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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TEAD1-CTR9 (FusionGDB2 ID:89331)

Fusion Gene Summary for TEAD1-CTR9

check button Fusion gene summary
Fusion gene informationFusion gene name: TEAD1-CTR9
Fusion gene ID: 89331
HgeneTgene
Gene symbol

TEAD1

CTR9

Gene ID

7003

9646

Gene nameTEA domain transcription factor 1CTR9 homolog, Paf1/RNA polymerase II complex component
SynonymsAA|NTEF-1|REF1|TCF-13|TCF13|TEAD-1|TEF-1SH2BP1|TSBP|p150|p150TSP
Cytomap

11p15.3

11p15.4

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional enhancer factor TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)protein GT-IICtranscription factor 13transcriptional enhancer factor 1RNA polymerase-associated protein CTR9 homologCtr9, Paf1/RNA polymerase II complex component, homologSH2 domain binding protein 1 (tetratricopeptide repeat containing)TPR-containing, SH2-binding phosphoprotein
Modification date2020032920200313
UniProtAcc.

Q6PD62

Ensembl transtripts involved in fusion geneENST00000361905, ENST00000527636, 
ENST00000527575, ENST00000334310, 
ENST00000361985, ENST00000526600, 
ENST00000361367, 
Fusion gene scores* DoF score19 X 11 X 12=25086 X 6 X 4=144
# samples 236
** MAII scorelog2(23/2508*10)=-3.44683158185766
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TEAD1 [Title/Abstract] AND CTR9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTEAD1(12923660)-CTR9(10784978), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTEAD1

GO:0035329

hippo signaling

18579750|19324877

TgeneCTR9

GO:0010390

histone monoubiquitination

16307923

TgeneCTR9

GO:0019827

stem cell population maintenance

19345177

TgeneCTR9

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

20178742

TgeneCTR9

GO:0033523

histone H2B ubiquitination

16307923

TgeneCTR9

GO:0045638

negative regulation of myeloid cell differentiation

20541477

TgeneCTR9

GO:0045944

positive regulation of transcription by RNA polymerase II

20178742


check buttonFusion gene breakpoints across TEAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CTR9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A3KU-01ATEAD1chr11

12923660

+CTR9chr11

10784978

+
ChimerDB4UCECTCGA-EO-A3KU-01ATEAD1chr11

12923660

+CTR9chr11

10784978

+
ChimerDB4UCECTCGA-EO-A3KU-01ATEAD1chr11

12923660

-CTR9chr11

10784978

+


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Fusion Gene ORF analysis for TEAD1-CTR9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361905ENST00000361367TEAD1chr11

12923660

+CTR9chr11

10784978

+
In-frameENST00000527636ENST00000361367TEAD1chr11

12923660

+CTR9chr11

10784978

+
intron-3CDSENST00000527575ENST00000361367TEAD1chr11

12923660

+CTR9chr11

10784978

+
intron-3CDSENST00000334310ENST00000361367TEAD1chr11

12923660

+CTR9chr11

10784978

+
In-frameENST00000361985ENST00000361367TEAD1chr11

12923660

+CTR9chr11

10784978

+
In-frameENST00000526600ENST00000361367TEAD1chr11

12923660

+CTR9chr11

10784978

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361905TEAD1chr1112923660+ENST00000361367CTR9chr1110784978+4804149354241651207
ENST00000527636TEAD1chr1112923660+ENST00000361367CTR9chr1110784978+4635132437339961207
ENST00000361985TEAD1chr1112923660+ENST00000361367CTR9chr1110784978+4338102713336991188
ENST00000526600TEAD1chr1112923660+ENST00000361367CTR9chr1110784978+411980811534801121

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361905ENST00000361367TEAD1chr1112923660+CTR9chr1110784978+0.0018953070.9981047
ENST00000527636ENST00000361367TEAD1chr1112923660+CTR9chr1110784978+0.0015249510.998475
ENST00000361985ENST00000361367TEAD1chr1112923660+CTR9chr1110784978+0.0010433320.9989567
ENST00000526600ENST00000361367TEAD1chr1112923660+CTR9chr1110784978+0.0005545340.9994455

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Fusion Genomic Features for TEAD1-CTR9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TEAD1chr1112923660+CTR9chr1110784977+1.74E-050.9999826
TEAD1chr1112923660+CTR9chr1110784977+1.74E-050.9999826

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TEAD1-CTR9


check button Go to

FGviewer for the breakpoints of chr11:12923660-chr11:10784978

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTR9

Q6PD62

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTEAD1chr11:12923660chr11:10784978ENST00000361905+1013143_204276.0412.0Compositional biasNote=Pro-rich
HgeneTEAD1chr11:12923660chr11:10784978ENST00000361905+101328_104276.0412.0DNA bindingTEA
TgeneCTR9chr11:12923660chr11:10784978ENST000003613676251015_1172283.01174.0Compositional biasNote=Ser-rich
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625844_1011283.01174.0Compositional biasNote=Lys-rich
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625904_908283.01174.0Compositional biasNote=Poly-Gly
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625933_936283.01174.0Compositional biasNote=Poly-Lys
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625956_959283.01174.0Compositional biasNote=Poly-Lys
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625306_339283.01174.0RepeatNote=TPR 6
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625341_374283.01174.0RepeatNote=TPR 7
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625412_444283.01174.0RepeatNote=TPR 8
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625451_484283.01174.0RepeatNote=TPR 9
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625497_530283.01174.0RepeatNote=TPR 10
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625531_564283.01174.0RepeatNote=TPR 11
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625566_598283.01174.0RepeatNote=TPR 12
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625613_646283.01174.0RepeatNote=TPR 13
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625647_680283.01174.0RepeatNote=TPR 14
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625681_714283.01174.0RepeatNote=TPR 15
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625717_750283.01174.0RepeatNote=TPR 16

