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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TESK2-GNA12 (FusionGDB2 ID:89513)

Fusion Gene Summary for TESK2-GNA12

check button Fusion gene summary
Fusion gene informationFusion gene name: TESK2-GNA12
Fusion gene ID: 89513
HgeneTgene
Gene symbol

TESK2

GNA12

Gene ID

10420

2768

Gene nametestis associated actin remodelling kinase 2G protein subunit alpha 12
Synonyms-NNX3|RMP|gep
Cytomap

1p34.1

7p22.3-p22.2

Type of geneprotein-codingprotein-coding
Descriptiondual specificity testis-specific protein kinase 2testicular protein kinase 2testis-specific kinase 2guanine nucleotide-binding protein subunit alpha-12WUGSC:H_GS165O14.2g alpha-12guanine nucleotide binding protein (G protein) alpha 12
Modification date2020032020200313
UniProtAcc.

Q03113

Ensembl transtripts involved in fusion geneENST00000372084, ENST00000372086, 
ENST00000341771, ENST00000486676, 
ENST00000538496, ENST00000451835, 
ENST00000275364, ENST00000544127, 
ENST00000491117, ENST00000407904, 
ENST00000407653, ENST00000396960, 
Fusion gene scores* DoF score11 X 8 X 7=6167 X 6 X 4=168
# samples 139
** MAII scorelog2(13/616*10)=-2.24441872766645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TESK2 [Title/Abstract] AND GNA12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTESK2(45851584)-GNA12(2834777), # samples:3
Anticipated loss of major functional domain due to fusion event.TESK2-GNA12 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TESK2-GNA12 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TESK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GNA12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EK-A2IR-01ATESK2chr1

45851584

-GNA12chr7

2834777

-
ChimerDB4CESCTCGA-EK-A2IR-01ATESK2chr1

45851584

-GNA12chr7

2834777

-
ChimerDB4CESCTCGA-EK-A2IR-01ATESK2chr1

45851584

-GNA12chr7

2834777

-


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Fusion Gene ORF analysis for TESK2-GNA12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000372084ENST00000275364TESK2chr1

45851584

-GNA12chr7

2834777

-
In-frameENST00000372084ENST00000544127TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372084ENST00000491117TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372084ENST00000407904TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372084ENST00000407653TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372084ENST00000396960TESK2chr1

45851584

-GNA12chr7

2834777

-
Frame-shiftENST00000372086ENST00000275364TESK2chr1

45851584

-GNA12chr7

2834777

-
Frame-shiftENST00000372086ENST00000544127TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372086ENST00000491117TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372086ENST00000407904TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372086ENST00000407653TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000372086ENST00000396960TESK2chr1

45851584

-GNA12chr7

2834777

-
Frame-shiftENST00000341771ENST00000275364TESK2chr1

45851584

-GNA12chr7

2834777

-
Frame-shiftENST00000341771ENST00000544127TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000341771ENST00000491117TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000341771ENST00000407904TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000341771ENST00000407653TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000341771ENST00000396960TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-3CDSENST00000486676ENST00000275364TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-3CDSENST00000486676ENST00000544127TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000486676ENST00000491117TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000486676ENST00000407904TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000486676ENST00000407653TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000486676ENST00000396960TESK2chr1

45851584

-GNA12chr7

2834777

-
Frame-shiftENST00000538496ENST00000275364TESK2chr1

45851584

-GNA12chr7

2834777

-
Frame-shiftENST00000538496ENST00000544127TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000538496ENST00000491117TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000538496ENST00000407904TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000538496ENST00000407653TESK2chr1

45851584

-GNA12chr7

2834777

-
5CDS-intronENST00000538496ENST00000396960TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-3CDSENST00000451835ENST00000275364TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-3CDSENST00000451835ENST00000544127TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000451835ENST00000491117TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000451835ENST00000407904TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000451835ENST00000407653TESK2chr1

45851584

-GNA12chr7

2834777

-
intron-intronENST00000451835ENST00000396960TESK2chr1

45851584

-GNA12chr7

2834777

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372084TESK2chr145851584-ENST00000275364GNA12chr72834777-4313407141243409
ENST00000372084TESK2chr145851584-ENST00000544127GNA12chr72834777-1560407141192392

