAGGCTCTAGGTGGAACCTACAGCCAGTGTCCTCGACTTGAACATTATGGACAAGTGCAAGTCAAGCCAGAACA
GGGGTGCCCAGTGGGGTCTGACTCCACAGGACTGGCACCCTGCCTCAATGCCCACCCCAGTGAGGGGCCCCCACATCCACAGCCTCTCTT
TTCCCATTACCCCCAGCCCTCTCCTCCCCAATATCTCCAGTCAGGCCCCTATACCCAGCCACCCCCTGATTATCTTCCTTCAGAACCCAG
GCCTTGCCTGGACTTTGATTCCCCCACCCATTCCACAGGGCAGCTCAAGGCTCAGCTTGTGTGTAATTATGTTCAATCTCAACAGGAGCT
ACTGTGGGAGGGTGGGGGCAGGGAAGATGCCCCCGCCCAGGAACCTTCCTACCAGAGTCCCAAGTTTCTGGGGGGTTCCCAGGTTAGCCC
AAGCCGTGCTAAAGCTCCAGTGAACACATATGGACCTGGCTTTGGACCCAACTTGCCCAATCACAAGTCAGGTTCCTATCCCACCCCTTC
ACCATGCCATGAAAATTTTGTAGTGGGGGCAAATAGGGCTTCACATAGGGCAGCAGCACCACCTCGACTTCTGCCCCCATTGCCCACTTG
CTATGGGCCTCTCAAAGTGGGAGGCACAAACCCCAGCTGTGGTCATCCTGAGGTGGGCAGGCTAGGAGGGGGTCCTGCCTTGTACCCTCC
TCCCGAAGGACAGGTATGTAACCCCCTGGACTCTCTTGATCTTGACAACACTCAGCTGGACTTTGTGGCTATTCTGGATGAGCCCCAGGG
GCTGAGTCCTCCTCCTTCCCATGATCAGCGGGGCAGCTCTGGACATACCCCACCTCCCTCTGGGCCCCCCAACATGGCTGTGGGCAACAT
GAGTGTCTTACTGAGATCCCTACCTGGGGAAACAGAATTCCTCAACTCTAGTGCCTAAAGAGTAGGGAATCTCATCCATCACAGATCGCA
TTTCCTAAGGGGTTTCTATCCTTCCAGAAAAATTGGGGGAGCTGCAGTCCCATGCACAAGATGCCCCAGGGATGGGAGGTATGGGCTGGG

>In-frame_ENST00000535286_ENST00000546141_TCGA-41-5651-01A_TDRD3_chr13_60971539_+_GLI1_chr12_57864100_length(amino acids)=546AA_start in transcript=217_stop in transcript=1857
MASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPA
PARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAA
EPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLA
PCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPA
QEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPS
CGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TDRD3-GLI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012283_291525.33333333333341107.0DNA
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012345_350525.33333333333341107.0DNA
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012375_381525.33333333333341107.0DNA
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911283_291484.33333333333331066.0DNA
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911345_350484.33333333333331066.0DNA
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911375_381484.33333333333331066.0DNA
TgeneGLI1chr13:60971539chr12:57864100ENST000002286821012120_124525.33333333333341107.0SUFU
TgeneGLI1chr13:60971539chr12:57864100ENST00000546141911120_124484.33333333333331066.0SUFU


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TDRD3-GLI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TDRD3-GLI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGLI1C0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneGLI1C0005695Bladder Neoplasm1CTD_human
TgeneGLI1C0013903Ellis-Van Creveld Syndrome1ORPHANET
TgeneGLI1C0023487Acute Promyelocytic Leukemia1CTD_human
TgeneGLI1C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneGLI1C0238198Gastrointestinal Stromal Tumors1CTD_human
TgeneGLI1C1395852Polydactyly preaxial type 11GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneGLI1C2239176Liver carcinoma1CTD_human
TgeneGLI1C3179349Gastrointestinal Stromal Sarcoma1CTD_human
TgeneGLI1C4721453Peripheral Nervous System Diseases1CTD_human
TgeneGLI1C4748277POLYDACTYLY, POSTAXIAL, TYPE A81GENOMICS_ENGLAND