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTEAD1chr11:12923660chr11:10784978ENST00000361905+1013306_328276.0412.0Compositional biasNote=Ser/Thr/Tyr-rich
HgeneTEAD1chr11:12923660chr11:10784978ENST00000361905+1013167_426276.0412.0RegionTranscriptional activation
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625129_162283.01174.0RepeatNote=TPR 2
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625163_196283.01174.0RepeatNote=TPR 3
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625198_231283.01174.0RepeatNote=TPR 4
TgeneCTR9chr11:12923660chr11:10784978ENST00000361367625235_268283.01174.0RepeatNote=TPR 5
TgeneCTR9chr11:12923660chr11:10784978ENST0000036136762541_75283.01174.0RepeatNote=TPR 1


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Fusion Gene Sequence for TEAD1-CTR9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000361905_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(transcript)=4804nt_BP=1493nt
TTCCGAACATTCTTAGCATCGCTCGCGCCGCGCCGCGCCGCCTGAGCCGAGCCGAGCCTCTGCTGCCGCCGCCGCGGCCCCGCCGCCCGC
CGCGGGCGCCCACCAAGCACTTTGCAGACTCGCTTCCACCCTGCGGGCCATTCCGCGCGGCGGGGCCCGGGCCCGGGGCGGCCGCGTCCA
GGCACAGGCCATGCAGTGACGCCCCCCCACCCCTCCACCTTTGCCCGGAGCGCGGGCAGCAGCCCAGCGCGCCAGCCGGCCCCGGGGCAG
GAGCGGTGCTAGGCAGGGGTGGGGTGGCCGGGCCCAGGGACCGGGAGCCGGGGAGGGAGCCGGGCACCGAGCAGAGGGCGGGGGAAGCGG
CGCCGAAGTTTGCCTCGGACTCGCCGGGCGCTGCGGTGGCTCCCTGGGCCGAGGACTGTTGCTGCCGCTGCCGCCGCCGCTTCATTGCAC
ATTCAAGTGGAAAATTTTCAGGAGTCAGCAGAAACATTGTGTCCAAAAAAGACTGAGTCGCAGTTACCACCAAACCCAGGAGGAGACTCT
CCCTGGAAAACTTCCCTTCCCTTTCGGTTTATTTTCTTGAAAAGGCTCCAGGCTTCGGCTTGGAAAATCCCACCGCCAAAATTGAGCCCA
GCAGCTGGAGCGGCAGTGAGAGCCCTGCCGAAAACATGGAAAGGATGAGTGACTCTGCAGATAAGCCAATTGACAATGATGCAGAAGGGG
TCTGGAGCCCCGACATCGAGCAAAGCTTTCAGGAGGCCCTGGCTATCTATCCACCATGTGGGAGGAGGAAAATCATCTTATCAGACGAAG
GCAAAATGTATGGTAGGAATGAATTGATAGCCAGATACATCAAACTCAGGACAGGCAAGACGAGGACCAGAAAACAGGTGTCTAGTCACA
TTCAGGTTCTTGCCAGAAGGAAATCTCGTGATTTTCATTCCAAGCTAAAGGATCAGACTGCAAAGGATAAGGCCCTGCAGCACATGGCGG
CCATGTCCTCAGCCCAGATCGTCTCGGCCACTGCCATTCATAACAAGCTGGGGCTGCCTGGGATTCCACGCCCGACCTTCCCAGGGGCGC
CGGGGTTCTGGCCGGGAATGATTCAAACAGGGCAGCCAGGATCCTCACAAGACGTCAAGCCTTTTGTGCAGCAGGCCTACCCCATCCAGC
CAGCGGTCACAGCCCCCATTCCAGGGTTTGAGCCTGCATCGGCCCCAGCTCCCTCAGTCCCTGCCTGGCAAGGTCGCTCCATTGGCACAA
CCAAGCTTCGCCTGGTGGAATTTTCAGCTTTTCTCGAGCAGCAGCGAGACCCAGACTCGTACAACAAACACCTCTTCGTGCACATTGGGC
ATGCCAACCATTCTTACAGTGACCCATTGCTTGAATCAGTGGACATTCGTCAGATTTATGACAAATTTCCTGAAAAGAAAGGTGGCTTAA
AGGAACTGTTTGGAAAGGGCCCTCAAAATGCCTTCTTCCTCGTAAAATTCTGGGATTATAGTAAAGTCCAGCATCTGGCCCTCCATGCAT
TCCATAATACAGAAGTGGAAGCTATGCAAGCAGAGAGCTGCTATCAGCTAGCTAGATCATTCCATGTTCAGGAAGATTATGACCAAGCTT
TTCAGTACTATTATCAAGCCACACAGTTTGCCTCATCCTCTTTTGTGCTCCCATTTTTTGGTTTGGGACAAATGTATATTTATCGAGGTG
ACAAAGAAAATGCATCTCAGTGCTTTGAGAAGGTTTTGAAAGCTTATCCTAATAATTACGAAACTATGAAAATTCTCGGCTCTCTCTATG
CTGCCTCAGAAGATCAAGAAAAACGAGATATTGCCAAGGGCCATTTGAAGAAGGTCACAGAACAGTATCCCGATGATGTTGAAGCTTGGA
