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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:TES-MET (FusionGDB2 ID:89495) |
Fusion Gene Summary for TES-MET |
Fusion gene summary |
Fusion gene information | Fusion gene name: TES-MET | Fusion gene ID: 89495 | Hgene | Tgene | Gene symbol | TES | MET | Gene ID | 26136 | 8731 |
Gene name | testin LIM domain protein | RNA guanine-7 methyltransferase | |
Synonyms | TESS|TESS-2 | CMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet | |
Cytomap | 7q31.2 | 18p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | testintestis derived transcript (3 LIM domains) | mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | Q9H1A3 | |
Ensembl transtripts involved in fusion gene | ENST00000358204, ENST00000537767, ENST00000393481, ENST00000485009, | ENST00000397752, ENST00000318493, ENST00000436117, ENST00000495962, ENST00000539704, | |
Fusion gene scores | * DoF score | 10 X 7 X 4=280 | 14 X 18 X 10=2520 |
# samples | 9 | 27 | |
** MAII score | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/2520*10)=-3.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TES [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MET(116340338)-TES(115874588), # samples:1 TES(115850788)-MET(116339125), # samples:1 TES(115850788)-MET(116371722), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MET | GO:0006370 | 7-methylguanosine mRNA capping | 27422871 |
Fusion gene breakpoints across TES (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MET (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-D7-8576-01A | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
ChimerDB4 | STAD | TCGA-D7-8576-01A | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
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Fusion Gene ORF analysis for TES-MET |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000358204 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5CDS-5UTR | ENST00000358204 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5CDS-intron | ENST00000358204 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5CDS-intron | ENST00000358204 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5CDS-intron | ENST00000358204 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5UTR-5UTR | ENST00000537767 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5UTR-5UTR | ENST00000537767 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5UTR-intron | ENST00000537767 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5UTR-intron | ENST00000537767 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
5UTR-intron | ENST00000537767 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-5UTR | ENST00000393481 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-5UTR | ENST00000393481 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-intron | ENST00000393481 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-intron | ENST00000393481 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-intron | ENST00000393481 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-5UTR | ENST00000485009 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-5UTR | ENST00000485009 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-intron | ENST00000485009 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-intron | ENST00000485009 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
intron-intron | ENST00000485009 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116339125 | + |
In-frame | ENST00000358204 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
In-frame | ENST00000358204 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
In-frame | ENST00000358204 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
5CDS-3UTR | ENST00000358204 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
5CDS-intron | ENST00000358204 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
5UTR-3CDS | ENST00000537767 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
5UTR-3CDS | ENST00000537767 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
5UTR-3CDS | ENST00000537767 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
5UTR-3UTR | ENST00000537767 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
5UTR-intron | ENST00000537767 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3CDS | ENST00000393481 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3CDS | ENST00000393481 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3CDS | ENST00000393481 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3UTR | ENST00000393481 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-intron | ENST00000393481 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3CDS | ENST00000485009 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3CDS | ENST00000485009 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3CDS | ENST00000485009 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-3UTR | ENST00000485009 | ENST00000495962 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
intron-intron | ENST00000485009 | ENST00000539704 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000358204 | TES | chr7 | 115850788 | + | ENST00000397752 | MET | chr7 | 116371722 | + | 5477 | 242 | 5 | 3214 | 1069 |
ENST00000358204 | TES | chr7 | 115850788 | + | ENST00000318493 | MET | chr7 | 116371722 | + | 3487 | 242 | 5 | 3268 | 1087 |
ENST00000358204 | TES | chr7 | 115850788 | + | ENST00000436117 | MET | chr7 | 116371722 | + | 1337 | 242 | 5 | 1336 | 444 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000358204 | ENST00000397752 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + | 0.000115863 | 0.9998841 |