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372084ENST00000275364TESK2chr145851584-GNA12chr72834777-0.0026023760.99739766
ENST00000372084ENST00000544127TESK2chr145851584-GNA12chr72834777-0.0056590090.994341

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Fusion Genomic Features for TESK2-GNA12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TESK2-GNA12


check button Go to

FGviewer for the breakpoints of chr1:45851584-chr7:2834777

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GNA12

Q03113

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). {ECO:0000250|UniProtKB:P27600, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:15980433, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:17565996, ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:23762476, ECO:0000269|PubMed:27084452}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTESK2chr1:45851584chr7:2834777ENST00000341771-41064_72131.0543.0Nucleotide bindingATP
HgeneTESK2chr1:45851584chr7:2834777ENST00000372084-3964_72131.0543.0Nucleotide bindingATP
HgeneTESK2chr1:45851584chr7:2834777ENST00000372086-41164_72131.0572.0Nucleotide bindingATP
TgeneGNA12chr1:45851584chr7:2834777ENST0000027536404202_205103.0382.0Nucleotide bindingGTP
TgeneGNA12chr1:45851584chr7:2834777ENST0000027536404296_299103.0382.0Nucleotide bindingGTP
TgeneGNA12chr1:45851584chr7:2834777ENST0000027536404200_208103.0382.0RegionG2 motif
TgeneGNA12chr1:45851584chr7:2834777ENST0000027536404223_232103.0382.0RegionG3 motif
TgeneGNA12chr1:45851584chr7:2834777ENST0000027536404292_299103.0382.0RegionG4 motif
TgeneGNA12chr1:45851584chr7:2834777ENST0000027536404351_356103.0382.0RegionG5 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTESK2chr1:45851584chr7:2834777ENST00000341771-41058_313131.0543.0DomainProtein kinase
HgeneTESK2chr1:45851584chr7:2834777ENST00000372084-3958_313131.0543.0DomainProtein kinase
HgeneTESK2chr1:45851584chr7:2834777ENST00000372086-41158_313131.0572.0DomainProtein kinase
TgeneGNA12chr1:45851584chr7:2834777ENST000002753640456_381103.0382.0DomainG-alpha
TgeneGNA12chr1:45851584chr7:2834777ENST000002753640467_72103.0382.0Nucleotide bindingGTP
TgeneGNA12chr1:45851584chr7:2834777ENST000002753640459_72103.0382.0RegionG1 motif