TTGAATTGGCACAAATCTTAGAACAGACTGATATACAGGGTGCCCTTTCAGCCTATGGAACAGCAACACGAATCCTTCAGGAGAAAGTGC
AGGCCGATGTTCCTCCAGAGATTCTCAATAATGTGGGTGCCCTCCATTTTAGACTTGGAAACCTAGGGGAGGCTAAGAAATATTTTTTGG
CGTCATTGGACCGTGCAAAAGCAGAAGCGGAACACGATGAGCATTACTATAACGCCATTTCCGTTACCACGTCATATAATCTCGCCAGGC
TATATGAGGCGATGTGTGAATTCCATGAAGCAGAAAAACTGTATAAAAACATCTTACGCGAACATCCTAATTATGTTGACTGCTATTTGC
GCCTAGGAGCCATGGCTAGAGATAAGGGAAACTTTTATGAGGCTTCAGATTGGTTTAAGGAAGCTCTTCAGATTAATCAGGATCATCCAG
ATGCTTGGTCTTTGATTGGCAATCTTCATTTGGCAAAACAAGAATGGGGTCCTGGGCAGAAGAAGTTTGAGAGGATATTAAAACAGCCAT
CCACACAGAGTGATACCTATTCTATGCTAGCCCTTGGCAACGTGTGGCTCCAAACTTTACATCAGCCCACCCGAGATCGAGAAAAGGAAA
AGCGTCATCAAGATCGTGCTCTGGCCATCTACAAACAAGTACTCAGAAATGATGCAAAGAATCTGTATGCTGCCAATGGCATAGGAGCTG
TTTTGGCCCACAAAGGATATTTTCGTGAAGCTCGTGATGTATTTGCCCAAGTAAGAGAAGCAACAGCAGATATTAGTGATGTGTGGCTGA
ACTTAGCACACATCTATGTGGAGCAAAAGCAGTACATCAGCGCCGTTCAGATGTATGAAAACTGCCTCCGAAAGTTCTATAAGCACCAAA
ACACTGAAGTTGTACTCTATTTGGCCCGGGCCCTCTTCAAGTGTGGCAAGTTACAGGAATGCAAACAGACTTTGCTGAAGGCTAGACATG
TGGCACCCAGTGATACAGTTCTTATGTTTAATGTGGCCTTGGTCCTGCAAAGATTAGCTACCTCTGTCCTGAAAGATGAAAAAAGTAATC
TGAAGGAAGTACTTAATGCTGTGAAAGAACTGGAGCTTGCACATAGATACTTCAGTTATTTGAGTAAAGTGGGAGATAAAATGAGATTTG
ATTTGGCCCTTGCTGCTACAGAAGCCAGGCAGTGTTCTGACTTACTGAGCCAGGCCCAGTACCATGTGGCCCGGGCACGCAAACAAGATG
AAGAAGAGCGGGAGCTGCGGGCCAAGCAAGAGCAAGAAAAGGAGCTGTTAAGGCAGAAACTTCTTAAAGAACAGGAAGAGAAACGTCTCA
GAGAAAAGGAAGAGCAAAAGAAACTTTTGGAACAGCGGGCCCAGTATGTGGAGAAGACCAAAAATATTCTTATGTTTACTGGTGAGACTG
AAGCAACAAAAGAGAAGAAAAGAGGTGGTGGTGGTGGACGGCGTTCTAAGAAGGGAGGAGAGTTTGATGAATTTGTCAATGATGACACTG
ATGATGACCTACCTATATCCAAAAAGAAGAAGAGAAGAAAGGGTAGTGGCAGTGAACAAGAAGGTGAAGATGAGGAGGGTGGTGAGAGAA
AGAAGAAAAAGAGGAGAAGACATCCAAAGGGAGAAGAAGGATCTGATGATGATGAAACAGAAAATGGCCCCAAACCAAAAAAACGACGTC
CACCAAAAGCAGAGAAGAAAAAGGCTCCCAAGCCAGAACGTCTGCCTCCATCAATGAAGGGAAAAATAAAATCCAAAGCCATAATTTCAT
CAAGTGATGACTCTTCGGATGAGGATAAACTTAAAATTGCTGATGAAGGACATCCCAGGAACAGCAACAGCAACAGTGACTCAGACGAGG
ACGAACAACGAAAGAAATGTGCCTCATCAGAGAGTGATTCCGATGAGAACCAGAACAAGTCTGGCAGCGAGGCCGGCAGTCCCCGGAGGC
CACGAAGACAGCGGTCAGATCAGGACTCAGACAGTGACCAGCCATCCAGAAAGAGAAGGCCCTCCGGTTCTGAGCAGTCTGACAATGAAT
CTGTGCAGTCAGGGAGAAGCCACTCAGGAGTTTCTGAGAACGACTCTCGCCCAGCTTCTCCAAGTGCCGAATCAGATCACGAATCGGAGA
GAGGATCTGATAATGAGGGTTCTGGCCAAGGCTCTGGAAATGAATCGGAACCAGAGGGATCCAACAATGAGGCCTCAGATAGAGGCTCAG
AACATGGGTCAGATGATAGTGACTAGGTTTTATTTCATCAATAAGCTTCATCTCTGGAGGAAACTTTTTTAATATATGAAAGCTGTGATA
AAAATGTTTCAGATGTTTAGTCAATTGTGAAATTTTTCTTAAGGCAATTTTCTTTTCTATCAGTTTGTATATTACTAAGCCCCAAGAGAC
ATTTCCTGTGCTAGAGTCCAATATTTGAGTCTCTCGTGCAAATGAGACTATTCTTTGTGGTACAATTCCACCTATCATATGTGAAAACTG
CAGTAAAAATAAACCCAGATGCTAAATCATTCCTACAAAGGTTTGACTGAAACTGTGGCAGATGTCTCATCTTCTTTATATGTTAAGCAG
CATACTCTTCTGATTTTTATTGCAATCTTTTACCAAGTGGTGCACAAACTTGGTATTGATGTCTTTATTCCATTTTGAGTTTAGATTGAG
AATATTTTTATTTTCTGAAGGCAGAGATATCTACTGTATAATTGCACCAAAGTACATTTGAAAGGAAGGTTTTCAATAGTGTAATACTGC
AGCGATGTAGATAAAATCACAAATGTATAATGTGTTAGGTTGAATAAGGTGTGGAAAATGCTTTTCTGTTAGTAGAATGCAAAAACCTAC