ENST00000358204 | ENST00000318493 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + | 0.000171418 | 0.9998286 |
ENST00000358204 | ENST00000436117 | TES | chr7 | 115850788 | + | MET | chr7 | 116371722 | + | 0.002379813 | 0.99762017 |
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Fusion Genomic Features for TES-MET |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
TES | chr7 | 115850788 | + | MET | chr7 | 116371721 | + | 0.042319432 | 0.95768064 |
TES | chr7 | 115850788 | + | MET | chr7 | 116339124 | + | 0.000380586 | 0.99961936 |
TES | chr7 | 115850788 | + | MET | chr7 | 116371721 | + | 0.042319432 | 0.95768064 |
TES | chr7 | 115850788 | + | MET | chr7 | 116339124 | + | 0.000380586 | 0.99961936 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TES-MET |
Go to FGviewer for the breakpoints of chr7:115850788-chr7:116371722 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | MET |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 1078_1345 | 400.0 | 1409.0 | Domain | Protein kinase | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 563_655 | 400.0 | 1409.0 | Domain | Note=IPT/TIG 1 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 657_739 | 400.0 | 1409.0 | Domain | Note=IPT/TIG 2 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 742_836 | 400.0 | 1409.0 | Domain | Note=IPT/TIG 3 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 1078_1345 | 400.0 | 1391.0 | Domain | Protein kinase | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 563_655 | 400.0 | 1391.0 | Domain | Note=IPT/TIG 1 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 657_739 | 400.0 | 1391.0 | Domain | Note=IPT/TIG 2 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 742_836 | 400.0 | 1391.0 | Domain | Note=IPT/TIG 3 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 1078_1345 | 400.0 | 765.0 | Domain | Protein kinase | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 563_655 | 400.0 | 765.0 | Domain | Note=IPT/TIG 1 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 657_739 | 400.0 | 765.0 | Domain | Note=IPT/TIG 2 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 742_836 | 400.0 | 765.0 | Domain | Note=IPT/TIG 3 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 1084_1092 | 400.0 | 1409.0 | Nucleotide binding | ATP | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 1084_1092 | 400.0 | 1391.0 | Nucleotide binding | ATP | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 1084_1092 | 400.0 | 765.0 | Nucleotide binding | ATP | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 956_1390 | 400.0 | 1409.0 | Topological domain | Cytoplasmic | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 956_1390 | 400.0 | 1391.0 | Topological domain | Cytoplasmic | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 956_1390 | 400.0 | 765.0 | Topological domain | Cytoplasmic | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 933_955 | 400.0 | 1409.0 | Transmembrane | Helical | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 933_955 | 400.0 | 1391.0 | Transmembrane | Helical | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 933_955 | 400.0 | 765.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000358204 | + | 1 | 7 | 22_46 | 9.0 | 422.0 | Compositional bias | Note=Cys-rich |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000393481 | + | 1 | 7 | 22_46 | 0 | 413.0 | Compositional bias | Note=Cys-rich |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000358204 | + | 1 | 7 | 234_297 | 9.0 | 422.0 | Domain | LIM zinc-binding 1 |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000358204 | + | 1 | 7 | 299_359 | 9.0 | 422.0 | Domain | LIM zinc-binding 2 |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000358204 | + | 1 | 7 | 362_421 | 9.0 | 422.0 | Domain | LIM zinc-binding 3 |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000358204 | + | 1 | 7 | 92_199 | 9.0 | 422.0 | Domain | PET |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000393481 | + | 1 | 7 | 234_297 | 0 | 413.0 | Domain | LIM zinc-binding 1 |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000393481 | + | 1 | 7 | 299_359 | 0 | 413.0 | Domain | LIM zinc-binding 2 |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000393481 | + | 1 | 7 | 362_421 | 0 | 413.0 | Domain | LIM zinc-binding 3 |
Hgene | TES | chr7:115850788 | chr7:116371722 | ENST00000393481 | + | 1 | 7 | 92_199 | 0 | 413.0 | Domain | PET |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 27_515 | 400.0 | 1409.0 | Domain | Sema | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 27_515 | 400.0 | 1391.0 | Domain | Sema | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 27_515 | 400.0 | 765.0 | Domain | Sema | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 25_932 | 400.0 | 1409.0 | Topological domain | Extracellular | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 25_932 | 400.0 | 1391.0 | Topological domain | Extracellular | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 25_932 | 400.0 | 765.