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Fusion Gene Sequence for TESK2-GNA12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000372084_ENST00000275364_TCGA-EK-A2IR-01A_TESK2_chr1_45851584_-_GNA12_chr7_2834777_length(transcript)=4313nt_BP=407nt
TGATTATTTAGACTATGGATCGGAGCAAACGGAATTCAATTGCAGGATTTCCTCCACGTGTGGAGCGTCTTGAAGAGTTTGAAGGAGGTG
GTGGAGGAGAAGGAAATGTGAGCCAGGTGGGAAGAGTTTGGCCATCTTCGTATCGAGCTCTTATAAGTGCCTTTTCCAGACTGACGCGTT
TGGATGATTTCACCTGTGAAAAAATAGGGTCTGGCTTCTTTTCTGAAGTGTTCAAGGTACGACACCGAGCTTCTGGTCAGGTGATGGCTC
TTAAGATGAACACATTGAGCAGTAACCGGGCAAACATGCTGAAAGAAGTACAGCTCATGAATAGACTCTCCCATCCCAACATCCTTAGGT
TCATGGGTGTATGTGTTCATCAAGGACAATTGCATGCACTTACAGAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTC
CTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCC
AGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGGGAGT
CGGTGAAGTACTTCCTGGACAACTTGGACCGGATCGGCCAGCTGAATTACTTTCCTAGTAAGCAAGATATCCTGCTGGCTAGGAAAGCCA
CCAAGGGAATTGTGGAGCATGACTTCGTTATTAAGAAGATCCCCTTTAAGATGGTGGATGTGGGCGGCCAGCGGTCCCAGCGCCAGAAGT
GGTTCCAGTGCTTCGACGGGATCACGTCCATCCTGTTCATGGTCTCCTCCAGCGAGTACGACCAGGTCCTCATGGAGGACAGGCGCACCA
ACCGGCTGGTGGAGTCCATGAACATCTTCGAGACCATCGTCAACAACAAGCTCTTCTTCAACGTCTCCATCATTCTCTTCCTCAACAAGA
TGGACCTCCTGGTGGAGAAGGTGAAGACCGTGAGCATCAAGAAGCACTTCCCGGACTTCAGGGGCGACCCGCACAGGCTGGAGGACGTCC
AGCGCTACCTGGTCCAGTGCTTCGACAGGAAGAGACGGAACCGCAGCAAGCCACTCTTCCACCACTTCACCACCGCCATCGACACCGAGA
ACGTCCGCTTCGTGTTCCATGCTGTGAAAGACACCATCCTGCAGGAGAACCTGAAGGACATCATGCTGCAGTGAGCGAGGAAGCCCCGGG
GTTTGTCGTCGTTGAGCAGCCCCCACGGCTGTCGGTCAGACTCTTGGGTGTGTGTTGTCTGTGTGGTCCTTGAGTGGGTTTCTCGGATCC
GTGCCCTGGAATACCTGGCTCAGGAATGCTGTCAGACCAGCCAGCCAGCGAGCTCTAGGCAAAAGGACATGGAAACTGTCACGTTAGCTA
CTGAATCCTGGGGGCGAGTGAAACTACTGAAAATCCGAGTGATGATGTTGTGAATACGGAACACCTAATCACACAGCTTGCTTTGCTTTT
ACAGAAACGTTCCTCTTTTTCTGACGCAGTTTAATTGAGGACCGTGTTGTGTGTGTATGTGTGTACACACGCTCTGTCTTTAATGACAGA
AACACAAAAACCAGCTGGCCTTGCAGACGGCTTTTCTAACTCACAAGTCTTCCCTGAGACAGACTAACCTGAAAGCTTTGCCTAACAGTA
GCTTGTAGAGATCCAGTGCACGCCGATGCTGCTAAACTCAGTGCCTGAGCCCGGCCCTGCAGCCCCAGCCGCAGTGTCTGAAGGCCACCT
CCCAAAGGGAGCACGTTGCCTTTTCAAACTCCCGTGCCGATTTCCTAAGAGCCCCTAGTCCAAGCCTCTCAGATGAAGCTGAGGAGCCGT
GCCTAGGATCCCTTCCCAGCTCTGAGGACGGGCTGCAGAGCTCTGCAGGTGTGGATTCACCTTACGCCCCTACAGCAGGCTCAGCCCTTC