>In-frame_ENST00000361905_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(amino acids)=1207AA_start in transcript=542_stop in transcript=4165
MENFPSLSVYFLEKAPGFGLENPTAKIEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEG
KMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAP
GFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGH
ANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAF
QYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWI
ELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARL
YEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPS
TQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLN
LAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNL
KEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLR
EKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERK
KKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDED
EQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESER

--------------------------------------------------------------
>In-frame_ENST00000527636_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(transcript)=4635nt_BP=1324nt
GGCCGCGTCCAGGCACAGGCCATGCAGTGACGCCCCCCCACCCCTCCACCTTTGCCCGGAGCGCGGGCAGCAGCCCAGCGCGCCAGCCGG
CCCCGGGGCAGGAGCGGTGCTAGGCAGGGGTGGGGTGGCCGGGCCCAGGGACCGGGAGCCGGGGAGGGAGCCGGGCACCGAGCAGAGGGC
GGGGGAAGCGGCGCCGAAGTTTGCCTCGGACTCGCCGGGCGCTGCGGTGGCTCCCTGGGCCGAGGACTGTTGCTGCCGCTGCCGCCGCCG
CTTCATTGCACATTCAAGTGGAAAATTTTCAGGAGTCAGCAGAAACATTGTGTCCAAAAAAGACTGAGTCGCAGTTACCACCAAACCCAG
GAGGAGACTCTCCCTGGAAAACTTCCCTTCCCTTTCGGTTTATTTTCTTGAAAAGGCTCCAGGCTTCGGCTTGGAAAATCCCACCGCCAA
AATTGAGCCCAGCAGCTGGAGCGGCAGTGAGAGCCCTGCCGAAAACATGGAAAGGATGAGTGACTCTGCAGATAAGCCAATTGACAATGA
TGCAGAAGGGGTCTGGAGCCCCGACATCGAGCAAAGCTTTCAGGAGGCCCTGGCTATCTATCCACCATGTGGGAGGAGGAAAATCATCTT
ATCAGACGAAGGCAAAATGTATGGTAGGAATGAATTGATAGCCAGATACATCAAACTCAGGACAGGCAAGACGAGGACCAGAAAACAGGT
GTCTAGTCACATTCAGGTTCTTGCCAGAAGGAAATCTCGTGATTTTCATTCCAAGCTAAAGGATCAGACTGCAAAGGATAAGGCCCTGCA
GCACATGGCGGCCATGTCCTCAGCCCAGATCGTCTCGGCCACTGCCATTCATAACAAGCTGGGGCTGCCTGGGATTCCACGCCCGACCTT
CCCAGGGGCGCCGGGGTTCTGGCCGGGAATGATTCAAACAGGGCAGCCAGGATCCTCACAAGACGTCAAGCCTTTTGTGCAGCAGGCCTA
CCCCATCCAGCCAGCGGTCACAGCCCCCATTCCAGGGTTTGAGCCTGCATCGGCCCCAGCTCCCTCAGTCCCTGCCTGGCAAGGTCGCTC
CATTGGCACAACCAAGCTTCGCCTGGTGGAATTTTCAGCTTTTCTCGAGCAGCAGCGAGACCCAGACTCGTACAACAAACACCTCTTCGT
GCACATTGGGCATGCCAACCATTCTTACAGTGACCCATTGCTTGAATCAGTGGACATTCGTCAGATTTATGACAAATTTCCTGAAAAGAA
AGGTGGCTTAAAGGAACTGTTTGGAAAGGGCCCTCAAAATGCCTTCTTCCTCGTAAAATTCTGGGATTATAGTAAAGTCCAGCATCTGGC
CCTCCATGCATTCCATAATACAGAAGTGGAAGCTATGCAAGCAGAGAGCTGCTATCAGCTAGCTAGATCATTCCATGTTCAGGAAGATTA
TGACCAAGCTTTTCAGTACTATTATCAAGCCACACAGTTTGCCTCATCCTCTTTTGTGCTCCCATTTTTTGGTTTGGGACAAATGTATAT
TTATCGAGGTGACAAAGAAAATGCATCTCAGTGCTTTGAGAAGGTTTTGAAAGCTTATCCTAATAATTACGAAACTATGAAAATTCTCGG
CTCTCTCTATGCTGCCTCAGAAGATCAAGAAAAACGAGATATTGCCAAGGGCCATTTGAAGAAGGTCACAGAACAGTATCCCGATGATGT
