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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TENM4-INTS4 (FusionGDB2 ID:89456)

Fusion Gene Summary for TENM4-INTS4

check button Fusion gene summary
Fusion gene informationFusion gene name: TENM4-INTS4
Fusion gene ID: 89456
HgeneTgene
Gene symbol

TENM4

INTS4

Gene ID

26011

92105

Gene nameteneurin transmembrane protein 4integrator complex subunit 4
SynonymsDoc4|ETM5|ODZ4|TEN4|TNM4|Ten-M4|ten-4INT4|MST093
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionteneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4integrator complex subunit 4MSTP093
Modification date2020031320200313
UniProtAcc.

Q96HW7

Ensembl transtripts involved in fusion geneENST00000278550, ENST00000533038, 
ENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 
Fusion gene scores* DoF score13 X 13 X 7=118313 X 9 X 8=936
# samples 1316
** MAII scorelog2(13/1183*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/936*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TENM4 [Title/Abstract] AND INTS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTENM4(78600830)-INTS4(77594998), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINTS4

GO:0016180

snRNA processing

16239144


check buttonFusion gene breakpoints across TENM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across INTS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0HY-01ATENM4chr11

78600830

-INTS4chr11

77594998

-
ChimerDB4BRCATCGA-BH-A0HY-01ATENM4chr11

78600830

-INTS4chr11

77594998

-


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Fusion Gene ORF analysis for TENM4-INTS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000278550ENST00000534064TENM4chr11

78600830

-INTS4chr11

77594998

-
In-frameENST00000278550ENST00000535943TENM4chr11

78600830

-INTS4chr11

77594998

-
5CDS-intronENST00000278550ENST00000525931TENM4chr11

78600830

-INTS4chr11

77594998

-
5CDS-intronENST00000278550ENST00000529807TENM4chr11

78600830

-INTS4chr11

77594998

-
5CDS-intronENST00000278550ENST00000527522TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-3CDSENST00000533038ENST00000534064TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-3CDSENST00000533038ENST00000535943TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-intronENST00000533038ENST00000525931TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-intronENST00000533038ENST00000529807TENM4chr11

78600830

-INTS4chr11

77594998

-
intron-intronENST00000533038ENST00000527522TENM4chr11

78600830

-INTS4chr11

77594998

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000278550TENM4chr1178600830-ENST00000534064INTS4chr1177594998-207615474091752447
ENST00000278550TENM4chr1178600830-ENST00000535943INTS4chr1177594998-207415474091752447

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000278550ENST00000534064TENM4chr1178600830-INTS4chr1177594998-0.19321290.80678713
ENST00000278550ENST00000535943TENM4chr1178600830-INTS4chr1177594998-0.192621750.80737823

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Fusion Genomic Features for TENM4-INTS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TENM4-INTS4


