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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TEAD4-ERC1 (FusionGDB2 ID:89356)

Fusion Gene Summary for TEAD4-ERC1

check button Fusion gene summary
Fusion gene informationFusion gene name: TEAD4-ERC1
Fusion gene ID: 89356
HgeneTgene
Gene symbol

TEAD4

ERC1

Gene ID

7004

23085

Gene nameTEA domain transcription factor 4ELKS/RAB6-interacting/CAST family member 1
SynonymsEFTR-2|RTEF1|TCF13L1|TEF-3|TEF3|TEFR-1|hRTEF-1BCast2|ELKS|ERC-1|RAB6IP2
Cytomap

12p13.33

12p13.33

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional enhancer factor TEF-3TEA domain family member 4related transcription enhancer factor 1Btranscription factor 13-like 1transcription factor RTEF-1transcriptional enhancer factor 1-relatedtranscriptional enhancer factor 3ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2
Modification date2020032220200313
UniProtAcc.

Q8IUD2

Ensembl transtripts involved in fusion geneENST00000358409, ENST00000359864, 
ENST00000397122, 		ENST00000543086, 
ENST00000546231, ENST00000397203, 
ENST00000360905, ENST00000589028, 
ENST00000355446, ENST00000536573, 
Fusion gene scores* DoF score12 X 5 X 8=48023 X 29 X 12=8004
# samples 1333
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/8004*10)=-4.60018323765993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TEAD4 [Title/Abstract] AND ERC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTEAD4(3069362)-ERC1(1553728), # samples:1
TEAD4(3069206)-ERC1(1553728), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTEAD4

GO:0035329

hippo signaling

18579750|19324877

TgeneERC1

GO:0007252

I-kappaB phosphorylation

15218148


check buttonFusion gene breakpoints across TEAD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ERC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3TO-01ATEAD4chr12

3069362

+ERC1chr12

1553728

+
ChimerDB4SARCTCGA-FX-A3TO-01ATEAD4chr12

3069206

-ERC1chr12

1553728

+


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Fusion Gene ORF analysis for TEAD4-ERC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000358409ENST00000543086TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000358409ENST00000546231TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000358409ENST00000397203TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000358409ENST00000360905TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000358409ENST00000589028TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000358409ENST00000355446TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-intronENST00000358409ENST00000536573TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000359864ENST00000543086TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000359864ENST00000546231TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000359864ENST00000397203TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000359864ENST00000360905TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000359864ENST00000589028TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000359864ENST00000355446TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-intronENST00000359864ENST00000536573TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000397122ENST00000543086TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000397122ENST00000546231TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000397122ENST00000397203TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000397122ENST00000360905TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000397122ENST00000589028TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-3CDSENST00000397122ENST00000355446TEAD4chr12

3069362

+ERC1chr12

1553728

+
intron-intronENST00000397122ENST00000536573TEAD4chr12

3069362

+ERC1chr12

1553728

+
5UTR-3CDSENST00000358409ENST00000543086TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000358409ENST00000546231TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000358409ENST00000397203TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000358409ENST00000360905TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000358409ENST00000589028TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000358409ENST00000355446TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-intronENST00000358409ENST00000536573TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000359864ENST00000543086TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000359864ENST00000546231TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000359864ENST00000397203TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000359864ENST00000360905TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000359864ENST00000589028TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000359864ENST00000355446TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-intronENST00000359864ENST00000536573TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000397122ENST00000543086TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000397122ENST00000546231TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000397122ENST00000397203TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000397122ENST00000360905TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000397122ENST00000589028TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-3CDSENST00000397122ENST00000355446TEAD4chr12

3069206

-ERC1chr12

1553728

+
5UTR-intronENST00000397122ENST00000536573TEAD4chr12

3069206

-ERC1chr12

1553728

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TEAD4-ERC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TEAD4-ERC1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ERC1

Q8IUD2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TEAD4-ERC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TEAD4-ERC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TEAD4-ERC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TEAD4-ERC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneERC1C0238463Papillary thyroid carcinoma1ORPHANET
TgeneERC1C4749581Distal monosomy 12p1ORPHANET