TGAAGCTTGGATTGAATTGGCACAAATCTTAGAACAGACTGATATACAGGGTGCCCTTTCAGCCTATGGAACAGCAACACGAATCCTTCA
GGAGAAAGTGCAGGCCGATGTTCCTCCAGAGATTCTCAATAATGTGGGTGCCCTCCATTTTAGACTTGGAAACCTAGGGGAGGCTAAGAA
ATATTTTTTGGCGTCATTGGACCGTGCAAAAGCAGAAGCGGAACACGATGAGCATTACTATAACGCCATTTCCGTTACCACGTCATATAA
TCTCGCCAGGCTATATGAGGCGATGTGTGAATTCCATGAAGCAGAAAAACTGTATAAAAACATCTTACGCGAACATCCTAATTATGTTGA
CTGCTATTTGCGCCTAGGAGCCATGGCTAGAGATAAGGGAAACTTTTATGAGGCTTCAGATTGGTTTAAGGAAGCTCTTCAGATTAATCA
GGATCATCCAGATGCTTGGTCTTTGATTGGCAATCTTCATTTGGCAAAACAAGAATGGGGTCCTGGGCAGAAGAAGTTTGAGAGGATATT
AAAACAGCCATCCACACAGAGTGATACCTATTCTATGCTAGCCCTTGGCAACGTGTGGCTCCAAACTTTACATCAGCCCACCCGAGATCG
AGAAAAGGAAAAGCGTCATCAAGATCGTGCTCTGGCCATCTACAAACAAGTACTCAGAAATGATGCAAAGAATCTGTATGCTGCCAATGG
CATAGGAGCTGTTTTGGCCCACAAAGGATATTTTCGTGAAGCTCGTGATGTATTTGCCCAAGTAAGAGAAGCAACAGCAGATATTAGTGA
TGTGTGGCTGAACTTAGCACACATCTATGTGGAGCAAAAGCAGTACATCAGCGCCGTTCAGATGTATGAAAACTGCCTCCGAAAGTTCTA
TAAGCACCAAAACACTGAAGTTGTACTCTATTTGGCCCGGGCCCTCTTCAAGTGTGGCAAGTTACAGGAATGCAAACAGACTTTGCTGAA
GGCTAGACATGTGGCACCCAGTGATACAGTTCTTATGTTTAATGTGGCCTTGGTCCTGCAAAGATTAGCTACCTCTGTCCTGAAAGATGA
AAAAAGTAATCTGAAGGAAGTACTTAATGCTGTGAAAGAACTGGAGCTTGCACATAGATACTTCAGTTATTTGAGTAAAGTGGGAGATAA
AATGAGATTTGATTTGGCCCTTGCTGCTACAGAAGCCAGGCAGTGTTCTGACTTACTGAGCCAGGCCCAGTACCATGTGGCCCGGGCACG
CAAACAAGATGAAGAAGAGCGGGAGCTGCGGGCCAAGCAAGAGCAAGAAAAGGAGCTGTTAAGGCAGAAACTTCTTAAAGAACAGGAAGA
GAAACGTCTCAGAGAAAAGGAAGAGCAAAAGAAACTTTTGGAACAGCGGGCCCAGTATGTGGAGAAGACCAAAAATATTCTTATGTTTAC
TGGTGAGACTGAAGCAACAAAAGAGAAGAAAAGAGGTGGTGGTGGTGGACGGCGTTCTAAGAAGGGAGGAGAGTTTGATGAATTTGTCAA
TGATGACACTGATGATGACCTACCTATATCCAAAAAGAAGAAGAGAAGAAAGGGTAGTGGCAGTGAACAAGAAGGTGAAGATGAGGAGGG
TGGTGAGAGAAAGAAGAAAAAGAGGAGAAGACATCCAAAGGGAGAAGAAGGATCTGATGATGATGAAACAGAAAATGGCCCCAAACCAAA
AAAACGACGTCCACCAAAAGCAGAGAAGAAAAAGGCTCCCAAGCCAGAACGTCTGCCTCCATCAATGAAGGGAAAAATAAAATCCAAAGC
CATAATTTCATCAAGTGATGACTCTTCGGATGAGGATAAACTTAAAATTGCTGATGAAGGACATCCCAGGAACAGCAACAGCAACAGTGA
CTCAGACGAGGACGAACAACGAAAGAAATGTGCCTCATCAGAGAGTGATTCCGATGAGAACCAGAACAAGTCTGGCAGCGAGGCCGGCAG
TCCCCGGAGGCCACGAAGACAGCGGTCAGATCAGGACTCAGACAGTGACCAGCCATCCAGAAAGAGAAGGCCCTCCGGTTCTGAGCAGTC
TGACAATGAATCTGTGCAGTCAGGGAGAAGCCACTCAGGAGTTTCTGAGAACGACTCTCGCCCAGCTTCTCCAAGTGCCGAATCAGATCA
CGAATCGGAGAGAGGATCTGATAATGAGGGTTCTGGCCAAGGCTCTGGAAATGAATCGGAACCAGAGGGATCCAACAATGAGGCCTCAGA
TAGAGGCTCAGAACATGGGTCAGATGATAGTGACTAGGTTTTATTTCATCAATAAGCTTCATCTCTGGAGGAAACTTTTTTAATATATGA
AAGCTGTGATAAAAATGTTTCAGATGTTTAGTCAATTGTGAAATTTTTCTTAAGGCAATTTTCTTTTCTATCAGTTTGTATATTACTAAG
CCCCAAGAGACATTTCCTGTGCTAGAGTCCAATATTTGAGTCTCTCGTGCAAATGAGACTATTCTTTGTGGTACAATTCCACCTATCATA
TGTGAAAACTGCAGTAAAAATAAACCCAGATGCTAAATCATTCCTACAAAGGTTTGACTGAAACTGTGGCAGATGTCTCATCTTCTTTAT
ATGTTAAGCAGCATACTCTTCTGATTTTTATTGCAATCTTTTACCAAGTGGTGCACAAACTTGGTATTGATGTCTTTATTCCATTTTGAG
TTTAGATTGAGAATATTTTTATTTTCTGAAGGCAGAGATATCTACTGTATAATTGCACCAAAGTACATTTGAAAGGAAGGTTTTCAATAG
TGTAATACTGCAGCGATGTAGATAAAATCACAAATGTATAATGTGTTAGGTTGAATAAGGTGTGGAAAATGCTTTTCTGTTAGTAGAATG