check button Go to

FGviewer for the breakpoints of chr11:78600830-chr11:77594998

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INTS4

Q96HW7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934179_182361.33333333333332770.0Compositional biasNote=Poly-Pro
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341_341361.33333333333332770.0DomainTeneurin N-terminal
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341_345361.33333333333332770.0Topological domainCytoplasmic
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807012145_1830506.0RepeatNote=HEAT 2
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807012190_2280506.0RepeatNote=HEAT 3
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807012229_2630506.0RepeatNote=HEAT 4
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807012277_3130506.0RepeatNote=HEAT 5
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807012369_4050506.0RepeatNote=HEAT 6
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807012406_4440506.0RepeatNote=HEAT 7
TgeneINTS4chr11:78600830chr11:77594998ENST00000529807012446_4840506.0RepeatNote=HEAT 8
TgeneINTS4chr11:78600830chr11:77594998ENST0000052980701266_1050506.0RepeatNote=HEAT 1
TgeneINTS4chr11:78600830chr11:77594998ENST0000053594369277_313239.0339.0RepeatNote=HEAT 5
TgeneINTS4chr11:78600830chr11:77594998ENST0000053594369369_405239.0339.0RepeatNote=HEAT 6
TgeneINTS4chr11:78600830chr11:77594998ENST0000053594369406_444239.0339.0RepeatNote=HEAT 7
TgeneINTS4chr11:78600830chr11:77594998ENST0000053594369446_484239.0339.0RepeatNote=HEAT 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934562_593361.33333333333332770.0DomainEGF-like 1
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934594_624361.33333333333332770.0DomainEGF-like 2
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934626_658361.33333333333332770.0DomainEGF-like 3
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934659_690361.33333333333332770.0DomainEGF-like 4
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934692_725361.33333333333332770.0DomainEGF-like 5
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934726_757361.33333333333332770.0DomainEGF-like 6
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934758_787361.33333333333332770.0DomainEGF-like 7
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934788_831361.33333333333332770.0DomainEGF-like 8
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341216_1259361.33333333333332770.0RepeatNote=NHL 1
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341264_1308361.33333333333332770.0RepeatNote=NHL 2
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341334_1378361.33333333333332770.0RepeatNote=NHL 3
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341393_1444361.33333333333332770.0RepeatNote=NHL 4
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341523_1566361.33333333333332770.0RepeatNote=NHL 5
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341576_1595361.33333333333332770.0RepeatNote=YD 1
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341612_1632361.33333333333332770.0RepeatNote=YD 2
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341675_1694361.33333333333332770.0RepeatNote=YD 3
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341695_1717361.33333333333332770.0RepeatNote=YD 4
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341887_1906361.33333333333332770.0RepeatNote=YD 5
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341928_1946361.33333333333332770.0RepeatNote=YD 6
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341947_1967361.33333333333332770.0RepeatNote=YD 7
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341974_1991361.33333333333332770.0RepeatNote=YD 8
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9341992_2013361.33333333333332770.0RepeatNote=YD 9
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342014_2031361.33333333333332770.0RepeatNote=YD 10
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342034_2054361.33333333333332770.0RepeatNote=YD 11
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342057_2077361.33333333333332770.0RepeatNote=YD 12
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342085_2104361.33333333333332770.0RepeatNote=YD 13
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342110_2127361.33333333333332770.0RepeatNote=YD 14
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342128_2154361.33333333333332770.0RepeatNote=YD 15
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342156_2169361.33333333333332770.0RepeatNote=YD 16
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342170_2193361.33333333333332770.0RepeatNote=YD 17
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342196_2216361.33333333333332770.0RepeatNote=YD 18
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342217_2237361.33333333333332770.0RepeatNote=YD 19
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342239_2259361.33333333333332770.0RepeatNote=YD 20
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342271_2291361.33333333333332770.0RepeatNote=YD 21
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342293_2313361.33333333333332770.0RepeatNote=YD 22
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-9342339_2380361.33333333333332770.0RepeatNote=YD 23
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934367_2769361.33333333333332770.0Topological domainExtracellular
HgeneTENM4chr11:78600830chr11:77594998ENST00000278550-934346_366361.33333333333332770.0TransmembraneHelical
TgeneINTS4chr11:78600830chr11:77594998ENST000005340642023145_183864.0964.0RepeatNote=HEAT 2
TgeneINTS4chr11:78600830chr11:77594998ENST000005340642023190_228864.0964.0RepeatNote=HEAT 3
TgeneINTS4chr11:78600830chr11:77594998ENST000005340642023229_263864.0964.0RepeatNote=HEAT 4
TgeneINTS4chr11:78600830chr11:77594998ENST000005340642023277_313864.0964.0RepeatNote=HEAT 5
TgeneINTS4chr11:78600830chr11:77594998ENST000005340642023369_405864.0964.0RepeatNote=HEAT 6
TgeneINTS4chr11:78600830chr11:77594998ENST000005340642023406_444864.0964.0RepeatNote=HEAT 7
TgeneINTS4chr11:78600830chr11:77594998ENST000005340642023446_484864.0964.0RepeatNote=HEAT 8
TgeneINTS4chr11:78600830chr11:77594998ENST00000534064202366_105864.0964.0RepeatNote=HEAT 1
TgeneINTS4chr11:78600830chr11:77594998ENST0000053594369145_183239.0339.0RepeatNote=HEAT 2
TgeneINTS4chr11:78600830chr11:77594998ENST0000053594369190_228239.0339.0RepeatNote=HEAT 3
TgeneINTS4chr11:78600830chr11:77594998ENST0000053594369229_263239.0339.0RepeatNote=HEAT 4
TgeneINTS4chr11:78600830chr11:77594998ENST000005359436966_105239.0339.0RepeatNote=HEAT 1