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for TES-MET |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000358204_ENST00000397752_TCGA-D7-8576-01A_TES_chr7_115850788_+_MET_chr7_116371722_length(transcript)=5477nt_BP=242nt ATTGGCTGCCCGGCCCCCTTTGTTCCCGGGTCCGGGCCGCAGGCCCGCTGCGGCGGACTGGGCGGCGGAAGTTCGACGGCGCCGGGCGAG TGGCTGTTGAGCGGCGCCGCGGGAGTTCCGCAGGTTTCCCGTGTTCGCAGCGGAGCCGGAGGCCAGCTGAACCCGGCCGTGGGATCCCGG ATAGGAGGAGGAGGGGACCCATAGGACGCGTTAACATGGACCTGGAAAACAAAGTGAAGAAGACACTTCTGAGAAATTCATCAGGCTGTG AAGCGCGCCGTGATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAA CATCTATATCCACCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGAT CAGGACCATCAACCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATG GCTACACACTGGTTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCC TCTCTGCCCCACCCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGA TCTGTCTGCCTGCAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGAT TTCGGAGGAATAATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGA ATACATTGAAATGCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACA GTACATTCTCCTATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAA ATTACCTAAACAGTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTT ATACCCCAGCCCAAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTG AAGATCCCATTGTCTATGAAATTCATCCAACCAAATCTTTTATTAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAG TTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAGCAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCT GTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGCAACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAAT ACTTTGATCTCATTTATGTACATAATCCTGTGTTTAAGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAA TTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTG AAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCC TTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTG GGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATT TGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAG ATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACT CTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAG TGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACA ATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCA TCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACA TGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCA AAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGG TTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGA TGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAG GAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAG ACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGA TCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGT CATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAG TCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGA CTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGAC CAATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTT GATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCG GCAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGAT GGTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTG CAGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCC GGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCT CAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAAT ATTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTA AGAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTA ATGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAG ATAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTG GATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGC ATTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAAT AGCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACT GGTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAA AACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAA ATGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTC ACACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAG ACACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAA ATGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACT CGGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAAC TTGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTG >In-frame_ENST00000358204_ENST00000397752_TCGA-D7-8576-01A_TES_chr7_115850788_+_MET_chr7_116371722_length(amino acids)=1069AA_start in transcript=5_stop in transcript=3214 MPGPLCSRVRAAGPLRRTGRRKFDGAGRVAVERRRGSSAGFPCSQRSRRPAEPGRGIPDRRRRGPIGRVNMDLENKVKKTLLRNSSGCEA RRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGY TLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFR RNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY LNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVS VPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIK GNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGF FLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSD ISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIM KDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVA DFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDP -------------------------------------------------------------- >In-frame_ENST00000358204_ENST00000318493_TCGA-D7-8576-01A_TES_chr7_115850788_+_MET_chr7_116371722_length(transcript)=3487nt_BP=242nt ATTGGCTGCCCGGCCCCCTTTGTTCCCGGGTCCGGGCCGCAGGCCCGCTGCGGCGGACTGGGCGGCGGAAGTTCGACGGCGCCGGGCGAG TGGCTGTTGAGCGGCGCCGCGGGAGTTCCGCAGGTTTCCCGTGTTCGCAGCGGAGCCGGAGGCCAGCTGAACCCGGCCGTGGGATCCCGG ATAGGAGGAGGAGGGGACCCATAGGACGCGTTAACATGGACCTGGAAAACAAAGTGAAGAAGACACTTCTGAGAAATTCATCAGGCTGTG AAGCGCGCCGTGATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAA CATCTATATCCACCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGAT CAGGACCATCAACCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATG GCTACACACTGGTTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCC TCTCTGCCCCACCCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGA TCTGTCTGCCTGCAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGAT TTCGGAGGAATAATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGA ATACATTGAAATGCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACA GTACATTCTCCTATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAA ATTACCTAAACAGTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTT ATACCCCAGCCCAAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTG AAGATCCCATTGTCTATGAAATTCATCCAACCAAATCTTTTATTAGTACTTGGTGGAAAGAACCTCTCAACATTGTCAGTTTTCTATTTT GCTTTGCCAGTGGTGGGAGCACAATAACAGGTGTTGGGAAAAACCTGAATTCAGTTAGTGTCCCGAGAATGGTCATAAATGTGCATGAAG CAGGAAGGAACTTTACAGTGGCATGTCAACATCGCTCTAATTCAGAGATAATCTGTTGTACCACTCCTTCCCTGCAACAGCTGAATCTGC AACTCCCCCTGAAAACCAAAGCCTTTTTCATGTTAGATGGGATCCTTTCCAAATACTTTGATCTCATTTATGTACATAATCCTGTGTTTA AGCCTTTTGAAAAGCCAGTGATGATCTCAATGGGCAATGAAAATGTACTGGAAATTAAGGGAAATGATATTGACCCTGAAGCAGTTAAAG GTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGAAGCCGTTTTATGCACGGTCCCCAATGACCTGCTGA AATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCTTGGAAAAGTAATAGTTCAACCAGATCAGAATTTCA CAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGGGTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTA AAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTTGGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAA CTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCC GACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCC ACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATG AAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCT TGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGC TCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATG AGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCC ACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATA AAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCA CCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATA TAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACC CTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATG TGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACAC GACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGAC CTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAA >In-frame_ENST00000358204_ENST00000318493_TCGA-D7-8576-01A_TES_chr7_115850788_+_MET_chr7_116371722_length(amino acids)=1087AA_start in transcript=5_stop in transcript=3268 MPGPLCSRVRAAGPLRRTGRRKFDGAGRVAVERRRGSSAGFPCSQRSRRPAEPGRGIPDRRRRGPIGRVNMDLENKVKKTLLRNSSGCEA RRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGY TLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFR RNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY LNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCF ASGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKP FEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTG LIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQ VQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN RITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHR DLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDIT VYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRP -------------------------------------------------------------- >In-frame_ENST00000358204_ENST00000436117_TCGA-D7-8576-01A_TES_chr7_115850788_+_MET_chr7_116371722_length(transcript)=1337nt_BP=242nt ATTGGCTGCCCGGCCCCCTTTGTTCCCGGGTCCGGGCCGCAGGCCCGCTGCGGCGGACTGGGCGGCGGAAGTTCGACGGCGCCGGGCGAG TGGCTGTTGAGCGGCGCCGCGGGAGTTCCGCAGGTTTCCCGTGTTCGCAGCGGAGCCGGAGGCCAGCTGAACCCGGCCGTGGGATCCCGG ATAGGAGGAGGAGGGGACCCATAGGACGCGTTAACATGGACCTGGAAAACAAAGTGAAGAAGACACTTCTGAGAAATTCATCAGGCTGTG AAGCGCGCCGTGATGAATATCGAACAGAGTTTACCACAGCTTTGCAGCGCGTTGACTTATTCATGGGTCAATTCAGCGAAGTCCTCTTAA CATCTATATCCACCTTCATTAAAGGAGACCTCACCATAGCTAATCTTGGGACATCAGAGGGTCGCTTCATGCAGGTTGTGGTTTCTCGAT CAGGACCATCAACCCCTCATGTGAATTTTCTCCTGGACTCCCATCCAGTGTCTCCAGAAGTGATTGTGGAGCATACATTAAACCAAAATG GCTACACACTGGTTATCACTGGGAAGAAGATCACGAAGATCCCATTGAATGGCTTGGGCTGCAGACATTTCCAGTCCTGCAGTCAATGCC TCTCTGCCCCACCCTTTGTTCAGTGTGGCTGGTGCCACGACAAATGTGTGCGATCGGAGGAATGCCTGAGCGGGACATGGACTCAACAGA TCTGTCTGCCTGCAATCTACAAGGTTTTCCCAAATAGTGCACCCCTTGAAGGAGGGACAAGGCTGACCATATGTGGCTGGGACTTTGGAT TTCGGAGGAATAATAAATTTGATTTAAAGAAAACTAGAGTTCTCCTTGGAAATGAGAGCTGCACCTTGACTTTAAGTGAGAGCACGATGA ATACATTGAAATGCACAGTTGGTCCTGCCATGAATAAGCATTTCAATATGTCCATAATTATTTCAAATGGCCACGGGACAACACAATACA GTACATTCTCCTATGTGGATCCTGTAATAACAAGTATTTCGCCGAAATACGGTCCTATGGCTGGTGGCACTTTACTTACTTTAACTGGAA ATTACCTAAACAGTGGGAATTCTAGACACATTTCAATTGGTGGAAAAACATGTACTTTAAAAAGTGTGTCAAACAGTATTCTTGAATGTT ATACCCCAGCCCAAACCATTTCAACTGAGTTTGCTGTTAAATTGAAAATTGACTTAGCCAACCGAGAGACAAGCATCTTCAGTTACCGTG >In-frame_ENST00000358204_ENST00000436117_TCGA-D7-8576-01A_TES_chr7_115850788_+_MET_chr7_116371722_length(amino acids)=444AA_start in transcript=5_stop in transcript=1336 MPGPLCSRVRAAGPLRRTGRRKFDGAGRVAVERRRGSSAGFPCSQRSRRPAEPGRGIPDRRRRGPIGRVNMDLENKVKKTLLRNSSGCEA RRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGY TLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFR RNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TES-MET |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 1320_1359 | 400.0 | 1409.0 | MUC20 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 1320_1359 | 400.0 | 1391.0 | MUC20 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 1320_1359 | 400.0 | 765.0 | MUC20 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000318493 | 1 | 21 | 1212_1390 | 400.0 | 1409.0 | RANBP9 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000397752 | 1 | 21 | 1212_1390 | 400.0 | 1391.0 | RANBP9 | |
Tgene | MET | chr7:115850788 | chr7:116371722 | ENST00000436117 | 0 | 9 | 1212_1390 | 400.0 | 765.0 | RANBP9 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TES-MET |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TES-MET |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TES | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | TES | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | TES | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