>In-frame_ENST00000527636_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(amino acids)=1207AA_start in transcript=373_stop in transcript=3996
MENFPSLSVYFLEKAPGFGLENPTAKIEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEG
KMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAP
GFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGH
ANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAF
QYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWI
ELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARL
YEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPS
TQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLN
LAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNL
KEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLR
EKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERK
KKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDED
EQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESER

--------------------------------------------------------------
>In-frame_ENST00000361985_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(transcript)=4338nt_BP=1027nt
AGGGAGTGTGGTGGCATTGCTCTGCAGAGACATGAACAGCTCCCTGGGAGACACTGCTGGGGAAAGATGAGTCGAGTCTACGGTTTTTTC
TCATCCTCCTGTTTATTTTCTTGAAAAGGCTCCAGGCTTCGGCTTGGAAAATCCCACCGCCAAAATTGAGCCCAGCAGCTGGAGCGGCAG
TGAGAGCCCTGCCGAAAACATGGAAAGGATGAGTGACTCTGCAGATAAGCCAATTGACAATGATGCAGAAGGGGTCTGGAGCCCCGACAT
CGAGCAAAGCTTTCAGGAGGCCCTGGCTATCTATCCACCATGTGGGAGGAGGAAAATCATCTTATCAGACGAAGGCAAAATGTATGGTAG
GAATGAATTGATAGCCAGATACATCAAACTCAGGACAGGCAAGACGAGGACCAGAAAACAGGTGTCTAGTCACATTCAGGTTCTTGCCAG
AAGGAAATCTCGTGATTTTCATTCCAAGCTAAAGGATCAGACTGCAAAGGATAAGGCCCTGCAGCACATGGCGGCCATGTCCTCAGCCCA
GATCGTCTCGGCCACTGCCATTCATAACAAGCTGGGGCTGCCTGGGATTCCACGCCCGACCTTCCCAGGGGCGCCGGGGTTCTGGCCGGG
AATGATTCAAACAGGGCAGCCAGGATCCTCACAAGACGTCAAGCCTTTTGTGCAGCAGGCCTACCCCATCCAGCCAGCGGTCACAGCCCC
CATTCCAGGGTTTGAGCCTGCATCGGCCCCAGCTCCCTCAGTCCCTGCCTGGCAAGGTCGCTCCATTGGCACAACCAAGCTTCGCCTGGT
GGAATTTTCAGCTTTTCTCGAGCAGCAGCGAGACCCAGACTCGTACAACAAACACCTCTTCGTGCACATTGGGCATGCCAACCATTCTTA
CAGTGACCCATTGCTTGAATCAGTGGACATTCGTCAGATTTATGACAAATTTCCTGAAAAGAAAGGTGGCTTAAAGGAACTGTTTGGAAA
GGGCCCTCAAAATGCCTTCTTCCTCGTAAAATTCTGGGATTATAGTAAAGTCCAGCATCTGGCCCTCCATGCATTCCATAATACAGAAGT
GGAAGCTATGCAAGCAGAGAGCTGCTATCAGCTAGCTAGATCATTCCATGTTCAGGAAGATTATGACCAAGCTTTTCAGTACTATTATCA
AGCCACACAGTTTGCCTCATCCTCTTTTGTGCTCCCATTTTTTGGTTTGGGACAAATGTATATTTATCGAGGTGACAAAGAAAATGCATC
TCAGTGCTTTGAGAAGGTTTTGAAAGCTTATCCTAATAATTACGAAACTATGAAAATTCTCGGCTCTCTCTATGCTGCCTCAGAAGATCA
AGAAAAACGAGATATTGCCAAGGGCCATTTGAAGAAGGTCACAGAACAGTATCCCGATGATGTTGAAGCTTGGATTGAATTGGCACAAAT
CTTAGAACAGACTGATATACAGGGTGCCCTTTCAGCCTATGGAACAGCAACACGAATCCTTCAGGAGAAAGTGCAGGCCGATGTTCCTCC
AGAGATTCTCAATAATGTGGGTGCCCTCCATTTTAGACTTGGAAACCTAGGGGAGGCTAAGAAATATTTTTTGGCGTCATTGGACCGTGC
AAAAGCAGAAGCGGAACACGATGAGCATTACTATAACGCCATTTCCGTTACCACGTCATATAATCTCGCCAGGCTATATGAGGCGATGTG
TGAATTCCATGAAGCAGAAAAACTGTATAAAAACATCTTACGCGAACATCCTAATTATGTTGACTGCTATTTGCGCCTAGGAGCCATGGC
TAGAGATAAGGGAAACTTTTATGAGGCTTCAGATTGGTTTAAGGAAGCTCTTCAGATTAATCAGGATCATCCAGATGCTTGGTCTTTGAT
TGGCAATCTTCATTTGGCAAAACAAGAATGGGGTCCTGGGCAGAAGAAGTTTGAGAGGATATTAAAACAGCCATCCACACAGAGTGATAC
CTATTCTATGCTAGCCCTTGGCAACGTGTGGCTCCAAACTTTACATCAGCCCACCCGAGATCGAGAAAAGGAAAAGCGTCATCAAGATCG
TGCTCTGGCCATCTACAAACAAGTACTCAGAAATGATGCAAAGAATCTGTATGCTGCCAATGGCATAGGAGCTGTTTTGGCCCACAAAGG
ATATTTTCGTGAAGCTCGTGATGTATTTGCCCAAGTAAGAGAAGCAACAGCAGATATTAGTGATGTGTGGCTGAACTTAGCACACATCTA
TGTGGAGCAAAAGCAGTACATCAGCGCCGTTCAGATGTATGAAAACTGCCTCCGAAAGTTCTATAAGCACCAAAACACTGAAGTTGTACT
CTATTTGGCCCGGGCCCTCTTCAAGTGTGGCAAGTTACAGGAATGCAAACAGACTTTGCTGAAGGCTAGACATGTGGCACCCAGTGATAC
AGTTCTTATGTTTAATGTGGCCTTGGTCCTGCAAAGATTAGCTACCTCTGTCCTGAAAGATGAAAAAAGTAATCTGAAGGAAGTACTTAA
TGCTGTGAAAGAACTGGAGCTTGCACATAGATACTTCAGTTATTTGAGTAAAGTGGGAGATAAAATGAGATTTGATTTGGCCCTTGCTGC
TACAGAAGCCAGGCAGTGTTCTGACTTACTGAGCCAGGCCCAGTACCATGTGGCCCGGGCACGCAAACAAGATGAAGAAGAGCGGGAGCT
GCGGGCCAAGCAAGAGCAAGAAAAGGAGCTGTTAAGGCAGAAACTTCTTAAAGAACAGGAAGAGAAACGTCTCAGAGAAAAGGAAGAGCA
AAAGAAACTTTTGGAACAGCGGGCCCAGTATGTGGAGAAGACCAAAAATATTCTTATGTTTACTGGTGAGACTGAAGCAACAAAAGAGAA
GAAAAGAGGTGGTGGTGGTGGACGGCGTTCTAAGAAGGGAGGAGAGTTTGATGAATTTGTCAATGATGACACTGATGATGACCTACCTAT
ATCCAAAAAGAAGAAGAGAAGAAAGGGTAGTGGCAGTGAACAAGAAGGTGAAGATGAGGAGGGTGGTGAGAGAAAGAAGAAAAAGAGGAG
AAGACATCCAAAGGGAGAAGAAGGATCTGATGATGATGAAACAGAAAATGGCCCCAAACCAAAAAAACGACGTCCACCAAAAGCAGAGAA
GAAAAAGGCTCCCAAGCCAGAACGTCTGCCTCCATCAATGAAGGGAAAAATAAAATCCAAAGCCATAATTTCATCAAGTGATGACTCTTC
GGATGAGGATAAACTTAAAATTGCTGATGAAGGACATCCCAGGAACAGCAACAGCAACAGTGACTCAGACGAGGACGAACAACGAAAGAA
ATGTGCCTCATCAGAGAGTGATTCCGATGAGAACCAGAACAAGTCTGGCAGCGAGGCCGGCAGTCCCCGGAGGCCACGAAGACAGCGGTC
AGATCAGGACTCAGACAGTGACCAGCCATCCAGAAAGAGAAGGCCCTCCGGTTCTGAGCAGTCTGACAATGAATCTGTGCAGTCAGGGAG
AAGCCACTCAGGAGTTTCTGAGAACGACTCTCGCCCAGCTTCTCCAAGTGCCGAATCAGATCACGAATCGGAGAGAGGATCTGATAATGA
GGGTTCTGGCCAAGGCTCTGGAAATGAATCGGAACCAGAGGGATCCAACAATGAGGCCTCAGATAGAGGCTCAGAACATGGGTCAGATGA
TAGTGACTAGGTTTTATTTCATCAATAAGCTTCATCTCTGGAGGAAACTTTTTTAATATATGAAAGCTGTGATAAAAATGTTTCAGATGT
TTAGTCAATTGTGAAATTTTTCTTAAGGCAATTTTCTTTTCTATCAGTTTGTATATTACTAAGCCCCAAGAGACATTTCCTGTGCTAGAG
TCCAATATTTGAGTCTCTCGTGCAAATGAGACTATTCTTTGTGGTACAATTCCACCTATCATATGTGAAAACTGCAGTAAAAATAAACCC
AGATGCTAAATCATTCCTACAAAGGTTTGACTGAAACTGTGGCAGATGTCTCATCTTCTTTATATGTTAAGCAGCATACTCTTCTGATTT
TTATTGCAATCTTTTACCAAGTGGTGCACAAACTTGGTATTGATGTCTTTATTCCATTTTGAGTTTAGATTGAGAATATTTTTATTTTCT
GAAGGCAGAGATATCTACTGTATAATTGCACCAAAGTACATTTGAAAGGAAGGTTTTCAATAGTGTAATACTGCAGCGATGTAGATAAAA
TCACAAATGTATAATGTGTTAGGTTGAATAAGGTGTGGAAAATGCTTTTCTGTTAGTAGAATGCAAAAACCTACCTAAGCCACATAATAA