CCACCCTGCCCCATGCCCAGCAGCACAACACGGAGTGAGACAGGATGCCCACGGTGACTGCCGCTCCGTCCGTGCACACACAGCGGTGCT
CTTCTCCCCTTAGCCACCCACTGCCCAACCCAACGGCAAAGACACAGAAACCAGGTCCCCTTGCAGACGGCTCTCCCATCTTCCTGCAAG
TCATCTGCTCACACACAGTTGGCAGCACATAGCGTTTCCTTCTTTCAGAAACATTCCTCTTCTGGGGCTTCAGAAAGCTGGCAAGGCCAC
TAGCAGAGCTTTTGTTAATGCCCCAGCTGCTTGGCGAGCTAACAGCTGACCTTTCGGGAAGCCCACAGACGCTGGAGGAATCTTGAGTTT
CTCCAAACTGCCGCTCCACCAGTGCCTTTGGACAGCCGTGCCTGTTCGCCGCTCTCCCTAAGTCTGATTCTCATCGAGGCCCCTCGCTTC
TATGACTGTGCTTGCAGAAGAGTAAACACTCTCGGATGCCGCTGTCCTGGGGGAGCCCGCGGGAGCCTGTGAATGTTGATACGAGCTGGC
CAGTCCTGGGCCCAGCTCACTTGTCCAGCTACCTGCCAGGTGGCTTTCACTGTGTTTAAAATACATTGCATTCCAAGCTGGTCCCCTCTG
TGTATCACTCTACTGAGAAATCCTGCCTAGTGTGTTTTGGGATGTGTCCTAGCATTTACAAGAAAATGAAAAGCGTCCTCTTAATTGGCA
CCCGAATGTTGCTGTGGCTCAGTCACATATCCCAGGGCCCTCGTCCCGAGGCCGTGCTGCCCCGAGCCCCGAGCCCCTCTGCAGCTCACC
CTTGGCTTGTTTTCCGCAAACCCGGTAAACGCAAGCCCTTGGGGCAGATGCAGAAGCAGAAGAGGGAGGGGAAACCTGCCTCTGGGTCAC
CCTGTTAGCACAGCGTTCTCATCGGGAGACAGCATGGAACTCTCTCTCGCAGTGCTCGAGGCTGTGTGTCAGTGTTTGCTGGGCTTGTGG
CTCCTTTTTTGGCTGGATAAAGAAGTCGCTGTTTTTGTACTGCTTCTGTGGCTCTTCACAGACCTCACGGATGTGACCGGAGATGAGTGC
CGATGACCACGTTTTAAAGGAGAAAGAGAGCTCCTGGTGGGGCCCTCGGGGTGGTCTCAGGTCCCATTTGCAGTCTGCAACAGTGACGCG
CAGCCCGGTCCGGAGCGTGGTGAGCTTTGTTTGCCTTCTGGGTCAGCTTTCGCTGTGTCTCCTGTGTGTGTTAGAATCCAGAGCCCAGAG
GAAGTGCAAGCGGGTCCTCCGCCAACGGGGAGAGCCTCTTCGCGGCGCTGTTGGCGACAGCAGCGCTGTGATTCGCGTAGCAGGGGAGTT
GTTTGAAACACCTTCCTGAGTAGTCCGGCCTTGTCAATGAGTGCTTGTTTTCCTTTAAACAGTCTGACATATTTACTCGTCACTTTCAAA
CCAGAAGCATGAGAGGAAGGAGATATTGTGGGGTCCGTTTAACTCGATAGAAAGCGCAGGGGGATGGCCCCCGGCGCGGGCTCTTGACCC
GCTCAGCGCTGACCCCACCGCCCTGGCCGAGGCACTTGGCCTTGCTGAGCTGGACTTCCTCCTCCTCCTCCTCATGACCGGGGTGAATTA
GAACGTTTTTAAAGACACCCCCTTCCAAATTCTGTAACACATTGTAATTGGAGAAGAAGGAAACTCTGCAAGGCTAAACTGTCATTCACA
ACTTGGCTACACATAGACTCTAGTCAGTTTTGTCTCCAGAACCTTAGGCTTTTGTATTTTTTAATTTTAATTTCACTGTTAATCCTTATT
GTCTTTTTTATTAAGATGTTGGAAAAGCAGGAGGTAGTTGTGCCTCAATTATTGCAAAAATGTAACAATAAAGTTCCTCAAAATAAGATC
TGTTCCTCATAGCTATACTGTGTACACATAAGACGCATATAGGGTTTTACTGAAATCTATTTTTAACTCTTATGTTCGTAGAGAAATTGT
TTCAAGGATTTTGAGTCATAGGTCTGTAATTTATAGAGATCTCTAGAATTCTTATTGTAATTTTCCTACTTCTTTGATAAAAGAAAAATA
AGTCAGATTGTTAACTCCAAGATTGAAAAAAAAAACTCTTGAAAGAAGATTATTAGTTGTAACTAATTTAGGGGTTCTGGGCACAGACAT
CTAACCTGGTATTGTAAGGCAGAGGCTCCCATTGGAATGGTAGTGGTCCGGGTCAGTTGTTCATGGTGTAAGCTTTGCACAGTGTATTAA