Hgene | TES | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |
Tgene | MET | C1306837 | Papillary Renal Cell Carcinoma | 9 | CGI;CLINGEN;CTD_human;ORPHANET |
Tgene | MET | C1336078 | Papillary renal cell carcinoma, sporadic | 7 | CLINGEN |
Tgene | MET | C1336839 | Type 1 Papillary Renal Cell Carcinoma | 5 | UNIPROT |
Tgene | MET | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CGI;CTD_human |
Tgene | MET | C1836723 | Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum | 4 | ORPHANET |
Tgene | MET | C4085248 | OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO | 4 | ORPHANET |
Tgene | MET | C0001418 | Adenocarcinoma | 2 | CTD_human |
Tgene | MET | C0004352 | Autistic Disorder | 2 | CTD_human |
Tgene | MET | C0024623 | Malignant neoplasm of stomach | 2 | CGI;CTD_human;UNIPROT |
Tgene | MET | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Tgene | MET | C0038356 | Stomach Neoplasms | 2 | CGI;CTD_human |
Tgene | MET | C0205641 | Adenocarcinoma, Basal Cell | 2 | CTD_human |
Tgene | MET | C0205642 | Adenocarcinoma, Oxyphilic | 2 | CTD_human |
Tgene | MET | C0205643 | Carcinoma, Cribriform | 2 | CTD_human |
Tgene | MET | C0205644 | Carcinoma, Granular Cell | 2 | CTD_human |
Tgene | MET | C0205645 | Adenocarcinoma, Tubular | 2 | CTD_human |
Tgene | MET | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | CTD_human |
Tgene | MET | C0004114 | Astrocytoma | 1 | CTD_human |
Tgene | MET | C0007097 | Carcinoma | 1 | CTD_human |
Tgene | MET | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | MET | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | MET | C0009241 | Cognition Disorders | 1 | CTD_human |
Tgene | MET | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | MET | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | MET | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
Tgene | MET | C0019207 | Hepatoma, Morris | 1 | CTD_human |
Tgene | MET | C0019208 | Hepatoma, Novikoff | 1 | CTD_human |
Tgene | MET | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | MET | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Tgene | MET | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | MET | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
Tgene | MET | C0025202 | melanoma | 1 | CTD_human |
Tgene | MET | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
Tgene | MET | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | MET | C0027819 | Neuroblastoma | 1 | CTD_human |
Tgene | MET | C0029463 | Osteosarcoma | 1 | CTD_human |
Tgene | MET | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | MET | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | MET | C0037199 | Sinusitis | 1 | CTD_human |
Tgene | MET | C0086404 | Experimental Hepatoma | 1 | CTD_human |
Tgene | MET | C0149519 | Chronic Persistent Hepatitis | 1 | CTD_human |
Tgene | MET | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
Tgene | MET | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
Tgene | MET | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
Tgene | MET | C0205699 | Carcinomatosis | 1 | CTD_human |
Tgene | MET | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human |
Tgene | MET | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Tgene | MET | C0279606 | Childhood Hepatocellular Carcinoma | 1 | ORPHANET |
Tgene | MET | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CGI;CTD_human |
Tgene | MET | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human |
Tgene | MET | C0280785 | Diffuse Astrocytoma | 1 | CTD_human |
Tgene | MET | C0334579 | Anaplastic astrocytoma | 1 | CTD_human |
Tgene | MET | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human |
Tgene | MET | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human |
Tgene | MET | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human |
Tgene | MET | C0334583 | Pilocytic Astrocytoma | 1 | CTD_human |
Tgene | MET | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
Tgene | MET | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human |
Tgene | MET | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | MET | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Tgene | MET | C0520463 | Chronic active hepatitis | 1 | CTD_human |
Tgene | MET | C0524611 | Cryptogenic Chronic Hepatitis | 1 | CTD_human |
Tgene | MET | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
Tgene | MET | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human |
Tgene | MET | C0750935 | Cerebral Astrocytoma | 1 | CTD_human |
Tgene | MET | C0750936 | Intracranial Astrocytoma | 1 | CTD_human |
Tgene | MET | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | MET | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
Tgene | MET | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
Tgene | MET | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
Tgene | MET | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
Tgene | MET | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |
Tgene | MET | C1704230 | Grade I Astrocytoma | 1 | CTD_human |
Tgene | MET | C1708353 | Hereditary Paraganglioma-Pheochromocytoma Syndrome | 1 | CLINGEN |
Tgene | MET | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
Tgene | MET | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
Tgene | MET | C2239176 | Liver carcinoma | 1 | CGI;CTD_human;UNIPROT |
Tgene | MET | C3711374 | Nonsyndromic Deafness | 1 | CLINGEN |
Tgene | MET | C4084709 | DEAFNESS, AUTOSOMAL RECESSIVE 97 | 1 | CTD_human;UNIPROT |