>In-frame_ENST00000361985_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(amino acids)=1188AA_start in transcript=133_stop in transcript=3699
MENPTAKIEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGK
TRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVK
PFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIY
DKFPEKKGGLKELFGKGPQNAFFLVKFWDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFF
GLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYG
TATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILR
EHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTL
HQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYE
NCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSY
LSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKT
KNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDET
ENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNK
SGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSGQGSGNESEPEG

--------------------------------------------------------------
>In-frame_ENST00000526600_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(transcript)=4119nt_BP=808nt
TGAGAGGCTTCACATTCTGTTGGAAAATGGATTTAATCCCTAAAAAAAGCCTTGCCCCATTGGGTCTTCCCAGTAAATGTTGAGAGGTAC
GGTAGGTTGAGTGTGGTTTAGCCTTCTGGCTGTGTTATTTATCCATGCATGTTTGCTTTTTTTGGCCTATTTTGTGGCTCTGTATTTTAG
TCCATGTGCTCGTGGCTGTGCCTGTGTAACCTGCCTGGTAGCCATGCGTTATGTATTAAGTTGGTGTGTCACTGTCACCTTCAAGGATCA
GACTGCAAAGGATAAGGCCCTGCAGCACATGGCGGCCATGTCCTCAGCCCAGATCGTCTCGGCCACTGCCATTCATAACAAGCTGGGGCT
GCCTGGGATTCCACGCCCGACCTTCCCAGGGGCGCCGGGGTTCTGGCCGGGAATGATTCAAACAGGGCAGCCAGGATCCTCACAAGACGT
CAAGCCTTTTGTGCAGCAGGCCTACCCCATCCAGCCAGCGGTCACAGCCCCCATTCCAGGGTTTGAGCCTGCATCGGCCCCAGCTCCCTC
AGTCCCTGCCTGGCAAGGTCGCTCCATTGGCACAACCAAGCTTCGCCTGGTGGAATTTTCAGCTTTTCTCGAGCAGCAGCGAGACCCAGA
CTCGTACAACAAACACCTCTTCGTGCACATTGGGCATGCCAACCATTCTTACAGTGACCCATTGCTTGAATCAGTGGACATTCGTCAGAT
TTATGACAAATTTCCTGAAAAGAAAGGTGGCTTAAAGGAACTGTTTGGAAAGGGCCCTCAAAATGCCTTCTTCCTCGTAAAATTCTGGGA
TTATAGTAAAGTCCAGCATCTGGCCCTCCATGCATTCCATAATACAGAAGTGGAAGCTATGCAAGCAGAGAGCTGCTATCAGCTAGCTAG
ATCATTCCATGTTCAGGAAGATTATGACCAAGCTTTTCAGTACTATTATCAAGCCACACAGTTTGCCTCATCCTCTTTTGTGCTCCCATT
TTTTGGTTTGGGACAAATGTATATTTATCGAGGTGACAAAGAAAATGCATCTCAGTGCTTTGAGAAGGTTTTGAAAGCTTATCCTAATAA
TTACGAAACTATGAAAATTCTCGGCTCTCTCTATGCTGCCTCAGAAGATCAAGAAAAACGAGATATTGCCAAGGGCCATTTGAAGAAGGT
CACAGAACAGTATCCCGATGATGTTGAAGCTTGGATTGAATTGGCACAAATCTTAGAACAGACTGATATACAGGGTGCCCTTTCAGCCTA
TGGAACAGCAACACGAATCCTTCAGGAGAAAGTGCAGGCCGATGTTCCTCCAGAGATTCTCAATAATGTGGGTGCCCTCCATTTTAGACT
TGGAAACCTAGGGGAGGCTAAGAAATATTTTTTGGCGTCATTGGACCGTGCAAAAGCAGAAGCGGAACACGATGAGCATTACTATAACGC
CATTTCCGTTACCACGTCATATAATCTCGCCAGGCTATATGAGGCGATGTGTGAATTCCATGAAGCAGAAAAACTGTATAAAAACATCTT
ACGCGAACATCCTAATTATGTTGACTGCTATTTGCGCCTAGGAGCCATGGCTAGAGATAAGGGAAACTTTTATGAGGCTTCAGATTGGTT
TAAGGAAGCTCTTCAGATTAATCAGGATCATCCAGATGCTTGGTCTTTGATTGGCAATCTTCATTTGGCAAAACAAGAATGGGGTCCTGG
GCAGAAGAAGTTTGAGAGGATATTAAAACAGCCATCCACACAGAGTGATACCTATTCTATGCTAGCCCTTGGCAACGTGTGGCTCCAAAC
TTTACATCAGCCCACCCGAGATCGAGAAAAGGAAAAGCGTCATCAAGATCGTGCTCTGGCCATCTACAAACAAGTACTCAGAAATGATGC
AAAGAATCTGTATGCTGCCAATGGCATAGGAGCTGTTTTGGCCCACAAAGGATATTTTCGTGAAGCTCGTGATGTATTTGCCCAAGTAAG
AGAAGCAACAGCAGATATTAGTGATGTGTGGCTGAACTTAGCACACATCTATGTGGAGCAAAAGCAGTACATCAGCGCCGTTCAGATGTA