>In-frame_ENST00000372084_ENST00000275364_TCGA-EK-A2IR-01A_TESK2_chr1_45851584_-_GNA12_chr7_2834777_length(amino acids)=409AA_start in transcript=14_stop in transcript=1243
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRASGQVMALKMNT
LSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVP
ALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCF
DGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLV

--------------------------------------------------------------
>In-frame_ENST00000372084_ENST00000544127_TCGA-EK-A2IR-01A_TESK2_chr1_45851584_-_GNA12_chr7_2834777_length(transcript)=1560nt_BP=407nt
TGATTATTTAGACTATGGATCGGAGCAAACGGAATTCAATTGCAGGATTTCCTCCACGTGTGGAGCGTCTTGAAGAGTTTGAAGGAGGTG
GTGGAGGAGAAGGAAATGTGAGCCAGGTGGGAAGAGTTTGGCCATCTTCGTATCGAGCTCTTATAAGTGCCTTTTCCAGACTGACGCGTT
TGGATGATTTCACCTGTGAAAAAATAGGGTCTGGCTTCTTTTCTGAAGTGTTCAAGGTACGACACCGAGCTTCTGGTCAGGTGATGGCTC
TTAAGATGAACACATTGAGCAGTAACCGGGCAAACATGCTGAAAGAAGTACAGCTCATGAATAGACTCTCCCATCCCAACATCCTTAGGT
TCATGGGTGTATGTGTTCATCAAGGACAATTGCATGCACTTACAGAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTC
CTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCC
AGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGAATTACT
TTCCTAGTAAGCAAGATATCCTGCTGGCTAGGAAAGCCACCAAGGGAATTGTGGAGCATGACTTCGTTATTAAGAAGATCCCCTTTAAGA
TGGTGGATGTGGGCGGCCAGCGGTCCCAGCGCCAGAAGTGGTTCCAGTGCTTCGACGGGATCACGTCCATCCTGTTCATGGTCTCCTCCA
GCGAGTACGACCAGGTCCTCATGGAGGACAGGCGCACCAACCGGCTGGTGGAGTCCATGAACATCTTCGAGACCATCGTCAACAACAAGC
TCTTCTTCAACGTCTCCATCATTCTCTTCCTCAACAAGATGGACCTCCTGGTGGAGAAGGTGAAGACCGTGAGCATCAAGAAGCACTTCC
CGGACTTCAGGGGCGACCCGCACAGGCTGGAGGACGTCCAGCGCTACCTGGTCCAGTGCTTCGACAGGAAGAGACGGAACCGCAGCAAGC
CACTCTTCCACCACTTCACCACCGCCATCGACACCGAGAACGTCCGCTTCGTGTTCCATGCTGTGAAAGACACCATCCTGCAGGAGAACC
TGAAGGACATCATGCTGCAGTGAGCGAGGAAGCCCCGGGGTTTGTCGTCGTTGAGCAGCCCCCACGGCTGTCGGTCAGACTCTTGGGTGT
GTGTTGTCTGTGTGGTCCTTGAGTGGGTTTCTCGGATCCGTGCCCTGGAATACCTGGCTCAGGAATGCTGTCAGACCAGCCAGCCAGCGA
GCTCTAGGCAAAAGGACATGGAAACTGTCACGTTAGCTACTGAATCCTGGGGGCGAGTGAAACTACTGAAAATCCGAGTGATGATGTTGT
GAATACGGAACACCTAATCACACAGCTTGCTTTGCTTTTACAGAAACGTTCCTCTTTTTCTGACGCAGTTTAATTGAGGACCGTGTTGTG

>In-frame_ENST00000372084_ENST00000544127_TCGA-EK-A2IR-01A_TESK2_chr1_45851584_-_GNA12_chr7_2834777_length(amino acids)=392AA_start in transcript=14_stop in transcript=1192
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRASGQVMALKMNT
LSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVP
ALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQ
VLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHH

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Fusion Gene PPI Analysis for TESK2-GNA12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TESK2-GNA12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TESK2-GNA12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTESK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGNA12C0009324Ulcerative Colitis1CTD_human
TgeneGNA12C0033975Psychotic Disorders1PSYGENET
TgeneGNA12C0151744Myocardial Ischemia1CTD_human
TgeneGNA12C0349204Nonorganic psychosis1PSYGENET