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Fusion Gene Sequence for TENM4-INTS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000278550_ENST00000534064_TCGA-BH-A0HY-01A_TENM4_chr11_78600830_-_INTS4_chr11_77594998_length(transcript)=2076nt_BP=1547nt
ACCTGCTCCTTCCTGGGCGCCCCGCTACGGCTCGCGGAGCAGAGGAGCCGCGCCGCCGAGAGAGAGAGGAGCCACCGGCGCGGCGCCTTG
CCTCCCTGCCGCCGTCCTCGCCGCTTCCCCGGCGGTAGCAGCCTGCAGCCACGATGGAAAAACTGAGAATCAGAGAGGGCTAGTGATCTC
TCAGACACTTGGTCGGTAGAAAAGATCCCGCACCATCCTCCAGGATCCAATGGCCTTGGAGAGAGGGCTGCAGGGCCCACGGACATTGCT
GACTCTTCAGAACGTGCTGACATGGAGCCAGGTAGACTGAAATTACCATGTGTCCAAATTAAAATTGCATACTTCAAGGATTATTTGAAG
GACTATTCTTAGACCCTTTTAAGAAGATTTAAAGAAAAACCACTCGGCCCTGAGTGCGGCGAGGACCCTGTTTGTGGATGTGGAGGAGCG
CGGGCCGGAGGCCATGGACGTGAAGGAGAGGAAGCCTTACCGCTCGCTGACCCGGCGCCGCGACGCCGAGCGCCGCTACACCAGCTCGTC
CGCGGACAGCGAGGAGGGCAAAGCCCCGCAGAAATCGTACAGCTCCAGCGAGACCCTGAAGGCCTACGACCAGGACGCCCGCCTAGCCTA
TGGCAGCCGCGTCAAGGACATTGTGCCGCAGGAGGCCGAGGAATTCTGCCGCACAGGTGCCAACTTCACCCTGCGGGAGCTGGGGCTGGA
AGAAGTAACGCCCCCTCACGGGACCCTGTACCGGACAGACATTGGCCTCCCCCACTGCGGCTACTCCATGGGGGCTGGCTCTGATGCCGA
CATGGAGGCTGACACGGTGCTGTCCCCTGAGCACCCCGTGCGTCTGTGGGGCCGGAGCACACGGTCAGGGCGCAGCTCCTGCCTGTCCAG
CCGGGCCAATTCCAATCTCACACTCACCGACACCGAGCATGAAAACACTGAGACTGATCATCCGGGCGGCCTGCAGAACCACGCGCGGCT
CCGGACGCCGCCGCCGCCGCTCTCGCACGCCCACACCCCCAACCAGCACCACGCGGCCTCCATTAACTCCCTGAACCGGGGCAACTTCAC
GCCGAGGAGCAACCCCAGCCCGGCCCCCACGGACCACTCGCTCTCCGGAGAGCCCCCTGCCGGCGGCGCCCAGGAGCCTGCCCACGCCCA
GGAGAACTGGCTGCTCAACAGCAACATCCCCCTGGAGACCAGAAACCTAGGCAAGCAGCCATTCCTAGGGACATTGCAGGACAACCTCAT
TGAGATGGACATTCTCGGCGCCTCCCGCCATGATGGGGCTTACAGTGACGGGCACTTCCTCTTCAAGCCTGGAGGCACCTCCCCGCTCTT
CTGCACCACATCACCAGGGTACCCACTGACGTCCAGCACAGTGTACTCTCCTCCGCCCCGACCCCTGCCCCGCAGCACCTTCGCCCGGCC
GGCCTTTAACCTCAAGAAGCCCTCCAAGTACTGTAACTGGAAGTGCGCAGCCCTGAGCGCCATCGTCATCTCAGCCACTCTGGTCATCCT
GCTGGCATACTTTGTGGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGC
GGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACT
CCAGTGCTCGCATTCCAAAATGCCCCTGGATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCA
GCAAGCCTGTAAAAGTTTATATAATGCCCAAACCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTT
AGGTGTCAGAATGAGCCAAGCCTGAAGCACTTCACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTA
TCAAACACAGGATAAATTGTTTCTTCATTAAAAAATAAAAAACCTTCAAGTCTACTTACCCTTCTCCTGTCCACAATAAAGTTGAGAAAA

>In-frame_ENST00000278550_ENST00000534064_TCGA-BH-A0HY-01A_TENM4_chr11_78600830_-_INTS4_chr11_77594998_length(amino acids)=447AA_start in transcript=409_stop in transcript=1752
MSAARTLFVDVEERGPEAMDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFC
RTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENT
ETDHPGGLQNHARLRTPPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWLLNSNIPLETRNL
GKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPGGTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCA

--------------------------------------------------------------
>In-frame_ENST00000278550_ENST00000535943_TCGA-BH-A0HY-01A_TENM4_chr11_78600830_-_INTS4_chr11_77594998_length(transcript)=2074nt_BP=1547nt
ACCTGCTCCTTCCTGGGCGCCCCGCTACGGCTCGCGGAGCAGAGGAGCCGCGCCGCCGAGAGAGAGAGGAGCCACCGGCGCGGCGCCTTG
CCTCCCTGCCGCCGTCCTCGCCGCTTCCCCGGCGGTAGCAGCCTGCAGCCACGATGGAAAAACTGAGAATCAGAGAGGGCTAGTGATCTC
TCAGACACTTGGTCGGTAGAAAAGATCCCGCACCATCCTCCAGGATCCAATGGCCTTGGAGAGAGGGCTGCAGGGCCCACGGACATTGCT
GACTCTTCAGAACGTGCTGACATGGAGCCAGGTAGACTGAAATTACCATGTGTCCAAATTAAAATTGCATACTTCAAGGATTATTTGAAG
GACTATTCTTAGACCCTTTTAAGAAGATTTAAAGAAAAACCACTCGGCCCTGAGTGCGGCGAGGACCCTGTTTGTGGATGTGGAGGAGCG
CGGGCCGGAGGCCATGGACGTGAAGGAGAGGAAGCCTTACCGCTCGCTGACCCGGCGCCGCGACGCCGAGCGCCGCTACACCAGCTCGTC
CGCGGACAGCGAGGAGGGCAAAGCCCCGCAGAAATCGTACAGCTCCAGCGAGACCCTGAAGGCCTACGACCAGGACGCCCGCCTAGCCTA
TGGCAGCCGCGTCAAGGACATTGTGCCGCAGGAGGCCGAGGAATTCTGCCGCACAGGTGCCAACTTCACCCTGCGGGAGCTGGGGCTGGA
AGAAGTAACGCCCCCTCACGGGACCCTGTACCGGACAGACATTGGCCTCCCCCACTGCGGCTACTCCATGGGGGCTGGCTCTGATGCCGA
CATGGAGGCTGACACGGTGCTGTCCCCTGAGCACCCCGTGCGTCTGTGGGGCCGGAGCACACGGTCAGGGCGCAGCTCCTGCCTGTCCAG
CCGGGCCAATTCCAATCTCACACTCACCGACACCGAGCATGAAAACACTGAGACTGATCATCCGGGCGGCCTGCAGAACCACGCGCGGCT
CCGGACGCCGCCGCCGCCGCTCTCGCACGCCCACACCCCCAACCAGCACCACGCGGCCTCCATTAACTCCCTGAACCGGGGCAACTTCAC
GCCGAGGAGCAACCCCAGCCCGGCCCCCACGGACCACTCGCTCTCCGGAGAGCCCCCTGCCGGCGGCGCCCAGGAGCCTGCCCACGCCCA
GGAGAACTGGCTGCTCAACAGCAACATCCCCCTGGAGACCAGAAACCTAGGCAAGCAGCCATTCCTAGGGACATTGCAGGACAACCTCAT
TGAGATGGACATTCTCGGCGCCTCCCGCCATGATGGGGCTTACAGTGACGGGCACTTCCTCTTCAAGCCTGGAGGCACCTCCCCGCTCTT
CTGCACCACATCACCAGGGTACCCACTGACGTCCAGCACAGTGTACTCTCCTCCGCCCCGACCCCTGCCCCGCAGCACCTTCGCCCGGCC
GGCCTTTAACCTCAAGAAGCCCTCCAAGTACTGTAACTGGAAGTGCGCAGCCCTGAGCGCCATCGTCATCTCAGCCACTCTGGTCATCCT
GCTGGCATACTTTGTGGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGC
GGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACT
CCAGTGCTCGCATTCCAAAATGCCCCTGGATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCA
GCAAGCCTGTAAAAGTTTATATAATGCCCAAACCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTT
AGGTGTCAGAATGAGCCAAGCCTGAAGCACTTCACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTA
TCAAACACAGGATAAATTGTTTCTTCATTAAAAAATAAAAAACCTTCAAGTCTACTTACCCTTCTCCTGTCCACAATAAAGTTGAGAAAA

>In-frame_ENST00000278550_ENST00000535943_TCGA-BH-A0HY-01A_TENM4_chr11_78600830_-_INTS4_chr11_77594998_length(amino acids)=447AA_start in transcript=409_stop in transcript=1752
MSAARTLFVDVEERGPEAMDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFC
RTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENT
ETDHPGGLQNHARLRTPPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWLLNSNIPLETRNL
GKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPGGTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCA

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Fusion Gene PPI Analysis for TENM4-INTS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TENM4-INTS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TENM4-INTS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTENM4C0005586Bipolar Disorder1CTD_human
HgeneTENM4C0005587Depression, Bipolar1CTD_human
HgeneTENM4C0024713Manic Disorder1CTD_human
HgeneTENM4C0033975Psychotic Disorders1PSYGENET
HgeneTENM4C0036341Schizophrenia1PSYGENET
HgeneTENM4C0338831Manic1CTD_human
HgeneTENM4C0349204Nonorganic psychosis1PSYGENET
HgeneTENM4C4225223TREMOR, HEREDITARY ESSENTIAL, 51CTD_human;UNIPROT
TgeneINTS4C0033578Prostatic Neoplasms1CTD_human
TgeneINTS4C0376358Malignant neoplasm of prostate1CTD_human