TGAAAACTGCCTCCGAAAGTTCTATAAGCACCAAAACACTGAAGTTGTACTCTATTTGGCCCGGGCCCTCTTCAAGTGTGGCAAGTTACA
GGAATGCAAACAGACTTTGCTGAAGGCTAGACATGTGGCACCCAGTGATACAGTTCTTATGTTTAATGTGGCCTTGGTCCTGCAAAGATT
AGCTACCTCTGTCCTGAAAGATGAAAAAAGTAATCTGAAGGAAGTACTTAATGCTGTGAAAGAACTGGAGCTTGCACATAGATACTTCAG
TTATTTGAGTAAAGTGGGAGATAAAATGAGATTTGATTTGGCCCTTGCTGCTACAGAAGCCAGGCAGTGTTCTGACTTACTGAGCCAGGC
CCAGTACCATGTGGCCCGGGCACGCAAACAAGATGAAGAAGAGCGGGAGCTGCGGGCCAAGCAAGAGCAAGAAAAGGAGCTGTTAAGGCA
GAAACTTCTTAAAGAACAGGAAGAGAAACGTCTCAGAGAAAAGGAAGAGCAAAAGAAACTTTTGGAACAGCGGGCCCAGTATGTGGAGAA
GACCAAAAATATTCTTATGTTTACTGGTGAGACTGAAGCAACAAAAGAGAAGAAAAGAGGTGGTGGTGGTGGACGGCGTTCTAAGAAGGG
AGGAGAGTTTGATGAATTTGTCAATGATGACACTGATGATGACCTACCTATATCCAAAAAGAAGAAGAGAAGAAAGGGTAGTGGCAGTGA
ACAAGAAGGTGAAGATGAGGAGGGTGGTGAGAGAAAGAAGAAAAAGAGGAGAAGACATCCAAAGGGAGAAGAAGGATCTGATGATGATGA
AACAGAAAATGGCCCCAAACCAAAAAAACGACGTCCACCAAAAGCAGAGAAGAAAAAGGCTCCCAAGCCAGAACGTCTGCCTCCATCAAT
GAAGGGAAAAATAAAATCCAAAGCCATAATTTCATCAAGTGATGACTCTTCGGATGAGGATAAACTTAAAATTGCTGATGAAGGACATCC
CAGGAACAGCAACAGCAACAGTGACTCAGACGAGGACGAACAACGAAAGAAATGTGCCTCATCAGAGAGTGATTCCGATGAGAACCAGAA
CAAGTCTGGCAGCGAGGCCGGCAGTCCCCGGAGGCCACGAAGACAGCGGTCAGATCAGGACTCAGACAGTGACCAGCCATCCAGAAAGAG
AAGGCCCTCCGGTTCTGAGCAGTCTGACAATGAATCTGTGCAGTCAGGGAGAAGCCACTCAGGAGTTTCTGAGAACGACTCTCGCCCAGC
TTCTCCAAGTGCCGAATCAGATCACGAATCGGAGAGAGGATCTGATAATGAGGGTTCTGGCCAAGGCTCTGGAAATGAATCGGAACCAGA
GGGATCCAACAATGAGGCCTCAGATAGAGGCTCAGAACATGGGTCAGATGATAGTGACTAGGTTTTATTTCATCAATAAGCTTCATCTCT
GGAGGAAACTTTTTTAATATATGAAAGCTGTGATAAAAATGTTTCAGATGTTTAGTCAATTGTGAAATTTTTCTTAAGGCAATTTTCTTT
TCTATCAGTTTGTATATTACTAAGCCCCAAGAGACATTTCCTGTGCTAGAGTCCAATATTTGAGTCTCTCGTGCAAATGAGACTATTCTT
TGTGGTACAATTCCACCTATCATATGTGAAAACTGCAGTAAAAATAAACCCAGATGCTAAATCATTCCTACAAAGGTTTGACTGAAACTG
TGGCAGATGTCTCATCTTCTTTATATGTTAAGCAGCATACTCTTCTGATTTTTATTGCAATCTTTTACCAAGTGGTGCACAAACTTGGTA
TTGATGTCTTTATTCCATTTTGAGTTTAGATTGAGAATATTTTTATTTTCTGAAGGCAGAGATATCTACTGTATAATTGCACCAAAGTAC
ATTTGAAAGGAAGGTTTTCAATAGTGTAATACTGCAGCGATGTAGATAAAATCACAAATGTATAATGTGTTAGGTTGAATAAGGTGTGGA

>In-frame_ENST00000526600_ENST00000361367_TCGA-EO-A3KU-01A_TEAD1_chr11_12923660_+_CTR9_chr11_10784978_length(amino acids)=1121AA_start in transcript=115_stop in transcript=3480
MAVLFIHACLLFLAYFVALYFSPCARGCACVTCLVAMRYVLSWCVTVTFKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTF
PGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFV
HIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDY
DQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDV
EAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYN
LARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERIL
KQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISD
VWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDE
KSNLKEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEE
KRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEG
GERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSD
SDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDH

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Fusion Gene PPI Analysis for TEAD1-CTR9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TEAD1-CTR9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TEAD1-CTR9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTEAD1C1862382SVEINSSON CHORIORETINAL ATROPHY3CTD_human;ORPHANET;UNIPROT